{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:16:19Z","timestamp":1783458979595,"version":"3.55.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008810","name":"NSW Ministry of Health","doi-asserted-by":"publisher","award":["H22\/98586"],"award-info":[{"award-number":["H22\/98586"]}],"id":[{"id":"10.13039\/501100008810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["105622"],"award-info":[{"award-number":["105622"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["108207-2024"],"award-info":[{"award-number":["108207-2024"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001773","name":"University of New South Wales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT230100249"],"award-info":[{"award-number":["FT230100249"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT210100668"],"award-info":[{"award-number":["FT210100668"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP250103558"],"award-info":[{"award-number":["DP250103558"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["IE240100061"],"award-info":[{"award-number":["IE240100061"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009287","name":"NSW Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009287","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.actbio.2026.06.006","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:22:29Z","timestamp":1780503749000},"page":"323-337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["MCC950-loaded silk microgel-hydrogel composite scaffolds effectively modulate inflammation for improving tissue interaction and remodeling"],"prefix":"10.1016","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4756-2644","authenticated-orcid":false,"given":"Kieran","family":"Lau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9056-7139","authenticated-orcid":false,"given":"Angus J.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-7673","authenticated-orcid":false,"given":"Alex H.P.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khoon S.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6121-4676","authenticated-orcid":false,"given":"Jelena","family":"Rnjak-Kovacina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.actbio.2026.06.006_bib0001","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.stem.2018.02.009","article-title":"Vascular tissue engineering: progress, challenges, and clinical promise","volume":"22","author":"Song","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.actbio.2026.06.006_bib0002","first-page":"316","article-title":"Hydrogel scaffolds for tissue engineering: progress and challenges","volume":"2013","author":"El-Sherbiny","year":"2013","journal-title":"Glob. Cardiol. Sci. Pr."},{"key":"10.1016\/j.actbio.2026.06.006_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/3606765","article-title":"Advancements in the use of hydrogels for regenerative medicine: properties and biomedical applications","volume":"2022","author":"Revete","year":"2022","journal-title":"Int. J. Biomater."},{"key":"10.1016\/j.actbio.2026.06.006_bib0004","series-title":"Biomedical Engineering - Frontiers and Challenges","first-page":"275","author":"Mequanint","year":"2011"},{"issue":"40","key":"10.1016\/j.actbio.2026.06.006_bib0005","doi-asserted-by":"crossref","first-page":"8111","DOI":"10.1039\/D1TB02628C","article-title":"Porous biomaterials for tissue engineering: a review","volume":"10","author":"Maksoud","year":"2022","journal-title":"J. Mater. Chem. B"},{"issue":"24","key":"10.1016\/j.actbio.2026.06.006_bib0006","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1016\/S0142-9612(03)00340-5","article-title":"Hydrogels for tissue engineering: scaffold design variables and applications","volume":"24","author":"Drury","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2026.06.006_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119294","article-title":"Enzymatically-degradable alginate hydrogels promote cell spreading and in vivo tissue infiltration","volume":"217","author":"Lueckgen","year":"2019","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.actbio.2026.06.006_bib0008","first-page":"3692","article-title":"Modulating degradation of sodium alginate\/bioglass hydrogel for improving tissue infiltration and promoting wound healing","volume":"6","author":"Zhang","year":"2021","journal-title":"Bioact. Mater."},{"issue":"3","key":"10.1016\/j.actbio.2026.06.006_bib0009","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1021\/acsbiomaterials.9b01624","article-title":"Microchannels are an architectural cue that promotes integration and vascularization of Silk biomaterials in Vivo","volume":"6","author":"Tang","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"11","key":"10.1016\/j.actbio.2026.06.006_bib0010","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.tibtech.2019.04.004","article-title":"Microchannels in development, survival, and vascularisation of tissue analogues for regenerative medicine","volume":"37","author":"Lim","year":"2019","journal-title":"Trends Biotechnol."},{"issue":"1","key":"10.1016\/j.actbio.2026.06.006_bib0011","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41578-019-0148-6","article-title":"Hydrogel microparticles for biomedical applications","volume":"5","author":"Daly","year":"2020","journal-title":"Nat. Rev. Mater."},{"issue":"13","key":"10.1016\/j.actbio.2026.06.006_bib0012","article-title":"Multisized photoannealable microgels regulate cell spreading, aggregation, and macrophage phenotype through microporous void space","volume":"12","author":"Lowen","year":"2023","journal-title":"Adv. Heal. Mater."},{"issue":"19","key":"10.1016\/j.actbio.2026.06.006_bib0013","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1016\/j.biomaterials.2008.03.026","article-title":"The effect of sustained delivery of vascular endothelial growth factor on angiogenesis in tissue-engineered intestine","volume":"29","author":"Rocha","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2026.06.006_bib0014","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.biomaterials.2015.08.049","article-title":"Biomaterials with persistent growth factor gradients in vivo accelerate vascularized tissue formation","volume":"72","author":"Akar","year":"2015","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.actbio.2026.06.006_bib0015","article-title":"Strategies for regenerative vascular tissue engineering","volume":"7","author":"Wang","year":"2023","journal-title":"Adv. Biol."},{"issue":"3","key":"10.1016\/j.actbio.2026.06.006_bib0016","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3390\/ijms20030636","article-title":"Biomaterials: foreign bodies or tuners for the immune response?","volume":"20","author":"Mariani","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"23","key":"10.1016\/j.actbio.2026.06.006_bib0017","doi-asserted-by":"crossref","first-page":"9415","DOI":"10.1073\/pnas.1300290110","article-title":"Macrophages are required for adult salamander limb regeneration","volume":"110","author":"Godwin","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.actbio.2026.06.006_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108595","article-title":"MCC950 in the treatment of NLRP3-mediated inflammatory diseases: latest evidence and therapeutic outcomes","volume":"106","author":"Bakhshi","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"32","key":"10.1016\/j.actbio.2026.06.006_bib0019","article-title":"Selective immunosuppression targeting the NLRP3 inflammasome mitigates the foreign body response to implanted biomaterials while preserving angiogenesis","volume":"12","author":"Chan","year":"2023","journal-title":"Adv. Heal. Mater."},{"key":"10.1016\/j.actbio.2026.06.006_bib0020","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fmolb.2020.00037","article-title":"MCC950, a selective inhibitor of NLRP3 inflammasome, reduces the inflammatory response and improves neurological outcomes in mice model of spinal cord injury","volume":"7","author":"Jiao","year":"2020","journal-title":"Front. Mol. Biosci."},{"issue":"4","key":"10.1016\/j.actbio.2026.06.006_bib0021","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3390\/molecules26040976","article-title":"NLRP3 Inflammasome inhibitors in cardiovascular diseases","volume":"26","author":"Mezzaroma","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.actbio.2026.06.006_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175091","article-title":"Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome","volume":"928","author":"Li","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"28","key":"10.1016\/j.actbio.2026.06.006_bib0023","doi-asserted-by":"crossref","first-page":"33322","DOI":"10.1021\/acsami.3c04206","article-title":"Encapsulation of MCC950 in liposomes decorated with anti-frizzled 1 improves drug bioavailability and effectiveness in fatty liver disease","volume":"15","author":"Negro","year":"2023","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"10.1016\/j.actbio.2026.06.006_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.913648","article-title":"Mussel-inspired microgel encapsulated NLRP3 inhibitor as a synergistic strategy against dry eye","volume":"10","author":"Zha","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2026.06.006_bib0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jconrel.2014.03.054","article-title":"Controlled drug delivery systems: past forward and future back","volume":"190","author":"Park","year":"2014","journal-title":"J. Control Release"},{"issue":"20","key":"10.1016\/j.actbio.2026.06.006_bib0026","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202300521","article-title":"Selective NLRP3 inflammasome inhibitor MCC950 suppresses inflammation and facilitates healing in vascular materials","volume":"10","author":"Grant","year":"2023","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2026.06.006_bib0027","article-title":"The biomedical use of silk: past, present, future","volume":"8","author":"Holland","year":"2019","journal-title":"Adv. Heal. Mater."},{"issue":"10","key":"10.1016\/j.actbio.2026.06.006_bib0028","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1038\/nprot.2011.379","article-title":"Materials fabrication from Bombyx mori silk fibroin","volume":"6","author":"Rockwood","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.actbio.2026.06.006_bib0029","unstructured":"S. Dowland, Masson\u2019s trichrome staining for histology, protocols.io."},{"key":"10.1016\/j.actbio.2026.06.006_bib0030","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.actbio.2017.09.020","article-title":"Molecular and macro-scale analysis of enzyme-crosslinked silk hydrogels for rational biomaterial design","volume":"63","author":"McGill","year":"2017","journal-title":"Acta Biomater."},{"issue":"29","key":"10.1016\/j.actbio.2026.06.006_bib0031","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1002\/adfm.201400526","article-title":"Highly tunable elastomeric silk biomaterials","volume":"24","author":"Partlow","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2026.06.006_bib0032","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.biomaterials.2017.03.046","article-title":"Enzymatically crosslinked silk-hyaluronic acid hydrogels","volume":"131","author":"Raia","year":"2017","journal-title":"Biomaterials"},{"issue":"20","key":"10.1016\/j.actbio.2026.06.006_bib0033","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.3390\/polym16202879","article-title":"Formulation-property effects in novel injectable and resilient natural polymer-based hydrogels for soft tissue regeneration","volume":"16","author":"Goder Orbach","year":"2024","journal-title":"Polymers"},{"issue":"18","key":"10.1016\/j.actbio.2026.06.006_bib0034","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.2174\/1385272819666140806200355","article-title":"Hybrid organic-inorganic scaffolding biomaterials for regenerative therapies","volume":"18","author":"Sachot","year":"2014","journal-title":"Curr. Org. Chem."},{"key":"10.1016\/j.actbio.2026.06.006_bib0035","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.ijbiomac.2020.06.086","article-title":"Development of Satureja cuneifolia-loaded sodium alginate\/polyethylene glycol scaffolds produced by 3D-printing technology as a diabetic wound dressing material","volume":"161","author":"Ilhan","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.actbio.2026.06.006_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123659","article-title":"Sustained release silicon from 3D bioprinting scaffold using silk\/gelatin inks to promote osteogenesis","volume":"234","author":"Yunsheng","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.actbio.2026.06.006_bib0037","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/jbm.a.36537","article-title":"Tailoring degradation rates of silk fibroin scaffolds for tissue engineering","volume":"107","author":"Zhang","year":"2019","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"10.1016\/j.actbio.2026.06.006_bib0038","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.actbio.2014.09.013","article-title":"Impact of silk biomaterial structure on proteolysis","volume":"11","author":"Brown","year":"2015","journal-title":"Acta Biomater."},{"issue":"4","key":"10.1016\/j.actbio.2026.06.006_bib0039","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/mabi.200900388","article-title":"Stabilization and release of enzymes from silk films","volume":"10","author":"Lu","year":"2010","journal-title":"Macromol. Biosci."},{"issue":"5","key":"10.1016\/j.actbio.2026.06.006_bib0040","first-page":"1750","article-title":"Recombinant spider silk hydrogels for sustained release of biologicals","volume":"4","author":"Kumari","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"4","key":"10.1016\/j.actbio.2026.06.006_bib0041","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1517\/17425241003602259","article-title":"Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems","volume":"7","author":"Fu","year":"2010","journal-title":"Expert. Opin. Drug Deliv."},{"issue":"12","key":"10.1016\/j.actbio.2026.06.006_bib0042","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.3390\/polym10121379","article-title":"Implantable polymeric drug delivery devices: classification, manufacture, materials, and clinical applications","volume":"10","author":"Stewart","year":"2018","journal-title":"Polymers"},{"issue":"22","key":"10.1016\/j.actbio.2026.06.006_bib0043","doi-asserted-by":"crossref","first-page":"11875","DOI":"10.1073\/pnas.94.22.11875","article-title":"Growth and viability of macrophages continuously stimulated to produce nitric oxide","volume":"94","author":"Zhuang","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.actbio.2026.06.006_bib0044","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/09553002.2016.1206224","article-title":"Evaluation of cell viability, DNA single-strand breaks, and nitric oxide production in LPS-stimulated macrophage RAW264 exposed to a 50-hz magnetic field","volume":"92","author":"Nakayama","year":"2016","journal-title":"Int. J. Radiat. Biol."},{"issue":"1","key":"10.1016\/j.actbio.2026.06.006_bib0045","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-98437-3","article-title":"The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages","volume":"11","author":"Zeng","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.actbio.2026.06.006_bib0046","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-74786-3","article-title":"Inhibition of NLRP3 inflammasome by MCC950 improves the metabolic outcome of islet transplantation by suppressing IL-1beta and islet cellular death","volume":"10","author":"Matsuoka","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2026.06.006_bib0047","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.ijbiomac.2019.05.068","article-title":"Highly elastomeric photocurable silk hydrogels","volume":"134","author":"Kuang","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.actbio.2026.06.006_bib0048","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0006-3495(00)76279-5","article-title":"Cell movement is guided by the rigidity of the substrate","volume":"79","author":"Lo","year":"2000","journal-title":"Biophys. J."},{"issue":"11","key":"10.1016\/j.actbio.2026.06.006_bib0049","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1021\/bm201170h","article-title":"Injectable microgel-hydrogel composites for prolonged small-molecule drug delivery","volume":"12","author":"Sivakumaran","year":"2011","journal-title":"Biomacromolecules"},{"issue":"29","key":"10.1016\/j.actbio.2026.06.006_bib0050","article-title":"Photocrosslinked silk fibroin microgel scaffolds for biomedical applications","volume":"34","author":"Karimi","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"10.1016\/j.actbio.2026.06.006_bib0051","first-page":"86","article-title":"3D printing-based drug-loaded implanted prosthesis to prevent breast cancer recurrence post-conserving surgery","volume":"16","author":"Hao","year":"2021","journal-title":"Asian J. Pharm. Sci."},{"issue":"12","key":"10.1016\/j.actbio.2026.06.006_bib0052","article-title":"Immunomodulation strategies for the successful regeneration of a tissue-engineered vascular graft","volume":"11","author":"Zhang","year":"2022","journal-title":"Adv. Heal. Mater."},{"issue":"3","key":"10.1016\/j.actbio.2026.06.006_bib0053","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/s10439-014-1156-8","article-title":"Macrophages modulate engineered human tissues for enhanced vascularization and healing","volume":"43","author":"Spiller","year":"2015","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.actbio.2026.06.006_bib0054","article-title":"Effect of plasma ion immersion implantation on physiochemical and biological properties of silk towards creating a versatile biomaterial platform","volume":"13","author":"Lau","year":"2022","journal-title":"Mater. Today Adv."},{"issue":"12","key":"10.1016\/j.actbio.2026.06.006_bib0055","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2115857119","article-title":"Prevention of the foreign body response to implantable medical devices by inflammasome inhibition","volume":"119","author":"Barone","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"24","key":"10.1016\/j.actbio.2026.06.006_bib0056","article-title":"Annealing high aspect ratio microgels into macroporous 3D scaffolds allows for higher porosities and effective cell migration","volume":"11","author":"Suturin","year":"2022","journal-title":"Adv. Heal. Mater."},{"key":"10.1016\/j.actbio.2026.06.006_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108046","article-title":"Selective inhibition of NLRP3 inflammasome reverses pressure overload-induced pathological cardiac remodeling by attenuating hypertrophy, fibrosis, and inflammation","volume":"99","author":"Zhao","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"Pt A","key":"10.1016\/j.actbio.2026.06.006_bib0058","article-title":"MCC950 promotes diabetic wound healing through modulating macrophage polarization in an MDSC-dependent manner","volume":"142","author":"Yan","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.actbio.2026.06.006_bib0059","doi-asserted-by":"crossref","DOI":"10.1002\/sstr.202300281","article-title":"Multifunctionalized and dual-crosslinked hydrogel promotes inflammation resolution and bone regeneration via NLRP3 inhibition in periodontitis","volume":"5","author":"Liu","year":"2024","journal-title":"Small. Struct."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126003636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126003636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:42:31Z","timestamp":1783456951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126003636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":59,"alternative-id":["S1742706126003636"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.06.006","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MCC950-loaded silk microgel-hydrogel composite scaffolds effectively modulate inflammation for improving tissue interaction and remodeling","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}