{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:47:51Z","timestamp":1793321271449,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006250","name":"Southwest University","doi-asserted-by":"publisher","award":["SWU-XDPY22010"],"award-info":[{"award-number":["SWU-XDPY22010"]}],"id":[{"id":"10.13039\/501100006250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["SWU-KT24013"],"award-info":[{"award-number":["SWU-KT24013"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012459","name":"Chongqing Graduate Student Research Innovation Project","doi-asserted-by":"publisher","award":["CYB240128"],"award-info":[{"award-number":["CYB240128"]}],"id":[{"id":"10.13039\/501100012459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-LZX0018"],"award-info":[{"award-number":["CSTB2024NSCQ-LZX0018"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["cstc2021jcyj-cxtt0005"],"award-info":[{"award-number":["cstc2021jcyj-cxtt0005"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.actbio.2025.12.043","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:16:20Z","timestamp":1766535380000},"page":"235-250","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["A silk fibroin\/tannic acid hydrogel with acid-enhanced adhesion and procoagulant nanofiber reinforcement for gastric hemorrhage management"],"prefix":"10.1016","volume":"212","author":[{"given":"Qing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangqian","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2025.12.043_bib0001","doi-asserted-by":"crossref","first-page":"l536","DOI":"10.1136\/bmj.l536","article-title":"Management of acute upper gastrointestinal bleeding","volume":"364","author":"Stanley","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.actbio.2025.12.043_bib0002","doi-asserted-by":"crossref","first-page":"899","DOI":"10.14309\/ajg.0000000000001245","article-title":"ACG clinical guideline: upper gastrointestinal and ulcer bleeding","volume":"116","author":"Laine","year":"2021","journal-title":"AM. J. Gastroenterol."},{"key":"10.1016\/j.actbio.2025.12.043_bib0003","article-title":"Sprayable hydrogel sealant for gastrointestinal wound shielding","volume":"36","author":"Taboada","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2025.12.043_bib0004","doi-asserted-by":"crossref","first-page":"5983","DOI":"10.1039\/D4MH00837E","article-title":"Ionically assembled hemostatic powders with rapid self-gelation, strong acid resistance, and on-demand removability for upper gastrointestinal bleeding","volume":"11","author":"Liu","year":"2024","journal-title":"Mater Horiz."},{"key":"10.1016\/j.actbio.2025.12.043_bib0005","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.3748\/wjg.v30.i15.2087","article-title":"Advancements in hemostatic strategies for managing upper gastrointestinal bleeding: a comprehensive review","volume":"30","author":"Lee","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.actbio.2025.12.043_bib0006","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12890-024-02993-z","article-title":"Transient pulmonary and gastric bleeding after iopamidol administration in a patient with marginal zone lymphoma: a case report","volume":"24","author":"Xu","year":"2024","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.actbio.2025.12.043_bib0007","doi-asserted-by":"crossref","first-page":"2411959","DOI":"10.1002\/adfm.202411959","article-title":"Bio-inspired self-healing hydrogel for fast hemostasis and accelerated wound healing of gastric ulcers","volume":"35","author":"Wen","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2025.12.043_bib0008","doi-asserted-by":"crossref","first-page":"376","DOI":"10.4253\/wjge.v16.i7.376","article-title":"Advancements in endoscopic hemostasis for non-variceal upper gastrointestinal bleeding","volume":"16","author":"Li","year":"2024","journal-title":"World J. Gastro Endos"},{"key":"10.1016\/j.actbio.2025.12.043_bib0009","doi-asserted-by":"crossref","first-page":"6449","DOI":"10.1126\/sciadv.abl6449","article-title":"Injectable hydrogel microspheres with self-renewable hydration layers alleviate osteoarthritis","volume":"8","author":"Lei","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.actbio.2025.12.043_bib0010","doi-asserted-by":"crossref","first-page":"2","DOI":"10.7326\/M21-0975","article-title":"Comparison of a hemostatic powder and standard treatment in the control of active bleeding from upper nonvariceal lesions","volume":"175","author":"Lau","year":"2022","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.actbio.2025.12.043_bib0011","doi-asserted-by":"crossref","first-page":"805","DOI":"10.7326\/M19-1795","article-title":"Management of nonvariceal upper gastrointestinal bleeding: guideline recommendations from the international consensus group","volume":"171","author":"Barkun","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.actbio.2025.12.043_bib0012","doi-asserted-by":"crossref","first-page":"2109332","DOI":"10.1002\/adfm.202109332","article-title":"Adhesive hemostatic hydrogel with ultrafast gelation arrests acute upper gastrointestinal hemorrhage in pigs","volume":"32","author":"Xia","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2025.12.043_bib0013","doi-asserted-by":"crossref","first-page":"2405290","DOI":"10.1002\/adma.202405290","article-title":"Blue laser triggered hemostatic peptide hydrogel for gastrointestinal bleeding treatment","volume":"36","author":"Luo","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2025.12.043_bib0014","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s40820-020-00585-0","article-title":"Injectable self-healing adhesive pH-responsive hydrogels accelerate gastric hemostasis and wound healing","volume":"13","author":"He","year":"2021","journal-title":"Nano Micro Lett."},{"key":"10.1016\/j.actbio.2025.12.043_bib0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41570-024-00673-4","article-title":"Catechol redox maintenance in mussel adhesion","volume":"9","author":"Wang","year":"2025","journal-title":"Nat. Rev. Chem."},{"key":"10.1016\/j.actbio.2025.12.043_bib0016","doi-asserted-by":"crossref","first-page":"202419684","DOI":"10.1002\/anie.202419684","article-title":"Electrosynthesis of mussel-inspired adhesive polymers as a novel class of transient enzyme stabilizers","volume":"64","author":"Neubert","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.actbio.2025.12.043_bib0017","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1126\/science.adl2002","article-title":"A dynamic biointerface controls mussel adhesion","volume":"382","author":"Pan","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.actbio.2025.12.043_bib0018","doi-asserted-by":"crossref","first-page":"2004786","DOI":"10.1002\/advs.202004786","article-title":"Bioinspired biomaterial composite for all-water-based high-performance adhesives","volume":"8","author":"Presti","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.actbio.2025.12.043_bib0019","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nnano.2014.199","article-title":"Strong underwater adhesives made by self-assembling multi-protein nanofibres","volume":"9","author":"Zhong","year":"2014","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.actbio.2025.12.043_bib0020","doi-asserted-by":"crossref","first-page":"2302442","DOI":"10.1002\/adfm.202302442","article-title":"Precipitation-based silk fibroin fast gelling, highly adhesive, and magnetic nanocomposite hydrogel for repair of irregular bone defects","volume":"33","author":"Zou","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2025.12.043_bib0021","doi-asserted-by":"crossref","first-page":"2307628","DOI":"10.1002\/smll.202307628","article-title":"Natural underwater bioadhesive offering cohesion modulation via hydrogen bond disruptor: a highly injectable and in vivo stable remedy for gastric ulcer resolution","volume":"20","author":"Wang","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.actbio.2025.12.043_bib0022","doi-asserted-by":"crossref","first-page":"2303153","DOI":"10.1002\/adhm.202303153","article-title":"A drop-by-drop self-assembled all-natural hydrogel as a desensitizer for rapid and enduring management of Dentin hypersensitivity","volume":"13","author":"Gao","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.actbio.2025.12.043_bib0023","doi-asserted-by":"crossref","first-page":"101908","DOI":"10.1016\/j.progpolymsci.2024.101908","article-title":"The multifaceted role of tannic acid: from its extraction and structure to antibacterial properties and applications","volume":"160","author":"Hosseini","year":"2025","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.actbio.2025.12.043_bib0024","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.mattod.2023.03.027","article-title":"Emerging silk fibroin materials and their applications: new functionality arising from innovations in silk crosslinking","volume":"65","author":"Tran","year":"2023","journal-title":"Mater. Today"},{"key":"10.1016\/j.actbio.2025.12.043_bib0025","doi-asserted-by":"crossref","first-page":"2406909","DOI":"10.1002\/smll.202406909","article-title":"Artificial plateletoids recruit blood proteins to shield symbiotic thrombin: a silk fibroin\/calcium interface medicated thrombin generation and preservation","volume":"21","author":"Shi","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.actbio.2025.12.043_bib0026","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41929-021-00654-6","article-title":"Unusual zymogen activation patterns in the protein corona of Ca-zeolites","volume":"4","author":"Shang","year":"2021","journal-title":"Nat. Catal."},{"key":"10.1016\/j.actbio.2025.12.043_bib0027","doi-asserted-by":"crossref","first-page":"2403679","DOI":"10.1002\/adhm.202403679","article-title":"Nanofiber-based multifunctional microspheres for rapid hemostasis and microorganism removal of water","volume":"14","author":"Li","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.actbio.2025.12.043_bib0028","doi-asserted-by":"crossref","first-page":"2404811","DOI":"10.1002\/adma.202404811","article-title":"An injectable hydrogel with ultrahigh burst pressure and innate antibacterial activity for emergency hemostasis and wound repair","volume":"36","author":"Yang","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2025.12.043_bib0029","doi-asserted-by":"crossref","first-page":"161262","DOI":"10.1016\/j.cej.2025.161262","article-title":"A mussel-inspired wet-adhesive prolonged-acting antibacterial hydrogels for the treatment of periodontitis","volume":"509","author":"Fan","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2025.12.043_bib0030","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1039\/C9NH00317G","article-title":"A silk-based sealant with tough adhesion for instant hemostasis of bleeding tissues","volume":"4","author":"Bai","year":"2019","journal-title":"Nanoscale Horiz."},{"key":"10.1016\/j.actbio.2025.12.043_bib0031","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s42765-023-00280-w","article-title":"Gemini dressing with both super-hydrophilicity and -hydrophobicity pursuing isolation of blood cells for hemostasis and wound healing","volume":"5","author":"Li","year":"2023","journal-title":"Adv. Fiber Mater."},{"key":"10.1016\/j.actbio.2025.12.043_bib0032","doi-asserted-by":"crossref","first-page":"2417801","DOI":"10.1002\/adma.202417801","article-title":"Andrias davidianus derived glycosaminoglycans direct diabetic wound repair by reprogramming reparative macrophage glucolipid metabolism","volume":"37","author":"Yang","year":"2025","journal-title":"Adv. Mater"},{"key":"10.1016\/j.actbio.2025.12.043_bib0033","first-page":"2829","article-title":"A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings","volume":"6","author":"Qiao","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2025.12.043_bib0034","doi-asserted-by":"crossref","first-page":"2419037","DOI":"10.1002\/adfm.202419037","article-title":"Network-remodeling, electroactive and antibacterial cryogel with tissue sealing and pro-coagulant activity for hemostasis and skin wound healing","author":"Luo","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2025.12.043_bib0035","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1038\/s41467-024-49933-3","article-title":"Neutrophil extracellular traps-inspired DNA hydrogel for wound hemostatic adjuvant","volume":"15","author":"Ye","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.12.043_bib0036","doi-asserted-by":"crossref","first-page":"103425","DOI":"10.1016\/j.cis.2025.103425","article-title":"Recent advances in tannic acid-based gels: design, properties, and applications","volume":"339","author":"Tang","year":"2025","journal-title":"Adv. Colloid Interface"},{"key":"10.1016\/j.actbio.2025.12.043_bib0037","doi-asserted-by":"crossref","first-page":"1908381","DOI":"10.1002\/adfm.201908381","article-title":"Bioinspired mineral\u2013Organic bone adhesives for stable fracture fixation and accelerated bone regeneration","volume":"30","author":"Bai","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2025.12.043_bib0038","doi-asserted-by":"crossref","first-page":"2210764","DOI":"10.1002\/adfm.202210764","article-title":"Silk fibroin as sustainable advanced material: material properties and characteristics, processing, and applications","volume":"33","author":"Reizabal","year":"2023","journal-title":"Adv. Funct. Mater"},{"key":"10.1016\/j.actbio.2025.12.043_bib0039","first-page":"1","article-title":"Physically cross-linked cellulose nanofiber (LCNF\/CNF) hydrogels: impact of the composition on mechanical and swelling properties","volume":"8","author":"Baraka","year":"2025","journal-title":"Adv. Compos. Hybrid MA"},{"key":"10.1016\/j.actbio.2025.12.043_bib0040","doi-asserted-by":"crossref","first-page":"2401278","DOI":"10.1002\/advs.202401278","article-title":"Bioinspired mechanically robust and recyclable hydrogel microfibers based on hydrogen-bond nanoclusters","volume":"11","author":"Liang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.actbio.2025.12.043_bib0041","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/s41467-025-56726-9","article-title":"Molecular self-assembly strategy tuning a dry crosslinking protein patch for biocompatible and biodegradable haemostatic sealing","volume":"16","author":"Yu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2025.12.043_bib0042","doi-asserted-by":"crossref","first-page":"122240","DOI":"10.1016\/j.biomaterials.2023.122240","article-title":"Hemostatic patch with ultra-strengthened mechanical properties for efficient adhesion to wet surfaces","volume":"301","author":"Zheng","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2025.12.043_bib0043","doi-asserted-by":"crossref","first-page":"2401030","DOI":"10.1002\/adfm.202401030","article-title":"Novel natural polymer-based hydrogel patches with Janus asymmetric-adhesion for emergency hemostasis and wound healing","volume":"34","author":"Sun","year":"2024","journal-title":"Adv. Funct. Mater."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174270612500950X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174270612500950X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:01:30Z","timestamp":1778824890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S174270612500950X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":43,"alternative-id":["S174270612500950X"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2025.12.043","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A silk fibroin\/tannic acid hydrogel with acid-enhanced adhesion and procoagulant nanofiber reinforcement for gastric hemorrhage management","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2025.12.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}