{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:00:45Z","timestamp":1790452845563,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["1R01HL157346-01A1"],"award-info":[{"award-number":["1R01HL157346-01A1"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.actbio.2026.09.016","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:41:46Z","timestamp":1788968506000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined use of a factor XIIa inhibitor with a polycarboxybetaine coating creates potent anticoagulation with preserved hemostasis during ambulatory, 24-hour, rabbit extracorporeal life support"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8323-9919","authenticated-orcid":false,"given":"Suji","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9963-6970","authenticated-orcid":false,"given":"Yeahwa","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4825-9413","authenticated-orcid":false,"given":"Helen","family":"Scala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3562-031X","authenticated-orcid":false,"given":"Adel","family":"Akhavanmalayeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9171-541X","authenticated-orcid":false,"given":"Umar","family":"Nasim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2492-1070","authenticated-orcid":false,"given":"Alexander","family":"Potchernikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2838-9247","authenticated-orcid":false,"given":"Virginia","family":"Yost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8112-9031","authenticated-orcid":false,"given":"Hassana","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8734-9485","authenticated-orcid":false,"given":"Anna","family":"Iacocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8044-0027","authenticated-orcid":false,"given":"Christina","family":"Tavlarakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4470-0290","authenticated-orcid":false,"given":"Chenjue","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9863-6899","authenticated-orcid":false,"given":"Shaoyi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5604-3718","authenticated-orcid":false,"given":"Keith E.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.actbio.2026.09.016_bib0001","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1111\/jth.12961","article-title":"Medical device-induced thrombosis: what causes it and how can we prevent it?","volume":"13","author":"Jaffer","year":"2015","journal-title":"J. Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.actbio.2026.09.016_bib0002","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.athoracsur.2010.09.005","article-title":"Extracorporeal circulatory systems as a bridge to lung transplantation at remote transplant centers","volume":"91","author":"Haneya","year":"2011","journal-title":"Ann. Thorac. Surg."},{"issue":"2","key":"10.1016\/j.actbio.2026.09.016_bib0003","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.athoracsur.2015.07.046","article-title":"Bleeding, transfusion, and mortality on extracorporeal life support: ECLS working group on thrombosis and hemostasis","volume":"101","author":"Mazzeffi","year":"2016","journal-title":"Ann. Thorac. Surg."},{"issue":"3","key":"10.1016\/j.actbio.2026.09.016_bib0004","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/MAT.0b013e3182904a52","article-title":"Extracorporeal life support organization registry report 2012","volume":"59","author":"Paden","year":"2013","journal-title":"ASAIO J."},{"key":"10.1016\/j.actbio.2026.09.016_bib0005","series-title":"Biomaterials Science: An Introduction to Materials in Medicine","first-page":"1051","article-title":"Extracorporeal artificial organs and therapeutic devices","author":"Ukita","year":"2020"},{"key":"10.1016\/j.actbio.2026.09.016_bib0006","series-title":"The Artificial Lung","article-title":"Biocompatibility of artificial lungs","author":"Cook","year":"2002"},{"issue":"7","key":"10.1016\/j.actbio.2026.09.016_bib0007","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1097\/CCM.0000000000004944","article-title":"Comparison of anticoagulation strategies in patients requiring venovenous extracorporeal membrane oxygenation: heparin versus Bivalirudin","volume":"49","author":"Rivosecchi","year":"2021","journal-title":"Crit. Care Med."},{"issue":"3","key":"10.1016\/j.actbio.2026.09.016_bib0008","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/MAT.0000000000001230","article-title":"Thrombosis and bleeding in extracorporeal membrane oxygenation (ECMO) without anticoagulation: a systematic review","volume":"67","author":"Olson","year":"2021","journal-title":"ASAIO J."},{"issue":"1","key":"10.1016\/j.actbio.2026.09.016_bib0009","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13613-017-0275-4","article-title":"Systematic review and meta-analysis of complications and mortality of veno-venous extracorporeal membrane oxygenation for refractory acute respiratory distress syndrome","volume":"7","author":"Vaquer","year":"2017","journal-title":"Ann. Intensive Care"},{"issue":"5","key":"10.1016\/j.actbio.2026.09.016_bib0010","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.3390\/jcm11051224","article-title":"ECMO predictors of mortality: a 10-year referral centre experience","volume":"11","author":"Treml","year":"2022","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.actbio.2026.09.016_bib0011","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1186\/s13054-020-03348-w","article-title":"Comparison of anticoagulation strategies for veno-venous ECMO support in acute respiratory failure","volume":"24","author":"Seeliger","year":"2020","journal-title":"Crit. Care"},{"key":"10.1016\/j.actbio.2026.09.016_bib0012","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jcrc.2017.02.014","article-title":"Anticoagulation practices and the prevalence of major bleeding, thromboembolic events, and mortality in venoarterial extracorporeal membrane oxygenation: a systematic review and meta-analysis","volume":"39","author":"Sy","year":"2017","journal-title":"J. Crit. Care"},{"issue":"2","key":"10.1016\/j.actbio.2026.09.016_bib0013","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/PCC.0000000000000317","article-title":"Shriver National Institute of Child, N. Human development collaborative pediatric critical care research, association of bleeding and thrombosis with outcome in extracorporeal life support","volume":"16","author":"Dalton","year":"2015","journal-title":"Pediatr. Crit. Care Med."},{"issue":"1\u20132","key":"10.1016\/j.actbio.2026.09.016_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ten.2005.11.1","article-title":"Mediation of biomaterial-cell interactions by adsorbed proteins: a review","volume":"11","author":"Wilson","year":"2005","journal-title":"Tissue Eng."},{"issue":"13","key":"10.1016\/j.actbio.2026.09.016_bib0015","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S0142-9612(96)80004-4","article-title":"Proteins involved in the Vroman effect during exposure of human blood plasma to glass and polyethylene","volume":"17","author":"Turbill","year":"1996","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.actbio.2026.09.016_bib0016","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/MOT.0000000000001163","article-title":"Progress towards permanent respiratory support","volume":"29","author":"Shin","year":"2024","journal-title":"Curr. Opin. Organ Transpl."},{"key":"10.1016\/j.actbio.2026.09.016_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112753","article-title":"Factor XII\/XIIa inhibitors: their discovery, development, and potential indications","volume":"208","author":"Davoine","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"6","key":"10.1016\/j.actbio.2026.09.016_bib0018","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/joim.12430","article-title":"Factor XII: a novel target for safe prevention of thrombosis and inflammation","volume":"278","author":"Kenne","year":"2015","journal-title":"J. Intern. Med."},{"issue":"6","key":"10.1016\/j.actbio.2026.09.016_bib0019","doi-asserted-by":"crossref","DOI":"10.1002\/admi.201400071","article-title":"Achieving one-step surface coating of highly hydrophilic poly(Carboxybetaine Methacrylate) polymers on hydrophobic and hydrophilic surfaces","volume":"1","author":"Sundaram","year":"2014","journal-title":"Adv. Mater. Interfaces"},{"key":"10.1016\/j.actbio.2026.09.016_bib0020","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.actbio.2019.05.019","article-title":"Zwitterionic poly-carboxybetaine coating reduces artificial lung thrombosis in sheep and rabbits","volume":"92","author":"Ukita","year":"2019","journal-title":"Acta Biomater."},{"issue":"20","key":"10.1016\/j.actbio.2026.09.016_bib0021","doi-asserted-by":"crossref","first-page":"10999","DOI":"10.1021\/acs.analchem.7b02876","article-title":"Paper sensor coated with a poly(carboxybetaine)-multiple DOPA conjugate via dip-coating for biosensing in complex Media","volume":"89","author":"Sun","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.actbio.2026.09.016_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120778","article-title":"Combination of polycarboxybetaine coating and factor XII inhibitor reduces clot formation while preserving normal tissue coagulation during extracorporeal life support","volume":"272","author":"Naito","year":"2021","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.actbio.2026.09.016_bib0023","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1038\/s41467-020-17648-w","article-title":"Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs","volume":"11","author":"Wilbs","year":"2020","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.actbio.2026.09.016_bib0024","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/MAT.0000000000002557","article-title":"ELSO 2025 narrative guideline on the use of ECMO for accidental hypothermia","volume":"71","author":"Cools","year":"2025","journal-title":"ASAIO J."},{"key":"10.1016\/j.actbio.2026.09.016_bib0025","doi-asserted-by":"crossref","unstructured":"D.J. Skoog, Fourteen day In vivo testing of a compliant thoracic artificial lung, 63(5) (2017) 644\u2013649.","DOI":"10.1097\/MAT.0000000000000627"},{"issue":"5","key":"10.1016\/j.actbio.2026.09.016_bib0026","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1097\/TP.0000000000003481","article-title":"Month-long Respiratory support by a wearable pumping artificial lung in an ovine model","volume":"105","author":"Orizondo","year":"2021","journal-title":"Transplantation"},{"issue":"24","key":"10.1016\/j.actbio.2026.09.016_bib0027","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1002\/cbic.201600336","article-title":"Improving the binding affinity of in-vitro-evolved cyclic peptides by inserting atoms into the macrocycle backbone","volume":"17","author":"Wilbs","year":"2016","journal-title":"Chembiochem"},{"issue":"3","key":"10.1016\/j.actbio.2026.09.016_bib0028","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1021\/acs.jmedchem.6b01548","article-title":"Peptide macrocycle inhibitor of coagulation factor XII with subnanomolar affinity and high target selectivity","volume":"60","author":"Middendorp","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.actbio.2026.09.016_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108750","article-title":"Strategies for the production of long-acting therapeutics and efficient drug delivery for cancer treatment","volume":"113","author":"AlQahtani","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.actbio.2026.09.016_bib0030","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1517\/14728214.2015.1113254","article-title":"What is the future of PEGylated therapies?","volume":"20","author":"Swierczewska","year":"2015","journal-title":"Expert. Opin. Emerg. Drugs"},{"issue":"222","key":"10.1016\/j.actbio.2026.09.016_bib0031","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006804","article-title":"A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk","volume":"6","author":"Larsson","year":"2014","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.actbio.2026.09.016_bib0032","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/cts.13180","article-title":"A phase I, first-in-human, randomized dose-escalation study of anti-activated factor XII monoclonal antibody garadacimab","volume":"15","author":"McKenzie","year":"2022","journal-title":"Clin. Transl. Sci."},{"issue":"3","key":"10.1016\/j.actbio.2026.09.016_bib0033","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/cts.13192","article-title":"Pharmacokinetic\/pharmacodynamic modeling for dose selection for the first-in-human trial of the activated Factor XII inhibitor garadacimab (CSL312)","volume":"15","author":"Pawaskar","year":"2022","journal-title":"Clin. Transl. Sci."},{"issue":"10328","key":"10.1016\/j.actbio.2026.09.016_bib0034","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0140-6736(21)02225-X","article-title":"Prophylactic use of an anti-activated factor XII monoclonal antibody, garadacimab, for patients with C1-esterase inhibitor-deficient hereditary angioedema: a randomised, double-blind, placebo-controlled, phase 2 trial","volume":"399","author":"Craig","year":"2022","journal-title":"Lancet"},{"issue":"10382","key":"10.1016\/j.actbio.2026.09.016_bib0035","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0140-6736(23)00350-1","article-title":"Efficacy and safety of garadacimab, a factor XIIa inhibitor for hereditary angioedema prevention (VANGUARD): a global, multicentre, randomised, double-blind, placebo-controlled, phase 3 trial","volume":"401","author":"Craig","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.actbio.2026.09.016_bib0036","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.thromres.2020.08.040","article-title":"Knockdown of liver-derived factor XII by GalNAc-siRNA ALN-F12 prevents thrombosis in mice without impacting hemostatic function","volume":"196","author":"Liu","year":"2020","journal-title":"Thromb. Res."},{"issue":"2","key":"10.1016\/j.actbio.2026.09.016_bib0037","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1261\/rna.068916.118","article-title":"An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema","volume":"25","author":"Liu","year":"2019","journal-title":"RNA"},{"key":"10.1016\/j.actbio.2026.09.016_bib0038","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.thromres.2022.04.013","article-title":"Coagulation factors XI and XII as possible targets for anticoagulant therapy","volume":"214","author":"Kluge","year":"2022","journal-title":"Thromb. Res."},{"issue":"2","key":"10.1016\/j.actbio.2026.09.016_bib0039","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/rth2.12309","article-title":"Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates","volume":"4","author":"Wallisch","year":"2020","journal-title":"Res Pr. Thromb. Haemost."},{"issue":"8","key":"10.1016\/j.actbio.2026.09.016_bib0040","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1182\/bloodadvances.2022007586","article-title":"Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation","volume":"7","author":"Tweddell","year":"2023","journal-title":"Blood Adv."},{"issue":"6","key":"10.1016\/j.actbio.2026.09.016_bib0041","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/MAT.0000000000001876","article-title":"Factor XII silencing using siRNA prevents thrombus formation in a rat model of extracorporeal life support","volume":"69","author":"Umei","year":"2023","journal-title":"ASAIO J."},{"issue":"13","key":"10.1016\/j.actbio.2026.09.016_bib0042","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1182\/blood-2013-12-540872","article-title":"Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits","volume":"123","author":"Yau","year":"2014","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.actbio.2026.09.016_bib0043","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s40259-022-00549-3","article-title":"Therapeutic siRNA: state-of-the-art and future perspectives","volume":"36","author":"Friedrich","year":"2022","journal-title":"BioDrugs"},{"issue":"2","key":"10.1016\/j.actbio.2026.09.016_bib0044","doi-asserted-by":"crossref","DOI":"10.3390\/pharmacy12020058","article-title":"A comparison of currently approved small interfering RNA (siRNA) medications to alternative treatments by costs, indications, and Medicaid coverage","volume":"12","author":"Sehgal","year":"2024","journal-title":"Pharmacy"},{"issue":"6","key":"10.1016\/j.actbio.2026.09.016_bib0045","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1213\/ANE.0b013e31827e4e62","article-title":"Review article: heparin sensitivity and resistance: management during cardiopulmonary bypass","volume":"116","author":"Finley","year":"2013","journal-title":"Anesth. Analg."},{"issue":"3","key":"10.1016\/j.actbio.2026.09.016_bib0046","article-title":"Heparin-induced thrombocytopenia: pathophysiology","volume":"12","author":"Patriarcheas","year":"2020","journal-title":"Diagn. Manag. Cureus"},{"issue":"1","key":"10.1016\/j.actbio.2026.09.016_bib0047","doi-asserted-by":"crossref","first-page":"19","DOI":"10.21037\/acs.2018.12.02","article-title":"Heparin-induced thrombocytopenia during extracorporeal life support: incidence, management and outcomes","volume":"8","author":"Choi","year":"2019","journal-title":"Ann. Cardiothorac. Surg."},{"issue":"1","key":"10.1016\/j.actbio.2026.09.016_bib0048","doi-asserted-by":"crossref","DOI":"10.1080\/19420862.2025.2451789","article-title":"Cost and supply considerations for antibody therapeutics","volume":"17","author":"Chen","year":"2025","journal-title":"MAbs"},{"issue":"1","key":"10.1016\/j.actbio.2026.09.016_bib0049","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41392-022-00904-4","article-title":"Therapeutic peptides: current applications and future directions","volume":"7","author":"Wang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.actbio.2026.09.016_bib0050","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1414658","article-title":"Antisense oligonucleotides and their applications in rare neurological diseases","volume":"18","author":"McDowall","year":"2024","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.actbio.2026.09.016_bib0051","unstructured":"C.s.D. Agency, Garadacimab (Andembry), 2026."},{"issue":"15","key":"10.1016\/j.actbio.2026.09.016_bib0052","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1056\/NEJMoa2513880","article-title":"Asundexian for secondary stroke prevention","volume":"394","author":"Sharma","year":"2026","journal-title":"N. Engl. J. Med."},{"issue":"23","key":"10.1016\/j.actbio.2026.09.016_bib0053","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1056\/NEJMoa2113194","article-title":"Milvexian for the prevention of venous thromboembolism","volume":"385","author":"Weitz","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.actbio.2026.09.016_bib0054","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12959-015-0048-y","article-title":"Contact pathway of coagulation and inflammation","volume":"13","author":"Wu","year":"2015","journal-title":"Thromb. J."},{"issue":"2","key":"10.1016\/j.actbio.2026.09.016_bib0055","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s12016-016-8540-0","article-title":"Bradykinin: inflammatory product of the coagulation system","volume":"51","author":"Hofman","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"22","key":"10.1016\/j.actbio.2026.09.016_bib0056","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1182\/blood-2012-07-292094","article-title":"In vivo roles of factor XII","volume":"120","author":"Renne","year":"2012","journal-title":"Blood"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126006045?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126006045?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:48:56Z","timestamp":1790452136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126006045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":56,"alternative-id":["S1742706126006045"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.09.016","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined use of a factor XIIa inhibitor with a polycarboxybetaine coating creates potent anticoagulation with preserved hemostasis during ambulatory, 24-hour, rabbit extracorporeal life support","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Acta Materialia Inc.","name":"copyright","label":"Copyright"}]}}