{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T21:28:11Z","timestamp":1794259691392,"version":"4.9.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP FBGAK02634"],"award-info":[{"award-number":["JP FBGAK02634"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.actbio.2026.04.063","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:25:20Z","timestamp":1777674320000},"page":"272-285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Postoperative administration of mesenchymal stem cells enhances peri-implant tissue healing in a medication-related osteonecrosis of the jaw model"],"prefix":"10.1016","volume":"217","author":[{"given":"Bin","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7995-3493","authenticated-orcid":false,"given":"Ikiru","family":"Atsuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5762-5587","authenticated-orcid":false,"given":"Ikue","family":"Narimatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2380-513X","authenticated-orcid":false,"given":"Tingyu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Jinno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Ayukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpor.2017.06.004","article-title":"A systematic review of studies comparing conventional complete denture and implant retained overdenture","volume":"62","author":"Kutkut","year":"2018","journal-title":"J. Prosthodont. Res."},{"key":"10.1016\/j.actbio.2026.04.063_bib0002","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41413-020-0088-1","article-title":"Mitigating osteonecrosis of the jaw (ONJ) through preventive dental care and understanding of risk factors","volume":"8","author":"Wan","year":"2020","journal-title":"Bone Res."},{"issue":"5","key":"10.1016\/j.actbio.2026.04.063_bib0003","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","article-title":"American Association of Oral and Maxillofacial Surgeons' Position Paper on medication-related osteonecrosis of the jaws-2022 update","volume":"80","author":"Ruggiero","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"7","key":"10.1016\/j.actbio.2026.04.063_bib0004","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.3390\/jcm13072091","article-title":"Effect of antiresorptive drugs on osseointegrated dental implants: a systematic review","volume":"13","author":"Li","year":"2024","journal-title":"J. Clin. Med."},{"issue":"9","key":"10.1016\/j.actbio.2026.04.063_bib0005","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tips.2020.06.009","article-title":"Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential","volume":"41","author":"Song","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"issue":"7","key":"10.1016\/j.actbio.2026.04.063_bib0006","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.yexcr.2010.02.026","article-title":"Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays","volume":"316","author":"Walter","year":"2010","journal-title":"Exp. Cell Res."},{"issue":"7","key":"10.1016\/j.actbio.2026.04.063_bib0007","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/jbmr.37","article-title":"Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw-like disease in mice","volume":"25","author":"Kikuiri","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.actbio.2026.04.063_bib0008","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5125\/jkaoms.2021.47.2.65","article-title":"Mesenchymal stem cells in the treatment of osteonecrosis of the jaw","volume":"47","author":"Nifos\u00ec","year":"2021","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"10.1016\/j.actbio.2026.04.063_bib0009","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1338376","article-title":"Treatment of medication-related osteonecrosis of the jaw with cell therapy","volume":"12","author":"Bouland","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.actbio.2026.04.063_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090681","article-title":"Therapeutic interaction of systemically-administered mesenchymal stem cells with peri-implant mucosa","volume":"9","author":"Kondo","year":"2014","journal-title":"PLoS. One"},{"issue":"11","key":"10.1016\/j.actbio.2026.04.063_bib0011","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1902\/jop.2009.090249","article-title":"Alveolar bone regeneration by transplantation of periodontal ligament stem cells and bone marrow stem cells in a canine peri-implant defect model: a pilot study","volume":"80","author":"Kim","year":"2009","journal-title":"J. Periodontol."},{"issue":"9","key":"10.1016\/j.actbio.2026.04.063_bib0012","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/leu.2011.108","article-title":"Mesenchymal stromal cell 'licensing': a multistep process","volume":"25","author":"Krampera","year":"2011","journal-title":"Leukemia"},{"issue":"12","key":"10.1016\/j.actbio.2026.04.063_bib0013","doi-asserted-by":"crossref","first-page":"7963","DOI":"10.4049\/jimmunol.0803864","article-title":"Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype","volume":"182","author":"Romieu-Mourez","year":"2009","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0014","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/icb.2012.56","article-title":"Mechanisms of mesenchymal stromal cell immunomodulation","volume":"91","author":"English","year":"2013","journal-title":"Immunol. Cell Biol."},{"issue":"3","key":"10.1016\/j.actbio.2026.04.063_bib0015","doi-asserted-by":"crossref","first-page":"C675","DOI":"10.1152\/ajpcell.00437.2007","article-title":"Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B- but not JNK-dependent mechanism","volume":"294","author":"Crisostomo","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0016","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s13287-018-1007-x","article-title":"Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells","volume":"9","author":"Antebi","year":"2018","journal-title":"Stem Cell Res. Ther."},{"issue":"4","key":"10.1016\/j.actbio.2026.04.063_bib0017","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/biot.201200205","article-title":"Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength","volume":"8","author":"Vincent","year":"2013","journal-title":"Biotechnol. J."},{"issue":"7","key":"10.1016\/j.actbio.2026.04.063_bib0018","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3324\/haematol.10669","article-title":"Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD\/SCID mice","volume":"92","author":"Shi","year":"2007","journal-title":"Haematologica"},{"issue":"6","key":"10.1016\/j.actbio.2026.04.063_bib0019","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/aps.2013.50","article-title":"Mesenchymal stem cells: a new trend for cell therapy","volume":"34","author":"Wei","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0020","doi-asserted-by":"crossref","first-page":"51","DOI":"10.5966\/sctm.2011-0019","article-title":"Concise review: mesenchymal stem cells and translational medicine: emerging issues","volume":"1","author":"Ren","year":"2012","journal-title":"Stem Cells Transl. Med."},{"issue":"5","key":"10.1016\/j.actbio.2026.04.063_bib0021","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.cardfail.2013.03.011","article-title":"Impact of timing and dose of mesenchymal stromal cell therapy in a preclinical model of acute myocardial infarction","volume":"19","author":"Richardson","year":"2013","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.actbio.2026.04.063_bib0022","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.actbio.2016.06.022","article-title":"Multipotent mesenchymal stromal cell sheet therapy for bisphosphonate-related osteonecrosis of the jaw in a rat model","volume":"42","author":"Kaibuchi","year":"2016","journal-title":"Acta Biomater."},{"issue":"14","key":"10.1016\/j.actbio.2026.04.063_bib0023","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.biomaterials.2004.05.033","article-title":"Changes in the distribution of laminin-5 during peri-implant epithelium formation after immediate titanium implantation in rats","volume":"26","author":"Atsuta","year":"2005","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0024","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1365-2818.2011.03541.x","article-title":"Limitations of using micro-computed tomography to predict bone-implant contact and mechanical fixation","volume":"245","author":"Liu","year":"2012","journal-title":"J. Microsc."},{"issue":"7","key":"10.1016\/j.actbio.2026.04.063_bib0025","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.actbio.2026.04.063_bib0026","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1177\/0022034517732770","article-title":"Zoledronate impairs socket healing after extraction of teeth with experimental periodontitis","volume":"97","author":"Soundia","year":"2018","journal-title":"J. Dent. Res."},{"issue":"10","key":"10.1016\/j.actbio.2026.04.063_bib0027","doi-asserted-by":"crossref","first-page":"4976","DOI":"10.1021\/acsbiomaterials.9b00499","article-title":"Epithelial and connective tissue sealing around titanium implants with various typical surface finishes","volume":"5","author":"Narimatsu","year":"2019","journal-title":"ACS. Biomater. Sci. Eng."},{"issue":"9","key":"10.1016\/j.actbio.2026.04.063_bib0028","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0029","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-55383-5","article-title":"Endothelial progenitor cells inhibit jaw osteonecrosis in a rat model: a major adverse effect of bisphosphonate therapy","volume":"9","author":"Tamari","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2026.04.063_bib0030","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1172705","article-title":"Oral fibroblasts rescue osteogenic differentiation of mesenchymal stem cells after exposure to zoledronic acid in a paracrine effect","volume":"14","author":"Berg","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.actbio.2026.04.063_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115560","article-title":"Dynamic polarization shifting from M1 to M2 macrophages in reduced osteonecrosis of the jaw-like lesions by cessation of anti-RANKL antibody in mice","volume":"141","author":"Tamaki","year":"2020","journal-title":"Bone"},{"issue":"5411","key":"10.1016\/j.actbio.2026.04.063_bib0032","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0033","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/cre2.16","article-title":"Efficacy of stem cells on the healing of peri-implant defects: systematic review of preclinical studies","volume":"2","author":"Misawa","year":"2016","journal-title":"Clin. Exp. Dent. Res."},{"issue":"4","key":"10.1016\/j.actbio.2026.04.063_bib0034","first-page":"e529","article-title":"Bisphosphonate-related osteonecrosis. application of adipose-derived stem cells in an experimental murine model","volume":"24","author":"Alonso-Rodriguez","year":"2019","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"10.1016\/j.actbio.2026.04.063_bib0035","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bone.2015.01.011","article-title":"Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model","volume":"74","author":"Ogata","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2026.04.063_bib0036","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.929684","article-title":"Exosomes from adipose-derived stem cells can prevent medication-related osteonecrosis of the jaw","volume":"27","author":"Dong","year":"2021","journal-title":"Med. Sci. Monit."},{"issue":"5","key":"10.1016\/j.actbio.2026.04.063_bib0037","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1177\/0022034520906793","article-title":"Extracellular vesicles of stem cells to prevent BRONJ","volume":"99","author":"Watanabe","year":"2020","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0038","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41368-022-00182-4","article-title":"Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw (MRONJ)","volume":"14","author":"Yan","year":"2022","journal-title":"Int. J. Oral Sci."},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0039","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.1038\/s41598-020-61724-6","article-title":"Preventive effect of fluvastatin on the development of medication-related osteonecrosis of the jaw","volume":"10","author":"Adachi","year":"2020","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.actbio.2026.04.063_bib0040","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0278-2391(85)90257-5","article-title":"Alveolar wound healing and ridge remodeling after tooth extraction in the rat: a histologic, radiographic, and histometric study","volume":"43","author":"Guglielmotti","year":"1985","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"6","key":"10.1016\/j.actbio.2026.04.063_bib0041","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1177\/0022034513487558","article-title":"Intra-oral PTH administration promotes tooth extraction socket healing","volume":"92","author":"Kuroshima","year":"2013","journal-title":"J. Dent. Res."},{"issue":"2","key":"10.1016\/j.actbio.2026.04.063_bib0042","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jpor.2019.07.007","article-title":"The effects of hyperglycaemia on peri-implant tissues after osseointegration","volume":"64","author":"Yamazaki","year":"2020","journal-title":"J. Prosthodont. Res."},{"issue":"2","key":"10.1016\/j.actbio.2026.04.063_bib0043","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.transproceed.2006.12.019","article-title":"Stem cell transplantation: the lung barrier","volume":"39","author":"Schrepfer","year":"2007","journal-title":"TransPlant Proc."},{"key":"10.1016\/j.actbio.2026.04.063_bib0044","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3389\/fimmu.2012.00297","article-title":"Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion","volume":"3","author":"Eggenhofer","year":"2012","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.actbio.2026.04.063_bib0045","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1089\/scd.2008.0253","article-title":"Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect","volume":"18","author":"Fischer","year":"2009","journal-title":"Stem Cells Dev."},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0046","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.stem.2015.12.004","article-title":"To serve and protect: hydrogels to improve stem cell-based therapies","volume":"18","author":"Burdick","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0047","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41536-024-00347-1","article-title":"MSCs mediate long-term efficacy in a Crohn's disease model by sustained anti-inflammatory macrophage programming via efferocytosis","volume":"9","author":"Dave","year":"2024","journal-title":"NPJ. Regen. Med."},{"key":"10.1016\/j.actbio.2026.04.063_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2021.115942","article-title":"Alendronate\/dexamethasone combination therapy worsens soft and hard tissue wound healing around implants in rat maxillae","volume":"148","author":"Inoue","year":"2021","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.actbio.2026.04.063_bib0049","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1158\/1078-0432.CCR-10-1614","article-title":"Effect of zoledronate on oral wound healing in rats","volume":"17","author":"Yamashita","year":"2011","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.actbio.2026.04.063_bib0050","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/jbm4.10013","article-title":"Cytokine mixtures mimicking secretomes from mesenchymal stem cells improve medication-related osteonecrosis of the jaw in a rat model","volume":"2","author":"Ogata","year":"2018","journal-title":"JBMR Plus."},{"key":"10.1016\/j.actbio.2026.04.063_bib0051","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.2147\/IJN.S305361","article-title":"Small extracellular vesicles derived from adipose tissue prevent bisphosphonate-related osteonecrosis of the jaw by promoting angiogenesis","volume":"16","author":"Huang","year":"2021","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.actbio.2026.04.063_bib0052","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1908365","article-title":"The modulatory effects of mesenchymal stem cells on osteoclastogenesis","volume":"2016","author":"Sharaf-Eldin","year":"2016","journal-title":"Stem Cells Int."},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0053","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40729-017-0112-4","article-title":"The influence of systemically or locally administered mesenchymal stem cells on tissue repair in a rat oral implantation model","volume":"4","author":"Kanazawa","year":"2018","journal-title":"Int. J. ImPlant Dent."},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0054","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s13287-020-01691-x","article-title":"The role of hepatocyte growth factor in mesenchymal stem cell-induced recovery in spinal cord injured rats","volume":"11","author":"Song","year":"2020","journal-title":"Stem Cell Res. Ther."},{"issue":"12","key":"10.1016\/j.actbio.2026.04.063_bib0055","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1002\/stem.544","article-title":"Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37","volume":"28","author":"Krasnodembskaya","year":"2010","journal-title":"Stem Cells"},{"issue":"2","key":"10.1016\/j.actbio.2026.04.063_bib0056","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/sctm.19-0092","article-title":"Antibacterial activity of human mesenchymal stem cells mediated directly by constitutively secreted factors and indirectly by activation of innate immune effector cells","volume":"9","author":"Chow","year":"2020","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.actbio.2026.04.063_bib0057","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.addr.2018.09.010","article-title":"Therapeutic strategies for enhancing angiogenesis in wound healing","volume":"146","author":"Veith","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"5","key":"10.1016\/j.actbio.2026.04.063_bib0058","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.archoralbio.2010.11.003","article-title":"Bisphosphonate effects on the behaviour of oral epithelial cells and oral fibroblasts","volume":"56","author":"Ravosa","year":"2011","journal-title":"Arch. Oral Biol."},{"issue":"5","key":"10.1016\/j.actbio.2026.04.063_bib0059","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1365-2141.2008.07504.x","article-title":"Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis","volume":"144","author":"Scheper","year":"2009","journal-title":"Br. J. Haematol."},{"issue":"3","key":"10.1016\/j.actbio.2026.04.063_bib0060","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1601-0825.2010.01739.x","article-title":"In vivo effects of zoledronic acid on oral mucosal epithelial cells","volume":"17","author":"Allam","year":"2011","journal-title":"Oral Dis."},{"issue":"4","key":"10.1016\/j.actbio.2026.04.063_bib0061","doi-asserted-by":"crossref","first-page":"e1886","DOI":"10.1371\/journal.pone.0001886","article-title":"Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing","volume":"3","author":"Chen","year":"2008","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.actbio.2026.04.063_bib0062","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1089\/wound.2014.0533","article-title":"Laminins: roles and utility in wound repair","volume":"4","author":"Iorio","year":"2015","journal-title":"Adv. Wound Care (New. Rochelle)"},{"issue":"3","key":"10.1016\/j.actbio.2026.04.063_bib0063","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1177\/002215549804600309","article-title":"Laminin-5 expression is independent of the injury and the microenvironment during reepithelialization of wounds","volume":"46","author":"Kainulainen","year":"1998","journal-title":"J. Histochem. Cytochem."},{"issue":"19","key":"10.1016\/j.actbio.2026.04.063_bib0064","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.1016\/j.biomaterials.2010.03.003","article-title":"The role of a recombinant fragment of laminin-332 in integrin alpha3beta1-dependent cell binding, spreading and migration","volume":"31","author":"Yamashita","year":"2010","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.actbio.2026.04.063_bib0065","doi-asserted-by":"crossref","first-page":"282","DOI":"10.4012\/dmj.2022-040","article-title":"Evaluation of carbonate apatite as a bone substitute in rat extraction sockets from the perspective of mesenchymal stem cells","volume":"42","author":"Takahashi","year":"2023","journal-title":"Dent. Mater. J."},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0066","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13287-016-0367-3","article-title":"Therapeutic interactions between mesenchymal stem cells for healing medication-related osteonecrosis of the jaw","volume":"7","author":"Matsuura","year":"2016","journal-title":"Stem Cell Res. Ther."},{"issue":"10","key":"10.1016\/j.actbio.2026.04.063_bib0067","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.5966\/sctm.2015-0337","article-title":"Hepatocyte growth factor is required for mesenchymal stromal cell protection against bleomycin-induced pulmonary fibrosis","volume":"5","author":"Cahill","year":"2016","journal-title":"Stem Cells Transl. Med."},{"issue":"3","key":"10.1016\/j.actbio.2026.04.063_bib0068","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/STROKEAHA.112.677328","article-title":"Intra-arterial cell transplantation provides timing-dependent cell distribution and functional recovery after stroke","volume":"44","author":"Ishizaka","year":"2013","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.actbio.2026.04.063_bib0069","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1645\/15-754.1","article-title":"Therapeutic potential of mesenchymal stem cells on early and late experimental hepatic schistosomiasis model","volume":"101","author":"El-Shennawy","year":"2015","journal-title":"J. Parasitol."},{"issue":"2","key":"10.1016\/j.actbio.2026.04.063_bib0070","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00441-018-02981-w","article-title":"Early injection of human adipose tissue-derived mesenchymal stem cell after inflammation ameliorates dextran sulfate sodium-induced colitis in mice through the induction of M2 macrophages and regulatory T cells","volume":"376","author":"Kawata","year":"2019","journal-title":"Cell Tissue Res."},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0071","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s12967-023-04028-3","article-title":"Mesenchymal stem cells can prevent or promote the progression of colon cancer based on their timing of administration","volume":"21","author":"Hu","year":"2023","journal-title":"J. Transl. Med."},{"issue":"10","key":"10.1016\/j.actbio.2026.04.063_bib0072","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1182\/blood.V99.10.3838","article-title":"Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli","volume":"99","author":"Di Nicola","year":"2002","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.actbio.2026.04.063_bib0073","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1182\/blood-2002-07-2104","article-title":"Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide","volume":"101","author":"Krampera","year":"2003","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0074","doi-asserted-by":"crossref","first-page":"302","DOI":"10.4049\/jimmunol.0902007","article-title":"Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype","volume":"185","author":"Ghannam","year":"2010","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0075","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1182\/blood-2005-07-2657","article-title":"Human mesenchymal stem cells modulate B-cell functions","volume":"107","author":"Corcione","year":"2006","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.actbio.2026.04.063_bib0076","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1182\/blood-2005-07-2775","article-title":"Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation","volume":"107","author":"Spaggiari","year":"2006","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0077","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/01.tp.0000244572.24780.54","article-title":"Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle","volume":"83","author":"Ramasamy","year":"2007","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.actbio.2026.04.063_bib0078","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1634\/stemcells.2007-0416","article-title":"Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow niche","volume":"26","author":"Raffaghello","year":"2008","journal-title":"Stem. Cells"},{"issue":"3","key":"10.1016\/j.actbio.2026.04.063_bib0079","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.blre.2005.11.002","article-title":"The role of mesenchymal stem cells in haemopoiesis","volume":"20","author":"Dazzi","year":"2006","journal-title":"Blood Rev."},{"issue":"9","key":"10.1016\/j.actbio.2026.04.063_bib0080","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.3324\/haematol.12857","article-title":"The effect of mesenchymal stem cells on the viability, proliferation and differentiation of B-lymphocytes","volume":"93","author":"Tabera","year":"2008","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.actbio.2026.04.063_bib0081","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1634\/stemcells.2007-0528","article-title":"Bone marrow-derived mesenchymal stem cells induce both polyclonal expansion and differentiation of B cells isolated from healthy donors and systemic lupus erythematosus patients","volume":"26","author":"Traggiai","year":"2008","journal-title":"Stem. Cells"},{"issue":"2","key":"10.1016\/j.actbio.2026.04.063_bib0082","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1634\/stemcells.2005-0008","article-title":"Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells","volume":"24","author":"Krampera","year":"2006","journal-title":"Stem. Cells"},{"issue":"2","key":"10.1016\/j.actbio.2026.04.063_bib0083","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.stem.2007.11.014","article-title":"Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide","volume":"2","author":"Ren","year":"2008","journal-title":"Cell Stem Cell"},{"issue":"20","key":"10.1016\/j.actbio.2026.04.063_bib0084","doi-asserted-by":"crossref","first-page":"20743","DOI":"10.18632\/aging.104006","article-title":"Determination of the molecular mechanism by which macrophages and \u03b3\u03b4-T cells contribute to ZOL-induced ONJ","volume":"12","author":"Qu","year":"2020","journal-title":"Aging (Albany. NY)"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126002849?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126002849?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:23:43Z","timestamp":1783113823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126002849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":84,"alternative-id":["S1742706126002849"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.04.063","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Postoperative administration of mesenchymal stem cells enhances peri-implant tissue healing in a medication-related osteonecrosis of the jaw model","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.04.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}