{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:55:42Z","timestamp":1793073342611,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010104","name":"Tianjin Medical University","doi-asserted-by":"publisher","award":["PDJH-20220202"],"award-info":[{"award-number":["PDJH-20220202"]}],"id":[{"id":"10.13039\/501100010104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272470"],"award-info":[{"award-number":["82272470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472412"],"award-info":[{"award-number":["82472412"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.actbio.2026.02.006","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T08:02:39Z","timestamp":1770364959000},"page":"214-232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Sequential dual-drug delivery biomimetic hydrogel for temporal orchestration of acute neuroprotection and chronic regeneration in spinal cord injury"],"prefix":"10.1016","volume":"213","author":[{"given":"Junhao","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haopeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongda","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongpeng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junrui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1635-9902","authenticated-orcid":false,"given":"Guangzhi","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.actbio.2026.02.006_bib0001","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/S1474-4422(23)00287-9","article-title":"Global, regional, and national burden of spinal cord injury, 1990-2019: a systematic analysis for the global burden of disease study 2019 [J]","volume":"22","year":"2023","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.actbio.2026.02.006_bib0002","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3171\/jns.1991.75.1.0015","article-title":"Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms [J]","volume":"75","author":"Tator","year":"1991","journal-title":"J. Neurosurg"},{"key":"10.1016\/j.actbio.2026.02.006_bib0003","first-page":"14","article-title":"Clinical neurorestorative therapeutic guidelines for spinal cord injury (IANR\/CANR version 2019) [J]","volume":"20","author":"Huang","year":"2020","journal-title":"J. Orthop. Transl."},{"issue":"3s","key":"10.1016\/j.actbio.2026.02.006_bib0004","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1093\/neuros\/nyw080","article-title":"Traumatic spinal cord injury-repair and regeneration [J]","volume":"80","author":"Ahuja","year":"2017","journal-title":"Neurosurgery"},{"issue":"2","key":"10.1016\/j.actbio.2026.02.006_bib0005","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nrn1326","article-title":"Regeneration beyond the glial scar [J]","volume":"5","author":"Silver","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.actbio.2026.02.006_bib0006","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fncel.2016.00098","article-title":"Inflammogenesis of secondary spinal cord injury [J]","volume":"10","author":"Anwar","year":"2016","journal-title":"Front. Cell Neurosci."},{"issue":"5","key":"10.1016\/j.actbio.2026.02.006_bib0007","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.3171\/FOC.2008.25.11.E2","article-title":"Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon [J]","volume":"25","author":"Rowland","year":"2008","journal-title":"Neurosurg. Focus."},{"issue":"7575","key":"10.1016\/j.actbio.2026.02.006_bib0008","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death [J]","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.actbio.2026.02.006_bib0009","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41423-025-01275-w","article-title":"NLRP3 inflammasome in neuroinflammation and central nervous system diseases [J]","volume":"22","author":"Xu","year":"2025","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2026.02.006_bib0010","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1038\/s41467-019-11707-7","article-title":"Moving beyond the glial scar for spinal cord repair [J]","volume":"10","author":"Bradbury","year":"2019","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.actbio.2026.02.006_bib0011","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s13311-011-0026-4","article-title":"Antioxidant therapies for acute spinal cord injury [J]","volume":"8","author":"Hall","year":"2011","journal-title":"Neurother.: J. Am. Soc. Exp. NeuroTher."},{"issue":"7598","key":"10.1016\/j.actbio.2026.02.006_bib0012","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nature17623","article-title":"Astrocyte scar formation aids central nervous system axon regeneration [J]","volume":"532","author":"Anderson","year":"2016","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.actbio.2026.02.006_bib0013","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.3390\/ijms21207533","article-title":"Spinal Cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms [J]","volume":"21","author":"Anjum","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.actbio.2026.02.006_bib0014","doi-asserted-by":"crossref","DOI":"10.1038\/natrevmats.2016.71","article-title":"Designing hydrogels for controlled drug delivery [J]","volume":"1","author":"Li","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.actbio.2026.02.006_bib0015","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.18","article-title":"Traumatic spinal cord injury [J]","volume":"3","author":"Ahuja","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"7723","key":"10.1016\/j.actbio.2026.02.006_bib0016","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41586-018-0467-6","article-title":"Required growth facilitators propel axon regeneration across complete spinal cord injury [J]","volume":"561","author":"Anderson","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2026.02.006_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122995","article-title":"A sequential stimuli-responsive hydrogel promotes structural and functional recovery of severe spinal cord injury [J]","volume":"316","author":"Chen","year":"2025","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.actbio.2026.02.006_bib0018","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1527-3466.2008.00041.x","article-title":"The novel antioxidant edaravone: from bench to bedside [J]","volume":"26","author":"Watanabe","year":"2008","journal-title":"Cardiovasc. Ther."},{"issue":"Pt A","key":"10.1016\/j.actbio.2026.02.006_bib0019","article-title":"Edaravone dexborneol provides neuroprotective benefits by suppressing NLRP3 inflammasome-induced microglial pyroptosis in experimental ischemic stroke [J]","volume":"113","author":"Hu","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"49","key":"10.1016\/j.actbio.2026.02.006_bib0020","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202303930","article-title":"Sustained release of neuroprotective drugs curcumin and Edaravone from supramolecular hydrogel for ischemic stroke treatment [J]","volume":"33","author":"Jia","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"22","key":"10.1016\/j.actbio.2026.02.006_bib0021","doi-asserted-by":"crossref","first-page":"11028","DOI":"10.1073\/pnas.1821332116","article-title":"Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2Areceptor and SIRT1\u2013PGC-1\u03b1 axis [J]","volume":"116","author":"Fanibunda","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.actbio.2026.02.006_bib0022","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201352RR","article-title":"Serotonin\/5-HT7 receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP-PKA-MAPK, Rab27a\/RhoA, and PI3K\/AKT signaling pathways [J]","volume":"37","author":"Tang","year":"2023","journal-title":"FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol."},{"issue":"1","key":"10.1016\/j.actbio.2026.02.006_bib0023","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neuron.2012.09.013","article-title":"Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders [J]","volume":"76","author":"Lesch","year":"2012","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.actbio.2026.02.006_bib0024","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.3390\/ijms22052621","article-title":"5-Hydroxytryptamine modulates maturation and mitochondria function of Human oligodendrocyte progenitor M03-13 cells [J]","volume":"22","author":"Damiano","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"Suppl 1","key":"10.1016\/j.actbio.2026.02.006_bib0025","first-page":"S145","article-title":"Neuropharmacology of 5-hydroxytryptamine [J]","volume":"147","author":"Green","year":"2006","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.actbio.2026.02.006_bib0026","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1038\/jcbfm.2012.126","article-title":"Drug transport across the blood-brain barrier [J]","volume":"32","author":"Pardridge","year":"2012","journal-title":"J. Cereb. Blood flow Metab.: off. J. Int. Soc. Cereb. Blood Flow Metab."},{"issue":"9","key":"10.1016\/j.actbio.2026.02.006_bib0027","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.drudis.2017.03.007","article-title":"Biomimetic nanofibrous scaffolds for neural tissue engineering and drug development [J]","volume":"22","author":"Wu","year":"2017","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.actbio.2026.02.006_bib0028","article-title":"Ultrasound-driven wireless piezoelectric hydrogel synergizes with cotransplantation of NSCs-hUCMSCs for structural and functional recovery in spinal cord injury [J]","volume":"32","author":"Zhong","year":"2025","journal-title":"Mater. Today Bio."},{"issue":"5","key":"10.1016\/j.actbio.2026.02.006_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnrt.2025.100228","article-title":"Chitosan-citric acid hydrogels loaded with catalpol: a novel therapeutic strategy for spinal cord injury [J]","volume":"13","author":"Zhao","year":"2025","journal-title":"J. Neurorestoratology"},{"issue":"1","key":"10.1016\/j.actbio.2026.02.006_bib0030","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41467-017-00583-8","article-title":"An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling [J]","volume":"8","author":"Hong","year":"2017","journal-title":"Nat. Commun."},{"issue":"30","key":"10.1016\/j.actbio.2026.02.006_bib0031","doi-asserted-by":"crossref","first-page":"5753","DOI":"10.1039\/D2TB00792D","article-title":"A decellularized spinal cord extracellular matrix-gel\/GelMA hydrogel three-dimensional composite scaffold promotes recovery from spinal cord injury via synergism with human menstrual blood-derived stem cells [J]","volume":"10","author":"He","year":"2022","journal-title":"J. Mater. Chem. B"},{"issue":"5","key":"10.1016\/j.actbio.2026.02.006_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2024.03.007","article-title":"Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids [J]","volume":"31","author":"Sun","year":"2024","journal-title":"Cell Stem. Cell"},{"issue":"2","key":"10.1016\/j.actbio.2026.02.006_bib0033","first-page":"117","article-title":"Decellularization techniques pave the way for tissue engineering and regenerative medicine: a narrative review [J]","volume":"1","author":"Zhao","year":"2024","journal-title":"Regen. Med. Rep."},{"issue":"4","key":"10.1016\/j.actbio.2026.02.006_bib0034","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.biomaterials.2012.10.062","article-title":"Hydrogels derived from central nervous system extracellular matrix [J]","volume":"34","author":"Medberry","year":"2013","journal-title":"Biomaterials"},{"issue":"2 Suppl","key":"10.1016\/j.actbio.2026.02.006_bib0035","first-page":"221","article-title":"Comparison of spinal cord gray matter and white matter softness: measurement by pipette aspiration method [J]","volume":"95","author":"Ozawa","year":"2001","journal-title":"J. Neurosurg"},{"key":"10.1016\/j.actbio.2026.02.006_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112592","article-title":"Escin alleviates cerebral ischemia-induced intestinal pyroptosis via the GR-dependent p38 MAPK\/NF-\u03bab signaling and NLRP3 inflammasome activation [J]","volume":"138","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol"},{"issue":"5","key":"10.1016\/j.actbio.2026.02.006_bib0037","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.neuron.2014.01.013","article-title":"Microglia induce motor neuron death via the classical NF-\u03bab pathway in amyotrophic lateral sclerosis [J]","volume":"81","author":"Frakes","year":"2014","journal-title":"Neuron"},{"issue":"6881","key":"10.1016\/j.actbio.2026.02.006_bib0038","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/416636a","article-title":"Chondroitinase ABC promotes functional recovery after spinal cord injury [J]","volume":"416","author":"Bradbury","year":"2002","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.actbio.2026.02.006_bib0039","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1152\/physrev.00017.2017","article-title":"The biology of regeneration failure and success after spinal cord injury [J]","volume":"98","author":"Tran","year":"2018","journal-title":"Physiol. Rev."},{"issue":"13","key":"10.1016\/j.actbio.2026.02.006_bib0040","article-title":"Exosomes-loaded electroconductive hydrogel synergistically promotes tissue repair after spinal cord injury via immunoregulation and enhancement of myelinated axon growth [J]","volume":"9","author":"Fan","year":"2022","journal-title":"Adv. Sci. (Weinh)"},{"issue":"10","key":"10.1016\/j.actbio.2026.02.006_bib0041","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/nn.2401","article-title":"Transformation of nonfunctional spinal circuits into functional states after the loss of brain input [J]","volume":"12","author":"Courtine","year":"2009","journal-title":"Nat. Neurosci."},{"issue":"6085","key":"10.1016\/j.actbio.2026.02.006_bib0042","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1126\/science.1217416","article-title":"Restoring voluntary control of locomotion after paralyzing spinal cord injury [J]","volume":"336","author":"van den Brand","year":"2012","journal-title":"Sci. (N. Y. NY)"},{"issue":"1","key":"10.1016\/j.actbio.2026.02.006_bib0043","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s12974-020-01973-4","article-title":"Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages\/microglia polarization and affords neuroprotection after spinal cord injury [J]","volume":"17","author":"Fan","year":"2020","journal-title":"J. Neuroinflammation."},{"issue":"7371","key":"10.1016\/j.actbio.2026.02.006_bib0044","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature10558","article-title":"Non-canonical inflammasome activation targets caspase-11 [J]","volume":"479","author":"Kayagaki","year":"2011","journal-title":"Nature"},{"issue":"7521","key":"10.1016\/j.actbio.2026.02.006_bib0045","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature13683","article-title":"Inflammatory caspases are innate immune receptors for intracellular LPS [J]","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"issue":"7610","key":"10.1016\/j.actbio.2026.02.006_bib0046","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores [J]","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.actbio.2026.02.006_bib0047","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.immuni.2017.11.013","article-title":"The pore-forming protein gasdermin D regulates interleukin-1 secretion from living macrophages [J]","volume":"48","author":"Evavold","year":"2018","journal-title":"Immunity."},{"issue":"7705","key":"10.1016\/j.actbio.2026.02.006_bib0048","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41586-018-0068-4","article-title":"Dissecting spinal cord regeneration [J]","volume":"557","author":"Sofroniew","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2026.02.006_bib0049","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.expneurol.2013.12.024","article-title":"Functional regeneration beyond the glial scar [J]","volume":"253","author":"Cregg","year":"2014","journal-title":"Exp. Neurol."},{"issue":"10","key":"10.1016\/j.actbio.2026.02.006_bib0050","article-title":"Combinatorial therapies after spinal cord injury: how can biomaterials help? [J]","volume":"6","author":"F\u00fchrmann","year":"2017","journal-title":"Adv. Heal. Mater."},{"issue":"7","key":"10.1016\/j.actbio.2026.02.006_bib0051","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nrn3053","article-title":"Repertoire of microglial and macrophage responses after spinal cord injury [J]","volume":"12","author":"David","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"issue":"3","key":"10.1016\/j.actbio.2026.02.006_bib0052","doi-asserted-by":"crossref","first-page":"923","DOI":"10.4103\/NRR.NRR-D-24-00792","article-title":"Spinal cord injury and inflammatory mediators: role in \"fire barrier\" formation and potential for neural regeneration [J]","volume":"21","author":"Zhou","year":"2026","journal-title":"Neural Regen. Res."},{"issue":"8","key":"10.1016\/j.actbio.2026.02.006_bib0053","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1089\/neu.2009.1149","article-title":"A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury [J]","volume":"28","author":"Kwon","year":"2011","journal-title":"J. Neurotrauma"},{"issue":"2","key":"10.1016\/j.actbio.2026.02.006_bib0054","first-page":"172","article-title":"Epidermal growth factor receptor pathway in central nervous system regenerative medicine: a narrative review [J]","volume":"1","author":"Badenes","year":"2024","journal-title":"Regen. Med. Rep."},{"issue":"12","key":"10.1016\/j.actbio.2026.02.006_bib0055","first-page":"H41","article-title":"Hyaluronic acid hydrogels for biomedical applications [J]","volume":"23","author":"Burdick","year":"2011","journal-title":"Adv. Mater. (Deerf. Beach Fla)"},{"key":"10.1016\/j.actbio.2026.02.006_bib0056","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.copbio.2016.02.008","article-title":"Recent advances in hyaluronic acid hydrogels for biomedical applications [J]","volume":"40","author":"Highley","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.actbio.2026.02.006_bib0057","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2016.11.068","article-title":"Extracellular matrix hydrogels from decellularized tissues: structure and function [J]","volume":"49","author":"Saldin","year":"2017","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1016\/j.actbio.2026.02.006_bib0058","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41419-020-02824-z","article-title":"TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K\/AKT pathway after spinal cord injury [J]","volume":"11","author":"Xu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.actbio.2026.02.006_bib0059","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.intimp.2018.11.029","article-title":"Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats [J]","volume":"66","author":"Dai","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.actbio.2026.02.006_bib0060","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.tins.2009.08.002","article-title":"Molecular dissection of reactive astrogliosis and glial scar formation [J]","volume":"32","author":"Sofroniew","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.actbio.2026.02.006_bib0061","first-page":"151","article-title":"The role of the serotonergic system in locomotor recovery after spinal cord injury [J]","volume":"8","author":"Ghosh","year":"2014","journal-title":"Front. Neural Circuits"},{"issue":"1","key":"10.1016\/j.actbio.2026.02.006_bib0062","doi-asserted-by":"crossref","first-page":"7093","DOI":"10.1038\/s41467-021-27419-w","article-title":"An injury-induced serotonergic neuron subpopulation contributes to axon regrowth and function restoration after spinal cord injury in zebrafish [J]","volume":"12","author":"Huang","year":"2021","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.actbio.2026.02.006_bib0063","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nm.2160","article-title":"Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors [J]","volume":"16","author":"Murray","year":"2010","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.actbio.2026.02.006_bib0064","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/exnr.1996.0094","article-title":"The recovery of 5-HT immunoreactivity in lumbosacral spinal cord and locomotor function after thoracic hemisection [J]","volume":"139","author":"Saruhashi","year":"1996","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.actbio.2026.02.006_bib0065","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1152\/jn.00508.2013","article-title":"Synthesis, transport, and metabolism of serotonin formed from exogenously applied 5-HTP after spinal cord injury in rats [J]","volume":"111","author":"Li","year":"2014","journal-title":"J. Neurophysiol"},{"issue":"5","key":"10.1016\/j.actbio.2026.02.006_bib0066","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1089\/neu.2005.22.590","article-title":"Serotonin-related enhancement of recovery of hind limb motor functions in spinal rats after grafting of embryonic raphe nuclei [J]","volume":"22","author":"Majczy\u0144ski","year":"2005","journal-title":"J. Neurotrauma."},{"key":"10.1016\/j.actbio.2026.02.006_bib0067","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/549671","article-title":"Spinal cord hemisection facilitates aromatic L-amino acid decarboxylase cells to produce serotonin in the subchronic but not the chronic phase [J]","volume":"2015","author":"Azam","year":"2015","journal-title":"Neural Plast."},{"issue":"1","key":"10.1016\/j.actbio.2026.02.006_bib0068","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.expneurol.2009.10.003","article-title":"5-HT precursor loading, but not 5-HT receptor agonists, increases motor function after spinal cord contusion in adult rats [J]","volume":"221","author":"Hayashi","year":"2010","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.actbio.2026.02.006_bib0069","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/08977150150502613","article-title":"Automated quantitative gait analysis during overground locomotion in the rat: its application to spinal cord contusion and transection injuries [J]","volume":"18","author":"Hamers","year":"2001","journal-title":"J. Neurotrauma"},{"issue":"1","key":"10.1016\/j.actbio.2026.02.006_bib0070","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1523\/JNEUROSCI.22-01-00315.2002","article-title":"Functional redundancy of ventral spinal locomotor pathways [J]","volume":"22","author":"Loy","year":"2002","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126000796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126000796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:03:43Z","timestamp":1791403423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126000796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":70,"alternative-id":["S1742706126000796"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.02.006","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sequential dual-drug delivery biomimetic hydrogel for temporal orchestration of acute neuroprotection and chronic regeneration in spinal cord injury","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}