{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:08:33Z","timestamp":1789589313374,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.actbio.2026.07.052","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:29:58Z","timestamp":1785367798000},"page":"450-459","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Microporous annealed particle scaffold integrated with autologous tumor cells for personalized postsurgical tumor therapy"],"prefix":"10.1016","volume":"222","author":[{"given":"Gaizhen","family":"Kuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feika","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7704-2853","authenticated-orcid":false,"given":"Qingfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-4000","authenticated-orcid":false,"given":"Yuanjin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.actbio.2026.07.052_bib0001","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s12943-024-02069-w","article-title":"Cancer, metastasis, and the epigenome","volume":"23","author":"Kiri","year":"2024","journal-title":"Mol. Cancer"},{"issue":"2","key":"10.1016\/j.actbio.2026.07.052_bib0002","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41591-021-01233-9","article-title":"Intratumoral heterogeneity in cancer progression and response to immunotherapy","volume":"27","author":"Vitale","year":"2021","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.actbio.2026.07.052_bib0003","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.ccell.2024.05.017","article-title":"Engineering cancer\u2019s end: an interdisciplinary approach to confront the complexities of cancer","volume":"42","author":"Flores","year":"2024","journal-title":"Cancer Cell"},{"issue":"6723","key":"10.1016\/j.actbio.2026.07.052_bib0004","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1126\/science.adt9029","article-title":"To target, to escape, perchance to cure: borrowing a page from cancer\u2019s playbook, scientists learn to evade their own therapies","volume":"386","author":"Casirati","year":"2024","journal-title":"Science"},{"issue":"40","key":"10.1016\/j.actbio.2026.07.052_bib0005","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202408016","article-title":"Photothermal catalytic reduction and bone tissue engineering towards a three-in-one therapy strategy for osteosarcoma","volume":"36","author":"Lu","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2026.07.052_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123558","article-title":"Mimicking gingival endotoxin tolerance to modulate immune balance for tumor postoperative wound management","volume":"325","author":"Xie","year":"2026","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.actbio.2026.07.052_bib0007","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202311015","article-title":"Probiotic biofilm modified 3D-printing scaffolds for improving chemo-immunotherapy of bone tumor and promoting osteogenesis","volume":"34","author":"Gu","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2026.07.052_bib0008","first-page":"326","article-title":"Cryo-shocked cancer cell microgels for tumor postoperative combination immunotherapy and tissue regeneration","volume":"28","author":"Kuang","year":"2023","journal-title":"Bioact. Mater."},{"issue":"43","key":"10.1016\/j.actbio.2026.07.052_bib0009","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202506386","article-title":"Sono-controllable Janus hydrogel platform for sequential tumor eradication and bone regeneration in metastatic breast cancer","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2026.07.052_bib0010","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1186\/s12951-024-02982-8","article-title":"Living photosynthetic microneedle patches for in situ oxygenation and postsurgical melanoma therapy","volume":"22","author":"Jia","year":"2024","journal-title":"J. Nanobiotechnology."},{"key":"10.1016\/j.actbio.2026.07.052_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122959","article-title":"Injectable and adhesive MgO2-potentiated hydrogel with sequential tumor synergistic therapy and osteogenesis for challenging postsurgical osteosarcoma treatment","volume":"315","author":"Zhang","year":"2025","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.actbio.2026.07.052_bib0012","doi-asserted-by":"crossref","DOI":"10.26599\/NR.2025.94908002","article-title":"Nanocomposite cascading sequential treatment hydrogel patch for postoperative tumor elimination, immune regulation and tissue regeneration after melanoma surgery","volume":"18","author":"Yao","year":"2025","journal-title":"Nano Res."},{"key":"10.1016\/j.actbio.2026.07.052_bib0013","article-title":"3D-printed CoSi\/PCL composite scaffold with NIR-II photothermal ability and enhanced adipogenic activity for breast reconstruction after mastectomy","volume":"31","author":"Zhang","year":"2025","journal-title":"Mater. Today Bio."},{"issue":"4","key":"10.1016\/j.actbio.2026.07.052_bib0014","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1007\/s42765-026-00677-3","article-title":"Aligned fiber nerve conduit filled with chiral poly(amino acid) hydrogel for immunomodulation-driven repair of peripheral nerve injury","volume":"8","author":"Li","year":"2026","journal-title":"Adv. Fiber. Mater."},{"issue":"19","key":"10.1016\/j.actbio.2026.07.052_bib0015","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202520475","article-title":"Piezoelectric ceramic nanofiber aerogels direct neutrophil fate for diabetic tissue regeneration","volume":"38","author":"He","year":"2026","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2026.07.052_bib0016","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.actbio.2025.04.002","article-title":"A biomimetic nanofiber composite hydrogel with tissue adhesion, self-healing and antibacterial ability for infected wound healing","volume":"200","author":"Tian","year":"2025","journal-title":"Acta Biomater."},{"issue":"3","key":"10.1016\/j.actbio.2026.07.052_bib0017","doi-asserted-by":"crossref","DOI":"10.1002\/smmd.70016","article-title":"Mussel-inspired adhesive and tough hydrogel based on silk-triggered dopamine polymerization for wound healing","volume":"4","author":"Wang","year":"2025","journal-title":"Smart Med."},{"issue":"1","key":"10.1016\/j.actbio.2026.07.052_bib0018","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41467-025-55904-z","article-title":"Injectable supramolecular hydrogel co-loading abemaciclib\/NLG919 for neoadjuvant immunotherapy of triple-negative breast cancer","volume":"16","author":"Zhu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2026.07.052_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.140619","article-title":"Lyophilization-inactivated cancer cells composited Janus scaffold for tumor postoperative immuno-chemotherapy","volume":"455","author":"Kuang","year":"2023","journal-title":"Chem. Eng. J."},{"issue":"12","key":"10.1016\/j.actbio.2026.07.052_bib0020","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202417125","article-title":"MoS2 nanozyme-chlorella hydrogels: pioneering a hepatocellular carcinoma integrative therapy","volume":"35","author":"Zhang","year":"2025","journal-title":"Adv. Funct. Mater."},{"issue":"8","key":"10.1016\/j.actbio.2026.07.052_bib0021","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/s43018-024-00802-4","article-title":"Enhanced precision in immunotherapy","volume":"5","author":"Bergstrom","year":"2024","journal-title":"Nat. Cancer"},{"issue":"48","key":"10.1016\/j.actbio.2026.07.052_bib0022","article-title":"3D printing scaffold vaccine for antitumor immunity","volume":"33","author":"Zhang","year":"2021","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.actbio.2026.07.052_bib0023","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41578-019-0148-6","article-title":"Hydrogel microparticles for biomedical applications","volume":"5","author":"Daly","year":"2020","journal-title":"Nat. Rev. Mater."},{"issue":"7","key":"10.1016\/j.actbio.2026.07.052_bib0024","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nmat4294","article-title":"Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks","volume":"14","author":"Griffin","year":"2015","journal-title":"Nat. Mater."},{"key":"10.1016\/j.actbio.2026.07.052_bib0025","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.actbio.2019.02.054","article-title":"Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer","volume":"94","author":"Truong","year":"2019","journal-title":"Acta Biomater."},{"issue":"43","key":"10.1016\/j.actbio.2026.07.052_bib0026","article-title":"Injectable drug-releasing microporous annealed particle scaffolds for treating myocardial infarction","volume":"30","author":"Fang","year":"2020","journal-title":"Adv. Funct. Mater."},{"issue":"12","key":"10.1016\/j.actbio.2026.07.052_bib0027","doi-asserted-by":"crossref","first-page":"9176","DOI":"10.1021\/acsnano.4c01180","article-title":"Biomimetic tertiary lymphoid structures with microporous annealed particle scaffolds for cancer postoperative therapy","volume":"18","author":"Kuang","year":"2024","journal-title":"ACS. Nano"},{"key":"10.1016\/j.actbio.2026.07.052_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.mattod.2026.103228","article-title":"Haptenized whole tumor cell vaccines for cancer immunotherapy","volume":"94","author":"Chen","year":"2026","journal-title":"Mater. Today"},{"issue":"25","key":"10.1016\/j.actbio.2026.07.052_bib0029","doi-asserted-by":"crossref","first-page":"eaba4024","DOI":"10.1126\/sciadv.aba4024","article-title":"Engineering autologous tumor cell vaccine to locally mobilize antitumor immunity in tumor surgical bed","volume":"6","author":"Fang","year":"2020","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.actbio.2026.07.052_bib0030","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1038\/s41467-018-03915-4","article-title":"A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.actbio.2026.07.052_bib0031","doi-asserted-by":"crossref","first-page":"13041","DOI":"10.1021\/acsnano.1c02147","article-title":"Capturing magnesium ions via microfluidic hydrogel microspheres for promoting cancellous bone regeneration","volume":"15","author":"Zhao","year":"2021","journal-title":"ACS. Nano"},{"key":"10.1016\/j.actbio.2026.07.052_bib0032","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.biomaterials.2018.10.040","article-title":"Microfluidic-enabled bottom-up hydrogels from annealable naturally-derived protein microbeads","volume":"192","author":"Sheikhi","year":"2019","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2026.07.052_bib0033","doi-asserted-by":"crossref","DOI":"10.1002\/smmd.135","article-title":"MXene-integrated responsive hydrogel microneedles for oral ulcers healing","volume":"4","author":"Song","year":"2025","journal-title":"Smart Med."},{"issue":"3","key":"10.1016\/j.actbio.2026.07.052_bib0034","doi-asserted-by":"crossref","DOI":"10.1002\/smmd.70014","article-title":"Antibacterial and proangiogenic hydrogel microneedle patches for wound healing","volume":"4","author":"Zhang","year":"2025","journal-title":"Smart Med."},{"key":"10.1016\/j.actbio.2026.07.052_bib0035","first-page":"97","article-title":"Large-sized bone defect repair by combining a decalcified bone matrix framework and bone regeneration units based on photo-crosslinkable osteogenic microgels","volume":"14","author":"Hao","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2026.07.052_bib0036","doi-asserted-by":"crossref","DOI":"10.34133\/2022\/9784510","article-title":"Photopolymerized 3D printing scaffolds with Pt(IV) prodrug initiator for postsurgical tumor treatment","volume":"2022","author":"Zhang","year":"2022","journal-title":"Research"},{"issue":"3","key":"10.1016\/j.actbio.2026.07.052_bib0037","doi-asserted-by":"crossref","DOI":"10.1002\/smmd.70017","article-title":"Pollen integrated hydrogel patches with hierarchical structures and spatio-temporal actives release for wound healing","volume":"4","author":"Zhu","year":"2025","journal-title":"Smart Med."},{"issue":"1","key":"10.1016\/j.actbio.2026.07.052_bib0038","doi-asserted-by":"crossref","DOI":"10.1002\/smmd.137","article-title":"Multifunctional silk and gelatin composed microneedle patches for enhanced wound healing","volume":"4","author":"Fan","year":"2025","journal-title":"Smart Med."},{"issue":"43","key":"10.1016\/j.actbio.2026.07.052_bib0039","doi-asserted-by":"crossref","first-page":"48527","DOI":"10.1021\/acsami.2c16564","article-title":"Hierarchical microparticles delivering oxaliplatin and NLG919 nanoprodrugs for local chemo-immunotherapy","volume":"14","author":"Zhang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"41","key":"10.1016\/j.actbio.2026.07.052_bib0040","doi-asserted-by":"crossref","first-page":"19038","DOI":"10.1021\/jacs.2c07872","article-title":"Photoactivatable immunostimulatory nanomedicine for immunometabolic cancer therapy","volume":"144","author":"Wu","year":"2022","journal-title":"J. Am. Chem. Soc."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126005003?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126005003?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:59:12Z","timestamp":1789588752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126005003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":40,"alternative-id":["S1742706126005003"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.07.052","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microporous annealed particle scaffold integrated with autologous tumor cells for personalized postsurgical tumor therapy","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.07.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}