{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:26:14Z","timestamp":1787430374996,"version":"build-2736575974"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22475052"],"award-info":[{"award-number":["22475052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["23ZR1406800"],"award-info":[{"award-number":["23ZR1406800"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.actbio.2026.07.045","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:49:35Z","timestamp":1785307775000},"page":"173-191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Injectable and thermosensitive poly(2-ethyl-2-oxazoline)-poly(L-alanine) hydrogel with enhanced mechanical performance and extended in vivo persistence"],"prefix":"10.1016","volume":"221","author":[{"given":"Zixuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanxi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7660-3367","authenticated-orcid":false,"given":"Lin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2026.07.045_bib0001","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.actbio.2021.04.009","article-title":"PEG-based thermosensitive and biodegradable hydrogels","volume":"128","author":"Shi","year":"2021","journal-title":"Acta Biomater"},{"issue":"18","key":"10.1016\/j.actbio.2026.07.045_bib0002","doi-asserted-by":"crossref","first-page":"8835","DOI":"10.1021\/acs.chemrev.5c00182","article-title":"Therapeutic hydrogels: properties and biomedical applications","volume":"125","author":"Dong","year":"2025","journal-title":"Chem. Rev."},{"issue":"36","key":"10.1016\/j.actbio.2026.07.045_bib0003","article-title":"Sustained release of nitric oxide and cascade generation of reactive nitrogen\/oxygen species via an injectable hydrogel for tumor synergistic therapy","volume":"32","author":"Wang","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2026.07.045_bib0004","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.biomaterials.2018.01.001","article-title":"Injectable thermogel for 3D culture of stem cells","volume":"159","author":"Patel","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2026.07.045_bib0005","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbad039","article-title":"Thermo-induced physically crosslinked polypeptide-based block copolymer hydrogels for biomedical applications","volume":"10","author":"Zhao","year":"2023","journal-title":"Regen. Biomater."},{"issue":"8","key":"10.1016\/j.actbio.2026.07.045_bib0006","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1039\/b713009k","article-title":"Injectable hydrogels as unique biomedical materials","volume":"37","author":"Yu","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.actbio.2026.07.045_bib0007","first-page":"336","article-title":"Autophagy inhibition mediated via an injectable and NO-releasing hydrogel for amplifying the antitumor efficacy of mild magnetic hyperthermia","volume":"39","author":"Wang","year":"2024","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.actbio.2026.07.045_bib0008","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/s41467-025-56137-w","article-title":"Chiral polypeptide hydrogels regulating local immune microenvironment and anti-tumor immune response","volume":"16","author":"Ding","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2026.07.045_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113639","article-title":"Micelle-to-gel: thermosensitive intra-articular hydrogels for osteoarthritis management","volume":"381","author":"Rouco","year":"2025","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.actbio.2026.07.045_bib0010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jconrel.2011.07.008","article-title":"Enhancement of the fraction of the active form of an antitumor drug topotecan via an injectable hydrogel","volume":"156","author":"Chang","year":"2011","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2026.07.045_bib0011","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.actbio.2025.01.021","article-title":"Injectable hydrogel-assisted local lipopolysaccharide delivery improves immune checkpoint blockade therapy","volume":"194","author":"Li","year":"2025","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2026.07.045_bib0012","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.actbio.2026.03.011","article-title":"Thermosensitive hydrogel delivers nanoparticles for the modulation of immune homeostasis for salpingitis therapy","volume":"214","author":"Zhang","year":"2026","journal-title":"Acta Biomater"},{"issue":"15","key":"10.1016\/j.actbio.2026.07.045_bib0013","article-title":"Herbal products-powered thermosensitive hydrogel with phototherapy and microenvironment reconstruction for accelerating multidrug-resistant bacteria-infected wound healing","volume":"13","author":"Zhao","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2026.07.045_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114282","article-title":"Multifunctional self-healing hydrogels for chronic wound repair: design, mechanisms, and applications","volume":"388","author":"Ning","year":"2025","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.actbio.2026.07.045_bib0015","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/s41467-025-67580-0","article-title":"A bio-adaptive physical hydrogel enables dynamic tissue engineering for tracheal reconstruction","volume":"17","author":"Tang","year":"2026","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.actbio.2026.07.045_bib0016","article-title":"Versatile hypoxic extracellular vesicles laden in an injectable and bioactive hydrogel for accelerated bone regeneration","volume":"33","author":"Deng","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"3","key":"10.1016\/j.actbio.2026.07.045_bib0017","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1021\/acsami.1c20585","article-title":"Pralatrexate sustainably released from polypeptide thermogel is effective for chondrogenic differentiation of mesenchymal stem cells","volume":"14","author":"Woo","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2026.07.045_bib0018","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.actbio.2024.09.002","article-title":"Thermosensitive chitosan-based hydrogel: a vehicle for overcoming the limitations of nose-to-brain cell therapy","volume":"188","author":"Ojeda-Hern\u00e1ndez","year":"2024","journal-title":"Acta Biomater."},{"issue":"6","key":"10.1016\/j.actbio.2026.07.045_bib0019","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202512839","article-title":"Thermal-triggered polymerizable hydrogels with localized hyperthermia for shrinkage-driven starvation therapy","volume":"36","author":"Qing","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2026.07.045_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123723","article-title":"Fully synthetic nanofibrillar hydrogel for the growth and enzyme-free release of patient-derived ovarian tumor organoids","volume":"326","author":"Duan","year":"2026","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2026.07.045_bib0021","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-66034-x","article-title":"Thermo-reversible gelation of self-assembled conducting polymer colloids","volume":"16","author":"Damani","year":"2025","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.actbio.2026.07.045_bib0022","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1016\/j.biomaterials.2011.03.046","article-title":"Biodegradable and thermoreversible PCLA\u2013PEG\u2013PCLA hydrogel as a barrier for prevention of post-operative adhesion","volume":"32","author":"Zhang","year":"2011","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2026.07.045_bib0023","article-title":"Synthesis, characterization and application of reversible PDLLA-PEG-PDLLA copolymer thermogels in vitro and in vivo","volume":"6","author":"Shi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.actbio.2026.07.045_bib0024","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202512919","article-title":"Skin relevant biomaterials from wound healing, medical aesthetics, flexible electronics to artificial intelligence and beyond","author":"Zhang","year":"2025","journal-title":"Adv. Mater."},{"issue":"4","key":"10.1016\/j.actbio.2026.07.045_bib0025","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202514562","article-title":"Polymeric skin booster with moderate collagen regeneration","volume":"36","author":"Zhang","year":"2026","journal-title":"Adv. Funct. Mater."},{"issue":"6","key":"10.1016\/j.actbio.2026.07.045_bib0026","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1021\/bm900145g","article-title":"Mixing a sol and a precipitate of block copolymers with different block ratios leads to an injectable hydrogel","volume":"10","author":"Yu","year":"2009","journal-title":"Biomacromolecules"},{"issue":"14","key":"10.1016\/j.actbio.2026.07.045_bib0027","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1002\/anie.200503575","article-title":"A subtle end-group effect on macroscopic physical gelation of triblock copolymer aqueous solutions","volume":"45","author":"Yu","year":"2006","journal-title":"Angew. Chem. Int. Ed."},{"issue":"17","key":"10.1016\/j.actbio.2026.07.045_bib0028","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1039\/b922956f","article-title":"Block length affects secondary structure, nanoassembly and thermosensitivity of poly(ethylene glycol)-poly(L-alanine) block copolymers","volume":"20","author":"Choi","year":"2010","journal-title":"J. Mater. Chem."},{"issue":"18","key":"10.1016\/j.actbio.2026.07.045_bib0029","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.3390\/ma17184472","article-title":"Diverse strategies to develop poly(ethylene glycol)-polyester thermogels for modulating the release of antibodies","volume":"17","author":"Lipowska-Kur","year":"2024","journal-title":"Materials"},{"key":"10.1016\/j.actbio.2026.07.045_bib0030","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.actbio.2025.08.042","article-title":"Toward preclinical evaluation of a thermosensitive PEG-poly(L-alanine) hydrogel: a study on sterilization, storage stability, and in vivo performance","volume":"205","author":"Wang","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.07.045_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.143128","article-title":"Thermosensitive nanocomposite hydrogel composed of PVPylated poly(D,L-alanine) and laponite as an injectable and bioactive biomaterial","volume":"466","author":"Gu","year":"2023","journal-title":"Chem. Eng. J."},{"issue":"15","key":"10.1016\/j.actbio.2026.07.045_bib0032","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1002\/polb.22040","article-title":"A novel pH- and thermo-sensitive PVP\/CMC semi-IPN hydrogel: swelling, phase behavior, and drug release study","volume":"48","author":"L\u00fc","year":"2010","journal-title":"J. Polym. Sci., Part B: Polym. Phys."},{"issue":"6","key":"10.1016\/j.actbio.2026.07.045_bib0033","first-page":"673","article-title":"In situ forming hydrogels based on chitosan for drug delivery and tissue regeneration","volume":"11","author":"Liu","year":"2016","journal-title":"Asian J. Pharm. Sci."},{"issue":"6","key":"10.1016\/j.actbio.2026.07.045_bib0034","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/bm300085c","article-title":"Thermogelling Chitosan-g-(PAF-PEG) aqueous solution As an injectable scaffold","volume":"13","author":"Kang","year":"2012","journal-title":"Biomacromolecules"},{"issue":"4","key":"10.1016\/j.actbio.2026.07.045_bib0035","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/mabi.201400426","article-title":"PEG-poly(L-alanine) thermogel as a 3D scaffold of bone-marrow-derived mesenchymal stem cells","volume":"15","author":"Park","year":"2015","journal-title":"Macromol. Biosci."},{"issue":"1","key":"10.1016\/j.actbio.2026.07.045_bib0036","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jconrel.2009.03.008","article-title":"Enzymatically degradable temperature-sensitive polypeptide as a new in-situ gelling biomaterial","volume":"137","author":"Jeong","year":"2009","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.actbio.2026.07.045_bib0037","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/wnan.1339","article-title":"Anti-PEG immunity: emergence, characteristics, and unaddressed questions","volume":"7","author":"Yang","year":"2015","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"issue":"5","key":"10.1016\/j.actbio.2026.07.045_bib0038","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/s41565-025-01925-0","article-title":"Better the devil you know than the devil you don\u2019t \u2014 PEG challenges in nanomedicine","volume":"20","author":"Dobrovolskaia","year":"2025","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.actbio.2026.07.045_bib0039","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jconrel.2022.09.031","article-title":"Polyethylene glycol (PEG): the nature, immunogenicity, and role in the hypersensitivity of PEGylated products","volume":"351","author":"Ibrahim","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2026.07.045_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.carres.2025.109409","article-title":"Chitosan: an overview of its properties, solubility, functional technologies, food and health applications","volume":"550","author":"Edo","year":"2025","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.actbio.2026.07.045_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.progpolymsci.2020.101252","article-title":"Poly(2-oxazoline)-based stimulus-responsive (Co)polymers: an overview of their design, solution properties, surface-chemistries and applications","volume":"106","author":"Jana","year":"2020","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.actbio.2026.07.045_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2022.111779","article-title":"End-functionalized diblock copolymers by mix and match of poly(2-oxazoline) and polyester building blocks","volume":"184","author":"Stafast","year":"2023","journal-title":"Eur. Polym. J."},{"issue":"12","key":"10.1016\/j.actbio.2026.07.045_bib0043","doi-asserted-by":"crossref","first-page":"6098","DOI":"10.1021\/acs.macromol.5c00771","article-title":"Thermoresponsive poly(2-Oxazoline)s with pH-degradable acetal side chains as potential drug delivery vehicles","volume":"58","author":"Jana","year":"2025","journal-title":"Macromolecules"},{"key":"10.1016\/j.actbio.2026.07.045_bib0044","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.biomaterials.2018.05.022","article-title":"Poly(2-oxazoline)s based biomaterials: a comprehensive and critical update","volume":"178","author":"Lorson","year":"2018","journal-title":"Biomaterials"},{"issue":"16","key":"10.1016\/j.actbio.2026.07.045_bib0046","doi-asserted-by":"crossref","first-page":"6412","DOI":"10.1002\/anie.202000505","article-title":"Poly(2-Oxazoline)-based functional peptide mimics: eradicating MRSA infections and persisters while alleviating antimicrobial resistance","volume":"59","author":"Zhou","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"issue":"17","key":"10.1016\/j.actbio.2026.07.045_bib0047","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202200778","article-title":"Short guanidinium-functionalized poly(2-oxazoline)s displaying potent therapeutic efficacy on drug-resistant fungal infections","volume":"61","author":"Jiang","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"issue":"12","key":"10.1016\/j.actbio.2026.07.045_bib0048","doi-asserted-by":"crossref","first-page":"5690","DOI":"10.1021\/acsbiomaterials.1c01131","article-title":"Stromal barrier-dismantled nanodrill-like and cancer cell-targeted pH-responsive polymeric micelles for further enhancing the anticancer efficacy of doxorubicin","volume":"7","author":"Zhou","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.actbio.2026.07.045_bib0049","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jconrel.2021.09.005","article-title":"Charge-reversal biodegradable MSNs for tumor synergetic chemo\/photothermal and visualized therapy","volume":"338","author":"Li","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2026.07.045_bib0050","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.eurpolymj.2016.09.052","article-title":"Clinical development of a poly(2-oxazoline) (POZ) polymer therapeutic for the treatment of Parkinson\u2019s disease \u2013 Proof of concept of POZ as a versatile polymer platform for drug development in multiple therapeutic indications","volume":"88","author":"Moreadith","year":"2017","journal-title":"Eur. Polym. J."},{"issue":"8","key":"10.1016\/j.actbio.2026.07.045_bib0052","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/mabi.201200080","article-title":"Partial hydrolysis of poly(2-ethyl-2-oxazoline) and potential implications for biomedical applications?","volume":"12","author":"Van Kuringen","year":"2012","journal-title":"Macromol. Biosci."},{"issue":"17","key":"10.1016\/j.actbio.2026.07.045_bib0053","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1016\/j.biomaterials.2014.02.029","article-title":"On the biodegradability of polyethylene glycol, polypeptoids and poly(2-oxazoline)s","volume":"35","author":"Ulbricht","year":"2014","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.actbio.2026.07.045_bib0054","doi-asserted-by":"crossref","first-page":"8725","DOI":"10.1021\/acsami.9b01872","article-title":"Chiral polypeptide thermogels induce controlled inflammatory response as potential immunoadjuvants","volume":"11","author":"Wang","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"17","key":"10.1016\/j.actbio.2026.07.045_bib0055","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.3390\/app10175918","article-title":"Peak fitting applied to fourier transform infrared and raman spectroscopic analysis of proteins","volume":"10","author":"Sadat","year":"2020","journal-title":"Appl. Sci."},{"issue":"4","key":"10.1016\/j.actbio.2026.07.045_bib0056","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1021\/acs.biomac.5b00134","article-title":"Fast and living ring-opening polymerization of \u03b1-amino acid N-carboxyanhydrides triggered by an \u201calliance\u201d of primary and secondary amines at room temperature","volume":"16","author":"Zhao","year":"2015","journal-title":"Biomacromolecules"},{"issue":"1","key":"10.1016\/j.actbio.2026.07.045_bib0057","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41467-020-20724-w","article-title":"Accelerated polymerization of N-carboxyanhydrides catalyzed by crown ether","volume":"12","author":"Xia","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.actbio.2026.07.045_bib0058","doi-asserted-by":"crossref","first-page":"5470","DOI":"10.1038\/s41467-019-13502-w","article-title":"Enzyme-mimetic self-catalyzed polymerization of polypeptide helices","volume":"10","author":"Song","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2026.07.045_bib0059","first-page":"311","article-title":"Classification of surface-active agents by HLB","volume":"1","author":"Griffin","year":"1949","journal-title":"J. Soc. Cosmet. Chem."},{"issue":"41","key":"10.1016\/j.actbio.2026.07.045_bib0060","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202405966","article-title":"Dual-crosslinked bioactive hydrogel scaffold for accelerated repair of genital tract defect","volume":"34","author":"Wang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2026.07.045_bib0061","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.actbio.2025.06.024","article-title":"Decellularized amnion membrane-based thermosensitive vaginal hydrogel enhances ritodrine efficacy and reduces systemic side effects in preterm birth treatment","volume":"201","author":"Xin","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.07.045_bib0062","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbae012","article-title":"3D printing sequentially strengthening high-strength natural polymer hydrogel bilayer scaffold for cornea regeneration","volume":"11","author":"Nie","year":"2024","journal-title":"Regen. Biomater."},{"issue":"1","key":"10.1016\/j.actbio.2026.07.045_bib0063","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1038\/s41467-018-07299-3","article-title":"In situ monitoring of molecular aggregation using circular dichroism","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.actbio.2026.07.045_bib0064","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/chir.530030405","article-title":"Chirality of reverse micelles","volume":"3","author":"Colombo","year":"1991","journal-title":"Chirality"},{"issue":"9","key":"10.1016\/j.actbio.2026.07.045_bib0065","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1021\/bm9004436","article-title":"Reverse thermal gelation of PAF-PLX-PAF block copolymer aqueous solution","volume":"10","author":"Kim","year":"2009","journal-title":"Biomacromolecules"},{"issue":"7","key":"10.1016\/j.actbio.2026.07.045_bib0066","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1021\/ar300273v","article-title":"FRET-based small-molecule fluorescent probes: rational design and bioimaging applications","volume":"46","author":"Yuan","year":"2013","journal-title":"Acc. Chem. Res."},{"issue":"16","key":"10.1016\/j.actbio.2026.07.045_bib0067","doi-asserted-by":"crossref","first-page":"6405","DOI":"10.1021\/acs.macromol.8b01014","article-title":"Semi-bald micelles and corresponding percolated Micelle networks of thermogels","volume":"51","author":"Cui","year":"2018","journal-title":"Macromolecules"},{"issue":"7","key":"10.1016\/j.actbio.2026.07.045_bib0068","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1021\/acs.macromol.2c02309","article-title":"Degradation-influenced\/induced self-assembly of copolymers with the combinatory effects of changed molecular weight and dispersity","volume":"56","author":"Wei","year":"2023","journal-title":"Macromolecules"},{"issue":"16","key":"10.1016\/j.actbio.2026.07.045_bib0069","doi-asserted-by":"crossref","first-page":"7421","DOI":"10.1021\/acs.macromol.1c00959","article-title":"Decisive influence of hydrophobic side chains of polyesters on thermoinduced gelation of triblock copolymer aqueous solutions","volume":"54","author":"Wu","year":"2021","journal-title":"Macromolecules"},{"issue":"13","key":"10.1016\/j.actbio.2026.07.045_bib0070","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.1039\/c2jm15419f","article-title":"Sol\u2013gel transition of PEG\u2013PAF aqueous solution and its application for hGH sustained release","volume":"22","author":"Shinde","year":"2012","journal-title":"J. Mater. Chem."},{"issue":"3","key":"10.1016\/j.actbio.2026.07.045_bib0071","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/psc.923","article-title":"Conformational studies of alanine-rich peptide using CD and FTIR spectroscopy","volume":"14","author":"Bagi\u0144ska","year":"2008","journal-title":"J. Pept. Sci."},{"key":"10.1016\/j.actbio.2026.07.045_bib0072","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.139855","article-title":"Novel poly(2-ethyl-2-oxazoline) and poly(diallyldimethylammonium chloride) polymer functionalized montmorillonite: physicochemical aspects and near-IR study of hydration properties","volume":"1321","author":"Slan\u00fd","year":"2025","journal-title":"J. Mol. Struct."},{"issue":"35","key":"10.1016\/j.actbio.2026.07.045_bib0073","doi-asserted-by":"crossref","first-page":"13057","DOI":"10.1073\/pnas.0605504103","article-title":"The role of hydrophobic interactions in initiation and propagation of protein folding","volume":"103","author":"Dyson","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"10.1016\/j.actbio.2026.07.045_bib0074","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1038\/s41467-022-32053-1","article-title":"Intrinsically fluorescent polyureas toward conformation-assisted metamorphosis, discoloration and intracellular drug delivery","volume":"13","author":"Zhou","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.actbio.2026.07.045_bib0075","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10310","article-title":"A self-healable and highly stretchable supercapacitor based on a dual crosslinked polyelectrolyte","volume":"6","author":"Huang","year":"2015","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.actbio.2026.07.045_bib0076","doi-asserted-by":"crossref","first-page":"8265","DOI":"10.1021\/acs.macromol.6b01448","article-title":"Rheological behavior of tough PVP-in situ-PAAm hydrogels physically cross-linked by cooperative hydrogen bonding","volume":"49","author":"Song","year":"2016","journal-title":"Macromolecules"},{"issue":"12","key":"10.1016\/j.actbio.2026.07.045_bib0077","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1021\/acs.macromol.3c00611","article-title":"Urea as a hydrogen bond producer for fabricating mechanically very strong hydrogels","volume":"56","author":"Wu","year":"2023","journal-title":"Macromolecules"},{"issue":"5","key":"10.1016\/j.actbio.2026.07.045_bib0078","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3390\/gels9050385","article-title":"Effects of steam sterilization on the properties of stimuli-responsive polymer-based hydrogels","volume":"9","author":"Ferreira","year":"2023","journal-title":"Gels"},{"issue":"6","key":"10.1016\/j.actbio.2026.07.045_bib0079","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/aba40c","article-title":"Effect of sterilization treatment on mechanical properties, biodegradation, bioactivity and printability of GelMA hydrogels","volume":"15","author":"Rizwan","year":"2020","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.actbio.2026.07.045_bib0080","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbaf005","article-title":"Balancing sterilization and functional properties in Poloxamer 407 hydrogels: comparing heat and radiation techniques","volume":"12","author":"De Lauretis","year":"2025","journal-title":"Regen. Biomater."},{"issue":"4","key":"10.1016\/j.actbio.2026.07.045_bib0081","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.7150\/thno.120844","article-title":"Long-acting management of diabetes and associated complications using an injectable thermosensitive hydrogel incorporating IgG-conjugated GLP-1RA","volume":"16","author":"Wang","year":"2026","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.actbio.2026.07.045_bib0082","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/jbm.b.31370","article-title":"Acute toxicity evaluation of biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PEG-PCL-PEG hydrogel","volume":"91B","author":"Gong","year":"2009","journal-title":"J. Biomed. Mater. Res. Part B"},{"issue":"8","key":"10.1016\/j.actbio.2026.07.045_bib0083","doi-asserted-by":"crossref","DOI":"10.1002\/asia.202300021","article-title":"pH- and temperature-responsive hydrogels based on tertiary amine-modified polypeptides for stimuli-responsive drug delivery","volume":"18","author":"Lin","year":"2023","journal-title":"Chem. Asian J."},{"issue":"1","key":"10.1016\/j.actbio.2026.07.045_bib0084","first-page":"118","article-title":"DOX\/IL-2\/IFN-\u03b3 co-loaded thermo-sensitive polypeptide hydrogel for efficient melanoma treatment","volume":"3","author":"Lv","year":"2018","journal-title":"Bioact. Mater."},{"issue":"4","key":"10.1016\/j.actbio.2026.07.045_bib0085","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1021\/ma202809c","article-title":"PEG-L-PAF and PEG-D-PAF: comparative study on thermogellation and biodegradation","volume":"45","author":"Kang","year":"2012","journal-title":"Macromolecules"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126004927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126004927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:03:49Z","timestamp":1787429029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126004927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":83,"alternative-id":["S1742706126004927"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.07.045","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Injectable and thermosensitive poly(2-ethyl-2-oxazoline)-poly(L-alanine) hydrogel with enhanced mechanical performance and extended in vivo persistence","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.07.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}