{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:00:25Z","timestamp":1792623625345,"version":"4.5.0"},"reference-count":106,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["426335750"],"award-info":[{"award-number":["426335750"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010570","name":"Lower Saxony State Ministry of Science and Culture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010570","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005624","name":"Medizinischen Hochschule Hannover","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005624","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000825","name":"Institute of Biomedical Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["390874280"],"award-info":[{"award-number":["390874280"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["101158172"],"award-info":[{"award-number":["101158172"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["852178"],"award-info":[{"award-number":["852178"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["101100859"],"award-info":[{"award-number":["101100859"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011937","name":"Nieders\u00e4chsische Ministerium f\u00fcr Wissenschaft und Kultur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032750","name":"Instituto de Biologia Experimental e Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030859","name":"REBIRTH HANNOVER Forschungszentrum f\u00fcr translationale regenerative Medizin","doi-asserted-by":"publisher","award":["ZN3340"],"award-info":[{"award-number":["ZN3340"]}],"id":[{"id":"10.13039\/100030859","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030859","name":"REBIRTH HANNOVER Forschungszentrum f\u00fcr translationale regenerative Medizin","doi-asserted-by":"publisher","award":["LA 3680\/9-1"],"award-info":[{"award-number":["LA 3680\/9-1"]}],"id":[{"id":"10.13039\/100030859","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.actbio.2026.01.017","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:59:14Z","timestamp":1767891554000},"page":"266-280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Commensal microflora coating endows implants with biofilm-repellent, immunomodulatory and osteogenic properties"],"prefix":"10.1016","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6694-9882","authenticated-orcid":false,"given":"Muhammad Imran","family":"Rahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shehneela","family":"Baseer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6857-8784","authenticated-orcid":false,"given":"Daniela","family":"Paasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Steglich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0340-9648","authenticated-orcid":false,"given":"Syed Fakhar H.","family":"Waqas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4245-1497","authenticated-orcid":false,"given":"Nico","family":"Lachmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine S.","family":"Falk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Stiesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.actbio.2026.01.017_bib0001","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/adem.200700287","article-title":"Biomaterials for Tissue Engineering","volume":"9","author":"Eisenbarth","year":"2007","journal-title":"Advanced Engineering Materials"},{"issue":"2","key":"10.1016\/j.actbio.2026.01.017_bib0002","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201600791","article-title":"Biomaterials and Culture Technologies for Regenerative Therapy of Liver Tissue","volume":"6","author":"Perez","year":"2017","journal-title":"Advanced Healthcare Materials"},{"issue":"153","key":"10.1016\/j.actbio.2026.01.017_bib0003","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004528","article-title":"Biomaterial-associated infection: locating the finish line in the race for the surface","volume":"4","author":"Busscher","year":"2012","journal-title":"Sci Transl Med"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0004","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tim.2004.11.010","article-title":"Survival strategies of infectious biofilms","volume":"13","author":"Fux","year":"2005","journal-title":"Trends in Microbiology"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jcma.2017.07.012","article-title":"Bacterial biofilm and associated infections","volume":"81","author":"Jamal","year":"2018","journal-title":"J Chin Med Assoc"},{"issue":"12","key":"10.1016\/j.actbio.2026.01.017_bib0006","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1007\/s00784-020-03646-1","article-title":"Bioadhesion in the oral cavity and approaches for biofilm management by surface modifications","volume":"24","author":"Sterzenbach","year":"2020","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.actbio.2026.01.017_bib0007","unstructured":"Z. Yin, Y. Liu, A. Anniwaer, Y. You, J. Guo, Y. Tang, L. Fu, L. Yi, C. Huang, Rational Designs of Biomaterials for Combating Oral Biofilm Infections, Advanced Materials n\/a(n\/a) 2305633."},{"issue":"2","key":"10.1016\/j.actbio.2026.01.017_bib0008","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4103\/1735-3327.95239","article-title":"Microflora around teeth and dental implants","volume":"9","author":"Shahabouee","year":"2012","journal-title":"Dent Res J (Isfahan)"},{"issue":"S26","key":"10.1016\/j.actbio.2026.01.017_bib0009","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/jcpe.13822","article-title":"Supportive care for the prevention of disease recurrence\/progression following peri-implantitis treatment: A systematic review","volume":"50","author":"Stiesch","year":"2023","journal-title":"Journal of Clinical Periodontology"},{"issue":"5","key":"10.1016\/j.actbio.2026.01.017_bib0010","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/jre.12562","article-title":"Epidemiology and risk factors of peri-implantitis: A systematic review","volume":"53","author":"Dreyer","year":"2018","journal-title":"Journal of Periodontal Research"},{"issue":"10","key":"10.1016\/j.actbio.2026.01.017_bib0011","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/s41415-024-7402-z","article-title":"Peri-implant mucositis and peri-implantitis: key features and differences","volume":"236","author":"Heitz-Mayfield","year":"2024","journal-title":"British Dental Journal"},{"key":"10.1016\/j.actbio.2026.01.017_bib0012","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2491714","article-title":"Peri-Implant Bone Loss and Peri-Implantitis: A Report of Three Cases and Review of the Literature","volume":"2016","author":"John","year":"2016","journal-title":"Case Reports in Dentistry"},{"key":"10.1016\/j.actbio.2026.01.017_bib0013","article-title":"Immune dysregulation and macrophage polarization in peri-implantitis","volume":"12","author":"Li","year":"2024","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"key":"10.1016\/j.actbio.2026.01.017_bib0014","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.csbj.2021.02.010","article-title":"The oralome and its dysbiosis: New insights into oral microbiome-host interactions","volume":"19","author":"Radaic","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"issue":"11","key":"10.1016\/j.actbio.2026.01.017_bib0015","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.tibtech.2015.09.002","article-title":"Antibacterial Coatings: Challenges, Perspectives, and Opportunities","volume":"33","author":"Cloutier","year":"2015","journal-title":"Trends in Biotechnology"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0016","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41578-021-00362-4","article-title":"Biomaterial-based antimicrobial therapies for the treatment of bacterial infections","volume":"7","author":"Kalelkar","year":"2022","journal-title":"Nature Reviews Materials"},{"key":"10.1016\/j.actbio.2026.01.017_bib0017","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bioactmat.2024.08.042","article-title":"Surface modification strategies to reinforce the soft tissue seal at transmucosal region of dental implants","volume":"42","author":"Jin","year":"2024","journal-title":"Bioactive Materials"},{"issue":"44","key":"10.1016\/j.actbio.2026.01.017_bib0018","doi-asserted-by":"crossref","first-page":"eabb0025","DOI":"10.1126\/sciadv.abb0025","article-title":"Antibacterial infection and immune-evasive coating for orthopedic implants","volume":"6","author":"Chae","year":"2020","journal-title":"Science Advances"},{"issue":"22","key":"10.1016\/j.actbio.2026.01.017_bib0019","doi-asserted-by":"crossref","first-page":"E4960","DOI":"10.1073\/pnas.1801013115","article-title":"Hydrogel delivery of lysostaphin eliminates orthopedic implant infection by Staphylococcus aureus and supports fracture healing","volume":"115","author":"Johnson","year":"2018","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0020","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1038\/s41467-021-25383-z","article-title":"Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge","volume":"12","author":"Xi","year":"2021","journal-title":"Nature Communications"},{"issue":"7","key":"10.1016\/j.actbio.2026.01.017_bib0021","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41579-018-0019-y","article-title":"Implant infections: adhesion, biofilm formation and immune evasion","volume":"16","author":"Arciola","year":"2018","journal-title":"Nature Reviews Microbiology"},{"issue":"6","key":"10.1016\/j.actbio.2026.01.017_bib0022","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.mayocp.2018.11.005","article-title":"The Slow-Motion Catastrophe of Antimicrobial Resistance and Practical Interventions for All Prescribers","volume":"94","author":"Lesho","year":"2019","journal-title":"Mayo Clin Proc"},{"issue":"6327","key":"10.1016\/j.actbio.2026.01.017_bib0023","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.aaj2191","article-title":"Antibiotic tolerance facilitates the evolution of resistance","volume":"355","author":"Levin-Reisman","year":"2017","journal-title":"Science"},{"issue":"192","key":"10.1016\/j.actbio.2026.01.017_bib0024","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006055","article-title":"Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells","volume":"5","author":"Kalghatgi","year":"2013","journal-title":"Sci Transl Med"},{"issue":"10","key":"10.1016\/j.actbio.2026.01.017_bib0025","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41579-022-00682-4","article-title":"Tolerance and resistance of microbial biofilms","volume":"20","author":"Ciofu","year":"2022","journal-title":"Nature Reviews Microbiology"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0026","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41392-024-01866-5","article-title":"Bacterial persisters: molecular mechanisms and therapeutic development","volume":"9","author":"Niu","year":"2024","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"745","key":"10.1016\/j.actbio.2026.01.017_bib0027","doi-asserted-by":"crossref","first-page":"eade1683","DOI":"10.1126\/scisignal.ade1683","article-title":"Antibiotic-induced inflammation","volume":"15","author":"VanHook","year":"2022","journal-title":"Science Signaling"},{"key":"10.1016\/j.actbio.2026.01.017_bib0028","doi-asserted-by":"crossref","first-page":"112","DOI":"10.22203\/eCM.v028a09","article-title":"Challenges in linking preclinical anti-microbial research strategies with clinical outcomes for device-associated infections","volume":"28","author":"Moriarty","year":"2014","journal-title":"Eur Cell Mater"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0029","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s40824-022-00326-x","article-title":"Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies","volume":"26","author":"Dong","year":"2022","journal-title":"Biomaterials Research"},{"issue":"43","key":"10.1016\/j.actbio.2026.01.017_bib0030","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202002962","article-title":"Combating Implant Infections: Shifting Focus from Bacteria to Host","volume":"32","author":"Amin Yavari","year":"2020","journal-title":"Advanced Materials"},{"issue":"4","key":"10.1016\/j.actbio.2026.01.017_bib0031","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201801106","article-title":"Current Advances in Immunomodulatory Biomaterials for Bone Regeneration","volume":"8","author":"Lee","year":"2019","journal-title":"Advanced Healthcare Materials"},{"issue":"4","key":"10.1016\/j.actbio.2026.01.017_bib0032","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.chom.2011.10.004","article-title":"Role of the Commensal Microbiota in Normal and Pathogenic Host Immune Responses","volume":"10","author":"Littman","year":"2011","journal-title":"Cell Host & Microbe"},{"issue":"3","key":"10.1016\/j.actbio.2026.01.017_bib0033","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tim.2017.09.008","article-title":"Oral Biofilms: Pathogens, Matrix, and Polymicrobial Interactions in Microenvironments","volume":"26","author":"Bowen","year":"2018","journal-title":"Trends Microbiol"},{"issue":"Volume 73, 2019","key":"10.1016\/j.actbio.2026.01.017_bib0034","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-micro-090817-062503","article-title":"Biogeography of the Oral Microbiome: The Site-Specialist Hypothesis","volume":"73","author":"Mark Welch","year":"2019","journal-title":"Annual Review of Microbiology"},{"issue":"2","key":"10.1016\/j.actbio.2026.01.017_bib0035","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cels.2022.12.010","article-title":"Controlling the human microbiome","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Systems"},{"issue":"6","key":"10.1016\/j.actbio.2026.01.017_bib0036","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41579-022-00833-7","article-title":"Microbiota-mediated colonization resistance: mechanisms and regulation","volume":"21","author":"Caballero-Flores","year":"2023","journal-title":"Nature Reviews Microbiology"},{"issue":"12","key":"10.1016\/j.actbio.2026.01.017_bib0037","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","article-title":"The oral microbiota: dynamic communities and host interactions","volume":"16","author":"Lamont","year":"2018","journal-title":"Nature Reviews Microbiology"},{"issue":"19","key":"10.1016\/j.actbio.2026.01.017_bib0038","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1128\/JB.00542-10","article-title":"The human oral microbiome","volume":"192","author":"Dewhirst","year":"2010","journal-title":"J Bacteriol"},{"key":"10.1016\/j.actbio.2026.01.017_bib0039","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fcimb.2019.00282","article-title":"Commensal and Pathogenic Biofilms Alter Toll-Like Receptor Signaling in Reconstructed Human Gingiva","volume":"9","author":"Shang","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.actbio.2026.01.017_bib0040","doi-asserted-by":"crossref","DOI":"10.3402\/jom.v7.26941","article-title":"Modulation of host responses by oral commensal bacteria","volume":"7","author":"Devine","year":"2015","journal-title":"J Oral Microbiol"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0041","article-title":"Subgingival microbiome in patients with healthy and ailing dental implants","volume":"5","author":"Zheng","year":"2015","journal-title":"Scientific Reports"},{"issue":"12","key":"10.1016\/j.actbio.2026.01.017_bib0042","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.tim.2005.09.006","article-title":"Oral microbial communities in sickness and in health","volume":"13","author":"Jenkinson","year":"2005","journal-title":"Trends in Microbiology"},{"issue":"11","key":"10.1016\/j.actbio.2026.01.017_bib0043","doi-asserted-by":"crossref","DOI":"10.1128\/jb.00257-22","article-title":"Oral Commensal Streptococci: Gatekeepers of the Oral Cavity","volume":"204","author":"Baty","year":"2022","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.actbio.2026.01.017_bib0044","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01203","article-title":"Commensal Bacteria: An Emerging Player in Defense Against Respiratory Pathogens","volume":"10","author":"Khan","year":"2019","journal-title":"Frontiers in Immunology"},{"issue":"6","key":"10.1016\/j.actbio.2026.01.017_bib0045","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.chom.2020.03.012","article-title":"Commensal Bacteria Modulate Immunoglobulin A Binding in Response to Host Nutrition","volume":"27","author":"Huus","year":"2020","journal-title":"Cell Host & Microbe"},{"key":"10.1016\/j.actbio.2026.01.017_bib0046","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2018.03323","article-title":"Exploiting the Oral Microbiome to Prevent Tooth Decay: Has Evolution Already Provided the Best Tools?","volume":"9","author":"Baker","year":"2019","journal-title":"Frontiers in Microbiology"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0047","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0165-5876(01)00581-X","article-title":"A nasal spray with alpha-haemolytic streptococci as long term prophylaxis against recurrent otitis media","volume":"62","author":"Tano","year":"2002","journal-title":"International Journal of Pediatric Otorhinolaryngology"},{"issue":"7280","key":"10.1016\/j.actbio.2026.01.017_bib0048","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1136\/bmj.322.7280.210","article-title":"Effect of recolonisation with \"interfering\" alpha streptococci on recurrences of acute and secretory otitis media in children: randomised placebo controlled trial","volume":"322","author":"Roos","year":"2001","journal-title":"Bmj"},{"key":"10.1016\/j.actbio.2026.01.017_bib0049","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1129060","article-title":"Use of Streptococcus salivarius K12 in supporting the mucosal immune function of active young subjects: A randomised double-blind study","volume":"14","author":"Bertuccioli","year":"2023","journal-title":"Frontiers in Immunology"},{"issue":"46","key":"10.1016\/j.actbio.2026.01.017_bib0050","doi-asserted-by":"crossref","first-page":"eaba5723","DOI":"10.1126\/sciadv.aba5723","article-title":"Engineered probiotics biofilm enhances osseointegration via immunoregulation and anti-infection","volume":"6","author":"Tan","year":"2020","journal-title":"Science Advances"},{"issue":"3","key":"10.1016\/j.actbio.2026.01.017_bib0051","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/omi.12216","article-title":"Streptococcus oralis maintains homeostasis in oral biofilms by antagonizing the cariogenic pathogen Streptococcus mutans","volume":"33","author":"Thurnheer","year":"2018","journal-title":"Molecular oral microbiology"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0052","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1186\/s12879-018-3576-9","article-title":"Probiotics Streptococcus salivarius 24SMB and Streptococcus oralis 89a interfere with biofilm formation of pathogens of the upper respiratory tract","volume":"18","author":"Bidossi","year":"2018","journal-title":"BMC Infectious Diseases"},{"issue":"5","key":"10.1016\/j.actbio.2026.01.017_bib0053","doi-asserted-by":"crossref","DOI":"10.3390\/cells9051226","article-title":"In Vitro Effects of Streptococcus oralis Biofilm on Peri-Implant Soft Tissue Cells","volume":"9","author":"Ingendoh-Tsakmakidis","year":"2020","journal-title":"Cells"},{"issue":"23","key":"10.1016\/j.actbio.2026.01.017_bib0054","article-title":"Multilayered Adsorption of Commensal Microflora on Implant Surfaces: an Unconventional and Innovative Method to Prevent Bacterial Infections Associated with Biomaterials","volume":"8","author":"Rahim","year":"2021","journal-title":"Advanced Materials Interfaces"},{"key":"10.1016\/j.actbio.2026.01.017_bib0055","series-title":"Method for coating a medical device and coated medical device","author":"Stiesch","year":"2022"},{"key":"10.1016\/j.actbio.2026.01.017_bib0056","article-title":"Effects of sandblasting and acid etching on the surface properties of additively manufactured and machined titanium and their consequences for osteoblast adhesion under different storage conditions","author":"Akbas","year":"2025","journal-title":"Frontiers in Bioengineering and Biotechnology Volume 13 - 2025"},{"key":"10.1016\/j.actbio.2026.01.017_bib0057","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1227148","article-title":"Effect of titanium implants along with silver ions and tetracycline on type I interferon-beta expression during implant-related infections in co-culture and mouse model","volume":"11","author":"Rahim","year":"2023","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"issue":"17","key":"10.1016\/j.actbio.2026.01.017_bib0058","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"issue":"19","key":"10.1016\/j.actbio.2026.01.017_bib0059","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1093\/bioinformatics\/btw354","article-title":"MultiQC: summarize analysis results for multiple tools and samples in a single report","volume":"32","author":"Ewels","year":"2016","journal-title":"Bioinformatics"},{"issue":"14","key":"10.1016\/j.actbio.2026.01.017_bib0060","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/bioinformatics\/btu153","article-title":"Prokka: rapid prokaryotic genome annotation","volume":"30","author":"Seemann","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.actbio.2026.01.017_bib0061","unstructured":"H. Li, Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM, arXiv preprint arXiv:1303.3997 (2013)."},{"issue":"2","key":"10.1016\/j.actbio.2026.01.017_bib0062","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"GigaScience"},{"issue":"2","key":"10.1016\/j.actbio.2026.01.017_bib0063","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giab007","article-title":"HTSlib: C library for reading\/writing high-throughput sequencing data","volume":"10","author":"Bonfield","year":"2021","journal-title":"GigaScience"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0064","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00917-20","article-title":"FADU: a Quantification Tool for Prokaryotic Transcriptomic Analyses","volume":"6","author":"Chung","year":"2021","journal-title":"mSystems"},{"issue":"12","key":"10.1016\/j.actbio.2026.01.017_bib0065","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biology"},{"issue":"2","key":"10.1016\/j.actbio.2026.01.017_bib0066","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3390\/biomedicines10020286","article-title":"Bacterial-Specific Induction of Inflammatory Cytokines Significantly Decreases upon Dual Species Infections of Implant Materials with Periodontal Pathogens in a Mouse Model","volume":"10","author":"Rahim","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.actbio.2026.01.017_bib0067","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1227148","article-title":"Effect of titanium implants along with silver ions and tetracycline on type I interferon-beta expression during implant-related infections in co-culture and mouse model","volume":"11","author":"Rahim","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"issue":"8","key":"10.1016\/j.actbio.2026.01.017_bib0068","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0221234","article-title":"Gene expression of Porphyromonas gingivalis ATCC 33277 when growing in an in vitro multispecies biofilm","volume":"14","author":"Romero-Lastra","year":"2019","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.actbio.2026.01.017_bib0069","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183572","article-title":"Morphologic, phenotypic, and transcriptomic characterization of classically and alternatively activated canine blood-derived macrophages in vitro","volume":"12","author":"Heinrich","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0070","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1742-2094-8-58","article-title":"Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types","volume":"8","author":"Vereyken","year":"2011","journal-title":"Journal of Neuroinflammation"},{"issue":"47","key":"10.1016\/j.actbio.2026.01.017_bib0071","doi-asserted-by":"crossref","first-page":"E7554","DOI":"10.1073\/pnas.1607235113","article-title":"Gut microbiota induce IGF-1 and promote bone formation and growth","volume":"113","author":"Yan","year":"2016","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"3","key":"10.1016\/j.actbio.2026.01.017_bib0072","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ajpath.2014.11.008","article-title":"Oncostatin M, an Inflammatory Cytokine Produced by Macrophages, Supports Intramembranous Bone Healing in a Mouse Model of Tibia Injury","volume":"185","author":"Guihard","year":"2015","journal-title":"The American Journal of Pathology"},{"issue":"3","key":"10.1016\/j.actbio.2026.01.017_bib0073","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1432-0436.1990.tb00619.x","article-title":"Regulation of alkaline phosphatase and alpha 2(I) procollagen synthesis during early intramembranous bone formation in the rat mandible","volume":"44","author":"Zernik","year":"1990","journal-title":"Differentiation"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0074","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/clr.12160","article-title":"Antibiotic resistance in human peri-implantitis microbiota","volume":"25","author":"Rams","year":"2014","journal-title":"Clinical Oral Implants Research"},{"issue":"2","key":"10.1016\/j.actbio.2026.01.017_bib0075","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/jbm.b.31152","article-title":"Biomaterial and antibiotic strategies for peri-implantitis: A review","volume":"88B","author":"Norowski","year":"2009","journal-title":"Journal of Biomedical Materials Research Part B: Applied Biomaterials"},{"issue":"10","key":"10.1016\/j.actbio.2026.01.017_bib0076","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13078","article-title":"Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model","volume":"21","author":"Ingendoh-Tsakmakidis","year":"2019","journal-title":"Cell Microbiol"},{"issue":"6","key":"10.1016\/j.actbio.2026.01.017_bib0077","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1111\/j.1365-2672.2004.02420.x","article-title":"Identification of early microbial colonizers in human dental biofilm","volume":"97","author":"Li","year":"2004","journal-title":"J Appl Microbiol"},{"issue":"12","key":"10.1016\/j.actbio.2026.01.017_bib0078","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1016\/j.bioactmat.2021.05.003","article-title":"Calcium phosphate-based materials regulate osteoclast-mediated osseointegration","volume":"6","author":"Wang","year":"2021","journal-title":"Bioactive Materials"},{"key":"10.1016\/j.actbio.2026.01.017_bib0079","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.bioactmat.2022.06.020","article-title":"Improving hydroxyapatite coating ability on biodegradable metal through laser-induced hydrothermal coating in liquid precursor: Application in orthopedic implants","volume":"25","author":"Park","year":"2023","journal-title":"Bioactive Materials"},{"issue":"15","key":"10.1016\/j.actbio.2026.01.017_bib0080","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.1021\/acs.langmuir.3c00091","article-title":"Influence of Surface Roughness, Nanostructure, and Wetting on Bacterial Adhesion","volume":"39","author":"Mu","year":"2023","journal-title":"Langmuir"},{"issue":"4","key":"10.1016\/j.actbio.2026.01.017_bib0081","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.chom.2023.02.009","article-title":"Oral polymicrobial communities: Assembly, function, and impact on diseases","volume":"31","author":"Hajishengallis","year":"2023","journal-title":"Cell Host & Microbe"},{"issue":"7","key":"10.1016\/j.actbio.2026.01.017_bib0082","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1136\/gutjnl-2014-309059","article-title":"Antibiotics promote inflammation through the translocation of native commensal colonic bacteria","volume":"65","author":"Knoop","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.actbio.2026.01.017_bib0083","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111570","article-title":"The salivary pellicle on dental biomaterials","volume":"200","author":"Fischer","year":"2021","journal-title":"Colloids and Surfaces B: Biointerfaces"},{"issue":"10","key":"10.1016\/j.actbio.2026.01.017_bib0084","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1007\/s00784-023-05230-9","article-title":"Salivary pellicle modulates biofilm formation on titanium surfaces","volume":"27","author":"Mart\u00ednez-Hern\u00e1ndez","year":"2023","journal-title":"Clinical Oral Investigations"},{"issue":"9","key":"10.1016\/j.actbio.2026.01.017_bib0085","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.bbamem.2006.05.017","article-title":"Lipopolysaccharide (Endotoxin)-host defense antibacterial peptides interactions: Role in bacterial resistance and prevention of sepsis","volume":"1758","author":"Rosenfeld","year":"2006","journal-title":"Biochimica et Biophysica Acta (BBA) - Biomembranes"},{"issue":"9","key":"10.1016\/j.actbio.2026.01.017_bib0086","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.peptides.2010.06.001","article-title":"Antibiotic-induced Porphyromonas gingivalis LPS release and inhibition of LPS-stimulated cytokines by antimicrobial peptides","volume":"31","author":"Walters","year":"2010","journal-title":"Peptides"},{"issue":"8","key":"10.1016\/j.actbio.2026.01.017_bib0087","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.stem.2022.07.006","article-title":"Wound healing, fibroblast heterogeneity, and fibrosis","volume":"29","author":"Talbott","year":"2022","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0088","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1038\/s41598-017-03780-z","article-title":"Image based Machine Learning for identification of macrophage subsets","volume":"7","author":"Rostam","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.actbio.2026.01.017_bib0089","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10020313","article-title":"Functions of ROS in Macrophages and Antimicrobial Immunity","author":"Herb","year":"2021","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0090","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bbrc.2005.03.133","article-title":"Macrophages overexpressing tartrate-resistant acid phosphatase show altered profile of free radical production and enhanced capacity of bacterial killing","volume":"331","author":"R\u00e4is\u00e4nen","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0091","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/bbrc.2001.5715","article-title":"Tartrate-resistant acid phosphatase facilitates hydroxyl radical formation and colocalizes with phagocytosed Staphylococcus aureus in alveolar macrophages","volume":"288","author":"R\u00e4is\u00e4nen","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"10.1016\/j.actbio.2026.01.017_bib0092","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00476-23","article-title":"Macrophage fate: to kill or not to kill?","volume":"92","author":"Marrufo","year":"2024","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.actbio.2026.01.017_bib0093","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in Tissue Repair, Regeneration, and Fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.actbio.2026.01.017_bib0094","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.actbio.2020.12.016","article-title":"Macrophage-derived oncostatin M\/bone morphogenetic protein 6 in response to Mg-based materials influences pro-osteogenic activity of human umbilical cord perivascular cells","volume":"133","author":"Wang","year":"2021","journal-title":"Acta Biomaterialia"},{"issue":"4","key":"10.1016\/j.actbio.2026.01.017_bib0095","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/stem.1040","article-title":"Induction of Osteogenesis in Mesenchymal Stem Cells by Activated Monocytes\/Macrophages Depends on Oncostatin M Signaling","volume":"30","author":"Guihard","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.actbio.2026.01.017_bib0096","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110348","article-title":"Oncostatin M regulates macrophages polarization in osseointegration via yes-associated protein","volume":"120","author":"Yuan","year":"2023","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.actbio.2026.01.017_bib0097","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115627","article-title":"Bone regeneration is mediated by macrophage extracellular vesicles","volume":"141","author":"Kang","year":"2020","journal-title":"Bone"},{"issue":"10","key":"10.1016\/j.actbio.2026.01.017_bib0098","doi-asserted-by":"crossref","DOI":"10.3390\/nu12102999","article-title":"Macrophage Polarization and Osteoporosis: A Review","volume":"12","author":"Mu\u00f1oz","year":"2020","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0099","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41421-024-00689-6","article-title":"Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis","volume":"10","author":"Zhu","year":"2024","journal-title":"Cell Discovery"},{"key":"10.1016\/j.actbio.2026.01.017_bib0100","article-title":"The Bone Extracellular Matrix in Bone Formation and Regeneration","author":"Lin","year":"2020","journal-title":"Frontiers in Pharmacology Volume 11 - 2020"},{"issue":"1","key":"10.1016\/j.actbio.2026.01.017_bib0101","doi-asserted-by":"crossref","first-page":"7199","DOI":"10.1038\/s41467-021-27563-3","article-title":"Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta","volume":"12","author":"Chen","year":"2021","journal-title":"Nat Commun"},{"issue":"10","key":"10.1016\/j.actbio.2026.01.017_bib0102","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19106212","article-title":"Nanoporous Titanium Enriched with Calcium and Phosphorus Promotes Human Oral Osteoblast Bioactivity","volume":"19","author":"Pierfelice","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"9","key":"10.1016\/j.actbio.2026.01.017_bib0103","doi-asserted-by":"crossref","first-page":"10118","DOI":"10.1021\/acsami.9b22741","article-title":"Targeting Pathogenic Biofilms: Newly Developed Superhydrophobic Coating Favors a Host-Compatible Microbial Profile on the Titanium Surface","volume":"12","author":"Souza","year":"2020","journal-title":"ACS Applied Materials & Interfaces"},{"key":"10.1016\/j.actbio.2026.01.017_bib0104","doi-asserted-by":"crossref","DOI":"10.1016\/j.diamond.2023.110022","article-title":"Diamond-like carbon (DLC)-coated titanium surface inhibits bacterial growth and modulates human alveolar bone cell responses in vitro","volume":"136","author":"Jongwannasiri","year":"2023","journal-title":"Diamond and Related Materials"},{"key":"10.1016\/j.actbio.2026.01.017_bib0105","series-title":"MG-63 and FetMSC Cell Response on Atomic Layer Deposited TiO2 Nanolayers Prepared Using Titanium Tetrachloride and Tetraisopropoxide","author":"Nazarov","year":"2022"},{"key":"10.1016\/j.actbio.2026.01.017_bib0106","series-title":"A Titanium-Based Superhydrophobic Coating with Enhanced Antibacterial, Anticoagulant, and Anticorrosive Properties for Dental Applications","author":"Rao","year":"2024"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126000267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126000267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:01:10Z","timestamp":1778824870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126000267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":106,"alternative-id":["S1742706126000267"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.01.017","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Commensal microflora coating endows implants with biofilm-repellent, immunomodulatory and osteogenic properties","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}