{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:43Z","timestamp":1792471123399,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Biomaterialia"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.actbio.2026.10.028","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:03:04Z","timestamp":1792162984000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammation-Responsive baicalin-delivering glycocalyx-mimetic hydrogel-functionalized bioprosthetic valve for antithrombosis and immunomodulation"],"prefix":"10.1016","author":[{"given":"Lepeng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1402-9827","authenticated-orcid":false,"given":"Cheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunbing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actbio.2026.10.028_bib0001","article-title":"Demographics and mortality trends of valvular heart disease in older adults in the United States: insights from CDC-wonder database 1999\u20132019","volume":"22","author":"Ali","year":"2024","journal-title":"Int. J. Cardiol. Cardiovasc. Risk Prevent."},{"issue":"1","key":"10.1016\/j.actbio.2026.10.028_bib0002","first-page":"102","article-title":"Considerations for optimal device selection in transcatheter aortic valve replacement: a review","volume":"6","author":"Claessen","year":"2021","journal-title":"JAMA Cardiol."},{"issue":"8","key":"10.1016\/j.actbio.2026.10.028_bib0003","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1161\/CIR.0000000000001209","article-title":"2024 Heart disease and stroke statistics: a report of us and global data from the American heart association","volume":"149","author":"Martin","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.actbio.2026.10.028_bib0004","doi-asserted-by":"crossref","first-page":"m3956","DOI":"10.1136\/bmj.m3956","article-title":"Warfarin in patients with mechanical heart valves","volume":"371","author":"Catterall","year":"2020","journal-title":"BMJ"},{"issue":"Supplement_1","key":"10.1016\/j.actbio.2026.10.028_bib0005","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehae666.1856","article-title":"Bioprosthetic versus mechanical prostheses in patients aged 50 to 70 years undergoing aortic valve replacement surgery: outcomes analysis from propensity score matching","volume":"45","author":"Courtney","year":"2024","journal-title":"Eur. Heart J."},{"issue":"16","key":"10.1016\/j.actbio.2026.10.028_bib0006","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.125.043061","article-title":"Advancements and perspectives in the bioprosthetic heart valve: a comprehensive review on biomaterial processing and emerging polymeric materials","volume":"14","author":"Li","year":"2025","journal-title":"J. Am. Heart Assoc."},{"issue":"8","key":"10.1016\/j.actbio.2026.10.028_bib0007","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.030895","article-title":"Trends and disparities in valvular heart disease mortality in the United States from 1999 to 2020","volume":"13","author":"Tan","year":"2024","journal-title":"J. Am. Heart Assoc."},{"issue":"9","key":"10.1016\/j.actbio.2026.10.028_bib0008","doi-asserted-by":"crossref","first-page":"253","DOI":"10.31083\/j.rcm2409253","article-title":"Long-Term outcomes of bioprosthetic and mechanical valve replacement for patients aged between 50 and 70 years","volume":"24","author":"Zhao","year":"2023","journal-title":"Rev. Cardiovasc. Med."},{"issue":"8","key":"10.1016\/j.actbio.2026.10.028_bib0009","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/ehjci\/jeae127","article-title":"Prevalence of asymptomatic valvular heart disease in the elderly population: a community-based echocardiographic study","volume":"25","author":"Tsampasian","year":"2024","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"10.1016\/j.actbio.2026.10.028_bib0010","doi-asserted-by":"crossref","first-page":"rbad098","DOI":"10.1093\/rb\/rbad098","article-title":"Recent progress in functional modification and crosslinking of bioprosthetic heart valves","volume":"11","author":"Zheng","year":"2024","journal-title":"Regenerative Biomaterials"},{"issue":"3","key":"10.1016\/j.actbio.2026.10.028_bib0011","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.018921","article-title":"Noncalcific mechanisms of bioprosthetic structural valve degeneration","volume":"10","author":"Marro","year":"2021","journal-title":"J. Am. Heart Assoc."},{"issue":"13, Supplement","key":"10.1016\/j.actbio.2026.10.028_bib0012","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/S0735-1097(24)04174-3","article-title":"AGE-RELATED differential proteomic analysis reveals the role of platelet and neutrophil degranulation with oxidative damage in degenerated bioprosthetic heart valves","volume":"83","author":"Faridmoayer","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"issue":"7","key":"10.1016\/j.actbio.2026.10.028_bib0013","first-page":"833","article-title":"Differential immune response to bioprosthetic heart valve tissues in the \u03b11,3 Galactosyltransferase-Knockout mouse model","volume":"10","author":"Cas\u00f3s","year":"2023","journal-title":"Bioeng."},{"issue":"19","key":"10.1016\/j.actbio.2026.10.028_bib0014","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.018506","article-title":"Degeneration of bioprosthetic heart valves: update 2020","volume":"9","author":"Kostyunin","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.actbio.2026.10.028_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.971028","article-title":"The path to a hemocompatible cardiovascular implant: advances and challenges of current endothelialization strategies","volume":"9","author":"Exarchos","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.actbio.2026.10.028_bib0016","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.actbio.2019.08.042","article-title":"Endothelialization of cardiovascular devices","volume":"99","author":"Jana","year":"2019","journal-title":"Acta Biomater."},{"issue":"5","key":"10.1016\/j.actbio.2026.10.028_bib0017","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.005648","article-title":"Calcification and oxidative modifications are associated with progressive bioprosthetic heart valve dysfunction","volume":"6","author":"Lee","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.actbio.2026.10.028_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.909801","article-title":"Mechanisms and drug therapies of bioprosthetic heart valve calcification","volume":"13","author":"Wen","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.actbio.2026.10.028_bib0019","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.actbio.2025.05.062","article-title":"Degeneration mechanisms and advancements in optimization for preparation and crosslinking strategy of pericardium-based bioprosthetic heart valves","volume":"201","author":"Huang","year":"2025","journal-title":"Acta Biomater."},{"issue":"34","key":"10.1016\/j.actbio.2026.10.028_bib0020","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202506728","article-title":"Constructing immunomodulator biosynthesis factory in grafting-from dna hydrogel for heart valve regeneration","volume":"37","author":"Li","year":"2025","journal-title":"Adv. Mater."},{"issue":"3","key":"10.1016\/j.actbio.2026.10.028_bib0021","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1021\/acsabm.0c01544","article-title":"Anticalcification potential of POSS-PEG hybrid hydrogel as a scaffold material for the development of synthetic heart valve leaflets","volume":"4","author":"Guo","year":"2021","journal-title":"ACS Applied Bio Materials"},{"key":"10.1016\/j.actbio.2026.10.028_bib0022","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.actbio.2022.10.036","article-title":"Dual-crosslinked bioprosthetic heart valves prepared by glutaraldehyde crosslinked pericardium and poly-2-hydroxyethyl methacrylate exhibited improved antithrombogenicity and anticalcification properties","volume":"154","author":"Huang","year":"2022","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1016\/j.actbio.2026.10.028_bib0023","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.1021\/acsomega.1c00006","article-title":"Oxidation chemistry of catechol utilized in designing stimuli-responsive adhesives and antipathogenic biomaterials","volume":"6","author":"Pinnataip","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.actbio.2026.10.028_bib0024","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.biomaterials.2018.03.018","article-title":"Polyphenol uses in biomaterials engineering","volume":"167","author":"Shavandi","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.actbio.2026.10.028_bib0025","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.trsl.2022.03.014","article-title":"Form follows function: the endothelial glycocalyx","volume":"247","author":"Suzuki","year":"2022","journal-title":"Transl. Res."},{"key":"10.1016\/j.actbio.2026.10.028_bib0026","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.actbio.2017.07.028","article-title":"Manufacturing of hydrogel biomaterials with controlled mechanical properties for tissue engineering applications","volume":"62","author":"Vedadghavami","year":"2017","journal-title":"Acta Biomater."},{"issue":"3","key":"10.1016\/j.actbio.2026.10.028_bib0027","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3390\/md21030177","article-title":"Alginate-Based hydrogels and scaffolds for biomedical applications","volume":"21","author":"Tomi\u0107","year":"2023","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.actbio.2026.10.028_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2024.115429","article-title":"Drug delivery strategies for local immunomodulation in transplantation: bridging the translational gap","volume":"213","author":"Naaz","year":"2024","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.actbio.2026.10.028_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113971","article-title":"Local delivery strategies to restore immune homeostasis in the context of inflammation","volume":"178","author":"Bentley","year":"2021","journal-title":"Adv. Drug. Deliv. Rev."},{"issue":"1","key":"10.1016\/j.actbio.2026.10.028_bib0030","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1186\/s12951-025-03613-6","article-title":"Hydrogels as advanced drug delivery platforms for cancer immunotherapy: promising innovations and future outlook","volume":"23","author":"Mohammadzadeh","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.actbio.2026.10.028_bib0031","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejmech.2017.03.004","article-title":"Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders","volume":"131","author":"Dinda","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.actbio.2026.10.028_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104890","article-title":"Immunological regulatory effect of flavonoid baicalin on innate immune toll-like receptors","volume":"158","author":"Jiang","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.actbio.2026.10.028_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113198","article-title":"Traditional uses, ten-years research progress on phytochemistry and pharmacology, and clinical studies of the genus scutellaria","volume":"265","author":"Shen","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.actbio.2026.10.028_bib0034","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/fft2.494","article-title":"Structural insights and biological activities of flavonoids: implications for novel applications","volume":"6","author":"Tang","year":"2025","journal-title":"Food Front."},{"key":"10.1016\/j.actbio.2026.10.028_bib0035","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.brainresbull.2020.08.016","article-title":"Anti-inflammatory and immunomodulatory effects of baicalin in cerebrovascular and neurological disorders","volume":"164","author":"Li","year":"2020","journal-title":"Brain Res. Bull."},{"issue":"3","key":"10.1016\/j.actbio.2026.10.028_bib0036","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.apsb.2014.03.002","article-title":"Combined use of phospholipid complexes and self-emulsifying microemulsions for improving the oral absorption of a BCS class IV compound, baicalin","volume":"4","author":"Wu","year":"2014","journal-title":"Acta Pharmaceutica Sinica B"},{"issue":"16","key":"10.1016\/j.actbio.2026.10.028_bib0037","doi-asserted-by":"crossref","first-page":"13274","DOI":"10.1021\/acsami.7b14319","article-title":"Injectable coacervate hydrogel for delivery of anticancer drug-loaded nanoparticles in vivo","volume":"10","author":"Lee","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.actbio.2026.10.028_bib0038","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41536-023-00342-y","article-title":"Effective protection of photoreceptors using an inflammation-responsive hydrogel to attenuate outer retinal degeneration","volume":"8","author":"Kim","year":"2023","journal-title":"npj Regenerative Medicine"},{"issue":"31","key":"10.1016\/j.actbio.2026.10.028_bib0039","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202303167","article-title":"Triple cross-linked dynamic responsive hydrogel loaded with selenium nanoparticles for modulating the inflammatory microenvironment via PI3K\/Akt\/NF-\u03baB and MAPK signaling pathways","volume":"10","author":"Wang","year":"2023","journal-title":"Adv. Sci."},{"issue":"24","key":"10.1016\/j.actbio.2026.10.028_bib0040","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1039\/C4CS00185K","article-title":"Jack of all trades: versatile catechol crosslinking mechanisms","volume":"43","author":"Yang","year":"2014","journal-title":"Chem. Soc. Rev."},{"issue":"49","key":"10.1016\/j.actbio.2026.10.028_bib0041","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202305992","article-title":"A versatile glycopeptide hydrogel promotes chronic refractory wound healing through bacterial elimination, sustained oxygenation, immunoregulation, and neovascularization","volume":"33","author":"Wu","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"24","key":"10.1016\/j.actbio.2026.10.028_bib0042","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1016\/j.jacc.2016.09.958","article-title":"Prosthetic heart valve thrombosis","volume":"68","author":"Dangas","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.actbio.2026.10.028_bib0043","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1021\/acs.biomac.8b00077","article-title":"Optimizing glutaraldehyde-fixed tissue heart valves with chondroitin sulfate hydrogel for endothelialization and shielding against deterioration","volume":"19","author":"Lopez-Moya","year":"2018","journal-title":"Biomacromolecules"},{"issue":"13","key":"10.1016\/j.actbio.2026.10.028_bib0044","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.125.041505","article-title":"Transcatheter aortic valve durability: focus on structural valve deterioration","volume":"14","author":"Trimaille","year":"2025","journal-title":"J. Am. Heart Assoc."},{"issue":"21","key":"10.1016\/j.actbio.2026.10.028_bib0045","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.jacc.2015.09.022","article-title":"Bioprosthetic valve thrombosis versus structural failure: clinical and echocardiographic predictors","volume":"66","author":"Egbe","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"issue":"7","key":"10.1016\/j.actbio.2026.10.028_bib0046","first-page":"862","article-title":"Bioprosthetic valve deterioration: accumulation of circulating proteins and macrophages in the valve interstitium","volume":"8","author":"Sakaue","year":"2023","journal-title":"JACC"},{"issue":"9","key":"10.1016\/j.actbio.2026.10.028_bib0047","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.125.018036","article-title":"Progression of bioprosthetic aortic valve calcification and clinical outcome","volume":"18","author":"Li","year":"2025","journal-title":"Circ. Cardiovasc. Imaging"}],"container-title":["Acta Biomaterialia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126007063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1742706126007063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:49:00Z","timestamp":1792468140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1742706126007063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":47,"alternative-id":["S1742706126007063"],"URL":"https:\/\/doi.org\/10.1016\/j.actbio.2026.10.028","relation":{},"ISSN":["1742-7061"],"issn-type":[{"value":"1742-7061","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation-Responsive baicalin-delivering glycocalyx-mimetic hydrogel-functionalized bioprosthetic valve for antithrombosis and immunomodulation","name":"articletitle","label":"Article Title"},{"value":"Acta Biomaterialia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actbio.2026.10.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Acta Materialia Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}