{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:34:22Z","timestamp":1790192062703,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025MS1394"],"award-info":[{"award-number":["ZR2025MS1394"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MH135"],"award-info":[{"award-number":["ZR2024MH135"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MH237"],"award-info":[{"award-number":["ZR2024MH237"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MH236"],"award-info":[{"award-number":["ZR2022MH236"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.actbio.2026.03.007","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T03:39:30Z","timestamp":1772854770000},"page":"512-526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Poly (ADP-ribose) polymerase 1-targeted photosensitizer as a dual-activator of pyroptosis and the STING pathway for enhanced cancer photoimmunotherapy"],"prefix":"10.1016","volume":"214","author":[{"given":"Peixia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingru","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2861-4773","authenticated-orcid":false,"given":"Guiling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.actbio.2026.03.007_bib0001","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/bcr932","article-title":"The changing global patterns of female breast cancer incidence and mortality","volume":"6","author":"Bray","year":"2004","journal-title":"Breast Cancer Res."},{"issue":"2","key":"10.1016\/j.actbio.2026.03.007_bib0002","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrclinonc.2014.191","article-title":"The evolution of cancer surgery and future perspectives","volume":"12","author":"Wyld","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.actbio.2026.03.007_bib0003","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12916-016-0623-5","article-title":"Cancer immunotherapy: the beginning of the end of cancer?","volume":"14","author":"Farkona","year":"2016","journal-title":"BMC Med."},{"issue":"1","key":"10.1016\/j.actbio.2026.03.007_bib0004","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/imr.12534","article-title":"Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases","volume":"277","author":"Man","year":"2017","journal-title":"Immunol. Rev."},{"issue":"18","key":"10.1016\/j.actbio.2026.03.007_bib0005","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1016\/j.jmb.2018.07.002","article-title":"Mechanisms of Gasdermin Family members in inflammasome signaling and cell death","volume":"430","author":"Feng","year":"2018","journal-title":"J. Mol. Biol."},{"issue":"7661","key":"10.1016\/j.actbio.2026.03.007_bib0006","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2026.03.007_bib0007","first-page":"282","article-title":"Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury","volume":"19","author":"Wei","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2026.03.007_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122472","article-title":"Circulating immunotherapy strategy based on pyroptosis and STING pathway: Mn-loaded paclitaxel prodrug nanoplatform against tumor progression and metastasis","volume":"306","author":"Wang","year":"2024","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.actbio.2026.03.007_bib0009","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.3390\/cancers13112695","article-title":"STING agonists as cancer therapeutics","volume":"13","author":"Amouzegar","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"17","key":"10.1016\/j.actbio.2026.03.007_bib0010","doi-asserted-by":"crossref","first-page":"12069","DOI":"10.1021\/acs.jmedchem.3c00640","article-title":"Discovery, synthesis, and evaluation of novel dual inhibitors of a vascular endothelial growth factor receptor and poly(ADP-Ribose) polymerase for BRCA wild-type breast cancer therapy","volume":"66","author":"Li","year":"2023","journal-title":"J. Med. Chem."},{"issue":"24","key":"10.1016\/j.actbio.2026.03.007_bib0011","doi-asserted-by":"crossref","first-page":"16464","DOI":"10.1021\/acs.jmedchem.3c00865","article-title":"Advances in development of selective antitumor inhibitors that target PARP-1","volume":"66","author":"Liu","year":"2023","journal-title":"J. Med. Chem."},{"issue":"14","key":"10.1016\/j.actbio.2026.03.007_bib0012","doi-asserted-by":"crossref","first-page":"9065","DOI":"10.1021\/acs.chemrev.2c00851","article-title":"Regulation of biomolecular condensates by poly(ADP-ribose)","volume":"123","author":"Rhine","year":"2023","journal-title":"Chem. Rev."},{"key":"10.1016\/j.actbio.2026.03.007_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2019.102651","article-title":"PARP-1 and its associated nucleases in DNA damage response","volume":"81","author":"Wang","year":"2019","journal-title":"DNA Repair (Amst.)"},{"issue":"11","key":"10.1016\/j.actbio.2026.03.007_bib0014","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1016\/j.celrep.2018.11.054","article-title":"PARP inhibition elicits STING-dependent antitumor immunity in Brca1-deficient ovarian cancer","volume":"25","author":"Ding","year":"2018","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.actbio.2026.03.007_bib0015","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1158\/0008-5472.CAN-18-1003","article-title":"PARPi triggers the STING-dependent immune response and enhances the therapeutic efficacy of Immune checkpoint blockade independent of BRCAness","volume":"79","author":"Shen","year":"2019","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.actbio.2026.03.007_bib0016","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1470-2045(04)01529-3","article-title":"The present and future role of photodynamic therapy in cancer treatment","volume":"5","author":"Brown","year":"2004","journal-title":"Lancet Oncol."},{"issue":"1","key":"10.1016\/j.actbio.2026.03.007_bib0017","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40824-018-0140-z","article-title":"Clinical development of photodynamic agents and therapeutic applications","volume":"22","author":"Baskaran","year":"2018","journal-title":"Biomater. Res."},{"key":"10.1016\/j.actbio.2026.03.007_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115418","article-title":"Lysosome-targeting phenalenones as efficient type I\/II photosensitizers for anticancer photodynamic therapy","volume":"255","author":"Jiang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"5","key":"10.1016\/j.actbio.2026.03.007_bib0019","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41419-022-04851-4","article-title":"Which cell death modality wins the contest for photodynamic therapy of cancer?","volume":"13","author":"Mishchenko","year":"2022","journal-title":"Cell Death Dis."},{"issue":"16","key":"10.1016\/j.actbio.2026.03.007_bib0020","doi-asserted-by":"crossref","first-page":"10135","DOI":"10.1021\/acs.chemrev.3c00161","article-title":"Metal-based photosensitizers as inducers of regulated cell death mechanisms","volume":"123","author":"Zhang","year":"2023","journal-title":"Chem. Rev."},{"issue":"1","key":"10.1016\/j.actbio.2026.03.007_bib0021","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1021\/acsami.2c17579","article-title":"Carrier-free nanoplatform via evoking pyroptosis and immune response against breast cancer","volume":"15","author":"Li","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"8","key":"10.1016\/j.actbio.2026.03.007_bib0022","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1021\/acsmaterialslett.4c00581","article-title":"Photoimmunotherapy-induced pyroptosis remodels the microenvironment to enhance cancer immunotherapy","volume":"6","author":"Zhang","year":"2024","journal-title":"ACS Mater. Lett."},{"issue":"20","key":"10.1016\/j.actbio.2026.03.007_bib0023","doi-asserted-by":"crossref","first-page":"12830","DOI":"10.1021\/acsnano.4c00017","article-title":"Gas-amplified metalloimmunotherapy with dual activation of pyroptosis and the STING pathway for remodeling the immunosuppressive cervical cancer microenvironment","volume":"18","author":"Liu","year":"2024","journal-title":"ACS Nano"},{"issue":"33","key":"10.1016\/j.actbio.2026.03.007_bib0024","doi-asserted-by":"crossref","first-page":"43257","DOI":"10.1021\/acsami.4c07072","article-title":"Optimized bionic drug-delivery-inducing immunogenic cell death and cGAS-STING pathway activation for enhanced photodynamic-chemotherapy-driven immunotherapy in prostate cancer","volume":"16","author":"Wu","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"31","key":"10.1016\/j.actbio.2026.03.007_bib0025","article-title":"Nuclear PARP1-targeted photosensitizer as a dual-mode DNA-damaging agent and immune activator for tumor ablation","volume":"12","author":"Li","year":"2023","journal-title":"Adv. Heal. Mater."},{"key":"10.1016\/j.actbio.2026.03.007_bib0026","article-title":"A molecular-targeting photosensitizer to inhibit DNA damage repair system and induce cGAS-STING pathway activation for photo-immunotherapy of ovarian cancer","author":"Fan","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"5","key":"10.1016\/j.actbio.2026.03.007_bib0027","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.molcel.2015.10.013","article-title":"PARP-1 activation requires local unfolding of an autoinhibitory domain","volume":"60","author":"Jennine","year":"2015","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.actbio.2026.03.007_bib0028","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1594","article-title":"High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal","volume":"5","author":"Lotze","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2026.03.007_bib0029","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41419-023-06303-z","article-title":"Novel dual inhibitors of PARP and HDAC induce intratumoral STING-mediated antitumor immunity in triple-negative breast cancer","volume":"15","author":"Zhu","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.actbio.2026.03.007_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122512","article-title":"Cuproptotic nanoinducer-driven proteotoxic stress potentiates cancer immunotherapy by activating the mtDNA-cGAS-STING signaling","volume":"307","author":"Yu","year":"2024","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.actbio.2026.03.007_bib0031","article-title":"Alkaline adjuvant regulates proteolytic activity of macrophages for antigen cross-presentation and potentiates radioimmunotherapy","volume":"37","author":"Li","year":"2025","journal-title":"Adv. Mater. Weinh."},{"issue":"1","key":"10.1016\/j.actbio.2026.03.007_bib0032","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41467-019-13668-3","article-title":"Mitochondrial TCA cycle metabolites control physiology and disease","volume":"11","author":"Mart\u00ednez-Reyes","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.actbio.2026.03.007_bib0033","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13045-021-01096-0","article-title":"Nanomaterials for cancer therapy: current progress and perspectives","volume":"14","author":"Cheng","year":"2021","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.actbio.2026.03.007_bib0034","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41420-024-02236-4","article-title":"Advances in smart nanotechnology-supported photodynamic therapy for cancer","volume":"10","author":"Li","year":"2024","journal-title":"Cell Death Discov."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126001479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126001479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T10:45:03Z","timestamp":1779446703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126001479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":34,"alternative-id":["S1742706126001479"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.03.007","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Poly (ADP-ribose) polymerase 1-targeted photosensitizer as a dual-activator of pyroptosis and the STING pathway for enhanced cancer photoimmunotherapy","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc. on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}