{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T08:08:16Z","timestamp":1778227696092,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Histochemica"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1016\/j.acthis.2004.05.002","type":"journal-article","created":{"date-parts":[[2004,8,5]],"date-time":"2004-08-05T15:25:56Z","timestamp":1091719556000},"page":"289-297","source":"Crossref","is-referenced-by-count":37,"title":["Protective effects of caffeic acid phenethyl ester (CAPE) on carbon tetrachloride-induced hepatotoxicity in rats"],"prefix":"10.1016","volume":"106","author":[{"given":"Ilter","family":"Kus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neriman","family":"Colakoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidir","family":"Pekmez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilara","family":"Seckin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Ogeturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Sarsilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.acthis.2004.05.002_BIB1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0024-3205(99)00589-5","article-title":"Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice","volume":"66","author":"Al-Shabanah","year":"2000","journal-title":"Life Sci"},{"key":"10.1016\/j.acthis.2004.05.002_BIB2","first-page":"256","article-title":"Prophylactic effectiveness of propolis for immunostimulation","volume":"6","author":"Bratter","year":"1999","journal-title":"Forsch Komplementarmed"},{"key":"10.1016\/j.acthis.2004.05.002_BIB3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/path.1711700115","article-title":"Intrahepatic distribution of transforming growth factor-alpha (TGF-\u03b1) during liver regeneration following carbon tetrachloride-induced necrosis","volume":"170","author":"Burr","year":"1993","journal-title":"J Pathol"},{"key":"10.1016\/j.acthis.2004.05.002_BIB4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0168-8278(99)80218-9","article-title":"Inhibition of hepatic cell nuclear DNA fragmentation by zinc in carbon tetrachloride-treated rats","volume":"31","author":"Cabre","year":"1999","journal-title":"J Hepathol"},{"key":"10.1016\/j.acthis.2004.05.002_BIB5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1440-1746.2003.03291.x","article-title":"Role of l-carnitine in the prevention of acute liver damage induced by carbon tetrachloride in rats","volume":"19","author":"Demirdag","year":"2004","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.acthis.2004.05.002_BIB6","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0041-008X(75)90179-9","article-title":"Species differences in carbon tetrachloride-induced hepatotoxicity","volume":"34","author":"Diaz-Gomes","year":"1975","journal-title":"J Appl Pharmacol"},{"key":"10.1016\/j.acthis.2004.05.002_BIB7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/jat.945","article-title":"Protective effects of caffeic acid phenethyl ester on doxorubicin-induced cardiotoxicity in rats","volume":"24","author":"Fadillioglu","year":"2004","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.acthis.2004.05.002_BIB8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/BF01941717","article-title":"Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis","volume":"44","author":"Grunberger","year":"1988","journal-title":"Experientia"},{"key":"10.1016\/j.acthis.2004.05.002_BIB9","first-page":"513","article-title":"Growth inhibition and modulation of antigenic phenotype in human melanoma and glioblastoma multiforme cells by caffeic acid phenethyl ester (CAPE)","volume":"38","author":"Guarini","year":"1992","journal-title":"Cell Mol Biol"},{"key":"10.1016\/j.acthis.2004.05.002_BIB10","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S1010-7940(99)00246-8","article-title":"The effects of caffeic acid phenethyl ester (CAPE) on spinal cord ischemia\/reperfusion injury","volume":"16","author":"Ilhan","year":"1999","journal-title":"Eur J Cardio-thoracic Surg"},{"key":"10.1016\/j.acthis.2004.05.002_BIB11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s002400100185","article-title":"The effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in comparison with \u03b1-tocopherol in rat kidneys","volume":"29","author":"Irmak","year":"2001","journal-title":"Urol Res"},{"key":"10.1016\/j.acthis.2004.05.002_BIB12","first-page":"197","article-title":"Mechanisms involved in the antiinflammatory effect of propolis extract","volume":"19","author":"Khayyal","year":"1993","journal-title":"Drugs Exp Clin Res"},{"key":"10.1016\/j.acthis.2004.05.002_BIB13","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/019262338901700304","article-title":"Protection of hepatotoxic and lethal effects of CCl4 by partial hepatectomy","volume":"17","author":"Kodavanti","year":"1989","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.acthis.2004.05.002_BIB14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0378-8741(98)00131-7","article-title":"Antibacterial, antifungal and antiviral activity of propolis of different origin","volume":"64","author":"Kujumgiev","year":"1999","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.acthis.2004.05.002_BIB15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1142\/S0192415X99000112","article-title":"The influence of propolis ethanol extract on liver microsomal enzymes and glutathione after chronic alcohol administration","volume":"27","author":"Lin","year":"1999","journal-title":"Am J Chin Med"},{"key":"10.1016\/j.acthis.2004.05.002_BIB16","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/hep.1840210430","article-title":"Iron overload facilitates hepatic fibrosis in the rat alcohol\/low-dose carbon tetrachloride model","volume":"21","author":"Mackinnon","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.acthis.2004.05.002_BIB17","first-page":"309","article-title":"The protective effect of aqueous propolis extract on isolated rat hepatocytes against carbon tetrachloride toxicity","volume":"22","author":"Mahran","year":"1996","journal-title":"Drugs Exp Clin Res"},{"key":"10.1016\/j.acthis.2004.05.002_BIB18","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1016\/S0024-3205(00)00592-0","article-title":"Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice","volume":"66","author":"Mansour","year":"2000","journal-title":"Life Sci"},{"key":"10.1016\/j.acthis.2004.05.002_BIB19","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/S0021-9258(17)43327-8","article-title":"Oxygen and carbon-centered free radical formation during carbon tetrachloride metabolism. Observation of lipid radicals in vivo and in vitro","volume":"259","author":"McCay","year":"1984","journal-title":"J Biol Chem"},{"key":"10.1016\/j.acthis.2004.05.002_BIB20","first-page":"285","article-title":"Histopathological evaluation on the effect of red propolis on liver damage induced by CCl4 in rats","volume":"27","author":"Merino","year":"1996","journal-title":"Arch Med Res"},{"key":"10.1016\/j.acthis.2004.05.002_BIB21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0169-328X(03)00178-5","article-title":"Caffeic acid phenethyl ester (CAPE) prevents inflammatory stress in organotypic hippocampal slice cultures","volume":"115","author":"Montpied","year":"2003","journal-title":"Mol Brain Res"},{"key":"10.1016\/j.acthis.2004.05.002_BIB22","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1016\/S0968-0896(02)00138-4","article-title":"Selective antiproliferative activity of caffeic acid phenethyl ester analogues on highly liver-metastatic murine colon 26-L5 carcinoma cell line","volume":"10","author":"Nagaoka","year":"2002","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.acthis.2004.05.002_BIB23","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1172\/JCI114643","article-title":"Cellular distribution of transforming growth factor-\u03b21 and procollagen types I, III, IV transcripts in carbon tetrachloride-induced rat liver fibrosis","volume":"85","author":"Nakatsukasa","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1016\/j.acthis.2004.05.002_BIB24","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/jlb.66.4.601","article-title":"Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL-6-deficient mice","volume":"66","author":"Natsume","year":"1999","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.acthis.2004.05.002_BIB25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/(SICI)1099-0844(199912)17:4<253::AID-CBF837>3.0.CO;2-R","article-title":"Protective effects of vitamin E on carbon tetrachloride-induced liver damage in rats","volume":"17","author":"Naziroglu","year":"1999","journal-title":"Cell Biochem Funct"},{"key":"10.1016\/j.acthis.2004.05.002_BIB26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000026427","article-title":"Caffeic acid phenethyl ester induces leukocyte apoptosis modulates nuclear factor-K B and suppress acute inflammation","volume":"7","author":"Orban","year":"2000","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.acthis.2004.05.002_BIB27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jat.941","article-title":"Role of caffeic acid phenethyl ester, an active component of propolis, against cisplatin-induced nephrotoxicity in rats","volume":"24","author":"Ozen","year":"2004","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.acthis.2004.05.002_BIB28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/cbf.923","article-title":"Caffeic acid phenethyl ester changes the indices of oxidative stress in serum of rats with renal ischemia-reperfusion injury","volume":"19","author":"Ozyurt","year":"2001","journal-title":"Cell Biochem Funct"},{"key":"10.1016\/j.acthis.2004.05.002_BIB29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0163-7258(89)90050-8","article-title":"Mechanisms of carbon tetrachloride toxicity","volume":"43","author":"Recknagel","year":"1989","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.acthis.2004.05.002_BIB30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0367-326X(02)00187-9","article-title":"Antioxidant activity of propolis","volume":"73","author":"Russo","year":"2002","journal-title":"Fitoterapia"},{"key":"10.1016\/j.acthis.2004.05.002_BIB31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/nrc.10044","article-title":"Tissue xanthine oxidase activity and nitric oxide levels after spinal cord ischemia\/reperfusion injury in rabbits","volume":"31","author":"Sahin","year":"2002","journal-title":"Neurosci Res Commun"},{"key":"10.1016\/j.acthis.2004.05.002_BIB32","first-page":"76","article-title":"Protective role of propolis against alcohol-carbon tetrachloride-induced hepatotoxicity in rats","volume":"29","author":"Sharma","year":"1997","journal-title":"Indian J Pharmacol"},{"key":"10.1016\/j.acthis.2004.05.002_BIB33","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0002-9440(10)65594-0","article-title":"Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride","volume":"153","author":"Shi","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.acthis.2004.05.002_BIB34","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1042\/bj1230815","article-title":"The stimulatory effects of carbon tetrachloride on peroxidative reactions in rat liver fraction in vitro","volume":"123","author":"Slater","year":"1971","journal-title":"Biochem J"},{"key":"10.1016\/j.acthis.2004.05.002_BIB35","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1021\/jf010830b","article-title":"Free radical scavenging and antioxidative activity of caffeic acid amide and ester analogues","volume":"50","author":"Son","year":"2002","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.acthis.2004.05.002_BIB36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-3835(01)00787-X","article-title":"Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity","volume":"175","author":"Song","year":"2002","journal-title":"Cancer Lett"},{"key":"10.1016\/j.acthis.2004.05.002_BIB37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0041-008X(78)90025-X","article-title":"Dose-dependent toxicity of CCl4 in isolated rat hepatocytes and the effects of hepatoprotective treatments","volume":"45","author":"Stacey","year":"1978","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.acthis.2004.05.002_BIB38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-5793(93)80184-V","article-title":"Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties","volume":"329","author":"Sud\u2019ina","year":"1993","journal-title":"FEBS Lett"},{"key":"10.1016\/j.acthis.2004.05.002_BIB39","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0925-4439(00)00098-3","article-title":"Evaluation of oxidative stress during apoptosis and necrosis caused by carbon tetrachloride in rat liver","volume":"1535","author":"Sun","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.acthis.2004.05.002_BIB40","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0300-483X(01)00340-7","article-title":"Induction of metallothionein in the liver of carbon tetrachloride intoxicated rats","volume":"161","author":"Teocharis","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.acthis.2004.05.002_BIB41","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malondehyde precursor in tissues by thiobarbituric acid test","volume":"86","author":"Uchiyama","year":"1978","journal-title":"Anal Biochem"},{"key":"10.1016\/j.acthis.2004.05.002_BIB42","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s00345-002-0259-2","article-title":"The protective role of caffeic acid phenethyl ester (CAPE) on testicular tissue after testicular torsion and detorsion","volume":"20","author":"Uz","year":"2002","journal-title":"World J Urol"},{"key":"10.1016\/j.acthis.2004.05.002_BIB43","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1515\/znc-1993-11-1206","article-title":"Biochemical activities of propolis extracts. I. Standardization and antioxidative properties of ethanolic and aqueous derivates","volume":"48","author":"Volpert","year":"1993","journal-title":"Z Naturforsch"},{"key":"10.1016\/j.acthis.2004.05.002_BIB44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0944-7113(00)80014-8","article-title":"A comparative multi-centre study of the efficacy of propolis, acycovir and placebo in the treatment of genital herpes","volume":"7","author":"Vynograd","year":"2000","journal-title":"Phytomedicine"},{"key":"10.1016\/j.acthis.2004.05.002_BIB45","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0168-8278(99)80201-3","article-title":"Dietary iron overload inhibits carbon tetrachloride-induced promotion in chemical hepatocarcinogenesis","volume":"30","author":"Wang","year":"1999","journal-title":"J Hepathol"},{"key":"10.1016\/j.acthis.2004.05.002_BIB46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-3835(91)90065-P","article-title":"Inhibitory and promoting effects of carbon tetrachloride-induced liver cirrhosis on the diethylnitrosamine hepatocarcinogenesis in rats","volume":"57","author":"Zalatnai","year":"1991","journal-title":"Cancer Lett"}],"container-title":["Acta Histochemica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128104000583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128104000583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T21:10:14Z","timestamp":1624569014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065128104000583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["S0065128104000583"],"URL":"https:\/\/doi.org\/10.1016\/j.acthis.2004.05.002","relation":{},"ISSN":["0065-1281"],"issn-type":[{"value":"0065-1281","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}