{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:51:38Z","timestamp":1791406298264,"version":"4.3.3"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013061","name":"Jilin Scientific and Technological Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.actbio.2026.02.021","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:13:22Z","timestamp":1770970402000},"page":"594-608","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Transmucosal delivery of a dendritic cell-targeting intranasal nanovaccine boosts HIV-1 specific mucosal and systemic immune responses"],"prefix":"10.1016","volume":"213","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9099-993X","authenticated-orcid":false,"given":"Yaotian","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongshuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8373-6088","authenticated-orcid":false,"given":"Yaming","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"45","key":"10.1016\/j.actbio.2026.02.021_bib0001","doi-asserted-by":"crossref","first-page":"53630","DOI":"10.1021\/acsami.1c16989","article-title":"Surface-functionalized silica-coated calcium phosphate nanoparticles efficiently deliver DNA-based HIV-1 trimeric envelope vaccines against HIV-1","volume":"13","author":"Li","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"3","key":"10.1016\/j.actbio.2026.02.021_bib0002","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41577-022-00753-w","article-title":"Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies","volume":"23","author":"Haynes","year":"2023","journal-title":"Nat. Rev. Immunol."},{"issue":"7989","key":"10.1016\/j.actbio.2026.02.021_bib0003","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/s41586-023-06762-6","article-title":"HIV-1 env trimers asymmetrically engage CD4 receptors in membranes","volume":"623","author":"Li","year":"2023","journal-title":"Nature"},{"issue":"6151","key":"10.1016\/j.actbio.2026.02.021_bib0004","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1126\/science.1241144","article-title":"Antibodies in HIV-1 vaccine development and therapy","volume":"341","author":"Klein","year":"2013","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.actbio.2026.02.021_bib0005","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1084\/jem.183.1.215","article-title":"Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques","volume":"183","author":"Spira","year":"1996","journal-title":"J. Exp. Med."},{"issue":"5362","key":"10.1016\/j.actbio.2026.02.021_bib0006","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1126\/science.280.5362.427","article-title":"Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection","volume":"280","author":"Veazey","year":"1998","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.actbio.2026.02.021_bib0007","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1365-3083.2009.02319.x","article-title":"Mucosal immunity: induction, dissemination, and effector functions","volume":"70","author":"Brandtzaeg","year":"2009","journal-title":"Scand. J. Immunol."},{"issue":"654","key":"10.1016\/j.actbio.2026.02.021_bib0008","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abn1413","article-title":"Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity","volume":"14","author":"Hartwell","year":"2022","journal-title":"Sci. Transl. Med."},{"issue":"9","key":"10.1016\/j.actbio.2026.02.021_bib0009","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.hlife.2025.05.001","article-title":"Mucosal adenovirus vaccine Ad5-XBB.1.5 boosting elicits nasal IgA and transiently prevents JN.1 wave infection for less than 6 months in real-world settings","volume":"3","author":"Wang","year":"2025","journal-title":"hLife"},{"key":"10.1016\/j.actbio.2026.02.021_bib0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.imlet.2020.03.002","article-title":"An HIV-1 vaccine based on bacterium-like particles elicits env-specific mucosal immune responses","volume":"222","author":"Bi","year":"2020","journal-title":"Immunol. Lett."},{"issue":"7","key":"10.1016\/j.actbio.2026.02.021_bib0011","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1111\/1751-7915.14022","article-title":"Vaccine with bacterium-like particles displaying HIV-1 gp120 trimer elicits specific mucosal responses and neutralizing antibodies in rhesus macaques","volume":"15","author":"Wang","year":"2022","journal-title":"Microb. Biotechnol."},{"issue":"1","key":"10.1016\/j.actbio.2026.02.021_bib0012","first-page":"50","article-title":"Mucosal vaccine adjuvants update","volume":"1","author":"Rhee","year":"2012","journal-title":"cevr"},{"issue":"37","key":"10.1016\/j.actbio.2026.02.021_bib0013","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201907170","article-title":"Biomaterial approaches for understanding and overcoming immunological barriers to effective oral vaccinations","volume":"30","author":"Frizzell","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2026.02.021_bib0014","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.actbio.2017.10.019","article-title":"Engineering intranasal mRNA vaccines to enhance lymph node trafficking and immune responses","volume":"64","author":"Li","year":"2017","journal-title":"Acta Biomater."},{"issue":"22","key":"10.1016\/j.actbio.2026.02.021_bib0015","doi-asserted-by":"crossref","first-page":"10522","DOI":"10.1021\/acs.nanolett.3c03419","article-title":"Transmucosal delivery of nasal nanovaccines enhancing mucosal and systemic immunity","volume":"23","author":"Xu","year":"2023","journal-title":"Nano Lett."},{"issue":"5","key":"10.1016\/j.actbio.2026.02.021_bib0016","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1021\/acsami.8b18107","article-title":"Polydopamine coating enhances mucopenetration and cell uptake of nanoparticles","volume":"11","author":"Poinard","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2026.02.021_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2024.112820","article-title":"Bilayer-functionalized mesoporous silica nanoparticles for overcoming multiple barriers of mucus clearance, intestinal epithelium and P-glycoprotein efflux","volume":"240","author":"Li","year":"2024","journal-title":"Mater. Des."},{"issue":"21","key":"10.1016\/j.actbio.2026.02.021_bib0018","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201907665","article-title":"The Nano\u2013Intestine interaction: understanding the location-oriented effects of engineered nanomaterials in the Intestine","volume":"16","author":"Cui","year":"2020","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.actbio.2026.02.021_bib0019","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/nri713","article-title":"Competitive success","volume":"2","author":"Bell","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"6673","key":"10.1016\/j.actbio.2026.02.021_bib0020","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.actbio.2026.02.021_bib0021","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.alit.2018.09.004","article-title":"A comprehensive understanding of the gut mucosal immune system in allergic inflammation","volume":"68","author":"Tokuhara","year":"2019","journal-title":"Allergol. Int."},{"issue":"1","key":"10.1016\/j.actbio.2026.02.021_bib0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/153685903321538026","article-title":"Comparison of recombinant derivatives of chimeric TNT-3 antibody for the radioimaging of solid tumors","volume":"22","author":"Khawli","year":"2003","journal-title":"Hybrid. Hybridomics"},{"issue":"1","key":"10.1016\/j.actbio.2026.02.021_bib0023","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1182\/blood-2006-10-050856","article-title":"VEGF therapy: risky business for established plaques?","volume":"109","author":"Kadl","year":"2007","journal-title":"Blood"},{"issue":"s1","key":"10.1016\/j.actbio.2026.02.021_bib0024","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1046\/j.1432-1033.270.s1.6.x","article-title":"Specialized lectures (SL)","volume":"270","year":"2003","journal-title":"Eur. J. Biochem."},{"issue":"29","key":"10.1016\/j.actbio.2026.02.021_bib0025","doi-asserted-by":"crossref","first-page":"7221","DOI":"10.1016\/j.biomaterials.2012.06.049","article-title":"Microparticle surface modifications targeting dendritic cells for non-activating applications","volume":"33","author":"Lewis","year":"2012","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.actbio.2026.02.021_bib0026","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1182\/blood-2003-08-2729","article-title":"Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis","volume":"103","author":"Wilson","year":"2004","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.actbio.2026.02.021_bib0027","doi-asserted-by":"crossref","first-page":"4676","DOI":"10.1038\/s41467-023-40321-x","article-title":"Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs","volume":"14","author":"Niu","year":"2023","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.actbio.2026.02.021_bib0028","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau6769","article-title":"HIV-1 vaccine design through minimizing envelope metastability","volume":"4","author":"He","year":"2018","journal-title":"Sci. Adv."},{"issue":"16","key":"10.1016\/j.actbio.2026.02.021_bib0029","doi-asserted-by":"crossref","first-page":"15424","DOI":"10.1021\/acsnano.3c00991","article-title":"Periodic mesoporous organosilica as a nanoadjuvant for subunit vaccines elicits potent antigen-specific germinal center responses by activating naive B cells","volume":"17","author":"Li","year":"2023","journal-title":"ACS Nano"},{"issue":"6","key":"10.1016\/j.actbio.2026.02.021_bib0030","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jmb.2013.12.003","article-title":"Innate antiviral immune signaling, viral evasion and modulation by HIV-1","volume":"426","author":"Rustagi","year":"2014","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.actbio.2026.02.021_bib0031","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12041","article-title":"Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles","volume":"7","author":"He","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2026.02.021_bib0032","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.addr.2017.10.001","article-title":"Engineering nanomaterials to overcome the mucosal barrier by modulating surface properties","volume":"124","author":"Wu","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"12","key":"10.1016\/j.actbio.2026.02.021_bib0033","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1007\/s13346-025-01848-2","article-title":"Lactoferrin-modified PLGA nanoparticles for pregabalin: development, characterization, in vitro targeting and pharmacodynamic evaluation","volume":"15","author":"Rai","year":"2025","journal-title":"Drug Deliv. Transl. Res."},{"issue":"4","key":"10.1016\/j.actbio.2026.02.021_bib0034","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41577-021-00583-2","article-title":"Mucosal vaccines \u2014 Fortifying the frontiers","volume":"22","author":"Lavelle","year":"2022","journal-title":"Nat. Rev. Immunol."},{"issue":"4\u20135","key":"10.1016\/j.actbio.2026.02.021_bib0035","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3109\/08820131003680369","article-title":"Function of mucosa-associated lymphoid tissue in antibody formation","volume":"39","author":"Brandtzaeg","year":"2010","journal-title":"Immunol. Invest."},{"issue":"3","key":"10.1016\/j.actbio.2026.02.021_bib0036","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.jaci.2012.10.040","article-title":"Thymic function in MHC class II\u2013deficient patients","volume":"131","author":"Lev","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.actbio.2026.02.021_bib0037","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jconrel.2022.04.036","article-title":"Oil-in-ionic liquid nanoemulsion-based intranasal delivery system for influenza split-virus vaccine","volume":"346","author":"Lin","year":"2022","journal-title":"J. Control. Release"},{"issue":"18","key":"10.1016\/j.actbio.2026.02.021_bib0038","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202000771","article-title":"Mucosal vaccination for influenza protection enhanced by catalytic Immune-adjuvant","volume":"7","author":"Qin","year":"2020","journal-title":"Adv. Sci."},{"issue":"11","key":"10.1016\/j.actbio.2026.02.021_bib0039","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1128\/JVI.00296-15","article-title":"CpG oligodeoxynucleotides facilitate delivery of whole inactivated H9N2 influenza virus via transepithelial dendrites of dendritic cells in Nasal Mucosa","volume":"89","author":"Qin","year":"2015","journal-title":"J. Virol."},{"issue":"87","key":"10.1016\/j.actbio.2026.02.021_bib0040","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adc9584","article-title":"CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration","volume":"8","author":"Alanko","year":"2023","journal-title":"Sci. Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2026.02.021_bib0041","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/intimm\/dxad045","article-title":"Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue","volume":"36","author":"Sun","year":"2024","journal-title":"Int. Immunol."},{"issue":"6","key":"10.1016\/j.actbio.2026.02.021_bib0042","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cytogfr.2010.11.002","article-title":"The role of Th17 cytokines in primary mucosal immunity","volume":"21","author":"Kolls","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"issue":"6","key":"10.1016\/j.actbio.2026.02.021_bib0043","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1038\/s41385-018-0073-9","article-title":"IL-17-dependent SIgA-mediated protection against nasal bordetella pertussis infection by live attenuated BPZE1 vaccine","volume":"11","author":"Solans","year":"2018","journal-title":"Mucosal. Immunol."},{"issue":"5","key":"10.1016\/j.actbio.2026.02.021_bib0044","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/mi.2009.100","article-title":"Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa","volume":"2","author":"Khader","year":"2009","journal-title":"Mucosal. Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2026.02.021_bib0045","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12977-014-0109-5","article-title":"Are anti-HIV IgAs good guys or bad guys?","volume":"11","author":"Zhou","year":"2014","journal-title":"Retrovirology"},{"issue":"15","key":"10.1016\/j.actbio.2026.02.021_bib0046","article-title":"Similar epitope specificities of IgG and IgA antibodies elicited by Ad26 Vector Prime, env protein boost immunizations in Rhesus monkeys","volume":"92","author":"Kang Zi","year":"2018","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.actbio.2026.02.021_bib0047","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/s41467-019-08739-4","article-title":"HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge","volume":"10","author":"Jones","year":"2019","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.actbio.2026.02.021_bib0048","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1021\/acsnano.2c10818","article-title":"Chiral Nanosilica drug delivery systems stereoselectively interacted with the intestinal mucosa to improve the oral adsorption of insoluble drugs","volume":"17","author":"Chen","year":"2023","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.actbio.2026.02.021_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2025.112036","article-title":"Nanodelivery strategies modulating tumor stromal cells for reverting the immunosuppressive tumor microenvironment","volume":"37","author":"Sun","year":"2026","journal-title":"Chin. Chem. Lett."},{"issue":"1","key":"10.1016\/j.actbio.2026.02.021_bib0050","doi-asserted-by":"crossref","first-page":"7694","DOI":"10.1038\/s41467-023-43465-y","article-title":"Nanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery","volume":"14","author":"Sang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2026.02.021_bib0051","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jconrel.2014.10.026","article-title":"Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse","volume":"197","author":"Maisel","year":"2015","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.actbio.2026.02.021_bib0052","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.immuni.2019.10.008","article-title":"Vaccination with glycan-modified HIV NFL envelope trimer-liposomes elicits broadly neutralizing antibodies to multiple sites of vulnerability","volume":"51","author":"Dubrovskaya","year":"2019","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.actbio.2026.02.021_bib0053","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.immuni.2016.09.001","article-title":"Germinal center B cell dynamics","volume":"45","author":"Mesin","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.actbio.2026.02.021_bib0054","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.actbio.2024.12.056","article-title":"Periodic mesoporous organosilica-loaded mincle agonists enhance the immunogenicity of COVID-19 subunit vaccines by dual activation of B cells and dendritic cells","volume":"193","author":"Zhang","year":"2025","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.actbio.2026.02.021_bib0055","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/imr.12740","article-title":"T follicular helper cell heterogeneity: time, space, and function","volume":"288","author":"Song","year":"2019","journal-title":"Immunol. Rev."},{"issue":"8","key":"10.1016\/j.actbio.2026.02.021_bib0056","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nri3251","article-title":"Recent progress in mucosal vaccine development: potential and limitations","volume":"12","author":"Lycke","year":"2012","journal-title":"Nat. Rev. Immunol."},{"issue":"8062","key":"10.1016\/j.actbio.2026.02.021_bib0057","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41586-025-08910-6","article-title":"Nasal vaccines for respiratory infections","volume":"641","author":"Kiyono","year":"2025","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.actbio.2026.02.021_bib0058","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/mi.2016.28","article-title":"Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local IgA responses","volume":"10","author":"Christensen","year":"2017","journal-title":"Mucosal. Immunol."},{"key":"10.1016\/j.actbio.2026.02.021_bib0059","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.jconrel.2024.07.056","article-title":"Identification of a novel DEC-205 binding peptide to develop dendritic cell-targeting nanovaccine for cancer immunotherapy","volume":"373","author":"Zheng","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2026.02.021_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.157381","article-title":"NK cell membrane\/MnO2 hybrid nanoparticle-adjuvanted intranasal vaccines synergistically boost protective immunity against H1N1 influenza infection","volume":"500","author":"Cheng","year":"2024","journal-title":"Chem. Eng. J."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126000930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126000930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:58:12Z","timestamp":1791403092000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126000930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":60,"alternative-id":["S1742706126000930"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.02.021","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transmucosal delivery of a dendritic cell-targeting intranasal nanovaccine boosts HIV-1 specific mucosal and systemic immune responses","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.02.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}