{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T20:56:57Z","timestamp":1785704217014,"version":"3.56.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006250","name":"Southwest University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.actbio.2026.06.049","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T07:44:10Z","timestamp":1782373450000},"page":"633-647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Acid-responsive bone-targeting nanoplatform enables spatiotemporal control of osteogenesis and angiogenesis for osteoporosis rescue"],"prefix":"10.1016","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5212-2484","authenticated-orcid":false,"given":"Yingqi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0034-073X","authenticated-orcid":false,"given":"Yue","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huarui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7161-2624","authenticated-orcid":false,"given":"Yuhui","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9527","key":"10.1016\/j.actbio.2026.06.049_bib0001","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/S0140-6736(06)68891-0","article-title":"Osteoporosis","volume":"367","author":"Sambrook","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.actbio.2026.06.049_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122066","article-title":"Advances in materials-based therapeutic strategies against osteoporosis","volume":"296","author":"Lei","year":"2023","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.actbio.2026.06.049_bib0003","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1080\/03008207.2018.1439482","article-title":"Therapeutic ionizing radiation induced bone loss: a review of in vivo and in vitro findings","volume":"59","author":"Zhang","year":"2018","journal-title":"Connect. Tissue Res."},{"issue":"9","key":"10.1016\/j.actbio.2026.06.049_bib0004","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/s41574-023-00866-9","article-title":"Long-term and sequential treatment for osteoporosis","volume":"19","author":"Foessl","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"issue":"4","key":"10.1016\/j.actbio.2026.06.049_bib0005","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1210\/endrev\/bnab005","article-title":"Physiological and pharmacological roles of PTH and PTHrP in bone using their shared receptor, PTH1R","volume":"42","author":"Martin","year":"2021","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.actbio.2026.06.049_bib0006","article-title":"Ten years too long: strontium ranelate, cardiac events, and the European Medicines Agency","volume":"354","author":"Bolland","year":"2016","journal-title":"The BMJ"},{"key":"10.1016\/j.actbio.2026.06.049_bib0007","article-title":"Bisphosphonates for the prevention and treatment of osteoporosis","volume":"351","author":"Maraka","year":"2015","journal-title":"The BMJ"},{"issue":"10","key":"10.1016\/j.actbio.2026.06.049_bib0008","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1359\/jbmr.0707onj","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: report of a Task Force of the American Society for Bone and Mineral Research","volume":"22","author":"Khosla","year":"2007","journal-title":"J. Bone Miner. Res."},{"issue":"8","key":"10.1016\/j.actbio.2026.06.049_bib0009","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ejim.2013.03.012","article-title":"Osteoporosis treatment: focus on safety","volume":"24","author":"Reid","year":"2013","journal-title":"Eur. J. Intern. Med."},{"issue":"9","key":"10.1016\/j.actbio.2026.06.049_bib0010","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.drudis.2017.04.021","article-title":"Development of nanomaterials for bone-targeted drug delivery","volume":"22","author":"Cheng","year":"2017","journal-title":"Drug Discov. Today"},{"issue":"20","key":"10.1016\/j.actbio.2026.06.049_bib0011","doi-asserted-by":"crossref","first-page":"8987","DOI":"10.1021\/jacs.2c00749","article-title":"Acid neutralization and immune regulation by calcium\u2013Aluminum-layered double hydroxide for osteoporosis reversion","volume":"144","author":"Fu","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"31","key":"10.1016\/j.actbio.2026.06.049_bib0012","article-title":"Metal-polyDNA nanoparticles reconstruct osteoporoticmicroenvironment for enhanced osteoporosistreatment","volume":"9","author":"Xueliang Liu","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.actbio.2026.06.049_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112376","article-title":"Controlled release of dopamine coatings on titanium bidirectionally regulate osteoclastic and osteogenic response behaviors","volume":"129","author":"Wang","year":"2021","journal-title":"Mater. Sci. Eng., C"},{"issue":"8","key":"10.1016\/j.actbio.2026.06.049_bib0014","doi-asserted-by":"crossref","first-page":"13041","DOI":"10.1021\/acsnano.1c02147","article-title":"Capturing magnesium ions via microfluidic hydrogel microspheres for promoting cancellous bone regeneration","volume":"15","author":"Zhao","year":"2021","journal-title":"ACS. Nano"},{"issue":"5","key":"10.1016\/j.actbio.2026.06.049_bib0015","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1039\/D2LC00933A","article-title":"Design of functional nanoparticles by microfluidic platforms as advanced drug delivery systems for cancer therapy","volume":"23","author":"Fabozzi","year":"2023","journal-title":"Lab. Chip."},{"issue":"8","key":"10.1016\/j.actbio.2026.06.049_bib0016","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202007363","article-title":"Strategies for delivering nanoparticles across tumor blood vessels","volume":"31","author":"Sheth","year":"2021","journal-title":"Adv. Funct. Mater."},{"issue":"15","key":"10.1016\/j.actbio.2026.06.049_bib0017","article-title":"Multifunctional nanoparticle reinforced GelMA hydrogel for osteoporotic pathophysiological microenvironment improvement and bone defect regeneration","volume":"36","author":"Wang","year":"2026","journal-title":"Adv. Funct. Mater."},{"issue":"2","key":"10.1016\/j.actbio.2026.06.049_bib0018","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.nano.2014.09.014","article-title":"Mesoporous silica nanoparticles in drug delivery and biomedical applications","volume":"11","author":"Wang","year":"2015","journal-title":"Nanomed.: Nanotechnol., Biol. Med."},{"issue":"2","key":"10.1016\/j.actbio.2026.06.049_bib0019","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201902634","article-title":"Mesoporous silica nanoparticles for drug delivery","volume":"30","author":"Manzano","year":"2020","journal-title":"Adv. Funct. Mater."},{"issue":"26","key":"10.1016\/j.actbio.2026.06.049_bib0020","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202200756","article-title":"Mesoporous silica materials as an emerging tool for cancer immunotherapy","volume":"9","author":"Escriche-Navarro","year":"2022","journal-title":"Adv. Sci."},{"issue":"24","key":"10.1016\/j.actbio.2026.06.049_bib0021","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201900669","article-title":"Mesoporous silica-based materials with bactericidal properties","volume":"15","author":"Bernardos","year":"2019","journal-title":"Small."},{"key":"10.1016\/j.actbio.2026.06.049_bib0022","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jconrel.2024.11.063","article-title":"Stimuli-responsive mesoporous silica nanoplatforms for smart antibacterial therapies: from single to combination strategies","volume":"378","author":"Liao","year":"2025","journal-title":"J. Controlled Rel."},{"issue":"16","key":"10.1016\/j.actbio.2026.06.049_bib0023","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202101107","article-title":"Osteoporosis remission and new bone formation with mesoporous silica nanoparticles","volume":"8","author":"Mora-Raimundo","year":"2021","journal-title":"Adv. Sci."},{"issue":"12","key":"10.1016\/j.actbio.2026.06.049_bib0024","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202004586","article-title":"Smart cargo delivery system based on mesoporous nanoparticles for bone disease diagnosis and treatment","volume":"8","author":"Pan","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.actbio.2026.06.049_bib0025","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.intimp.2017.07.003","article-title":"Psoralidin suppresses osteoclastogenesis in BMMs and attenuates LPS-mediated osteolysis by inhibiting inflammatory cytokines","volume":"51","author":"Kong","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.actbio.2026.06.049_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152860","article-title":"Effect and mechanism of psoralidin on promoting osteogenesis and inhibiting adipogenesis","volume":"61","author":"Cao","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.actbio.2026.06.049_bib0027","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.phytochem.2017.08.004","article-title":"Isoflavones and anti-inflammatory constituents from the fruits of Psoralea corylifolia","volume":"143","author":"Chen","year":"2017","journal-title":"Phytochemistry"},{"key":"10.1016\/j.actbio.2026.06.049_bib0028","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.571535","article-title":"A review of the pharmacological properties of Psoralen","volume":"11","author":"Ren","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.actbio.2026.06.049_bib0029","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40659-019-0241-8","article-title":"Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells","volume":"52","author":"Wang","year":"2019","journal-title":"Biol. Res."},{"issue":"3","key":"10.1016\/j.actbio.2026.06.049_bib0030","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.3892\/etm.2017.4771","article-title":"Psoralen stimulates osteoblast proliferation through the activation of nuclear factor-\u03bab-mitogen-activated protein kinase signaling","volume":"14","author":"Li","year":"2017","journal-title":"Exp. Ther. Med."},{"issue":"4","key":"10.1016\/j.actbio.2026.06.049_bib0031","doi-asserted-by":"crossref","first-page":"5399","DOI":"10.1096\/fj.201801797R","article-title":"Psoralen accelerates bone fracture healing by activating both osteoclasts and osteoblasts","volume":"33","author":"Zhang","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.actbio.2026.06.049_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.147838","article-title":"Multifunctional methacrylated gelatin-hyaluronic acid-psoralen hydrogel for bone defect repair: synergistic anti-inflammatory, ROS-scavenging, and osteoinductive effects","volume":"330","author":"Liu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"21","key":"10.1016\/j.actbio.2026.06.049_bib0033","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202207319","article-title":"A metabolic driven bio-responsive hydrogel loading Psoralen for therapy of rheumatoid arthritis","volume":"19","author":"Wang","year":"2023","journal-title":"Small."},{"key":"10.1016\/j.actbio.2026.06.049_bib0034","doi-asserted-by":"crossref","first-page":"15863","DOI":"10.2147\/IJN.S567471","article-title":"Plant exosome-loaded intelligent hydrogels for osteoporotic bone regeneration: mechanisms and applications","volume":"Volume 20","author":"Li","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.actbio.2026.06.049_bib0035","doi-asserted-by":"crossref","first-page":"6337","DOI":"10.2147\/IJN.S456545","article-title":"pH-responsive mesoporous silica nanoparticles loaded with naringin for targeted osteoclast inhibition and bone regeneration","volume":"Volume 19","author":"Gong","year":"2024","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.actbio.2026.06.049_bib0036","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12951-024-02412-9","article-title":"Smart osteoclasts targeted nanomedicine based on amorphous CaCO3 for effective osteoporosis reversal","volume":"22","author":"Yu","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"32","key":"10.1016\/j.actbio.2026.06.049_bib0037","doi-asserted-by":"crossref","first-page":"36068","DOI":"10.1021\/acsomega.5c03693","article-title":"Erythrocyte membrane-cloaked and alendronate-loaded hollow prussian blue nanoparticles for synergistic osteoporosis therapy via antioxidant and targeted delivery mechanisms","volume":"10","author":"Yin","year":"2025","journal-title":"ACS. Omega"},{"key":"10.1016\/j.actbio.2026.06.049_bib0038","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.actbio.2023.05.038","article-title":"Calcium phosphate hybrid micelles inhibit orthotopic bone metastasis from triple negative breast cancer by simultaneously killing cancer cells and reprogramming the microenvironment of bone resorption and immunosuppression","volume":"166","author":"Liu","year":"2023","journal-title":"Acta Biomater."},{"issue":"18","key":"10.1016\/j.actbio.2026.06.049_bib0039","doi-asserted-by":"crossref","first-page":"5340","DOI":"10.1039\/D2BM00843B","article-title":"pH-sensitive nanocarrier assisted delivery of adenosine to treat osteoporotic bone loss","volume":"10","author":"Newman","year":"2022","journal-title":"Biomater. Sci."},{"issue":"7","key":"10.1016\/j.actbio.2026.06.049_bib0040","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.jbiomech.2013.02.016","article-title":"Counter-effect of constrained dynamic loading on osteoporosis in ovariectomized mice","volume":"46","author":"Li","year":"2013","journal-title":"J. Biomech."},{"issue":"1","key":"10.1016\/j.actbio.2026.06.049_bib0041","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/jsfa.7098","article-title":"Prevention of retinoic acid-induced osteoporosis in mice by isoflavone-enriched soy protein","volume":"96","author":"Yang","year":"2016","journal-title":"J. Sci. Food Agric."},{"issue":"10","key":"10.1016\/j.actbio.2026.06.049_bib0042","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1021\/jp710990b","article-title":"Polyelectrolyte controlled large-scale synthesis of hollow silica spheres with tunable sizes and wall thicknesses","volume":"112","author":"Wan","year":"2008","journal-title":"J. Phys. Chem. C"},{"issue":"10","key":"10.1016\/j.actbio.2026.06.049_bib0043","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41577-019-0178-8","article-title":"Osteoimmunology: evolving concepts in bone\u2013immune interactions in health and disease","volume":"19","author":"Tsukasaki","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.actbio.2026.06.049_bib0044","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/adfm.200800753","article-title":"Near-infrared mesoporous silica nanoparticles for optical imaging: characterization and In vivo biodistribution","volume":"19","author":"Lee","year":"2009","journal-title":"Adv. Funct. Mater."},{"issue":"2","key":"10.1016\/j.actbio.2026.06.049_bib0045","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/smll.201001459","article-title":"In vivo biodistribution and urinary excretion of mesoporous silica nanoparticles: effects of particle size and PEGylation","volume":"7","author":"He","year":"2011","journal-title":"Small."},{"key":"10.1016\/j.actbio.2026.06.049_bib0046","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bone.2015.04.039","article-title":"Heparin affects human bone marrow stromal cell fate: promoting osteogenic and reducing adipogenic differentiation and conversion","volume":"78","author":"Simann","year":"2015","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.actbio.2026.06.049_bib0047","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bbrc.2011.01.021","article-title":"Psoralen stimulates osteoblast differentiation through activation of BMP signaling","volume":"405","author":"Tang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.actbio.2026.06.049_bib0048","doi-asserted-by":"crossref","first-page":"940","DOI":"10.3892\/etm.2021.10372","article-title":"Psoralen accelerates osteogenic differentiation of human bone marrow mesenchymal stem cells by activating the TGF\u2011\u03b2\/Smad3 pathway","volume":"22","author":"Huang","year":"2021","journal-title":"Exp. Ther. Med."},{"issue":"10","key":"10.1016\/j.actbio.2026.06.049_bib0049","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1097\/gme.0b013e3182507e18","article-title":"The osteoprotective effect of psoralen in ovariectomy-induced osteoporotic rats via stimulating the osteoblastic differentiation from bone mesenchymal stem cells","volume":"19","author":"Yang","year":"2012","journal-title":"Menopause"},{"key":"10.1016\/j.actbio.2026.06.049_bib0050","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jconrel.2019.04.042","article-title":"Hexapeptide-conjugated calcitonin for targeted therapy of osteoporosis","volume":"304","author":"Liu","year":"2019","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.actbio.2026.06.049_bib0051","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fcimb.2018.00178","article-title":"New application of Psoralen and Angelicin on periodontitis with anti-bacterial, anti-inflammatory, and osteogenesis effects","volume":"8","author":"Li","year":"2018","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.actbio.2026.06.049_bib0052","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.actbio.2019.10.033","article-title":"Silicon substituted hydroxyapatite\/VEGF scaffolds stimulate bone regeneration in osteoporotic sheep","volume":"101","author":"Casarrubios","year":"2020","journal-title":"Acta Biomater."},{"issue":"18","key":"10.1016\/j.actbio.2026.06.049_bib0053","doi-asserted-by":"crossref","first-page":"9945","DOI":"10.3390\/ijms25189945","article-title":"Novel function of osteocalcin in chondrocyte differentiation and endochondral ossification revealed on a CRISPR\/Cas9 bglap\u2013bglap2 deficiency mouse model","volume":"25","author":"Yu","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2026.06.049_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2023.213622","article-title":"Garlic extract enhances bioceramic bone scaffolds through upregulating ALP & BGLAP expression in hMSC-monocyte co-culture","volume":"154","author":"Bose","year":"2023","journal-title":"Biomater. Adv."},{"issue":"21","key":"10.1016\/j.actbio.2026.06.049_bib0055","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1039\/D3TB00208J","article-title":"Additive manufacturing of barium-doped calcium silicate\/poly-\u03b5-caprolactone scaffolds to activate CaSR and AKT signalling and osteogenic differentiation of mesenchymal stem cells","volume":"11","author":"Chiu","year":"2023","journal-title":"J. Mater. Chem. B"},{"issue":"1","key":"10.1016\/j.actbio.2026.06.049_bib0056","article-title":"Akermanite bioceramics promote osteogenesis, angiogenesis and suppress osteoclastogenesis for osteoporotic bone regeneration","volume":"6","author":"Xia","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126004198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126004198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T20:36:21Z","timestamp":1785702981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126004198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":56,"alternative-id":["S1742706126004198"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.06.049","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acid-responsive bone-targeting nanoplatform enables spatiotemporal control of osteogenesis and angiogenesis for osteoporosis rescue","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.06.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}