{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:00:04Z","timestamp":1790114404270,"version":"4.0.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005153","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["51925104"],"award-info":[{"award-number":["51925104"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","award":["202511301201001"],"award-info":[{"award-number":["202511301201001"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025T016HB"],"award-info":[{"award-number":["2025T016HB"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52401307"],"award-info":[{"award-number":["52401307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52571268"],"award-info":[{"award-number":["52571268"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.actbio.2026.08.011","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:50:34Z","timestamp":1786492234000},"page":"502-519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Atomically engineered asymmetric nanozymes with enhanced photothermal-catalytic performance for periodontitis therapy and tooth whitening"],"prefix":"10.1016","volume":"222","author":[{"given":"Qitao","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renyuan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuihong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanpeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuilin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0499-3674","authenticated-orcid":false,"given":"Congyang","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2026.08.011_bib0001","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0140-6736(24)02811-3","article-title":"Trends in the global, regional, and national burden of oral conditions from 1990 to 2021: a systematic analysis for the Global burden of disease study 2021","volume":"405","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.actbio.2026.08.011_bib0002","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1038\/s41467-026-72766-1","article-title":"Periodontitis induces skeletal muscle atrophy by increasing circulating levels of activin A","volume":"17","author":"Shim","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2026.08.011_bib0003","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/prd.12192","article-title":"Dental geriatrics and periodontitis","volume":"74","author":"Persson","year":"2017","journal-title":"Periodontol 2000."},{"key":"10.1016\/j.actbio.2026.08.011_bib0004","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.actbio.2022.07.023","article-title":"Fibre-guiding biphasic scaffold for perpendicular periodontal ligament attachment","volume":"150","author":"Staples","year":"2022","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2026.08.011_bib0005","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41596-018-0035-4","article-title":"An experimental murine model to study periodontitis","volume":"13","author":"Marchesan","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.actbio.2026.08.011_bib0006","doi-asserted-by":"crossref","first-page":"13341","DOI":"10.1021\/acsnano.5c01112","article-title":"Interfacial engineering enhancing electron transfer of CaF2 nanoparticles for periodontitis treatment of sonotherapy and bone resorption","volume":"19","author":"Liu","year":"2025","journal-title":"ACS Nano."},{"key":"10.1016\/j.actbio.2026.08.011_bib0007","first-page":"474","article-title":"Advanced biomaterials for targeting mature biofilms in periodontitis therapy","volume":"48","author":"Tao","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0008","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202506438","article-title":"CGRP-loaded ROS-responsive hydrogel restores neuro-angiogenic signaling to promote bone regeneration in diabetes-associated periodontitis","volume":"12","author":"Zhan","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.actbio.2026.08.011_bib0009","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.actbio.2025.11.060","article-title":"Engineered extracellular vesicles as multifunctional therapeutics for restoring periodontal homeostasis","volume":"210","author":"Shi","year":"2026","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0010","first-page":"161","article-title":"Dual nanozymes-loaded core-shell microneedle patches with antibacterial and NETs-degradation bifunctional properties for periodontitis treatment","volume":"53","author":"Shan","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0011","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.actbio.2025.05.034","article-title":"A Chitosan-based hydrogel to modulate immune cells and promote periodontitis healing in the high-fat diet-induced periodontitis rat model","volume":"200","author":"Zhu","year":"2025","journal-title":"Acta Biomater"},{"key":"10.1016\/j.actbio.2026.08.011_bib0012","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202202887","article-title":"Reversing multidrug-resistant Escherichia coli by compromising its BAM biogenesis and enzymatic catalysis through microwave hyperthermia therapy","volume":"32","author":"Mao","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0013","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1007\/s12598-024-02797-4","article-title":"Microwave excited hyperthermy and catalysis of heterostructured Au\/Cu-BTA for effective bacteria killing by accelerating charge separation","volume":"43","author":"Zhang","year":"2024","journal-title":"Rare Met."},{"key":"10.1016\/j.actbio.2026.08.011_bib0014","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202512531","article-title":"Environmental response temporal release injectable hydrogel for controlled growth factor release to enhance inflammatory periodontal bone defect regeneration","volume":"38","author":"Qiu","year":"2026","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0015","article-title":"White peroxidase-mimicking nanozymes: colorimetric pesticide assay without interferences of O2 and color","volume":"30","author":"Liang","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0016","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12951-022-01295-y","article-title":"Nanozymes-recent development and biomedical applications","volume":"20","author":"Ren","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2026.08.011_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2026.03.040","article-title":"Slippery by design: mechanistic insights and biomedical applications of zwitterionic polymer interfaces","volume":"215","author":"Jiang","year":"2026","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0018","article-title":"Microenvironment-responsive nanozyme for all stages of infectious chronic wound management through macrophage reprogramming","volume":"36","author":"Wu","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0019","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41929-021-00609-x","article-title":"Matching the kinetics of natural enzymes with a single-atom iron nanozyme","volume":"4","author":"Ji","year":"2021","journal-title":"Nat. Catal."},{"key":"10.1016\/j.actbio.2026.08.011_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2026.175683","article-title":"Bioinspired dual-ligands three-dimensional rational regulation of single-atom nanozymes for simultaneous enhancement of peroxidase-mimicking catalytic activity and enantioselectivity","volume":"535","author":"Cai","year":"2026","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2026.08.011_bib0021","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1038\/s41467-024-50123-4","article-title":"Metal-ligand dual-site single-atom nanozyme mimicking urate oxidase with high substrates specificity","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2026.08.011_bib0022","article-title":"Single-atom enzymes: from evolutionary insights, precision engineering to breakthroughs in biomedical applications","volume":"21","author":"Xu","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.actbio.2026.08.011_bib0023","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1038\/s41467-024-45927-3","article-title":"Protective effects of Pt-N-C single-atom nanozymes against myocardial ischemia-reperfusion injury","volume":"15","author":"Ye","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2026.08.011_bib0024","doi-asserted-by":"crossref","first-page":"6174","DOI":"10.1038\/s41467-024-50416-8","article-title":"Enhancing radiation-resistance and peroxidase-like activity of single-atom copper nanozyme via local coordination manipulation","volume":"15","author":"Wu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2026.08.011_bib0025","doi-asserted-by":"crossref","first-page":"47648","DOI":"10.1039\/D5RA08106H","article-title":"Bimetallic and multimetallic nanozymes: synergistic catalysis for advanced biomedical and health applications","volume":"15","author":"He","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.actbio.2026.08.011_bib0026","article-title":"Bimetallic nanozymes: structure-activity, regulatory strategies, and adaptive applications","volume":"22","author":"Sun","year":"2026","journal-title":"Small"},{"key":"10.1016\/j.actbio.2026.08.011_bib0027","article-title":"Bioinspired enzyme-like mechanism enables adaptive local charge modulation for blue energy harvesting","volume":"38","author":"Li","year":"2026","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0028","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202509998","article-title":"Interfacial coordination-engineered emulgel modulates the osteo-immune microenvironment in periodontitis treatment via HIF1 signaling pathway-induced metabolic reprogramming","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.actbio.2026.08.011_bib0029","article-title":"Programmable electro-assembly of collagen: constructing porous Janus films with customized dual signals for immunomodulation and tissue regeneration in periodontitis treatment","volume":"11","author":"Lei","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.actbio.2026.08.011_bib0030","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.actbio.2020.12.046","article-title":"Exosomes from TNF-\u03b1-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss","volume":"122","author":"Nakao","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0031","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1021\/acsnano.5c16997","article-title":"Sr-, Ca-doped BaTiO3 with synergistic piezoelectric catalysis and microbial balance effects enables tooth whitening for home oral health","volume":"20","author":"Xing","year":"2026","journal-title":"ACS Nano."},{"key":"10.1016\/j.actbio.2026.08.011_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.163775","article-title":"Plasmonic hot-electron injection boosts piezocatalysis of barium titanate nanowires for dental biofilm eradication and tooth whitening","volume":"515","author":"Wang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2026.08.011_bib0033","doi-asserted-by":"crossref","first-page":"6666","DOI":"10.1038\/s41467-023-42337-9","article-title":"Highly active, ultra-low loading single-atom iron catalysts for catalytic transfer hydrogenation","volume":"14","author":"An","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2026.08.011_bib0034","doi-asserted-by":"crossref","first-page":"16924","DOI":"10.1021\/acsnano.1c07983","article-title":"Plasmonic-assisted thermocyclizations in living cells using metal-organic framework based nanoreactors","volume":"15","author":"Carrillo-Carri\u00f3n","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2026.08.011_bib0035","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1039\/D5MH01324K","article-title":"Stabilizing Pt-Fe dual-metal single atoms in ZIFs: a pathway to form heterogeneous catalysts","volume":"13","author":"Hsiao","year":"2026","journal-title":"Mater. Horiz."},{"key":"10.1016\/j.actbio.2026.08.011_bib0036","article-title":"Coordination engineering in Fe-Mn dual-atom nanozyme: yielding ROS storm to efficiently promote wound healing","volume":"35","author":"Jiang","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.138985","article-title":"Valence-switchable and biocatalytic vanadium-based MXene nanoplatform with photothermal-enhanced dual enzyme-like activities for anti-infective therapy","volume":"451","author":"Sun","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2026.08.011_bib0038","first-page":"4389","article-title":"Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria-infected wound therapy","volume":"6","author":"Wang","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0039","article-title":"Injectable thermogel-loaded Bi2S3 nanorods for synergistic photothermal bacterial elimination and anti-inflammation to remodel periodontitis microenvironment","volume":"22","author":"Yang","year":"2026","journal-title":"Small"},{"key":"10.1016\/j.actbio.2026.08.011_bib0040","article-title":"NIR-II fluorescent thermophoretic nanomotors for superficial tumor photothermal therapy","volume":"37","author":"Jiang","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0041","doi-asserted-by":"crossref","first-page":"16448","DOI":"10.1021\/acsnano.4c17748","article-title":"Collagenase degradable biomimetic nanocages attenuate Porphyromonas gingivalis mediated neurocognitive dysfunction via targeted intracerebral antimicrobial photothermal and gas therapy","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano."},{"key":"10.1016\/j.actbio.2026.08.011_bib0042","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1007\/s11434-016-1193-9","article-title":"Peroxidase-like properties of ruthenium nanoframes","volume":"61","author":"Ye","year":"2016","journal-title":"Sci. Bull."},{"key":"10.1016\/j.actbio.2026.08.011_bib0043","article-title":"Reversed regulation effects of ssDNA on the mimetic oxidase and peroxidase activities of covalent organic frameworks","volume":"19","author":"Zhang","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.actbio.2026.08.011_bib0044","doi-asserted-by":"crossref","first-page":"13333","DOI":"10.1021\/acs.est.0c05287","article-title":"Electron spin resonance evidence for electro-generated hydroxyl radicals","volume":"54","author":"Pei","year":"2020","journal-title":"Env. Sci. Technol."},{"key":"10.1016\/j.actbio.2026.08.011_bib0045","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bios.2018.01.018","article-title":"Fast and sensitive near-infrared fluorescent probes for ALP detection and 3D printed calcium phosphate scaffold imaging in vivo","volume":"105","author":"Park","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.actbio.2026.08.011_bib0046","first-page":"3999","article-title":"Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites: in vitro and in vivo studies","volume":"6","author":"Zhang","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0047","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1038\/s41467-020-15015-3","article-title":"Piezo-catalysis for nondestructive tooth whitening","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2026.08.011_bib0048","article-title":"DENTA: a dual enzymatic nanoagent for self-activating tooth whitening and biofilm disruption","volume":"36","author":"Kim","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0049","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/ijos.2013.31","article-title":"Effects of 45S5 bioglass on surface properties of dental enamel subjected to 35% hydrogen peroxide","volume":"5","author":"Deng","year":"2013","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.actbio.2026.08.011_bib0050","first-page":"181","article-title":"High special surface area and \u201cwarm light\u201d responsive ZnO: synthesis mechanism, application and optimization","volume":"7","author":"Miao","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.actbio.2026.08.011_bib0051","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202400882","article-title":"Outer membrane vesicles derived from Fusobacterium nucleatum trigger periodontitis through host overimmunity","volume":"11","author":"Zhang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.actbio.2026.08.011_bib0052","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202570196","article-title":"Zinc-cobalt bimetallic organic frameworks with antioxidative and osteogenic activities for periodontitis treatment","volume":"21","author":"Tang","year":"2025","journal-title":"Small"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126005349?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126005349?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:00:49Z","timestamp":1790110849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126005349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":52,"alternative-id":["S1742706126005349"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.08.011","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Atomically engineered asymmetric nanozymes with enhanced photothermal-catalytic performance for periodontitis therapy and tooth whitening","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}