{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:01:06Z","timestamp":1789189266180,"version":"build-2803163510"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.actbio.2026.07.040","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:21:56Z","timestamp":1784906516000},"page":"270-287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Targeting the mechanics-glycolysis-histone lactylation axis to rescue bone regeneration under insufficient mechanical stimulation"],"prefix":"10.1016","volume":"221","author":[{"given":"Qiyuan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2278-1576","authenticated-orcid":false,"given":"Chao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3612-0218","authenticated-orcid":false,"given":"Xiaoxia","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2026.07.040_bib0001","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/s001980200095","article-title":"Mechanical strain and bone cell function: a review","volume":"13","author":"Ehrlich","year":"2002","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.actbio.2026.07.040_bib0002","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.gene.2012.04.076","article-title":"Mechanical regulation of signaling pathways in bone","volume":"503","author":"Thompson","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.actbio.2026.07.040_bib0003","doi-asserted-by":"crossref","first-page":"12273","DOI":"10.1021\/acsami.2c19767","article-title":"Bioinspired piezoelectric periosteum to augment bone regeneration via synergistic immunomodulation and osteogenesis","volume":"15","author":"Liu","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2026.07.040_bib0004","first-page":"20157","article-title":"Intelligent and bioactive osseointegration of the implanted piezoelectric bone cement with the host bone is realized by biomechanical energy","volume":"16","author":"Wang","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2026.07.040_bib0005","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.biomaterials.2018.07.017","article-title":"Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives","volume":"180","author":"Ho-Shui-Ling","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2026.07.040_bib0006","article-title":"Mild photothermal-stimulation based on injectable and photocurable hydrogels orchestrates immunomodulation and osteogenesis for high-performance bone regeneration","volume":"19","author":"Wu","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.actbio.2026.07.040_bib0007","article-title":"Smart-responsive multifunctional therapeutic system for improved regenerative microenvironment and accelerated bone regeneration via mild photothermal therapy","volume":"11","author":"Wu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.actbio.2026.07.040_bib0008","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.7150\/thno.97335","article-title":"Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation and angiogenesis","volume":"14","author":"Wu","year":"2024","journal-title":"Theranostics"},{"issue":"Pt 4","key":"10.1016\/j.actbio.2026.07.040_bib0009","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1242\/jcs.105.4.883","article-title":"Changes in the cytoskeletal structure of cultured smooth muscle cells induced by calyculin-A","volume":"105","author":"Hosoya","year":"1993","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.actbio.2026.07.040_bib0010","doi-asserted-by":"crossref","first-page":"940","DOI":"10.3390\/toxins4100940","article-title":"Calyculin A from Discodermia Calyx is a dual ActionToxin that blocks calcium influx and inhibits protein ser\/thr phosphatases","volume":"4","author":"Holy","year":"2012","journal-title":"Toxins. (Basel)"},{"key":"10.1016\/j.actbio.2026.07.040_bib0011","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.freeradbiomed.2013.04.005","article-title":"Oxidative stress induces inactivation of protein phosphatase 2A, promoting proinflammatory NF-\u03bab in aged rat kidney","volume":"61","author":"Jin Jung","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.actbio.2026.07.040_bib0012","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejphar.2005.01.023","article-title":"Effect of melatonin on calyculin a-induced tau hyperphosphorylation","volume":"510","author":"Li","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.actbio.2026.07.040_bib0013","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3109\/09537104.2010.499156","article-title":"Protein phosphatase inhibitor calyculin-A modulates activation markers in TRAP-stimulated human platelets","volume":"21","author":"Simon","year":"2010","journal-title":"Platelets"},{"key":"10.1016\/j.actbio.2026.07.040_bib0014","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.actbio.2015.11.045","article-title":"Use of nanoscale mechanical stimulation for control and manipulation of cell behaviour","volume":"34","author":"Childs","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.07.040_bib0015","article-title":"Mechanisms of mechanical force in periodontal homeostasis: a review","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2026.07.040_bib0016","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.3390\/ijms23094580","article-title":"Mechanotransduction in mesenchymal stem cells (MSCs) differentiation: a review","volume":"23","author":"Raman","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2026.07.040_bib0017","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41580-020-00306-w","article-title":"Crosstalk between mechanotransduction and metabolism","volume":"22","author":"Romani","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.actbio.2026.07.040_bib0018","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1002\/j.2040-4603.2024.tb00289.x","article-title":"Mechanosensing in metabolism","volume":"14","author":"Tranter","year":"2023","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.actbio.2026.07.040_bib0019","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.actbio.2022.07.050","article-title":"N-cadherin mimetic hydrogel enhances MSC chondrogenesis through cell metabolism","volume":"150","author":"Ke","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.07.040_bib0020","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.actbio.2021.12.035","article-title":"Treatment of inflammatory bone loss in periodontitis by stem cell-derived exosomes","volume":"141","author":"Lei","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.07.040_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.141488","article-title":"Mechano-responsive microRNA-functionalized PDLSC exosomes as a novel therapeutic for inflammatory bone loss in periodontitis","volume":"458","author":"Wang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2026.07.040_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.128040","article-title":"Three-dimensional mechanical microenvironment enhanced osteogenic activity of mesenchymal stem cells-derived exosomes","volume":"417","author":"Yu","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2026.07.040_bib0023","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrm.2017.108","article-title":"Mechanical forces direct stem cell behaviour in development and regeneration","volume":"18","author":"Vining","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.actbio.2026.07.040_bib0024","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1021\/acsami.1c22138","article-title":"Local elimination of senescent cells promotes bone defect repair during aging","volume":"14","author":"Xing","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2026.07.040_bib0025","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/nprot.2015.063","article-title":"Standardized in vivo model for studying novel regenerative approaches for multitissue bone\u2013ligament interfaces","volume":"10","author":"Padial-Molina","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.actbio.2026.07.040_bib0026","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3390\/md80100122","article-title":"Calyculins and related marine natural products as serine-threonine protein phosphatase PP1 and PP2A inhibitors and total syntheses of calyculin A, B, and C","volume":"8","author":"Fagerholm","year":"2010","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.actbio.2026.07.040_bib0027","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nchembio.1573","article-title":"Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont","volume":"10","author":"Wakimoto","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.actbio.2026.07.040_bib0028","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jmbbm.2017.06.006","article-title":"Free energy analysis of cell spreading","volume":"74","author":"McEvoy","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.actbio.2026.07.040_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2015.04.008","article-title":"Mechanobiology of mesenchymal stem cells: perspective into mechanical induction of MSC fate","volume":"20","author":"Hao","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.07.040_bib0030","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.actbio.2019.06.048","article-title":"Extracellular matrix type modulates mechanotransduction of stem cells","volume":"96","author":"Stanton","year":"2019","journal-title":"Acta. Biomater."},{"key":"10.1016\/j.actbio.2026.07.040_bib0031","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1359\/JBMR.050703","article-title":"Osteoblasts generate harder, stiffer, and more delamination-resistant mineralized tissue on titanium than on polystyrene, associated with distinct tissue micro- and ultrastructure","volume":"20","author":"Saruwatari","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.actbio.2026.07.040_bib0032","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.3390\/polym12112457","article-title":"Polystyrene-based nanocomposites with different fillers: fabrication and mechanical properties","volume":"12","author":"Moskalyuk","year":"2020","journal-title":"Polymers. (Basel)"},{"key":"10.1016\/j.actbio.2026.07.040_bib0033","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.msec.2016.11.004","article-title":"High-definition micropatterning method for hard, stiff and brittle polymers","volume":"71","author":"Zhao","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.actbio.2026.07.040_bib0034","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix elasticity directs stem cell lineage specification","volume":"126","author":"Engler","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2026.07.040_bib0035","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2174\/1574888X15666200512105347","article-title":"Metabolic regulation and related molecular mechanisms in various stem cell functions","volume":"15","author":"Lee","year":"2020","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.actbio.2026.07.040_bib0036","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.15252\/embr.201744816","article-title":"Cell fate decisions: emerging roles for metabolic signals and cell morphology","volume":"18","author":"Tatapudy","year":"2017","journal-title":"EMBo Rep."},{"key":"10.1016\/j.actbio.2026.07.040_bib0037","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1038\/s12276-023-01095-w","article-title":"Lactate as a major epigenetic carbon source for histone acetylation via nuclear LDH metabolism","volume":"55","author":"An","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.actbio.2026.07.040_bib0038","doi-asserted-by":"crossref","first-page":"E330","DOI":"10.1152\/ajpendo.00159.2022","article-title":"Lactylation: novel epigenetic regulatory and therapeutic opportunities","volume":"324","author":"Fan","year":"2023","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.actbio.2026.07.040_bib0039","article-title":"Lactate-lactylation hands between metabolic reprogramming and immunosuppression","volume":"23","author":"Chen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2026.07.040_bib0040","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1089\/ars.2022.0190","article-title":"Mechanism of action of lactic acid on histones in cancer","volume":"40","author":"Sgarra","year":"2024","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.actbio.2026.07.040_bib0041","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2026.07.040_bib0042","article-title":"Histone lactylation in macrophage biology and disease: from plasticity regulation to therapeutic implications","volume":"111","author":"Bao","year":"2025","journal-title":"EBio Med."},{"key":"10.1016\/j.actbio.2026.07.040_bib0043","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.949252","article-title":"The role and mechanism of histone lactylation in health and diseases","volume":"13","author":"Xie","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.actbio.2026.07.040_bib0044","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/j.molcel.2021.04.015","article-title":"Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300\/CBP inhibition","volume":"81","author":"Hogg","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.actbio.2026.07.040_bib0045","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.cmet.2024.11.005","article-title":"Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis","volume":"37","author":"Liu","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.actbio.2026.07.040_bib0046","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1033223","article-title":"Ubiquitin modification in osteogenic differentiation and bone formation: from mechanisms to clinical significance","volume":"10","author":"Pan","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.actbio.2026.07.040_bib0047","first-page":"1","article-title":"E3 Ubiquitin ligases: potential therapeutic targets for skeletal pathology and degeneration","volume":"2022","author":"Zeng","year":"2022","journal-title":"Stem. Cells Int."},{"key":"10.1016\/j.actbio.2026.07.040_bib0048","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13578-025-01412-y","article-title":"Emerging roles of ribosome translation in stem cells and stem cell therapy - a review","volume":"15","author":"Gao","year":"2025","journal-title":"Cell Biosci."},{"key":"10.1016\/j.actbio.2026.07.040_bib0049","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1534-5807(04)00075-9","article-title":"Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment","volume":"6","author":"McBeath","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.actbio.2026.07.040_bib0050","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.217","article-title":"E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis","volume":"4","author":"S\u00e9v\u00e8re","year":"2013","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.actbio.2026.07.040_bib0051","first-page":"832","article-title":"Research progress on ubiquitin-specific proteases in regulation of bone remodeling","volume":"30","author":"Guorui","year":"2022","journal-title":"\u53e3\u8154\u75be\u75c5\u9632\u6cbb"},{"key":"10.1016\/j.actbio.2026.07.040_bib0052","article-title":"Knockdown of GCNT2 promoted osteoblast differentiation by activating PI3K\/AKT\/mTOR pathway in osteoblasts","volume":"15","author":"Huang","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2026.07.040_bib0053","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-017-0004-5","article-title":"mTOR signaling in skeletal development and disease","volume":"6","author":"Chen","year":"2018","journal-title":"Bone Res."},{"key":"10.1016\/j.actbio.2026.07.040_bib0054","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.125.326185","article-title":"Histone lactylation promotes pressure overload-induced cardiac hypertrophy and heart failure by regulating TGFB2 expression","volume":"138","author":"Chen","year":"2026","journal-title":"Circ. Res."},{"key":"10.1016\/j.actbio.2026.07.040_bib0055","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.2741\/1915","article-title":"Matrix metalloproteinases (MMPs) in health and disease: an overview","volume":"11","author":"Malemud","year":"2006","journal-title":"Front. Biosci."},{"key":"10.1016\/j.actbio.2026.07.040_bib0056","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrm2125","article-title":"Matrix metalloproteinases and the regulation of tissue remodelling","volume":"8","author":"Page-McCaw","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.actbio.2026.07.040_bib0057","first-page":"3062","article-title":"Injectable bio-responsive hydrogel for therapy of inflammation related eyelid diseases","volume":"6","author":"Chen","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2026.07.040_bib0058","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41586-020-1998-1","article-title":"Mechanical regulation of glycolysis via cytoskeleton architecture","volume":"578","author":"Park","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2026.07.040_bib0059","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1615\/CritRevBiomedEng.v31.i4.10","article-title":"Mechanosensing and mechanochemical transduction: how is mechanical energy sensed and converted into chemical energy in an extracellular matrix?","volume":"31","author":"Silver","year":"2003","journal-title":"Crit. Rev. Biomed. Eng."},{"key":"10.1016\/j.actbio.2026.07.040_bib0060","doi-asserted-by":"crossref","first-page":"7810","DOI":"10.1096\/fj.201900201RR","article-title":"Increased glycolysis mediates Wnt7b-induced bone formation","volume":"33","author":"Chen","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.actbio.2026.07.040_bib0061","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3892\/mmr.2022.12656","article-title":"Advanced glycation end products promote osteoporosis by inducing ferroptosis in osteoblasts","volume":"25","author":"Ge","year":"2022","journal-title":"Mol. Med. Rep."},{"issue":"8","key":"10.1016\/j.actbio.2026.07.040_bib0062","doi-asserted-by":"crossref","first-page":"13602","DOI":"10.1002\/jcp.28039","article-title":"Extracellular enzymatically synthesized glycogen promotes osteogenesis by activating osteoblast differentiation via Akt\/GSK-3\u03b2 signaling pathway","volume":"234","author":"Ida-Yonemochi","year":"2019","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.actbio.2026.07.040_bib0063","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1042\/BCJ20190888","article-title":"Glut1 expression is increased by p53 reduction to switch metabolism to glycolysis during osteoblast differentiation","volume":"477","author":"Ohnishi","year":"2020","journal-title":"Biochem. J."},{"key":"10.1016\/j.actbio.2026.07.040_bib0064","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.bbamcr.2016.01.010","article-title":"Skp2 inhibits osteogenesis by promoting ubiquitin\u2013proteasome degradation of Runx2","volume":"1863","author":"Thacker","year":"2016","journal-title":"Biochim. Biophys. Acta BBA - Mol. Cell Res."},{"key":"10.1016\/j.actbio.2026.07.040_bib0065","first-page":"1","article-title":"Ribosomes: an exciting avenue in stem cell research","volume":"2020","author":"Han","year":"2020","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.actbio.2026.07.040_bib0066","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41421-024-00689-6","article-title":"Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis","volume":"10","author":"Zhu","year":"2024","journal-title":"Cell Discov."},{"key":"10.1016\/j.actbio.2026.07.040_bib0067","article-title":"Polyphenol-derived nanoarmor-functionalized photothermal hydrogel platform for programmed modulation of the regenerative microenvironment and bone defect healing","volume":"22","author":"Yang","year":"2026","journal-title":"Small"},{"key":"10.1016\/j.actbio.2026.07.040_bib0068","doi-asserted-by":"crossref","first-page":"7140","DOI":"10.7150\/thno.102779","article-title":"Multifunctional injectable hydrogel system as a mild photothermal-assisted therapeutic platform for programmed regulation of inflammation and osteo-microenvironment for enhanced healing of diabetic bone defects in situ","volume":"14","author":"Zhu","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.actbio.2026.07.040_bib0069","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11427-004-0120-5","article-title":"Temporal and spatial expression of MMP-2, -9, -14 and their inhibitors TIMP-1, -2, -3 in the corpus luteum of the cycling rhesus monkey","volume":"49","author":"Chen","year":"2006","journal-title":"Sci. China C Life Sci."},{"key":"10.1016\/j.actbio.2026.07.040_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118457","article-title":"The role of MMPs and TIMPs in regenerative medicine: from pathological ECM remodeling to therapeutic applications","volume":"191","author":"Kazemi","year":"2025","journal-title":"Biomed. Pharmacother."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126004873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126004873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:46:17Z","timestamp":1787053577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126004873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":70,"alternative-id":["S1742706126004873"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.07.040","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the mechanics-glycolysis-histone lactylation axis to rescue bone regeneration under insufficient mechanical stimulation","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.07.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}