{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:36:51Z","timestamp":1791772611639,"version":"4.3.4"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["FOR5628"],"award-info":[{"award-number":["FOR5628"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["RTG2260"],"award-info":[{"award-number":["RTG2260"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["460333672 CRC1540 EBM"],"award-info":[{"award-number":["460333672 CRC1540 EBM"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["540759292 Sa901\/33-1 M5"],"award-info":[{"award-number":["540759292 Sa901\/33-1 M5"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["CRC1340 Matrix-in-vision"],"award-info":[{"award-number":["CRC1340 Matrix-in-vision"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.actbio.2026.02.002","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T01:10:09Z","timestamp":1770253809000},"page":"508-520","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["In vivo wideband MR elastography for assessing age-related viscoelasticity changes of the human brain"],"prefix":"10.1016","volume":"213","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3654-4578","authenticated-orcid":false,"given":"Jakob","family":"Schattenfroh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein S.","family":"Aghamiry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5647-593X","authenticated-orcid":false,"given":"Noah","family":"Jaitner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8511-0800","authenticated-orcid":false,"given":"Michael","family":"Fedders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2255-590X","authenticated-orcid":false,"given":"Steffen","family":"G\u00f6rner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6494-0833","authenticated-orcid":false,"given":"Helge","family":"Herthum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Hetzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1847-7870","authenticated-orcid":false,"given":"Melanie","family":"Estrella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Fl\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1490-947X","authenticated-orcid":false,"given":"Paul","family":"Steinmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2460-1444","authenticated-orcid":false,"given":"Ingolf","family":"Sack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"145","key":"10.1016\/j.actbio.2026.02.002_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pnmrs.2024.05.002","article-title":"Magnetic resonance elastography in a nutshell: Tomographic imaging of soft tissue viscoelasticity for detecting and staging disease with a focus on inflammation","volume":"144","author":"Meyer","year":"2024","journal-title":"Prog. Nucl. Magn. Reson. Spectrosc."},{"key":"10.1016\/j.actbio.2026.02.002_bib0002","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.neuroimage.2009.02.040","article-title":"The impact of aging and gender on brain viscoelasticity","volume":"46","author":"Sack","year":"2009","journal-title":"NeuroImage"},{"key":"10.1016\/j.actbio.2026.02.002_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2022.119590","article-title":"Mapping brain mechanical property maturation from childhood to adulthood","volume":"263","author":"McIlvain","year":"2022","journal-title":"NeuroImage"},{"key":"10.1016\/j.actbio.2026.02.002_bib0004","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/jmri.28747","article-title":"Magnetic resonance elastography in the study of neurodegenerative diseases","volume":"59","author":"Feng","year":"2024","journal-title":"J. Magn. Reson. Imaging JMRI"},{"key":"10.1016\/j.actbio.2026.02.002_bib0005","doi-asserted-by":"crossref","first-page":"fcz049","DOI":"10.1093\/braincomms\/fcz049","article-title":"Mechanical property alterations across the cerebral cortex due to Alzheimer\u2019s disease","volume":"2","author":"Hiscox","year":"2020","journal-title":"Brain Commun."},{"key":"10.1016\/j.actbio.2026.02.002_bib0006","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neurobiolaging.2025.01.001","article-title":"Brain mechanical properties predict longitudinal cognitive change in aging and Alzheimer\u2019s disease","volume":"147","author":"Pavuluri","year":"2025","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.actbio.2026.02.002_bib0007","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.nicl.2013.09.006","article-title":"Cerebral magnetic resonance elastography in supranuclear palsy and idiopathic Parkinson\u2019s disease","volume":"3","author":"Lipp","year":"2013","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.actbio.2026.02.002_bib0008","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1007\/s00330-017-5269-y","article-title":"Progressive supranuclear palsy and idiopathic Parkinson\u2019s disease are associated with local reduction of in vivo brain viscoelasticity","volume":"28","author":"Lipp","year":"2018","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2024.103606","article-title":"Low-frequency MR elastography reveals altered deep gray matter viscoelasticity in multiple sclerosis","volume":"42","author":"Kiss","year":"2024","journal-title":"NeuroImage Clin"},{"key":"10.1016\/j.actbio.2026.02.002_bib0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s00401-023-02658-x","article-title":"Cortical matrix remodeling as a hallmark of relapsing\u2013remitting neuroinflammation in MR elastography and quantitative MRI","volume":"147","author":"Silva","year":"2024","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"10.1016\/j.actbio.2026.02.002_bib0011","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3174\/ajnr.A5415","article-title":"MR elastography analysis of glioma stiffness and IDH1 -mutation status","volume":"39","author":"Pepin","year":"2018","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.102109","article-title":"REVIEW: MR elastography of brain tumors","volume":"25","author":"Bunevicius","year":"2020","journal-title":"NeuroImage Clin"},{"key":"10.1016\/j.actbio.2026.02.002_bib0013","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3390\/cancers14040884","article-title":"Inducing biomechanical heterogeneity in brain tumor modeling by MR elastography: effects on tumor growth, vascular density and delivery of therapeutics","volume":"14","author":"Harkos","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.actbio.2026.02.002_bib0014","first-page":"1","article-title":"Biomechanical stiffness of gliomas, meningiomas, and schwannomas assessed by MR elastography and virtual MR elastography: correlation with clinicopathological features","author":"He","year":"2025","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.actbio.2026.02.002_bib0015","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.1002\/hbm.25192","article-title":"Standard-space atlas of the viscoelastic properties of the human brain, Hum","volume":"41","author":"Hiscox","year":"2020","journal-title":"Brain Mapp"},{"key":"10.1016\/j.actbio.2026.02.002_bib0016","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.3174\/ajnr.A7117","article-title":"Relationship between shear stiffness measured by MR Elastography and perfusion metrics measured by perfusion CT of meningiomas","volume":"42","author":"Takamura","year":"2021","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.1056131","article-title":"Cerebral tomoelastography based on multifrequency MR elastography in two and three dimensions","volume":"10","author":"Herthum","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0018","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.nicl.2017.12.023","article-title":"Combining viscoelasticity, diffusivity and volume of the hippocampus for the diagnosis of Alzheimer\u2019s disease based on magnetic resonance imaging","volume":"18","author":"Gerischer","year":"2018","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.actbio.2026.02.002_bib0019","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jmbbm.2017.06.027","article-title":"Viscoelastic power law parameters of in vivo human brain estimated by MR elastography","volume":"74","author":"Testu","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2026.02.002_bib0020","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.actbio.2020.12.027","article-title":"Superviscous properties of the in vivo brain at large scales","volume":"121","author":"Herthum","year":"2021","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2026.02.002_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2022.105613","article-title":"Mechanical behavior of the hippocampus and corpus callosum: An attempt to reconcile ex vivo with in vivo and micro with macro properties","volume":"138","author":"Bertalan","year":"2023","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2026.02.002_bib0022","article-title":"The networking brain: how extracellular matrix, cellular networks, and vasculature shape the in vivo mechanical properties of the brain","volume":"11","author":"Bergs","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.actbio.2026.02.002_bib0023","doi-asserted-by":"crossref","first-page":"7275","DOI":"10.1088\/0031-9155\/57\/22\/7275","article-title":"Brain mechanical property measurement using MRE with intrinsic activation","volume":"57","author":"Weaver","year":"2012","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0024","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.acra.2020.03.009","article-title":"Poroelastic mechanical properties of the brain tissue of normal pressure hydrocephalus patients during lumbar drain treatment using intrinsic actuation MR elastography","volume":"28","author":"Solamen","year":"2021","journal-title":"Acad. Radiol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0025","article-title":"Cerebral stiffness changes during visual stimulation: differential physiological mechanisms characterized by opposing mechanical effects","volume":"1","author":"Forouhandehpour","year":"2021","journal-title":"Neuroimage Rep"},{"key":"10.1016\/j.actbio.2026.02.002_bib0026","doi-asserted-by":"crossref","DOI":"10.1098\/rsfs.2024.0058","article-title":"The pulsing brain: state of the art and an interdisciplinary perspective","volume":"15","author":"Lecchini-Visintini","year":"2025","journal-title":"Interface Focus"},{"key":"10.1016\/j.actbio.2026.02.002_bib0027","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1118\/1.4905048","article-title":"Suitability of poroelastic and viscoelastic mechanical models for high and low frequency MR elastography","volume":"42","author":"McGarry","year":"2015","journal-title":"Med. Phys."},{"key":"10.1016\/j.actbio.2026.02.002_bib0028","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ac9e40","article-title":"Theory of sleep\/wake cycles affecting brain elastography","volume":"67","author":"Ge","year":"2022","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0029","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/acc922","article-title":"Fluid compartments influence elastography of the aging mouse brain","volume":"68","author":"Ge","year":"2023","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0030","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ad4446","article-title":"Brain elastography in aging relates to fluid\/solid trendlines","volume":"69","author":"Parker","year":"2024","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0031","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12987-025-00668-3","article-title":"Perivascular interactions and tissue properties modulate directional glymphatic transport in the brain","volume":"22","author":"Li","year":"2025","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.actbio.2026.02.002_bib0032","doi-asserted-by":"crossref","first-page":"6575","DOI":"10.1002\/hbm.26524","article-title":"Estimating the viscoelastic properties of the human brain at 7 T MRI using intrinsic MRE and nonlinear inversion, Hum","volume":"44","author":"Burman Ingeberg","year":"2023","journal-title":"Brain Mapp"},{"key":"10.1016\/j.actbio.2026.02.002_bib0033","article-title":"Evaluating the performance and repeatability of poroelastic and poroviscoelastic models in intrinsic MR elastography","volume":"38","author":"Burman Ingeberg","year":"2025","journal-title":"NMR Biomed"},{"key":"10.1016\/j.actbio.2026.02.002_bib0034","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1177\/0271678X17691530","article-title":"Perfusion alters stiffness of deep gray matter","volume":"38","author":"Hetzer","year":"2018","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.actbio.2026.02.002_bib0035","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1002\/mrm.26006","article-title":"In vivo wideband multifrequency MR elastography of the human brain and liver","volume":"76","author":"Dittmann","year":"2016","journal-title":"Magn. Reson. Med"},{"key":"10.1016\/j.actbio.2026.02.002_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.media.2025.103642","article-title":"ElastoNet: Neural network-based multicomponent MR elastography wave inversion with uncertainty quantification","volume":"105","author":"Bustin","year":"2025","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.actbio.2026.02.002_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.media.2016.01.001","article-title":"Tomoelastography by multifrequency wave number recovery from time-harmonic propagating shear waves","volume":"30","author":"Tzsch\u00e4tzsch","year":"2016","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.actbio.2026.02.002_bib0038","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1016\/j.neuroimage.2009.06.018","article-title":"MR-elastography reveals degradation of tissue integrity in multiple sclerosis","volume":"49","author":"Wuerfel","year":"2010","journal-title":"NeuroImage"},{"key":"10.1016\/j.actbio.2026.02.002_bib0039","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2214\/AJR.16.17455","article-title":"MR elastography demonstrates unique regional brain stiffness patterns in dementias","volume":"209","author":"ElSheikh","year":"2017","journal-title":"Am. J. Roentgenol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0040","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuroimage.2015.02.016","article-title":"Measuring the effects of aging and sex on regional brain stiffness with MR elastography in healthy older adults","volume":"111","author":"Arani","year":"2015","journal-title":"NeuroImage"},{"key":"10.1016\/j.actbio.2026.02.002_bib0041","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023451","article-title":"The influence of physiological aging and atrophy on brain viscoelastic properties in humans","volume":"6","author":"Sack","year":"2011","journal-title":"PLOS ONE"},{"key":"10.1016\/j.actbio.2026.02.002_bib0042","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/jmri.25516","article-title":"Increasing the spatial resolution and sensitivity of magnetic resonance elastography by correcting for subject motion and susceptibility-induced image distortions: Motion and Distortion Correction for MRE","volume":"46","author":"Fehlner","year":"2017","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.actbio.2026.02.002_bib0043","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/hbm.460030303","article-title":"Spatial registration and normalization of images","volume":"3","author":"Friston","year":"1995","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.actbio.2026.02.002_bib0044","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s10851-017-0757-x","article-title":"Improved susceptibility artifact correction of echo-planar MRI using the alternating direction method of multipliers","volume":"60","author":"Macdonald","year":"2018","journal-title":"J. Math. Imaging Vis."},{"key":"10.1016\/j.actbio.2026.02.002_bib0045","series-title":"Statistical parametric mapping: the analysis of functional brain images,","author":"Friston","year":"2007"},{"key":"10.1016\/j.actbio.2026.02.002_bib0046","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1002\/mrm.29320","article-title":"Comparison of inversion methods in MR elastography: an open-access pipeline for processing multifrequency shear-wave data and demonstration in a phantom, human kidneys, and brain","volume":"88","author":"Meyer","year":"2022","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.actbio.2026.02.002_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.media.2022.102416","article-title":"Multiple motion encoding in phase-contrast MRI: A general theory and application to elastography imaging","volume":"78","author":"Herthum","year":"2022","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.actbio.2026.02.002_bib0048","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1088\/0031-9155\/54\/7\/025","article-title":"Scatter-based magnetic resonance elastography","volume":"54","author":"Papazoglou","year":"2009","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0049","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S1361-8415(03)00038-0","article-title":"Spatio-temporal directional filtering for improved inversion of MR elastography images","volume":"7","author":"Manduca","year":"2003","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.actbio.2026.02.002_bib0050","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1090\/S0025-5718-99-01033-9","article-title":"For numerical differentiation, dimensionality can be a blessing!","volume":"68","author":"Anderssen","year":"1999","journal-title":"Math. Comput."},{"key":"10.1016\/j.actbio.2026.02.002_bib0051","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1002\/mrm.28627","article-title":"MR elastography: principles, guidelines, and terminology","volume":"85","author":"Manduca","year":"2021","journal-title":"Magn. Reson. Med"},{"key":"10.1016\/j.actbio.2026.02.002_bib0052","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/nimg.1995.1012","article-title":"A probabilistic atlas of the human brain: theory and rationale for its development","volume":"2","author":"Mazziotta","year":"1995","journal-title":"NeuroImage"},{"key":"10.1016\/j.actbio.2026.02.002_bib0053","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neuroimage.2016.01.062","article-title":"New tissue priors for improved automated classification of subcortical brain structures on MRI","volume":"130","author":"Lorio","year":"2016","journal-title":"NeuroImage"},{"key":"10.1016\/j.actbio.2026.02.002_bib0054","article-title":"In vivo palpation of anisotropic human brain tissue using MRI","author":"Magdoom","year":"2025","journal-title":"BioRxiv Prepr"},{"key":"10.1016\/j.actbio.2026.02.002_bib0055","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ab0a7d","article-title":"Uniqueness of poroelastic and viscoelastic nonlinear inversion MR elastography at low frequencies","volume":"64","author":"McGarry","year":"2019","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0056","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ad4446","article-title":"Brain elastography in aging relates to fluid\/solid trendlines","volume":"69","author":"Parker","year":"2024","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0057","doi-asserted-by":"crossref","unstructured":"S. Hirsch, A Biphasic Poroelasticity Model for Soft Tissue, in: I. Sack, T. Schaeffter (Eds.), Quantif. Biophys. Parameters Med. Imaging, Springer International Publishing, Cham, 2024: pp. 63\u201375. https:\/\/doi.org\/10.1007\/978-3-031-61846-8_4.","DOI":"10.1007\/978-3-031-61846-8_4"},{"key":"10.1016\/j.actbio.2026.02.002_bib0058","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/mrm.28507","article-title":"Separation of fluid and solid shear wave fields and quantification of coupling density by magnetic resonance poroelastography","volume":"85","author":"Lilaj","year":"2021","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.actbio.2026.02.002_bib0059","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1002\/mrm.28898","article-title":"Inversion-recovery MR elastography of the human brain for improved stiffness quantification near fluid\u2013solid boundaries","volume":"86","author":"Lilaj","year":"2021","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.actbio.2026.02.002_bib0060","doi-asserted-by":"crossref","first-page":"e3854","DOI":"10.1002\/nbm.3854","article-title":"Spring\u2013damper equivalents of the fractional, poroelastic, and poroviscoelastic models for elastography","volume":"31","author":"Holm","year":"2018","journal-title":"NMR Biomed"},{"key":"10.1016\/j.actbio.2026.02.002_bib0061","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jmbbm.2019.04.039","article-title":"Dilatational and shear waves in poro-viscoelastic media","volume":"97","author":"Vena","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2026.02.002_bib0062","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s42254-022-00543-2","article-title":"Magnetic resonance elastography from fundamental soft-tissue mechanics to diagnostic imaging","volume":"5","author":"Sack","year":"2022","journal-title":"Nat. Rev. Phys."},{"key":"10.1016\/j.actbio.2026.02.002_bib0063","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1002\/mrm.27672","article-title":"Magnetic resonance elastography of the human brain using a multiphase DENSE acquisition","volume":"81","author":"Strasser","year":"2019","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.actbio.2026.02.002_bib0064","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081668","article-title":"Measuring the characteristic topography of brain stiffness with magnetic resonance elastography","volume":"8","author":"Murphy","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.actbio.2026.02.002_bib0065","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/jon.12619","article-title":"Optimization of a multifrequency magnetic resonance elastography protocol for the human brain","volume":"29","author":"Kurt","year":"2019","journal-title":"J. Neuroimaging"},{"key":"10.1016\/j.actbio.2026.02.002_bib0066","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1007\/s00330-020-07054-7","article-title":"MR elastography frequency\u2013dependent and independent parameters demonstrate accelerated decrease of brain stiffness in elder subjects","volume":"30","author":"Lv","year":"2020","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0067","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcae424","article-title":"The contributions of relative brain viscosity to brain function and health","volume":"6","author":"McIlvain","year":"2024","journal-title":"Brain Commun."},{"key":"10.1016\/j.actbio.2026.02.002_bib0068","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neurobiolaging.2018.01.010","article-title":"High-resolution magnetic resonance elastography reveals differences in subcortical gray matter viscoelasticity between young and healthy older adults","volume":"65","author":"Hiscox","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.actbio.2026.02.002_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2020.104204","article-title":"Dynamic mechanical characterization and viscoelastic modeling of bovine brain tissue","volume":"114","author":"Li","year":"2021","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2026.02.002_bib0070","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s10237-024-01833-7","article-title":"Frequency and time dependent viscoelastic characterization of pediatric porcine brain tissue in compression","volume":"23","author":"Li","year":"2024","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0071","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10334-007-0098-7","article-title":"Magnetic resonance elastography compared with rotational rheometry for in vitro brain tissue viscoelasticity measurement","volume":"20","author":"Vappou","year":"2007","journal-title":"Magn. Reson. Mater. Phys. Biol. Med."},{"key":"10.1016\/j.actbio.2026.02.002_bib0072","doi-asserted-by":"crossref","DOI":"10.3791\/54201","article-title":"Characterizing multiscale mechanical properties of brain tissue using atomic force microscopy, impact indentation, and rheometry","author":"Canovic","year":"2016","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.actbio.2026.02.002_bib0073","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/0006355X2005042003003","article-title":"Shear linear behavior of brain tissue over a large frequency range","volume":"42","author":"Nicolle","year":"2005","journal-title":"Biorheol. Off. J. Int. Soc. Biorheol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0074","first-page":"377","article-title":"Linear viscoelastic properties of bovine brain tissue in shear","volume":"34","author":"Bilston","year":"1997","journal-title":"Biorheology"},{"key":"10.1016\/j.actbio.2026.02.002_bib0075","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s11831-019-09352-w","article-title":"Fifty Shades of Brain: A Review on the Mechanical Testing and Modeling of Brain Tissue","volume":"27","author":"Budday","year":"2020","journal-title":"Arch. Comput. Methods Eng."},{"key":"10.1016\/j.actbio.2026.02.002_bib0076","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/jmri.26881","article-title":"Influence of Age on Global and Regional Brain Stiffness in Young and Middle-Aged Adults","volume":"51","author":"Takamura","year":"2020","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.actbio.2026.02.002_bib0077","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.actbio.2025.04.004","article-title":"Do human brain white matter and brain stem structures show direction-dependent mechanical behavior?","volume":"199","author":"Reiter","year":"2025","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2026.02.002_bib0078","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0006-3495(99)77181-X","article-title":"Three-dimensional imaging of nerve tissue by X-ray phase-contrast microtomography","volume":"76","author":"Beckmann","year":"1999","journal-title":"Biophys. J."},{"key":"10.1016\/j.actbio.2026.02.002_bib0079","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/mrm.29859","article-title":"Rapid MR elastography of the liver for subsecond stiffness sampling","volume":"91","author":"Anders","year":"2024","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.actbio.2026.02.002_bib0080","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.666456","article-title":"Real-time multifrequency MR elastography of the human brain reveals rapid changes in viscoelasticity in response to the valsalva maneuver","volume":"9","author":"Herthum","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0081","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/cne.10714","article-title":"Marked loss of myelinated nerve fibers in the human brain with age","volume":"462","author":"Marner","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.actbio.2026.02.002_bib0082","article-title":"Mapping cerebral pulse pressure and arterial compliance over the adult lifespan with optical imaging","volume":"12","author":"Tan","year":"2017","journal-title":"PLOS ONE"},{"key":"10.1016\/j.actbio.2026.02.002_bib0083","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1111\/ejn.14766","article-title":"Mechanobiology of the brain in ageing and Alzheimer\u2019s disease","volume":"53","author":"Hall","year":"2021","journal-title":"Eur. J. Neurosci."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126000759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126000759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:03:07Z","timestamp":1791403387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126000759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":83,"alternative-id":["S1742706126000759"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.02.002","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo wideband MR elastography for assessing age-related viscoelasticity changes of the human brain","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}