{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T11:07:59Z","timestamp":1779448079834,"version":"3.53.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFB3800900"],"award-info":[{"award-number":["2021YFB3800900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52373299"],"award-info":[{"award-number":["52373299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572339"],"award-info":[{"award-number":["82572339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.actbio.2026.03.005","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T03:39:27Z","timestamp":1772854767000},"page":"498-511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Absorbable microspheres co-delivering HIF-1\u03b1 inhibitor augment transarterial chemoembolization by reversing tumor hypoxia and immunosuppression"],"prefix":"10.1016","volume":"214","author":[{"given":"Jiakun","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7697-9874","authenticated-orcid":false,"given":"Chao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2026.03.005_bib0001","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nrclinonc.2014.122","article-title":"Treatment of intermediate-stage hepatocellular carcinoma","volume":"11","author":"Forner","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.actbio.2026.03.005_bib0002","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41575-020-00395-0","article-title":"Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma","volume":"18","author":"Llovet","year":"2021","journal-title":"Nature Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.actbio.2026.03.005_bib0003","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3390\/ph17081057","article-title":"Hypoxia as a target for combination with transarterial chemoembolization in hepatocellular carcinoma","volume":"17","author":"Wang","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.actbio.2026.03.005_bib0004","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202200544","article-title":"Cascade reaction of \u201cMn2+-catechol\u201d triggered by H2O2 to integrate firm tumor vessel embolization and hypoxic response relief","volume":"11","author":"Fan","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2026.03.005_bib0005","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41573-023-00848-6","article-title":"Targeting hypoxia-inducible factors: therapeutic opportunities and challenges","volume":"23","author":"Yuan","year":"2024","journal-title":"Nat. Rev. Drug Discovery"},{"key":"10.1016\/j.actbio.2026.03.005_bib0006","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.semcancer.2023.11.001","article-title":"Hypoxia signaling and metastatic progression","volume":"97","author":"Schito","year":"2023","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.actbio.2026.03.005_bib0007","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41392-022-01080-1","article-title":"Hypoxia signaling in human health and diseases: implications and prospects for therapeutics","volume":"7","author":"Luo","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.actbio.2026.03.005_bib0008","first-page":"167","article-title":"Tumour hypoxia in driving genomic instability and tumour evolution","volume":"25","author":"Suvac","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.actbio.2026.03.005_bib0009","doi-asserted-by":"crossref","first-page":"eade5111","DOI":"10.1126\/sciadv.ade5111","article-title":"Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development","volume":"9","author":"Cheu","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.actbio.2026.03.005_bib0010","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.actbio.2023.05.047","article-title":"Gradient tumor microenvironment-promoted penetrating micelles for hypoxia relief and immunosuppression reversion in pancreatic cancer treatment","volume":"167","author":"Luo","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.03.005_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.123018","article-title":"Pickering emulsion with tumor vascular destruction and microenvironment modulation for transarterial embolization therapy","volume":"316","author":"Zhang","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2026.03.005_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.161996","article-title":"A vascular heterogeneity-orienting TACE strategy addresses peripheral tumor and avascular deep tumor for complete hepatocellular carcinoma clearance","volume":"511","author":"Tang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2026.03.005_bib0013","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jconrel.2024.06.026","article-title":"Sustained release hypoxia-activated prodrug-loaded BSA nanoparticles enhance transarterial chemoembolization against hepatocellular carcinoma","volume":"372","author":"Hao","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2026.03.005_bib0014","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41570-025-00705-7","article-title":"Supramolecular approaches for the treatment of hypoxic regions in tumours","volume":"9","author":"Regeni","year":"2025","journal-title":"Nat. Rev. Chem."},{"key":"10.1016\/j.actbio.2026.03.005_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122901","article-title":"Engineered bacterium-metal-organic framework biohybrids for boosting radiotherapy with multiple effects","volume":"314","author":"Wang","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2026.03.005_bib0016","doi-asserted-by":"crossref","first-page":"8877","DOI":"10.1021\/jacs.3c10508","article-title":"Identification and development of cyclic peptide inhibitors of hypoxia inducible factors 1 and 2 that disrupt hypoxia-response signaling in cancer cells","volume":"146","author":"Ball","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.actbio.2026.03.005_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2021.02.030","article-title":"Hypoxia-modulatory nanomaterials to relieve tumor hypoxic microenvironment and enhance immunotherapy: where do we stand?","volume":"125","author":"Yuan","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.03.005_bib0018","article-title":"A multifunctional polyester nanoplatform for the synergistic anticancer: enhanced photodynamic therapy and targeted gene silencing","volume":"64","author":"Zhang","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.actbio.2026.03.005_bib0019","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202406860","article-title":"Dual oxygen-supply immunosuppression-inhibiting nanomedicine to avoid the intratumoral recruitment of myeloid-derived suppressor cells","volume":"20","author":"Yang","year":"2024","journal-title":"Small."},{"key":"10.1016\/j.actbio.2026.03.005_bib0020","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1200\/JCO.23.02745","article-title":"Systemic therapy for advanced hepatocellular carcinoma: ASCO guideline update","volume":"42","author":"Gordan","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.actbio.2026.03.005_bib0021","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1001\/jamaoncol.2023.2677","article-title":"Critical appraisal of guideline recommendations on systemic therapies for advanced hepatocellular carcinoma: a review","volume":"10","author":"Cappuyns","year":"2024","journal-title":"JAMa Oncol."},{"key":"10.1016\/j.actbio.2026.03.005_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114168","article-title":"In situ formed chemo-immunotherapeutic hydrogel for suppression of postoperative glioma recurrence and intraoperative hemostasis","volume":"387","author":"Meng","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2026.03.005_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121512","article-title":"HIF-2\u03b1-targeted interventional chemoembolization multifunctional microspheres for effective elimination of hepatocellular carcinoma","volume":"284","author":"Chen","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2026.03.005_bib0024","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12900","article-title":"Efficacy, mechanism, and safety of melatonin-loaded on thermosensitive nanogels for rabbit VX2 tumor embolization: a novel design","volume":"75","author":"Chen","year":"2023","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.actbio.2026.03.005_bib0025","doi-asserted-by":"crossref","first-page":"6239","DOI":"10.1038\/s41467-025-61621-4","article-title":"Tumor vessel-adaptable adhesive and absorbable microspheres for sustainable transarterial chemoembolization therapy","volume":"16","author":"Guo","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2026.03.005_bib0026","doi-asserted-by":"crossref","first-page":"11415","DOI":"10.1021\/acs.jmedchem.2c00573","article-title":"Acriflavine, an acridine derivative for biomedical application: current state of the art","volume":"65","author":"Piorecka","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.actbio.2026.03.005_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121801","article-title":"Tumor oxygenation nanoliposome synergistic hypoxia-inducible-factor-1 inhibitor enhanced Iodine-125 seed brachytherapy for esophageal cancer","volume":"289","author":"Yao","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2026.03.005_bib0028","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.actbio.2017.08.028","article-title":"Tumor acidity-activatable manganese phosphate nanoplatform for amplification of photodynamic cancer therapy and magnetic resonance imaging","volume":"62","author":"Hao","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.03.005_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122480","article-title":"Hypoxia-activated cascade nanovaccine for synergistic chemoembolization-immune therapy of hepatocellular carcinoma","volume":"306","author":"Shi","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2026.03.005_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2025.01.088","article-title":"Self-assembling chemodrug fiber-hydrogel for transarterial chemoembolization and radiotherapy-enhanced antitumor immunity","volume":"380","author":"Peng","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2026.03.005_bib0031","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.actbio.2025.04.042","article-title":"Immune-activated microspheres for enhanced chemoembolization of hepatocellular carcinoma by blocking the adenosine A2A receptor","volume":"199","author":"Chen","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.03.005_bib0032","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1200\/JCO.2025.43.4_suppl.542","article-title":"Concurrent transarterial chemoembolization plus atezolizumab and bevacizumab in unresectable hepatocellular carcinoma: interim analysis from a multicenter real-world study (CHANCE 023)","volume":"43","author":"Yan","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.actbio.2026.03.005_bib0033","doi-asserted-by":"crossref","first-page":"25536","DOI":"10.1021\/jacs.5c06039","article-title":"Engineered nano-micro pyroptosis generators: a magnetic-metallo-immunotherapeutic strategy to reinforce transarterial embolization","volume":"147","author":"Wang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.actbio.2026.03.005_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114003","article-title":"Oncolytic microgels with regulated antibody release augment tumor immunotherapy","volume":"385","author":"Guo","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2026.03.005_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114576","article-title":"Absorbable microspheres sustaining epirubicin and TLR7 agonist release for transarterial chemo-immuno-embolization in liver tumor","volume":"390","author":"Wang","year":"2026","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2026.03.005_bib0036","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202503561","article-title":"Long-acting in situ cancer vaccines by oncolytic STING-activating microgels","volume":"21","author":"Tan","year":"2025","journal-title":"Small."},{"key":"10.1016\/j.actbio.2026.03.005_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2022.07.019","article-title":"Embolization therapy with microspheres for the treatment of liver cancer: state-of-the-art of clinical translation","volume":"149","author":"P\u00e9rez-L\u00f3pez","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.03.005_bib0038","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrc1391","article-title":"Hyaluronan: from extracellular glue to pericellular cue","volume":"4","author":"Toole","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.actbio.2026.03.005_bib0039","doi-asserted-by":"crossref","first-page":"eadh4327","DOI":"10.1126\/sciadv.adh4327","article-title":"Injectable, self-healing hydrogel adhesives with firm tissue adhesion and on-demand biodegradation for sutureless wound closure","volume":"9","author":"Ren","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.actbio.2026.03.005_bib0040","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54469-7","article-title":"Regulating copper homeostasis of tumor cells to promote cuproptosis for enhancing breast cancer immunotherapy","volume":"15","author":"Guan","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2026.03.005_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2022.112537","article-title":"Inhibition of hypoxia-inducible factor 1 by acriflavine renders glioblastoma sensitive for photodynamic therapy","volume":"234","author":"Ma","year":"2022","journal-title":"J. Photochem. Photobiol., B"},{"key":"10.1016\/j.actbio.2026.03.005_bib0042","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jconrel.2022.08.015","article-title":"Polymersome-stabilized doxorubicin-lipiodol emulsions for high-efficacy chemoembolization therapy","volume":"350","author":"Liu","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2026.03.005_bib0043","doi-asserted-by":"crossref","first-page":"12870","DOI":"10.1021\/acsnano.4c00227","article-title":"A redox-triggered autophagy-induced nanoplatform with PD-L1 inhibition for enhancing combined chemo-immunotherapy","volume":"18","author":"Li","year":"2024","journal-title":"ACS. Nano"},{"key":"10.1016\/j.actbio.2026.03.005_bib0044","article-title":"Dendritic polymer-based nanomedicines remodel the tumor stroma: improve drug penetration and enhance antitumor immune response","volume":"36","author":"Zhang","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2026.03.005_bib0045","article-title":"Tailor-made autophagy cascade amplification polymeric nanoparticles for enhanced tumor immunotherapy","volume":"19","author":"Long","year":"2023","journal-title":"Small."},{"key":"10.1016\/j.actbio.2026.03.005_bib0046","first-page":"299","article-title":"A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody","volume":"21","author":"Li","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2026.03.005_bib0047","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.actbio.2025.08.021","article-title":"MIL-100(Fe)-based co-delivery platform as cascade synergistic chemotherapy and immunotherapy agents for colorectal cancer via the cGAS-STING pathway","volume":"204","author":"Wang","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.03.005_bib0048","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.actbio.2025.05.029","article-title":"Targeted nanosensitizer-augmented sono-immunotherapy with STING agonist to remodel the immune microenvironment in hepatocellular carcinoma","volume":"199","author":"Yang","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.03.005_bib0049","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.jconrel.2023.03.026","article-title":"HIF-1 inhibitor-based one-stone-two-birds strategy for enhanced cancer chemodynamic-immunotherapy","volume":"356","author":"Zhang","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2026.03.005_bib0050","article-title":"Spatiotemporal nano-regulator unleashes anti-tumor immunity by overcoming dendritic cell tolerance and T cell exhaustion in tumor-draining lymph nodes","volume":"37","author":"Wang","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2026.03.005_bib0051","article-title":"Dynamic size-change nanovaccine for enhancing lymph node deep penetration and eliciting robust antitumor immune responses","volume":"37","author":"Liu","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2026.03.005_bib0052","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202305563","article-title":"Tannic acid-based nanomaterials for tolerogenic immunotherapy of rheumatoid arthritis","volume":"33","author":"Wu","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2026.03.005_bib0053","doi-asserted-by":"crossref","first-page":"15072","DOI":"10.1021\/acsnano.2c06211","article-title":"Artificial antigen-presenting cell topology dictates T cell activation","volume":"16","author":"Wauters","year":"2022","journal-title":"ACS. Nano"},{"key":"10.1016\/j.actbio.2026.03.005_bib0054","doi-asserted-by":"crossref","first-page":"eadv0885","DOI":"10.1126\/sciadv.adv0885","article-title":"Magnesium microspheres for enhanced transarterial chemoembolization therapy of hepatocellular carcinoma: from animal models to a pilot clinical study","volume":"11","author":"Gong","year":"2025","journal-title":"Sci. Adv."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126001443?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126001443?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T10:41:23Z","timestamp":1779446483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126001443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":54,"alternative-id":["S1742706126001443"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.03.005","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Absorbable microspheres co-delivering HIF-1\u03b1 inhibitor augment transarterial chemoembolization by reversing tumor hypoxia and immunosuppression","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}