{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:53:49Z","timestamp":1791021229601,"version":"4.1.0"},"reference-count":170,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12372175"],"award-info":[{"award-number":["12372175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12402215"],"award-info":[{"award-number":["12402215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12532014"],"award-info":[{"award-number":["12532014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M782547"],"award-info":[{"award-number":["2025M782547"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0500800"],"award-info":[{"award-number":["2023ZD0500800"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20262BAC200091"],"award-info":[{"award-number":["20262BAC200091"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.actbio.2026.08.037","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:26:57Z","timestamp":1787153217000},"page":"83-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Harnessing the dual role of reactive oxygen species in bacterial infection: Therapeutic opportunities for controlled release and targeted modulation"],"prefix":"10.1016","volume":"223","author":[{"given":"Hongwei","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyue","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2274-905X","authenticated-orcid":false,"given":"Jianan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocen","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6581-895X","authenticated-orcid":false,"given":"Jianyong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.actbio.2026.08.037_bib0001","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41579-025-01155-0","article-title":"The role of bacterial metabolism in antimicrobial resistance","volume":"23","author":"Sender","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"issue":"2","key":"10.1016\/j.actbio.2026.08.037_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellin.2025.100237","article-title":"The interplay between Salmonella and host: mechanisms and strategies for bacterial survival","volume":"4","author":"Zhao","year":"2026","journal-title":"Cell Insight"},{"issue":"4","key":"10.1016\/j.actbio.2026.08.037_bib0003","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.chom.2015.09.004","article-title":"Group A streptococcal M1 protein sequesters cathelicidin to evade innate immune killing","volume":"18","author":"LaRock","year":"2015","journal-title":"Cell Host. Microbe"},{"issue":"6","key":"10.1016\/j.actbio.2026.08.037_bib0004","doi-asserted-by":"crossref","DOI":"10.1242\/jeb.246549","article-title":"Are reactive oxygen species always bad? Lessons from hypoxic ectotherms","volume":"227","author":"Bundgaard","year":"2024","journal-title":"J. Exp. Biol."},{"issue":"10","key":"10.1016\/j.actbio.2026.08.037_bib0005","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/s41580-022-00499-2","article-title":"Reactive oxygen species signalling in plant stress responses","volume":"23","author":"Mittler","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.actbio.2026.08.037_bib0006","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00034.2023","article-title":"NADPH oxidases: redox regulation of cell homeostasis and disease","volume":"105","author":"Kracun","year":"2025","journal-title":"Physiol. Rev."},{"issue":"9","key":"10.1016\/j.actbio.2026.08.037_bib0007","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","article-title":"NLRP3 inflammasome activation and cell death","volume":"18","author":"Huang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"2","key":"10.1016\/j.actbio.2026.08.037_bib0008","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.tim.2012.10.004","article-title":"Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections","volume":"21","author":"Rada","year":"2013","journal-title":"Trends Microbiol."},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0009","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41522-025-00738-2","article-title":"Immune system dynamics in response to Pseudomonas aeruginosa biofilms","volume":"11","author":"Sahu","year":"2025","journal-title":"Npj Biofilms Microbi."},{"issue":"5","key":"10.1016\/j.actbio.2026.08.037_bib0010","article-title":"Mitochondrial reactive oxygen species as major effectors of antimicrobial immunity","volume":"16","author":"Silverman","year":"2020","journal-title":"PLoS. Pathog."},{"issue":"7","key":"10.1016\/j.actbio.2026.08.037_bib0011","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00499-25","article-title":"Oxidative stress responses in Ehrlichia-induced sepsis: mechanisms and implications in pathogenesis","volume":"16","author":"Sharma","year":"2025","journal-title":"mBio"},{"issue":"3","key":"10.1016\/j.actbio.2026.08.037_bib0012","doi-asserted-by":"crossref","DOI":"10.1093\/femsre\/fuae013","article-title":"Determinants of bacterial survival and proliferation in blood","volume":"48","author":"L\u00ea-Bury","year":"2024","journal-title":"FEMS Microbiol. Rev."},{"issue":"2","key":"10.1016\/j.actbio.2026.08.037_bib0013","article-title":"The Global impact of bacterial antimicrobial resistance: addressing gaps and future strategies","volume":"5","author":"Jamil","year":"2026","journal-title":"Public Health Chall."},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0014","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41467-021-20965-3","article-title":"Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action","volume":"12","author":"Gao","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2026.08.037_bib0015","article-title":"Nanozymes for inflammatory disease therapy: ROS homeostasis and clinical prospects","volume":"531","author":"Chen","year":"2026","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2026.08.037_bib0016","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41434-026-00613-5","article-title":"Antimicrobial resistance and gene therapy: emerging molecular strategies for a global health threat","volume":"33","author":"Vitiello","year":"2026","journal-title":"Gene Ther."},{"issue":"5","key":"10.1016\/j.actbio.2026.08.037_bib0017","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1083\/jcb.200211118","article-title":"Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion","volume":"161","author":"Chiarugi","year":"2003","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0018","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"7","key":"10.1016\/j.actbio.2026.08.037_bib0019","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.tim.2021.12.011","article-title":"Mitochondria-mediated oxidative stress during viral infection","volume":"30","author":"Foo","year":"2022","journal-title":"Trends Microbiol."},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0020","doi-asserted-by":"crossref","DOI":"10.1155\/jimr\/2847417","article-title":"From defense to disease: NADPH oxidase in cellular function and dysregulation","volume":"2026","author":"Prasad","year":"2026","journal-title":"J. Immunol. Res."},{"issue":"6","key":"10.1016\/j.actbio.2026.08.037_bib0021","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3390\/antiox10060890","article-title":"NADPH oxidases (NOX): an overview from discovery, molecular mechanisms to physiology and pathology","volume":"10","author":"Vermot","year":"2021","journal-title":"Antioxidants"},{"issue":"4","key":"10.1016\/j.actbio.2026.08.037_bib0022","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s12276-023-00960-y","article-title":"Intestinal mucus components and secretion mechanisms: what we do and do not know","volume":"55","author":"Song","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.actbio.2026.08.037_bib0023","article-title":"Oxidative stress in chronic disease: mechanisms, therapeutic strategies, and future directions","volume":"20","author":"Nathan","year":"2026","journal-title":"Adv. Redox Res."},{"key":"10.1016\/j.actbio.2026.08.037_bib0024","article-title":"Reactive oxygen and reactive nitrogen species in herpesvirus infections: mechanisms, clinical implications, and therapeutic opportunities","author":"Reyes","year":"2026","journal-title":"Antioxid. Redox Signal."},{"issue":"3","key":"10.1016\/j.actbio.2026.08.037_bib0025","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bcp.2015.02.007","article-title":"Mitochondria: a target for bacteria","volume":"94","author":"Lobet","year":"2015","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.actbio.2026.08.037_bib0026","first-page":"784","article-title":"Loop between NLRP3 inflammasome and reactive oxygen species","volume":"36","author":"Dominic","year":"2021","journal-title":"Antioxid. Redox Signal."},{"issue":"7329","key":"10.1016\/j.actbio.2026.08.037_bib0027","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.actbio.2026.08.037_bib0028","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","article-title":"Pyroptosis: gasdermin-mediated programmed necrotic cell death","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem. Sci."},{"issue":"43","key":"10.1016\/j.actbio.2026.08.037_bib0029","doi-asserted-by":"crossref","first-page":"15514","DOI":"10.1073\/pnas.1414859111","article-title":"Inflammasome activation leads to Caspase-1\u2013dependent mitochondrial damage and block of mitophagy","volume":"111","author":"Yu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.actbio.2026.08.037_bib0030","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2013","journal-title":"Antioxid. Redox Signal."},{"issue":"5935","key":"10.1016\/j.actbio.2026.08.037_bib0031","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1126\/science.1171721","article-title":"Mitochondrial STAT3 supports ras-dependent oncogenic transformation","volume":"324","author":"Gough","year":"2009","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.actbio.2026.08.037_bib0032","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrmicro3032","article-title":"The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium","volume":"11","author":"Imlay","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"issue":"17","key":"10.1016\/j.actbio.2026.08.037_bib0033","doi-asserted-by":"crossref","first-page":"6326","DOI":"10.1128\/JB.00554-06","article-title":"Detection and quantification of superoxide formed within the periplasm of E. coli","volume":"188","author":"Korshunov","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0034","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/bs.ampbs.2023.04.002","article-title":"Bacterial metabolism and susceptibility to cell wall-active antibiotics","volume":"83","author":"Megan","year":"2023","journal-title":"Adv. Microb. Physiol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.667343","article-title":"How microbes defend themselves from incoming hydrogen peroxide","volume":"12","author":"Sen","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0036","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1073\/pnas.87.16.6181","article-title":"Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in E. coli","volume":"87","author":"Jean","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.actbio.2026.08.037_bib0037","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1128\/JB.00980-09","article-title":"The major catalase gene (katA) of Pseudomonas aeruginosa PA14 is under both positive and negative control of the global transactivator OxyR in response to hydrogen peroxide","volume":"192","author":"Heo","year":"2010","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0038","article-title":"Frontiers in Genetics,. Bacterial Response to Oxidative Stress and RNA Oxidation","volume":"12","author":"Seixas","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102800","article-title":"The role of glutathione in periplasmic redox homeostasis and oxidative protein folding in E. coli","volume":"64","author":"Knoke","year":"2023","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/toxsci\/kfh050","article-title":"Thioredoxin and its role in toxicology","volume":"78","author":"Watson","year":"2004","journal-title":"Toxicol. Sci."},{"issue":"48","key":"10.1016\/j.actbio.2026.08.037_bib0041","doi-asserted-by":"crossref","first-page":"18736","DOI":"10.1074\/jbc.TM118.003337","article-title":"Polyamine catabolism and oxidative damage","volume":"293","author":"Murray Stewart","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2026.08.037_bib0042","article-title":"New layers of regulation of the general stress response sigma factor RpoS","volume":"15","author":"Handler","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0043","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3390\/antiox9030227","article-title":"Extracellular redox regulation of \u03b17\u03b2 integrin-mediated cell migration is signaled via a dominant thiol-wwitch","volume":"9","author":"Bergerhausen","year":"2020","journal-title":"Antioxidants"},{"issue":"7","key":"10.1016\/j.actbio.2026.08.037_bib0044","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.bbagen.2012.04.016","article-title":"Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced \u03b25-integrin expression in human gastric cancer SC-M1 cells","volume":"1820","author":"Hung","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"14","key":"10.1016\/j.actbio.2026.08.037_bib0045","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1093\/emboj\/18.14.3956","article-title":"A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes","volume":"18","author":"Lecuit","year":"1999","journal-title":"EMBO J."},{"issue":"30","key":"10.1016\/j.actbio.2026.08.037_bib0046","doi-asserted-by":"crossref","first-page":"18316","DOI":"10.1074\/jbc.M115.657114","article-title":"NEU1 sialidase regulates membrane-tethered mucin (MUC1) ectodomain adhesiveness for Pseudomonas aeruginosa and decoy receptor release","volume":"290","author":"Lillehoj","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0047","first-page":"68","article-title":"MUC1 expression by human airway epithelial cells mediates Pseudomonas aeruginosa adhesion","volume":"2","author":"Kato","year":"2010","journal-title":"Front. Biosci."},{"issue":"9","key":"10.1016\/j.actbio.2026.08.037_bib0048","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.it.2021.07.005","article-title":"Lipid regulation of NLRP3 inflammasome activity through organelle stress","volume":"42","author":"Liang","year":"2021","journal-title":"Trends Immunol."},{"issue":"3","key":"10.1016\/j.actbio.2026.08.037_bib0049","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1440-1681.1996.tb02600.x","article-title":"Effect of the hydroxyl radical on fibroblast-mediated collagen remodelling in vitro","volume":"23","author":"Arisawa","year":"1996","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0050","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/1471-2180-14-191","article-title":"Collagen and hyaluronan at wound sites influence early polymicrobial biofilm adhesive events","volume":"14","author":"Birkenhauer","year":"2014","journal-title":"BMC Microbiol."},{"issue":"6","key":"10.1016\/j.actbio.2026.08.037_bib0051","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1152\/physiol.00029.2013","article-title":"Matrix metalloproteinase-9: many shades of function in cardiovascular disease","volume":"28","author":"Yabluchanskiy","year":"2013","journal-title":"Physiology"},{"key":"10.1016\/j.actbio.2026.08.037_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113922","article-title":"Harnessing RGDS peptides to regulate bacterial-host interfaces for targeted antimicrobial therapy","volume":"384","author":"Feng","year":"2025","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0053","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbrc.2007.12.123","article-title":"Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347","volume":"367","author":"Herscovitch","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.actbio.2026.08.037_bib0054","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1152\/ajplung.00109.2014","article-title":"Lipopolysaccharide induces ICAM-1 expression via a c-Src\/NADPH oxidase\/ROS-dependent NF-\u03baB pathway in human pulmonary alveolar epithelial cells","volume":"310","author":"Cho","year":"2016","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0055","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3390\/antiox10050642","article-title":"Oxidative stress in cancer cell metabolism","volume":"10","author":"Arfin","year":"2021","journal-title":"Antioxidants"},{"issue":"33","key":"10.1016\/j.actbio.2026.08.037_bib0056","doi-asserted-by":"crossref","first-page":"55684","DOI":"10.18632\/oncotarget.18264","article-title":"The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells","volume":"8","author":"Corre","year":"2017","journal-title":"Oncotarget"},{"issue":"12","key":"10.1016\/j.actbio.2026.08.037_bib0057","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.4049\/jimmunol.2300043","article-title":"Oxidative stress induces E-selectin expression through repression of endothelial transcription factor ERG","volume":"211","author":"Zhang","year":"2023","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.actbio.2026.08.037_bib0058","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/BST20150014","article-title":"Dissecting molecular cross-talk between Nrf2 and NF-\u03baB response pathways","volume":"43","author":"Wardyn","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.actbio.2026.08.037_bib0059","article-title":"Redox Regulation of the actin cytoskeleton in cell migration and adhesion: on the way to a spatiotemporal view","volume":"8","author":"Balta","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015146","article-title":"Degenerative and regenerative actin cytoskeleton rearrangements, cell death, and paradoxical proliferation in the gills of pearl gourami (Trichogaster leerii) exposed to suspended soot microparticles","volume":"24","author":"Sudakov","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.actbio.2026.08.037_bib0061","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000683","article-title":"The T3SS effector EspT defines a new category of invasive Enteropathogenic E. coli (EPEC) which form intracellular actin pedestals","volume":"5","author":"Bulgin","year":"2009","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.actbio.2026.08.037_bib0062","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.freeradbiomed.2017.04.007","article-title":"Nuclear protein HMGN2 attenuates pyocyanin-induced oxidative stress via Nrf2 signaling and inhibits Pseudomonas aeruginosa internalization in A549 cells","volume":"108","author":"Liu","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.actbio.2026.08.037_bib0063","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1083\/jcb.146.6.1319","article-title":"Activation of the Cdc42 effector N-Wasp by the Shigella flexneri Icsa protein promotes actin nucleation by Arp2\/3 complex and bacterial actin-based motility","volume":"146","author":"Egile","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0064","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3389\/fcimb.2014.00168","article-title":"Vibrio parahaemolyticus strengthens their virulence through modulation of cellular reactive oxygen species in vitro","volume":"4","author":"El-Malah","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0065","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1324760","article-title":"Effects of OxyR regulator on oxidative stress, Apx toxin secretion and virulence of Actinobacillus pleuropneumoniae","volume":"13","author":"Guo","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"10.1016\/j.actbio.2026.08.037_bib0066","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03022-21","article-title":"The fused methionine sulfoxide reductase MsrAB promotes oxidative stress defense and bacterial virulence in fusobacterium nucleatum","volume":"13","author":"Scheible","year":"2022","journal-title":"mBio"},{"issue":"21","key":"10.1016\/j.actbio.2026.08.037_bib0067","doi-asserted-by":"crossref","first-page":"6513","DOI":"10.1128\/JB.00943-09","article-title":"Single-residue changes in the C-terminal disulfide-bonded loop of the Pseudomonas aeruginosa Type IV pilin influence Pilus assembly and twitching motility","volume":"191","author":"Harvey","year":"2009","journal-title":"J. Bacteriol."},{"issue":"23","key":"10.1016\/j.actbio.2026.08.037_bib0068","doi-asserted-by":"crossref","first-page":"9095","DOI":"10.1073\/pnas.1200603109","article-title":"Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA","volume":"109","author":"Sun","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"18","key":"10.1016\/j.actbio.2026.08.037_bib0069","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1128\/JB.01889-14","article-title":"Biological cost of pyocin production during the SOS response in Pseudomonas aeruginosa","volume":"196","author":"Penterman","year":"2014","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0070","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.587159","article-title":"Fur represses Vibrio cholerae bofilm formation via direct regulation of vieSAB, cdgD, vpsU, and vpsA-K transcription","volume":"11","author":"Gao","year":"2020","journal-title":"Front. Microbiol."},{"issue":"18","key":"10.1016\/j.actbio.2026.08.037_bib0071","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00234-20","article-title":"VpsR directly activates transcription of multiple biofilm genes in V. cholerae","volume":"202","author":"Hsieh","year":"2020","journal-title":"J. Bacteriol."},{"issue":"2","key":"10.1016\/j.actbio.2026.08.037_bib0072","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/AEM.66.2.836-838.2000","article-title":"Effect of catalase on hydrogen peroxide penetration into Pseudomonas aeruginosa biofilms","volume":"66","author":"Stewart","year":"2000","journal-title":"Appl. Environ. Microbiol."},{"issue":"10","key":"10.1016\/j.actbio.2026.08.037_bib0073","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004442","article-title":"Involvement of a 1-Cys peroxiredoxin in bacterial virulence","volume":"10","author":"Kaihami","year":"2014","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.actbio.2026.08.037_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioflm.2024.100203","article-title":"Oxidative stress responses in biofilms","volume":"7","author":"da Cruz Nizer","year":"2024","journal-title":"Biofilm"},{"issue":"10","key":"10.1016\/j.actbio.2026.08.037_bib0075","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1093\/nar\/gks017","article-title":"Global regulation of gene expression by OxyR in an important human opportunistic pathogen","volume":"40","author":"Wei","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.actbio.2026.08.037_bib0076","article-title":"OxyR contributes to virulence of Acidovorax citrulli by regulating anti-oxidative stress and expression of flagellin FliC and type IV pili PilA","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Microbiol."},{"issue":"5","key":"10.1016\/j.actbio.2026.08.037_bib0077","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1128\/iai.63.5.1739-1744.1995","article-title":"Role of Salmonella typhimurium Mn-superoxide dismutase (SodA) in protection against early killing by J774 macrophages","volume":"63","author":"Tsolis","year":"1995","journal-title":"Infect. Immun."},{"issue":"3","key":"10.1016\/j.actbio.2026.08.037_bib0078","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004975","article-title":"Phagocytic superoxide specifically damages an extracytoplasmic target to inhibit or kill Salmonella","volume":"4","author":"Craig","year":"2009","journal-title":"PLoS. One"},{"issue":"568","key":"10.1016\/j.actbio.2026.08.037_bib0079","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aar5926","article-title":"Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO","volume":"12","author":"Herb","year":"2019","journal-title":"Sci. Signal."},{"issue":"3","key":"10.1016\/j.actbio.2026.08.037_bib0080","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0921-8777(99)00073-7","article-title":"Efficient repair of hydrogen peroxide-induced DNA damage by E. coli requires SOS induction of RecA and RuvA proteins","volume":"459","author":"Konola","year":"2000","journal-title":"Mutat. Res."},{"issue":"16","key":"10.1016\/j.actbio.2026.08.037_bib0081","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1128\/JB.182.16.4533-4544.2000","article-title":"Role of the Pseudomonas aeruginosa oxyR-recG operon in oxidative stress defense and DNA repair: OxyR-dependent regulation of katB-ankB, ahpB, and ahpC-ahpF","volume":"182","author":"Ochsner","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0082","doi-asserted-by":"crossref","DOI":"10.1590\/1678-5150-pvb-6645","article-title":"Expression of icaA and icaD genes in biofilm formation in Staphylococcus aureus isolates from bovine subclinical mastitis","volume":"41","author":"Marques","year":"2021","journal-title":"Pesqui. Vet. Bras."},{"issue":"4","key":"10.1016\/j.actbio.2026.08.037_bib0083","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123027","article-title":"SaeRS-dependent inhibition of biofilm formation in Staphylococcus aureus Newman","volume":"10","author":"Cue","year":"2015","journal-title":"PLoS. One"},{"issue":"36","key":"10.1016\/j.actbio.2026.08.037_bib0084","doi-asserted-by":"crossref","first-page":"27553","DOI":"10.1074\/jbc.M110.144394","article-title":"Francisella tularensis antioxidants harness reactive oxygen species to restrict macrophage signaling and cytokine production","volume":"285","author":"Melillo","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2026.08.037_bib0085","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.57837","article-title":"Reactive oxygen species oxidize STING and suppress interferon production","volume":"9","author":"Tao","year":"2020","journal-title":"Elife"},{"issue":"21","key":"10.1016\/j.actbio.2026.08.037_bib0086","doi-asserted-by":"crossref","first-page":"8803","DOI":"10.1073\/pnas.1010042108","article-title":"Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases","volume":"108","author":"Swanson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"44","key":"10.1016\/j.actbio.2026.08.037_bib0087","doi-asserted-by":"crossref","first-page":"38448","DOI":"10.1074\/jbc.M111.268938","article-title":"Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3","volume":"286","author":"Wentworth","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2026.08.037_bib0088","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/9741838","article-title":"Using ROS as a second messenger, NADPH oxidase 2 mediates macrophage senescence via interaction with NF-\u03baB during Pseudomonas aeruginosa infection","volume":"2018","author":"Li","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.actbio.2026.08.037_bib0089","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.canlet.2013.08.016","article-title":"Helicobacter pylori-induced gastric inflammation and gastric cancer","volume":"345","author":"Wang","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.actbio.2026.08.037_bib0090","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2025.1594239","article-title":"Resveratrol inhibits the formation of Staphylococcus aureus biofilms by reducing PIA, eDNA release, and ROS production","volume":"12","author":"He","year":"2025","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.actbio.2026.08.037_bib0091","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.freeradbiomed.2022.05.013","article-title":"A redox-dependent thiol-switch and a Ca2+ binding site within the hinge region hierarchically depend on each other in \u03b17\u03b21 integrin regulation","volume":"187","author":"Caliandro","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.actbio.2026.08.037_bib0092","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3389\/fcimb.2017.00373","article-title":"Neutrophils to the ROScue: mechanisms of NADPH oxidase activation and bacterial resistance","volume":"7","author":"Nguyen","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"23","key":"10.1016\/j.actbio.2026.08.037_bib0093","doi-asserted-by":"crossref","first-page":"5662","DOI":"10.3390\/molecules25235662","article-title":"Quinolones: mechanism, lethality and their contributions to antibiotic resistance","volume":"25","author":"Bush","year":"2020","journal-title":"Molecules"},{"issue":"17","key":"10.1016\/j.actbio.2026.08.037_bib0094","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1128\/JB.00128-18","article-title":"Reduce, induce, thrive: bacterial redox sensing during pathogenesis","volume":"200","author":"Reniere","year":"2018","journal-title":"J. Bacteriol."},{"issue":"6","key":"10.1016\/j.actbio.2026.08.037_bib0095","doi-asserted-by":"crossref","DOI":"10.1111\/hel.13024","article-title":"Reactive oxygen species and gastric carcinogenesis: the complex interaction between Helicobacter pylori and host","volume":"28","author":"Wu","year":"2023","journal-title":"Helicobacter"},{"issue":"1785","key":"10.1016\/j.actbio.2026.08.037_bib0096","doi-asserted-by":"crossref","DOI":"10.1098\/rspb.2013.3112","article-title":"The oxidative environment: a mediator of interspecies communication that drives symbiosis evolution","volume":"281","author":"Mon\u00e9","year":"2014","journal-title":"Proc. R. Soc. B: Biol. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0097","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3390\/ijms12010334","article-title":"The role of reactive-oxygen-species in microbial persistence and inflammation","volume":"12","author":"Spooner","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.actbio.2026.08.037_bib0098","article-title":"Dual and opposite roles of reactive oxygen species (ROS) in chagas disease: beneficial on the pathogen and harmful on the host","volume":"17","author":"Maldonado","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0099","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-02242-x","article-title":"MUC1 ectodomain is a flagellin-targeting decoy receptor and biomarker operative during Pseudomonas aeruginosa lung infection","volume":"11","author":"Verceles","year":"2021","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.actbio.2026.08.037_bib0100","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.3390\/microorganisms12102102","article-title":"Listeria in pregnancy\u2014the forgotten culprit","volume":"12","author":"Kraus","year":"2024","journal-title":"Microorganisms"},{"issue":"8","key":"10.1016\/j.actbio.2026.08.037_bib0101","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/glycob\/cww060","article-title":"The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo","volume":"26","author":"Hyun","year":"2016","journal-title":"Glycobiology"},{"issue":"15","key":"10.1016\/j.actbio.2026.08.037_bib0102","doi-asserted-by":"crossref","first-page":"7327","DOI":"10.3390\/ijms26157327","article-title":"Modeling the anti-adhesive role of punicalagin against Listeria Monocytogenes from the analysis of the interaction between internalin A and E-Cadherin","volume":"26","author":"Pedroni","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.actbio.2026.08.037_bib0103","article-title":"Role of the JAK2\/STAT3 pathway on infection of Francisella novicida","volume":"19","author":"Shokoohi","year":"2024","journal-title":"PLoS. One"},{"key":"10.1016\/j.actbio.2026.08.037_bib0104","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2026.116651","article-title":"Ethyl caffeate reprograms macrophage immunometabolism via the SIRT3\u2013FOXO3A\u2013AKT axis to enhance host defense against Candida auris","volume":"180","author":"Yang","year":"2026","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.actbio.2026.08.037_bib0105","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1021\/acsinfecdis.4c00086","article-title":"Bosutinib stimulates macrophage survival, phagocytosis, and intracellular killing of bacteria","volume":"10","author":"da Silva","year":"2024","journal-title":"ACS Infect. Dis."},{"issue":"8","key":"10.1016\/j.actbio.2026.08.037_bib0106","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.3390\/biomedicines11082322","article-title":"Apocynin, an NADPH oxidase enzyme inhibitor, prevents amebic liver abscess in hamster","volume":"11","author":"Higuera-Mart\u00ednez","year":"2023","journal-title":"Biomedicines"},{"issue":"7","key":"10.1016\/j.actbio.2026.08.037_bib0107","first-page":"3422","article-title":"NADPH oxidase 2 inhibitor diphenyleneiodonium enhances ROS-independent bacterial phagocytosis in murine macrophages via activation of the calcium-mediated p38 MAPK signaling pathway","volume":"9","author":"Zhu","year":"2017","journal-title":"Am. J. Transl. Res."},{"issue":"2","key":"10.1016\/j.actbio.2026.08.037_bib0108","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001271","article-title":"Inhibition of Nox2 oxidase activity ameliorates influenza A virus-Induced lung inflammation","volume":"7","author":"Vlahos","year":"2011","journal-title":"PLoS Pathog."},{"issue":"18","key":"10.1016\/j.actbio.2026.08.037_bib0109","doi-asserted-by":"crossref","first-page":"6911","DOI":"10.3390\/ijms21186911","article-title":"NOX1 inhibition attenuates kidney ischemia-reperfusion injury via inhibition of ROS-mediated ERK signaling","volume":"21","author":"Jung","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"43","key":"10.1016\/j.actbio.2026.08.037_bib0110","doi-asserted-by":"crossref","first-page":"8951","DOI":"10.1039\/D1TB01702K","article-title":"ROS-sensitive micelles for controlled delivery of antibiotics to combat intracellular -associated infections","volume":"9","author":"Qiao","year":"2021","journal-title":"J. Mater. Chem. B"},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0111","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/s42003-025-08770-w","article-title":"Systems-level exploitation of OxyR regulon unravels a potential antibacterial target in Pseudomonas aeruginosa","volume":"8","author":"Cui","year":"2025","journal-title":"Commun. Biol."},{"issue":"7","key":"10.1016\/j.actbio.2026.08.037_bib0112","doi-asserted-by":"crossref","DOI":"10.1111\/1751-7915.70199","article-title":"Synergy of ATP and meropenem in stimulating the TCA cycle to enhance killing of carbapenem-resistant acinetobacter baumannii","volume":"18","author":"Li","year":"2025","journal-title":"Microb. Biotechnol."},{"issue":"12","key":"10.1016\/j.actbio.2026.08.037_bib0113","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02714-24","article-title":"Metabolites augment oxidative stress to sensitize antibiotic-tolerant to fluoroquinolones","volume":"15","author":"Batchelder","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.actbio.2026.08.037_bib0114","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2026.124168","article-title":"A pH\/ROS dual-responsive metal-polyphenol-antibiotic nano-assembly for combating persistent infection by overcoming biofilm and cell membrane barriers","volume":"333","author":"Du","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2026.08.037_bib0115","doi-asserted-by":"crossref","DOI":"10.1063\/5.0312953","article-title":"Research advances in intelligent microenvironment-responsive hydrogels for myocardial infarction therapy","volume":"10","author":"Li","year":"2026","journal-title":"APL Bioeng."},{"key":"10.1016\/j.actbio.2026.08.037_bib0116","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114392","article-title":"A smart ROS-responsive hydrogel for on-demand antibacterial and platelet-rich plasma (PRP) activation in diabetic wound healing","volume":"388","author":"Li","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2026.08.037_bib0117","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113627","article-title":"Codelivery Ce6 and curcumin in antibacterial poly(\u03b2-amino ester) for anti-inflammatory and photodynamic antimicrobial combination therapy","volume":"381","author":"Liu","year":"2025","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0118","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-025-03275-4","article-title":"Injectable hydrogels with ROS-triggered drug release enable the co-delivery of antibacterial agent and anti-inflammatory nanoparticle for periodontitis treatment","volume":"23","author":"Zhu","year":"2025","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.actbio.2026.08.037_bib0119","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.168204","article-title":"ROS-responsive nanoassembly co-delivering chlorogenic acid and copper accelerates healing of infected burns via oxidative stress mitigation and macrophage M2 polarization","volume":"522","author":"Chen","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2026.08.037_bib0120","doi-asserted-by":"crossref","first-page":"16362","DOI":"10.1021\/jacs.5c02184","article-title":"Self-adaptive release of stem cell-derived exosomes from a multifunctional hydrogel for accelerating MRSA-infected diabetic wound repair","volume":"147","author":"Wang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.actbio.2026.08.037_bib0121","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1038\/s41467-026-68817-2","article-title":"Organic diselenide hydrogel microspheres for multimodal treatment of osteoarthritis","volume":"17","author":"Liu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actbio.2026.08.037_bib0122","first-page":"574","article-title":"A mitochondria-targeted nanoantioxidant restores alveolar bone homeostasis in periodontitis by quenching ROS and suppressing the cGAS-STING pathway","volume":"60","author":"Huang","year":"2026","journal-title":"Bioact. Mater."},{"issue":"47","key":"10.1016\/j.actbio.2026.08.037_bib0123","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.75611","article-title":"Co-delivery of cationic polymeric sonosensitizer and antimicrobial peptide mimic by polymeric nanoparticle for enhanced therapy of lethal bacterial pneumonia","volume":"36","author":"Zheng","year":"2026","journal-title":"Adv. Funct. Mater."},{"issue":"24","key":"10.1016\/j.actbio.2026.08.037_bib0124","doi-asserted-by":"crossref","DOI":"10.1002\/adma.72911","article-title":"Biodegradable nanospray for sunlight-activated photodynamic antibacterial therapy and wound healing","volume":"38","author":"Xu","year":"2026","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2026.08.037_bib0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.152511","article-title":"Ros-responsive hydrogel with size-dependent sequential release effects for anti-bacterial and anti-inflammation in diabetic wound healing","volume":"493","author":"Sun","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2026.08.037_bib0126","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114594","article-title":"Inflammation-responsive DNA hydrogel integrating probiotic outer membrane vesicles for infection monitoring and precision therapy of diabetic wounds","volume":"391","author":"Tai","year":"2026","journal-title":"J. Control. Release"},{"key":"10.1016\/j.actbio.2026.08.037_bib0127","first-page":"101","article-title":"ROS-responsive drug delivery systems for biomedical applications","volume":"13","author":"Tao","year":"2018","journal-title":"Asian J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.actbio.2026.08.037_bib0128","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202512719","article-title":"Hydrogel-based ROS-regulating strategy: reprogramming the oxidative stress imbalance in advanced diabetic wound repair","volume":"38","author":"Zhou","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.actbio.2026.08.037_bib0129","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbad110","article-title":"ROS-responsive hydrogels with spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs for the repair of MRSA-infected wounds","volume":"11","author":"Qiao","year":"2024","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.actbio.2026.08.037_bib0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2026.178161","article-title":"Recent advances in infection microenvironment-responsive antibacterial materials","volume":"543","author":"Chai","year":"2026","journal-title":"Chem. Eng. J."},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0131","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1186\/s12951-025-03558-w","article-title":"Advanced wound healing with stimuli-responsive nanozymes: mechanisms, design and applications","volume":"23","author":"Liu","year":"2025","journal-title":"J. Nanobiotechnology"},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0132","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s40820-024-01353-0","article-title":"ROS balance autoregulating core\u2013shell CeO2@ZIF-8\/Au nanoplatform for wound repair","volume":"16","author":"Zhou","year":"2024","journal-title":"Nano-Micro Lett."},{"issue":"11","key":"10.1016\/j.actbio.2026.08.037_bib0133","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202417314","article-title":"Biomolecular microneedle initiates Fe3O4\/MXene heterojunction-mediated nanozyme-like reactions and bacterial ferroptosis to repair diabetic wounds","volume":"12","author":"You","year":"2025","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0134","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1186\/s12951-026-04488-x","article-title":"Phase-engineered MoS2 nanosheets\/probiotic vesicles hydrogel for diabetic wound healing via dynamic ROS modulation","volume":"24","author":"Zhang","year":"2026","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.actbio.2026.08.037_bib0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.154517","article-title":"Cerium dioxide nanozyme doped hybrid hydrogel with antioxidant and antibacterial abilities for promoting diabetic wound healing","volume":"497","author":"Zhao","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.actbio.2026.08.037_bib0136","doi-asserted-by":"crossref","DOI":"10.1002\/bmm2.70103","article-title":"Sequential catalytic nanosystem of carbon dots and uricase integrated with polydopamine for therapy of gouty wound ulceration","author":"Yang","year":"2026","journal-title":"Bmemat"},{"issue":"32","key":"10.1016\/j.actbio.2026.08.037_bib0137","doi-asserted-by":"crossref","first-page":"29702","DOI":"10.1021\/acsnano.5c09764","article-title":"Biofilm-responsive nano-antibiotics for degradation of extracellular polymeric substance matrix and reduction of pathogenicity against drug-resistant bacterial infections","volume":"19","author":"Zou","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.actbio.2026.08.037_bib0138","article-title":"Selenium nanozymes effectively treat rheumatoid arthritis by specifically activating selenoproteins to block oxidative damage and cGAS\u2013STING signaling pathway","author":"Yang","year":"2026","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.actbio.2026.08.037_bib0139","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103574","article-title":"Dual-driven selenium Janus single-atom nanomotors for autonomous regulating mitochondrial oxygen imbalance to catalytic therapy of rheumatoid arthritis","volume":"81","author":"Chen","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122384","article-title":"Pillar arene Se nanozyme therapeutic systems with dual drive power effectively penetrated mucus layer combined therapy acute lung injury","volume":"304","author":"Chen","year":"2024","journal-title":"Biomaterials"},{"issue":"43","key":"10.1016\/j.actbio.2026.08.037_bib0141","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202403219","article-title":"A ROS-responsive lipid nanoparticles release multifunctional hydrogel based on microenvironment regulation promotes infected diabetic wound healing","volume":"11","author":"Yang","year":"2024","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0142","article-title":"ROS-responsive drug delivery systems for chronic wound healing: advances, challenges, and translational perspectives","volume":"13","author":"Xiong","year":"2026","journal-title":"Mil. Med. Res."},{"issue":"45","key":"10.1016\/j.actbio.2026.08.037_bib0143","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202512127","article-title":"Nanozyme-engineered probiotic microneedle patch for chronic diabetic wound therapy","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci."},{"issue":"6","key":"10.1016\/j.actbio.2026.08.037_bib0144","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3390\/antiox14060682","article-title":"The impact of the skin microbiome and oxidative stress on the initiation and development of cutaneous chronic wounds","volume":"14","author":"Martins-Green","year":"2025","journal-title":"Antioxidants"},{"issue":"18","key":"10.1016\/j.actbio.2026.08.037_bib0145","doi-asserted-by":"crossref","first-page":"8897","DOI":"10.3390\/ijms26188897","article-title":"Pathogenesis of cutaneous mycobacterial infections\u2014M. marinum and M. leprae","volume":"26","author":"Cruz","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"18","key":"10.1016\/j.actbio.2026.08.037_bib0146","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202503785","article-title":"Bergapten-loaded multifunctional soluble microneedle patch with bidirectional ROS regulation and pyroptosis suppression accelerates chronic infected wound healing via the Nrf2\u2013NF-\u03baB\u2013NLRP3 axis","volume":"15","author":"Chen","year":"2026","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.actbio.2026.08.037_bib0147","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124046","article-title":"Liposomal drug delivery strategies to eradicate bacterial biofilms: challenges, recent advances, and future perspectives","volume":"655","author":"Panthi","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"17","key":"10.1016\/j.actbio.2026.08.037_bib0148","doi-asserted-by":"crossref","first-page":"11012","DOI":"10.1021\/acsapm.5c01387","article-title":"ICG@ZIF@HA nanoparticles and GO-loaded freeze-drying microneedles mediated PDT\/PTT dual-modal phototherapeutic for efficient bacterial biofilm elimination","volume":"7","author":"Zheng","year":"2025","journal-title":"ACS Appl. Polym. Mater."},{"issue":"23","key":"10.1016\/j.actbio.2026.08.037_bib0149","doi-asserted-by":"crossref","first-page":"7372","DOI":"10.1039\/D6TB00905K","article-title":"A GSH-scavenging and synthesis-blocking microneedle patch for augmenting photodynamic eradication of diabetic wound biofilms","volume":"14","author":"Zhang","year":"2026","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.actbio.2026.08.037_bib0150","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.mattod.2025.12.003","article-title":"Synergizing ROS-biocatalysis and biofilm penetration via photothermal artificial enzymes with atomic homojunction sites to eradicate drug-resistant bacterial infections","volume":"92","author":"Wu","year":"2026","journal-title":"Mater. Today"},{"issue":"3","key":"10.1016\/j.actbio.2026.08.037_bib0151","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1021\/acsami.3c15689","article-title":"Biofilm microenvironment-sensitive piezoelectric nanomotors for enhanced penetration and ROS\/NO synergistic bacterial elimination","volume":"16","author":"Zhao","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2026.08.037_bib0152","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2026.177231","article-title":"A sequential mucus-penetrating and pH\/ROS-responsive organosilica nanoplatform for co-delivery of natural antibiotics to combat drug resistant lung infection","volume":"541","author":"Liao","year":"2026","journal-title":"Chem. Eng. J."},{"issue":"15","key":"10.1016\/j.actbio.2026.08.037_bib0153","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202319966","article-title":"De Novo Designed Ru(II) metallacycle as a microenvironment-adaptive sonosensitizer and sonocatalyst for multidrug-resistant biofilms eradication","volume":"63","author":"Xu","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.actbio.2026.08.037_bib0154","article-title":"Caspase-11 and NLRP3 exacerbate systemic Klebsiella infection through reducing mitochondrial ROS production","volume":"16","author":"Zhou","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0155","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.56656","article-title":"SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst","volume":"9","author":"Nguyen","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.actbio.2026.08.037_bib0156","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123944","article-title":"Multifunctional hollow manganese silicate nanoparticles for the treatment of acute lung injury and Pseudomonas aeruginosa pulmonary infection","volume":"329","author":"Ma","year":"2026","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.actbio.2026.08.037_bib0157","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202300580","article-title":"ROS-responsive Poly(\u03b1-l-lysine)-based nanoparticles loaded with doxycycline combat oxidative stress and bacterial infection","volume":"24","author":"Wang","year":"2024","journal-title":"Macromol. Biosci."},{"issue":"4","key":"10.1016\/j.actbio.2026.08.037_bib0158","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s00203-024-03919-3","article-title":"Quantum dots: a next generation approach for pathogenic microbial biofilm inhibition; mechanistic insights, existing challenges, and future potential","volume":"206","author":"Koul","year":"2024","journal-title":"Arch. Microbiol."},{"issue":"1","key":"10.1016\/j.actbio.2026.08.037_bib0159","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1038\/s41467-021-22286-x","article-title":"In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"issue":"33","key":"10.1016\/j.actbio.2026.08.037_bib0160","doi-asserted-by":"crossref","first-page":"47396","DOI":"10.1021\/acsami.5c11332","article-title":"Neutrophil extracellular traps-inspired hydrogen-bonded organic framework-based bio-orthogonal nanozymes for enhanced bacterial capture and sterilization","volume":"17","author":"Wang","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2026.08.037_bib0161","doi-asserted-by":"crossref","DOI":"10.1016\/j.carres.2025.109671","article-title":"Smart-responsive dual cross-linked chitooligosaccharide nanoparticles with high stability and ROS-triggered self-accelerating drug release for enhanced breast cancer therapy","volume":"558","author":"Sun","year":"2025","journal-title":"Carbohydr. Res."},{"issue":"3","key":"10.1016\/j.actbio.2026.08.037_bib0162","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acsnanomed.5c00131","article-title":"Nanotechnology strategies for ocular reactive oxygen species regulation and functional contact lens platforms","volume":"1","author":"Huang","year":"2026","journal-title":"ACS Nano Med."},{"key":"10.1016\/j.actbio.2026.08.037_bib0163","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2026.102617","article-title":"NanoPhyto formulations: a promising approach for targeted therapy of gastrointestinal infections, clinical advancements, and future perspectives","volume":"87","author":"Wahid","year":"2026","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0164","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2026.1866492","article-title":"Advances in phytochemical-derived nanotherapeutics for multimodal eradication of multidrug-resistant Staphylococcus aureus","volume":"17","author":"Gupta","year":"2026","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.actbio.2026.08.037_bib0165","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2023.1337468","article-title":"The \u201cBig Three\u201d in biocompatibility testing of medical devices: implementation of alternatives to animal experimentation\u2014are we there yet?","volume":"5","author":"Kan\u010f\u00e1rov\u00e1","year":"2024","journal-title":"Front. Toxicol."},{"issue":"35","key":"10.1016\/j.actbio.2026.08.037_bib0166","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202529194","article-title":"Structurally engineered ferrous metal\u2013organic framework as a chemodynamic therapy nanoagent for concurrent hydroxyl radical and singlet oxygen generation","volume":"36","author":"Wang","year":"2026","journal-title":"Adv. Funct. Mater."},{"issue":"6","key":"10.1016\/j.actbio.2026.08.037_bib0167","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s42255-022-00591-z","article-title":"Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo","volume":"4","author":"Murphy","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.actbio.2026.08.037_bib0168","series-title":"Cytotoxicity and Cell Viability Assessment of Biomaterials","article-title":"Cytotoxicity and cell viability assessment of biomaterials: cytotoxicity - understanding cellular damage and response","author":"Sukumaran Anil","year":"2023"},{"issue":"4","key":"10.1016\/j.actbio.2026.08.037_bib0169","doi-asserted-by":"crossref","first-page":"481","DOI":"10.26599\/NBE.2025.9290129","article-title":"Evaluating nanoparticle-induced cytotoxicity: mechanisms and methods","volume":"17","author":"Maria","year":"2025","journal-title":"Nano Biomed. Eng."},{"issue":"11","key":"10.1016\/j.actbio.2026.08.037_bib0170","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.dental.2024.07.020","article-title":"Guidance on the assessment of biocompatibility of biomaterials: fundamentals and testing considerations","volume":"40","author":"Rosa","year":"2024","journal-title":"Dent. Mater."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126005659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126005659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:02:57Z","timestamp":1791018177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126005659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":170,"alternative-id":["S1742706126005659"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.08.037","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Harnessing the dual role of reactive oxygen species in bacterial infection: Therapeutic opportunities for controlled release and targeted modulation","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.08.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}