{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:33:28Z","timestamp":1783118008845,"version":"3.54.6"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100031935","name":"Xi'an Jiaotong University","doi-asserted-by":"publisher","award":["XJTU1AF-CRF-2023-XK006"],"award-info":[{"award-number":["XJTU1AF-CRF-2023-XK006"]}],"id":[{"id":"10.13039\/100031935","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12472079"],"award-info":[{"award-number":["12472079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.actbio.2026.05.018","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:16:56Z","timestamp":1778761016000},"page":"369-377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The correlation between the deterioration of microstructural evolution and mechanical properties in human ascending aortas with and without dissections"],"prefix":"10.1016","volume":"217","author":[{"given":"Siyuan","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0894-0289","authenticated-orcid":false,"given":"Zhengjin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2026.05.018_bib0001","article-title":"Aortic dissection","volume":"2","author":"Nienaber","year":"2016","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.actbio.2026.05.018_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2019.08.017","article-title":"Biomechanics of aortic wall failure with a focus on dissection and aneurysm: a review","volume":"99","author":"Sherifova","year":"2019","journal-title":"Acta Biomater."},{"issue":"10","key":"10.1016\/j.actbio.2026.05.018_bib0003","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1001\/jamacardio.2022.2718","article-title":"Early mortality in type A acute aortic dissection: insights from the International Registry of Acute Aortic Dissection","volume":"7","author":"Harris","year":"2022","journal-title":"JAMa Cardiol."},{"issue":"Suppl_1","key":"10.1016\/j.actbio.2026.05.018_bib0004","doi-asserted-by":"crossref","DOI":"10.1161\/circ.146.suppl_1.9976","article-title":"Contrasting mortality trends of aortic emergency: dissection and rupture in the UK, Japan, USA, and Canada","volume":"146","author":"Hibino","year":"2022","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.actbio.2026.05.018_bib0005","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/eurheartj\/ehac757","article-title":"Acute aortic dissection: evidence, uncertainties, and future therapies","volume":"44","author":"Rylski","year":"2023","journal-title":"Eur. Heart. J."},{"issue":"1","key":"10.1016\/j.actbio.2026.05.018_bib0006","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/heartjnl-2015-308284","article-title":"Aortic dissection: medical, interventional and surgical management","volume":"103","author":"Silaschi","year":"2017","journal-title":"Heart"},{"issue":"21","key":"10.1016\/j.actbio.2026.05.018_bib0007","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz1173","article-title":"Avalanches and power law behavior in aortic dissection propagation","volume":"6","author":"Yu","year":"2020","journal-title":"Sci. Adv."},{"issue":"3","key":"10.1016\/j.actbio.2026.05.018_bib0008","doi-asserted-by":"crossref","first-page":"H540","DOI":"10.1152\/ajpheart.00117.2018","article-title":"Biomechanical relevance of the microstructure in artery walls with a focus on passive and active components","volume":"315","author":"Holzapfel","year":"2018","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"issue":"12","key":"10.1016\/j.actbio.2026.05.018_bib0009","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1016\/j.jbiomech.2015.06.025","article-title":"Age-related distensibility and histology of the ascending aorta in elderly patients with acute aortic dissection","volume":"48","author":"Yamada","year":"2015","journal-title":"J. Biomech."},{"key":"10.1016\/j.actbio.2026.05.018_bib0010","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jbiomech.2019.07.028","article-title":"Mechanical characterisation of human ascending aorta dissection","volume":"94","author":"Deplano","year":"2019","journal-title":"J. Biomech."},{"issue":"3","key":"10.1016\/j.actbio.2026.05.018_bib0011","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.humpath.2007.08.003","article-title":"Collagen is reduced and disrupted in human aneurysms and dissections of ascending aorta","volume":"39","author":"de Figueiredo Borges","year":"2008","journal-title":"Hum. Pathol."},{"issue":"14","key":"10.1016\/j.actbio.2026.05.018_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e34646","article-title":"Layer-specific biomechanical and histological properties of normal and dissected human ascending aortas","volume":"10","author":"Guo","year":"2024","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.actbio.2026.05.018_bib0013","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0009-8981(94)90100-7","article-title":"Glycosaminoglycan content is increased in dissecting aneurysms of human thoracic aorta","volume":"226","author":"Cattell","year":"1994","journal-title":"Clin. Chim. Acta"},{"issue":"9","key":"10.1016\/j.actbio.2026.05.018_bib0014","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1161\/ATVBAHA.118.312175","article-title":"Glycoproteomic analysis of the aortic extracellular matrix in Marfan patients","volume":"39","author":"Xiaoke","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.actbio.2026.05.018_bib0015","doi-asserted-by":"crossref","DOI":"10.1093\/ejcts\/ezac392","article-title":"Regional variation in biomechanical properties of ascending thoracic aortic aneurysms","volume":"62","author":"Salmasi","year":"2022","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.actbio.2026.05.018_bib0016","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.actbio.2024.10.010","article-title":"Effects of age, elastin density, and glycosaminoglycan accumulation on the delamination strength of human thoracic and abdominal aortas","volume":"189","author":"Shahbad","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.05.018_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111471","article-title":"Evolving structure-function relations during aortic maturation and aging revealed by multiphoton microscopy","volume":"196","author":"Cavinato","year":"2021","journal-title":"Mech. Ageing Dev."},{"issue":"12","key":"10.1016\/j.actbio.2026.05.018_bib0018","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1016\/j.jbiomech.2016.02.042","article-title":"Mechanical strength of aneurysmatic and dissected human thoracic aortas at different shear loading modes","volume":"49","author":"Sommer","year":"2016","journal-title":"J. Biomech."},{"issue":"6","key":"10.1016\/j.actbio.2026.05.018_bib0019","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s11517-012-0876-x","article-title":"Mechanical behaviour and rupture of normal and pathological human ascending aortic wall","volume":"50","author":"Garcia-Herrera","year":"2012","journal-title":"Med. Biol. Eng. Comput."},{"issue":"15","key":"10.1016\/j.actbio.2026.05.018_bib0020","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.016715","article-title":"Biomechanics of aortic dissection: a comparison of aortas associated with bicuspid and tricuspid aortic valves","volume":"9","author":"Chung","year":"2020","journal-title":"J. Am. Heart. Assoc."},{"issue":"2","key":"10.1016\/j.actbio.2026.05.018_bib0021","doi-asserted-by":"crossref","DOI":"10.1093\/icvts\/ivac068","article-title":"Gender differences in the dissection properties of ascending thoracic aortic aneurysms","volume":"35","author":"Tong","year":"2022","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"10.1016\/j.actbio.2026.05.018_bib0022","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.actbio.2024.11.002","article-title":"Age-related changes in the biochemical composition of the human aorta and their correlation with the delamination strength","volume":"190","author":"Suchy","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.05.018_bib0023","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.actbio.2023.08.016","article-title":"Regional biomechanical characterization of human ascending aortic aneurysms: microstructure and biaxial mechanical response","volume":"169","author":"Cosentino","year":"2023","journal-title":"Acta Biomater."},{"issue":"6","key":"10.1016\/j.actbio.2026.05.018_bib0024","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","article-title":"The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations","volume":"51","author":"Baron","year":"1986","journal-title":"J. Pers. Soc. Psychol."},{"key":"10.1016\/j.actbio.2026.05.018_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2022.105603","article-title":"Regional and directional delamination properties of healthy human ascending aorta and sinotubular junction","volume":"138","author":"Xuan","year":"2023","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"2","key":"10.1016\/j.actbio.2026.05.018_bib0027","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jtcvs.2011.07.058","article-title":"Effect of aneurysm on the mechanical dissection properties of the human ascending thoracic aorta","volume":"143","author":"Pasta","year":"2012","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.actbio.2026.05.018_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbiomech.2023.111615","article-title":"Effect of hypertension on the delamination and tensile strength of ascending thoracic aortic aneurysm with a focus on right lateral region","volume":"154","author":"Tong","year":"2023","journal-title":"J. Biomech."},{"issue":"9","key":"10.1016\/j.actbio.2026.05.018_bib0029","doi-asserted-by":"crossref","first-page":"e358","DOI":"10.1161\/ATVBAHA.123.319122","article-title":"Effects of age, sex, and extracellular matrix integrity on aortic dilatation and rupture in a mouse model of marfan syndrome","volume":"43","author":"Weiss","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"12","key":"10.1016\/j.actbio.2026.05.018_bib0030","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1016\/j.jbiomech.2016.02.027","article-title":"Arterial mechanics considering the structural and mechanical contributions of ECM constituents","volume":"49","author":"Wang","year":"2016","journal-title":"J. Biomech."},{"key":"10.1016\/j.actbio.2026.05.018_bib0031","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.actbio.2023.08.061","article-title":"Glycosaminoglycans modulate compressive stiffness and circumferential residual stress in the porcine thoracic aorta","volume":"170","author":"Ghadie","year":"2023","journal-title":"Acta Biomater."},{"issue":"12","key":"10.1016\/j.actbio.2026.05.018_bib0032","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1109\/TBME.2021.3074053","article-title":"The contribution of glycosaminoglycans\/proteoglycans to aortic mechanics in health and disease: a critical review","volume":"68","author":"Ghadie","year":"2021","journal-title":"IEEE Trans. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.actbio.2026.05.018_bib0033","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1161\/01.HYP.26.1.2","article-title":"Mechanical principles in arterial disease","volume":"26","author":"O'Rourke","year":"1995","journal-title":"Hypertension"},{"issue":"83","key":"10.1016\/j.actbio.2026.05.018_bib0034","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2012.1004","article-title":"Elastin and collagen fibre microstructure of the human aorta in ageing and disease: a review","volume":"10","author":"Tsamis","year":"2013","journal-title":"J. R. Soc. Interface"},{"issue":"4","key":"10.1016\/j.actbio.2026.05.018_bib0035","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1001\/archsurg.1984.01390160041009","article-title":"Elastolytic and collagenolytic studies of arteries. Implications for the mechanical properties of aneurysms","volume":"119","author":"Dobrin","year":"1984","journal-title":"Arch. Surg."},{"issue":"6","key":"10.1016\/j.actbio.2026.05.018_bib0036","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1053\/ejvs.2002.1620","article-title":"Alteration of elastin, collagen and their cross-links in abdominal aortic aneurysms","volume":"23","author":"Carmo","year":"2002","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"issue":"3","key":"10.1016\/j.actbio.2026.05.018_bib0037","article-title":"Biochemomechanics of the thoracic aorta in health and disease","volume":"2","author":"Sherifova","year":"2020","journal-title":"Progress Biomed. Eng."},{"key":"10.1016\/j.actbio.2026.05.018_bib0038","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/199606a0","article-title":"W, Aortic Wall as a 'Two-phase' Material","volume":"199","author":"Seymour","year":"1963","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.actbio.2026.05.018_bib0039","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/cvr\/cvr195","article-title":"Mechanical assessment of elastin integrity in fibrillin-1-deficient carotid arteries: implications for Marfan syndrome","volume":"92","author":"Ferruzzi","year":"2011","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.actbio.2026.05.018_bib0040","doi-asserted-by":"crossref","first-page":"H189","DOI":"10.1152\/ajpheart.00087.2018","article-title":"Elastin, arterial mechanics, and cardiovascular disease","volume":"315","author":"Cocciolone","year":"2018","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"issue":"5","key":"10.1016\/j.actbio.2026.05.018_bib0041","doi-asserted-by":"crossref","DOI":"10.1115\/1.4029637","article-title":"Contribution of collagen fiber undulation to regional biomechanical properties along porcine thoracic aorta","volume":"137","author":"Zeinali-Davarani","year":"2015","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.actbio.2026.05.018_bib0042","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.actbio.2024.01.014","article-title":"Contributions of collagen and elastin to elastic behaviours of tendon fascicle","volume":"176","author":"Ishizaki","year":"2024","journal-title":"Acta. Biomater."},{"issue":"2","key":"10.1016\/j.actbio.2026.05.018_bib0043","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.mvr.2006.10.005","article-title":"Structure of large arteries: orientation of elastin in rabbit aortic internal elastic lamina and in the elastic lamellae of aortic media","volume":"73","author":"Farand","year":"2007","journal-title":"Microvasc. Res."},{"issue":"1","key":"10.1016\/j.actbio.2026.05.018_bib0044","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10237-020-01370-z","article-title":"Mechanical and structural contributions of elastin and collagen fibers to interlamellar bonding in the arterial wall","volume":"20","author":"Wang","year":"2021","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.actbio.2026.05.018_bib0045","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.934941","article-title":"Wall shear stress predicts Media degeneration and biomechanical changes in Thoracic Aorta","volume":"13","author":"Kiema","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.actbio.2026.05.018_bib0046","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev.genom.8.080706.092303","article-title":"Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction","volume":"9","author":"Milewicz","year":"2008","journal-title":"Annu Rev. Genomics. Hum. Genet."},{"issue":"1","key":"10.1016\/j.actbio.2026.05.018_bib0047","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10237-013-0482-3","article-title":"Biomechanical roles of medial pooling of glycosaminoglycans in thoracic aortic dissection","volume":"13","author":"Roccabianca","year":"2014","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"3","key":"10.1016\/j.actbio.2026.05.018_bib0048","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.humpath.2008.08.002","article-title":"Tissue diffusion and retention of metalloproteinases in ascending aortic aneurysms and dissections","volume":"40","author":"Borges","year":"2009","journal-title":"Hum. Pathol."},{"issue":"5","key":"10.1016\/j.actbio.2026.05.018_bib0049","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41569-020-00472-6","article-title":"Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes","volume":"18","author":"Bossone","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"issue":"3","key":"10.1016\/j.actbio.2026.05.018_bib0050","first-page":"154","article-title":"Is it good to have a stiff aorta with aging? Causes and consequences","volume":"37","author":"Pierce","year":"2022","journal-title":"Physiology. (Bethesda)"},{"issue":"5","key":"10.1016\/j.actbio.2026.05.018_bib0051","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1161\/01.HYP.0000187016.06549.96","article-title":"Sex steroids modulate human aortic smooth muscle cell matrix protein deposition and matrix metalloproteinase expression","volume":"46","author":"Natoli","year":"2005","journal-title":"Hypertension"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126003119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126003119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:11:12Z","timestamp":1783073472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126003119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":50,"alternative-id":["S1742706126003119"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.05.018","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The correlation between the deterioration of microstructural evolution and mechanical properties in human ascending aortas with and without dissections","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.05.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}