{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:23:35Z","timestamp":1793132615379,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["231530"],"award-info":[{"award-number":["231530"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["331752"],"award-info":[{"award-number":["331752"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["346292"],"award-info":[{"award-number":["346292"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005366","name":"University of Oslo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009891","name":"DENTSPLY Implants","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.actbio.2026.08.041","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T23:09:20Z","timestamp":1787267360000},"page":"609-621","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Multi-scale assessment of scaffold-guided regeneration in human extraction sockets using an ultra-porous TiO\u2082 biomaterial"],"prefix":"10.1016","volume":"223","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5381-9392","authenticated-orcid":false,"given":"Reem","family":"Jamous","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingvild","family":"Nys\u00e6ther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6690-7233","authenticated-orcid":false,"given":"H\u00e5vard Jostein","family":"Haugen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Petter","family":"Lyngstadaas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8530-6548","authenticated-orcid":false,"given":"Malin Vestin","family":"Fredriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Eirik","family":"Ellingsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1187-8578","authenticated-orcid":false,"given":"Thaqif El","family":"Khassawna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 5","key":"10.1016\/j.actbio.2026.08.041_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0501.2011.02375.x","article-title":"A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans","volume":"23","author":"Tan","year":"2012","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.actbio.2026.08.041_bib0015","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1749-799X-9-18","article-title":"Bone regenerative medicine: classic options, novel strategies, and future directions","volume":"9","author":"Oryan","year":"2014","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.actbio.2026.08.041_bib0003","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41368-020-00107-z","article-title":"Titanium mesh for bone augmentation in oral implantology: current application and progress","volume":"12","author":"Xie","year":"2020","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.actbio.2026.08.041_bib0004","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jeurceramsoc.2012.08.016","article-title":"Processing of highly porous TiO2 bone scaffolds with improved compressive strength","volume":"33","author":"Tiainen","year":"2013","journal-title":"J. Eur. Ceram. Soc."},{"key":"10.1016\/j.actbio.2026.08.041_bib0005","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1007\/s10856-010-4142-1","article-title":"Ultra-porous titanium oxide scaffold with high compressive strength","volume":"21","author":"Tiainen","year":"2010","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.actbio.2026.08.041_bib0013","doi-asserted-by":"crossref","first-page":"960","DOI":"10.3389\/fphys.2018.00960","article-title":"Osteoconductive microarchitecture of bone substitutes for bone regeneration revisited","volume":"9","author":"Ghayor","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.actbio.2026.08.041_bib0006","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3389\/fimmu.2019.00713","article-title":"Immune modulation to enhance bone healing - A new concept to induce bone using prostacyclin to locally modulate immunity","volume":"10","author":"Wendler","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.actbio.2026.08.041_bib0007","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1016\/j.actbio.2012.02.020","article-title":"Bone formation in TiO2 bone scaffolds in extraction sockets of minipigs","volume":"8","author":"Tiainen","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.08.041_bib0008","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.1016\/j.actbio.2012.09.009","article-title":"Porous ceramic titanium dioxide scaffolds promote bone formation in rabbit peri-implant cortical defect model","volume":"9","author":"Haugen","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.actbio.2026.08.041_bib0009","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/clr.12725","article-title":"TiO2 scaffolds in peri-implant dehiscence defects: an experimental pilot study","volume":"27","author":"Verket","year":"2016","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.actbio.2026.08.041_bib0010","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/clr.13708","article-title":"Guided bone regeneration of chronic non-contained bone defects using a volume stable porous block TiO2 scaffold: an experimental in vivo study","volume":"32","author":"Le Thieu","year":"2021","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.actbio.2026.08.041_bib0011","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40824-021-00245-3","article-title":"Impact of simultaneous placement of implant and block bone graft substitute: an in vivo peri-implant defect model","volume":"25","author":"Le Thieu","year":"2021","journal-title":"Biomater. Res."},{"key":"10.1016\/j.actbio.2026.08.041_bib0002","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/clr.70074","article-title":"Clinical performance of ultra-porous TiO2 scaffold as bone graft substitute in Human alveolar ridge preservation - A feasibility study","volume":"37","author":"Nys\u00e6ther","year":"2026","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.actbio.2026.08.041_bib0012","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.msec.2015.12.087","article-title":"Role of pore size and morphology in musculo-skeletal tissue regeneration","volume":"61","author":"Perez","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.actbio.2026.08.041_bib0014","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1582-4934.2010.01224.x","article-title":"Bone regeneration and stem cells","volume":"15","author":"Arvidson","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.actbio.2026.08.041_bib0016","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","article-title":"3D Slicer as an image computing platform for the quantitative imaging network","volume":"30","author":"Fedorov","year":"2012","journal-title":"Magn. Reson. Imaging."},{"key":"10.1016\/j.actbio.2026.08.041_bib0017","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3390\/dj7030089","article-title":"Cone-beam computed tomography in orthodontics","volume":"7","author":"Abdelkarim","year":"2019","journal-title":"Dent. J."},{"key":"10.1016\/j.actbio.2026.08.041_bib0018","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3389\/fendo.2018.00666","article-title":"An optimized approach to perform bone histomorphometry","volume":"9","author":"Malhan","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.actbio.2026.08.041_bib0019","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3109\/10520297709116809","article-title":"Differential staining of calcified tissues in plastic embedded microtome sections by a modification of Movat's pentachrome stain","volume":"52","author":"Ol\u00e1h","year":"1977","journal-title":"Stain Technol."},{"key":"10.1016\/j.actbio.2026.08.041_bib0020","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00774-017-0844-5","article-title":"Computational segmentation of collagen fibers in bone matrix indicates bone quality in ovariectomized rat spine","volume":"36","author":"Daghma","year":"2018","journal-title":"J. Bone Min. Metab."},{"key":"10.1016\/j.actbio.2026.08.041_bib0021","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.bone.2012.07.011","article-title":"Deterioration of fracture healing in the mouse model of NF1 long bone dysplasia","volume":"51","author":"El Khassawna","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2026.08.041_bib0022","first-page":"2623","article-title":"A review on pore and porosity in tissue engineering, Mater","volume":"44","author":"Yadav","year":"2021","journal-title":"Today Proc."},{"key":"10.1016\/j.actbio.2026.08.041_bib0023","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2024.1444986","article-title":"Optimizing scaffold pore size for tissue engineering: insights across various tissue types","volume":"12","author":"Mukasheva","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.actbio.2026.08.041_bib0029","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0092-8674(00)80258-5","article-title":"Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts","volume":"89","author":"Komori","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.actbio.2026.08.041_bib0030","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1210\/edrv-14-4-424","article-title":"Molecular mechanisms mediating proliferation\/differentiation interrelationships during progressive development of the osteoblast phenotype","volume":"14","author":"Stein","year":"1993","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.actbio.2026.08.041_bib0027","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrrheum.2012.1","article-title":"Fracture healing under healthy and inflammatory conditions","volume":"8","author":"Claes","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.actbio.2026.08.041_bib0028","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.biocel.2007.06.009","article-title":"Endochondral ossification: how cartilage is converted into bone in the developing skeleton","volume":"40","author":"Mackie","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.actbio.2026.08.041_bib0031","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.biomaterials.2014.10.017","article-title":"Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds","volume":"37","author":"Spiller","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2026.08.041_bib0032","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1016\/j.biomaterials.2012.02.034","article-title":"Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine","volume":"33","author":"Brown","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2026.08.041_bib0033","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.biomaterials.2017.12.025","article-title":"Mesenchymal stem cell-macrophage crosstalk and bone healing","volume":"196","author":"Pajarinen","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2026.08.041_bib0034","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jbmr.320","article-title":"The amazing osteocyte","volume":"26","author":"Bonewald","year":"2011","journal-title":"J. Bone Min. Res."},{"key":"10.1016\/j.actbio.2026.08.041_bib0035","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature13146","article-title":"Endothelial Notch activity promotes angiogenesis and osteogenesis in bone","volume":"507","author":"Ramasamy","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.actbio.2026.08.041_bib0036","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bone.2014.09.017","article-title":"Bringing new life to damaged bone: the importance of angiogenesis in bone repair and regeneration","volume":"70","author":"Stegen","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2026.08.041_bib0037","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/j.injury.2016.10.008","article-title":"The roles of immune cells in bone healing; what we know, do not know and future perspectives","volume":"47","author":"El-Jawhari","year":"2016","journal-title":"Injury"},{"key":"10.1016\/j.actbio.2026.08.041_bib0038","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 macrophages and the Th1\/Th2 paradigm","volume":"164","author":"Mills","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.actbio.2026.08.041_bib0039","doi-asserted-by":"crossref","first-page":"19883","DOI":"10.1074\/jbc.M413274200","article-title":"Sclerostin binds to LRP5\/6 and antagonizes canonical wnt signaling","volume":"280","author":"Li","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2026.08.041_bib0040","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1096\/fj.05-4221fje","article-title":"Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation","volume":"19","author":"Poole","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.actbio.2026.08.041_bib0041","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1182\/blood-2008-03-145169","article-title":"The role of Dickkopf-1 in bone development, homeostasis, and disease","volume":"113","author":"Pinzone","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.actbio.2026.08.041_bib0042","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1074\/jbc.M705092200","article-title":"Mechanical stimulation of bone in vivo reduces osteocyte expression of sost\/sclerostin","volume":"283","author":"Robling","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actbio.2026.08.041_bib0043","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bone.2011.10.025","article-title":"Sost downregulation and local wnt signaling are required for the osteogenic response to mechanical loading","volume":"50","author":"Tu","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.actbio.2026.08.041_bib0044","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev-bioeng-070909-105302","article-title":"Osteocyte mechanobiology and pericellular mechanics","volume":"12","author":"Jacobs","year":"2010","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.actbio.2026.08.041_bib0045","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1210\/er.2012-1026","article-title":"The osteocyte: an endocrine cell \u2026 and more","volume":"34","author":"Dallas","year":"2013","journal-title":"Endocr. Rev."}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126005738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126005738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:33:04Z","timestamp":1790580784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126005738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":42,"alternative-id":["S1742706126005738"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.08.041","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-scale assessment of scaffold-guided regeneration in human extraction sockets using an ultra-porous TiO\u2082 biomaterial","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.08.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}