{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:56:06Z","timestamp":1792713366152,"version":"4.5.0"},"reference-count":115,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006459","name":"Children's Hospital Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01DE013085"],"award-info":[{"award-number":["5R01DE013085"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Histochemica"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.acthis.2006.05.009","type":"journal-article","created":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T15:25:10Z","timestamp":1157729110000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"title":["Palatal fusion \u2013 Where do the midline cells go?"],"prefix":"10.1016","volume":"109","author":[{"given":"Marek","family":"Dudas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai-Yee","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesa","family":"Kaartinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.acthis.2006.05.009_bib1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/tera.1420430205","article-title":"TCDD exposure of human embryonic palatal shelves in organ culture alters the differentiation of medial epithelial cells","volume":"43","author":"Abbott","year":"1991","journal-title":"Teratology"},{"key":"10.1016\/j.acthis.2006.05.009_bib2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0041-008X(89)90096-3","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin alters embryonic palatal medial epithelial cell differentiation in vitro","volume":"100","author":"Abbott","year":"1989","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.acthis.2006.05.009_bib3","first-page":"241","article-title":"Human embryonic palatal epithelial differentiation is altered by retinoic acid and epidermal growth factor in organ culture","volume":"7","author":"Abbott","year":"1987","journal-title":"J Craniofac Genet Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib4","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/0003-9969(83)90167-X","article-title":"Cortisol inhibition of development of various lysosomal enzymes in cultured palatal shelves from mouse embryos","volume":"28","author":"Ads","year":"1983","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ydbio.2004.09.010","article-title":"The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice","volume":"277","author":"Alappat","year":"2005","journal-title":"Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib6","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1242\/dev.01125","article-title":"Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development","volume":"131","author":"Andl","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.acthis.2006.05.009_bib7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00429-003-0366-x","article-title":"A re-evaluation of the premaxillary bone in humans","volume":"207","author":"Barteczko","year":"2004","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.acthis.2006.05.009_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/bdrc.20015","article-title":"Molecular mechanisms of neural crest induction","volume":"72","author":"Basch","year":"2004","journal-title":"Birth Defects Res C Embryo Today"},{"key":"10.1016\/j.acthis.2006.05.009_bib9","first-page":"117","article-title":"Epithelial alterations of secondary palate formation","volume":"11","author":"Bittencourt","year":"2000","journal-title":"Braz Dent J"},{"key":"10.1016\/j.acthis.2006.05.009_bib10","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1091\/mbc.12.5.1457","article-title":"TGF-beta3-induced palatogenesis requires matrix metalloproteinases","volume":"12","author":"Blavier","year":"2001","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.acthis.2006.05.009_bib11","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1177\/154405910208101206","article-title":"Matrix metalloproteinases have a role in palatogenesis","volume":"81","author":"Brown","year":"2002","journal-title":"J Dent Res"},{"key":"10.1016\/j.acthis.2006.05.009_bib12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1242\/dev.114.2.379","article-title":"The fate of medial edge epithelial cells during palatal fusion in vitro: an analysis by DiI labelling and confocal microscopy","volume":"114","author":"Carette","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.acthis.2006.05.009_bib13","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0092-8674(00)81732-8","article-title":"Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development","volume":"94","author":"Cecconi","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.acthis.2006.05.009_bib14","doi-asserted-by":"crossref","unstructured":"Chai Y, Maxson RE Jr. Recent advances in craniofacial morphogenesis. Dev Dyn 2006; in press, (Doi:10.1002\/dvdy.20833).","DOI":"10.1002\/dvdy.20833"},{"key":"10.1016\/j.acthis.2006.05.009_bib15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00429-004-0379-0","article-title":"Palatal shelf movement during palatogenesis: a fate map of the fetal mouse palate cultured in vitro","volume":"208","author":"Chou","year":"2004","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.acthis.2006.05.009_bib16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.0009-9163.2004.00225.x","article-title":"Taking it to the max: the genetic and developmental mechanisms coordinating midfacial morphogenesis and dysmorphology","volume":"65","author":"Cox","year":"2004","journal-title":"Clin Genet"},{"key":"10.1016\/j.acthis.2006.05.009_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1242\/dev.00907","article-title":"Death is the major fate of medial edge epithelial cells and the cause of basal lamina degradation during palatogenesis","volume":"131","author":"Cuervo","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.acthis.2006.05.009_bib18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/dbio.2002.0620","article-title":"Programmed cell death is required for palate shelf fusion and is regulated by retinoic acid","volume":"245","author":"Cuervo","year":"2002","journal-title":"Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/dvdy.10326","article-title":"TGF-beta3-dependent SMAD2 phosphorylation and inhibition of MEE proliferation during palatal fusion","volume":"227","author":"Cui","year":"2003","journal-title":"Dev Dyn"},{"key":"10.1016\/j.acthis.2006.05.009_bib20","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nature04639","article-title":"A Devonian tetrapod-like fish and the evolution of the tetrapod body plan","volume":"440","author":"Daeschler","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.acthis.2006.05.009_bib21","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1242\/dev.127.22.4775","article-title":"Sonic hedgehog regulates growth and morphogenesis of the tooth","volume":"127","author":"Dassule","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.acthis.2006.05.009_bib22","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/0003-9969(68)90138-6","article-title":"Ultrastructure of mouse and rat palatal processes prior to and during secondary palate formation","volume":"13","author":"DeAngelis","year":"1968","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib23","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/tera.1420410603","article-title":"Morphological observations in normal primary palate and cleft lip embryos in the Kyoto collection","volume":"41","author":"Diewert","year":"1990","journal-title":"Teratology"},{"key":"10.1016\/j.acthis.2006.05.009_bib24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0070-2153(05)66003-6","article-title":"Tgf-beta superfamily and mouse craniofacial development: Interplay of morphogenetic proteins and receptor signaling controls normal formation of the face","volume":"66","author":"Dudas","year":"2005","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib25","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ydbio.2006.05.030","article-title":"Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion","volume":"296","author":"Dudas","year":"2006","journal-title":"Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib26","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ydbio.2003.10.007","article-title":"Tgf-beta3-induced palatal fusion is mediated by Alk-5\/Smad pathway","volume":"266","author":"Dudas","year":"2004","journal-title":"Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.mod.2003.12.003","article-title":"Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells","volume":"121","author":"Dudas","year":"2004","journal-title":"Mech Dev"},{"key":"10.1016\/j.acthis.2006.05.009_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0012-1606(68)90038-9","article-title":"Electron microscope study of palate fusion in mouse embryos","volume":"18","author":"Farbman","year":"1968","journal-title":"Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/dbio.1999.9332","article-title":"A paraxial exclusion zone creates patterned cranial neural crest cell outgrowth adjacent to rhombomeres 3 and 5","volume":"213","author":"Farlie","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/bdrc.20013","article-title":"The neural crest: Basic biology and clinical relationships in the craniofacial and enteric nervous systems","volume":"72","author":"Farlie","year":"2004","journal-title":"Birth Defects Res Pt C: Embryo Today: Rev"},{"key":"10.1016\/j.acthis.2006.05.009_bib31","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0003-9969(81)90041-8","article-title":"The structure and development of the palate in Alligator mississippiensis","volume":"26","author":"Ferguson","year":"1981","journal-title":"Arch Oral Biol"},{"issue":"Suppl.","key":"10.1016\/j.acthis.2006.05.009_bib32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1242\/dev.103.Supplement.41","article-title":"Palate development","volume":"103","author":"Ferguson","year":"1988","journal-title":"Development"},{"key":"10.1016\/j.acthis.2006.05.009_bib33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/ar.1092090210","article-title":"Differentiation of cultured palatal shelves from alligator, chick, and mouse embryos","volume":"209","author":"Ferguson","year":"1984","journal-title":"Anat Rec"},{"key":"10.1016\/j.acthis.2006.05.009_bib34","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0012-1606(89)80017-X","article-title":"Medial edge epithelium transforms to mesenchyme after embryonic palatal shelves fuse","volume":"131","author":"Fitchett","year":"1989","journal-title":"Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF01003413","article-title":"Palatal shelf epithelium: a morphologic and histochemical study in X-irradiated and normal mice","volume":"10","author":"Gartner","year":"1978","journal-title":"Histochem J"},{"key":"10.1016\/j.acthis.2006.05.009_bib36","first-page":"133","article-title":"Succinic dehydrogenase activity during palate formation in the Mongolian gerbil","volume":"125","author":"Gartner","year":"1978","journal-title":"J Anat"},{"key":"10.1016\/j.acthis.2006.05.009_bib37","first-page":"135","article-title":"Inhibition of embryonic palatal shelf horizontalization and medial edge epithelial breakdown by cortisol: role of H-2 in the mouse","volume":"8","author":"Goldman","year":"1988","journal-title":"J Craniofac Genet Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/tera.1420110106","article-title":"Some aspects of corticosteroid-induced cleft palate: a review","volume":"11","author":"Greene","year":"1975","journal-title":"Teratology"},{"key":"10.1016\/j.acthis.2006.05.009_bib39","first-page":"225","article-title":"Developmental aspects of secondary palate formation","volume":"36","author":"Greene","year":"1976","journal-title":"J Embryol Exp Morphol"},{"key":"10.1016\/j.acthis.2006.05.009_bib40","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1242\/dev.116.4.1087","article-title":"Epithelial\u2013mesenchymal transformation during palatal fusion: carboxyfluorescein traces cells at light and electron microscopic levels","volume":"116","author":"Griffith","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.acthis.2006.05.009_bib41","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1097\/01.PRS.0000105342.08168.13","article-title":"Alterations in apoptosis and epithelial\u2013mesenchymal transformation in an in vitro cleft palate model","volume":"113","author":"Gurley","year":"2004","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.acthis.2006.05.009_bib42","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0003-9969(69)90188-5","article-title":"Ultrastructural changes in the epithelium during fusion of the palatal processes in rats","volume":"14","author":"Hayward","year":"1969","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib43","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1469-7580.2005.00474.x","article-title":"Regional regulation of palatal growth and patterning along the anterior\u2013posterior axis in mice","volume":"207","author":"Hilliard","year":"2005","journal-title":"J Anat"},{"key":"10.1016\/j.acthis.2006.05.009_bib44","series-title":"Manipulating the mouse embryo. A laboratory manual","author":"Hogan","year":"1994"},{"key":"10.1016\/j.acthis.2006.05.009_bib45","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1054\/jcms.2002.0323","article-title":"Apoptotic epithelial cell death: a prerequisite for palatal fusion. An in vivo study in rabbits","volume":"30","author":"Holtgrave","year":"2002","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.acthis.2006.05.009_bib46","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/dbio.1999.9585","article-title":"Adult Apaf-1-deficient mice exhibit male infertility","volume":"218","author":"Honarpour","year":"2000","journal-title":"Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bdrb.20062","article-title":"Reduction in diabetes-induced craniofacial defects by maternal immune stimulation","volume":"77","author":"Hrubec","year":"2006","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"key":"10.1016\/j.acthis.2006.05.009_bib48","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0003-9969(73)90022-8","article-title":"A radioautographic study of deoxyribonucleic acid synthesis in embryonic rat palatal shelf epithelium with reference to the concept of programmed cell death","volume":"18","author":"Hudson","year":"1973","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib49","first-page":"413","article-title":"Cytodifferentiation of the mouse secondary palate in vitro: morphological, biochemical, and histochemical aspects","volume":"27","author":"Idoyaga-Vargas","year":"1972","journal-title":"J Embryol Exp Morphol"},{"key":"10.1016\/j.acthis.2006.05.009_bib50","first-page":"281","article-title":"Microanalysis of epithelial and mesenchymal acid hydrolase activities in the developing palate","volume":"3","author":"Im","year":"1983","journal-title":"J Craniofac Genet Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib51","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1101\/gad.12.7.1046","article-title":"Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice","volume":"12","author":"Jiang","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.acthis.2006.05.009_bib52","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/neu.20162","article-title":"Role of morphogens in neural crest cell determination","volume":"64","author":"Jones","year":"2005","journal-title":"J Neurobiol"},{"key":"10.1016\/j.acthis.2006.05.009_bib53","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1097-0177(199707)209:3<255::AID-AJA1>3.0.CO;2-H","article-title":"Transforming growth factor-beta3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane","volume":"209","author":"Kaartinen","year":"1997","journal-title":"Dev Dyn"},{"key":"10.1016\/j.acthis.2006.05.009_bib54","first-page":"563","article-title":"TGFbeta3-induced activation of RhoA\/Rho-kinase pathway is necessary but not sufficient for epithelio\u2013mesenchymal transdifferentiation: implications for palatogenesis","volume":"9","author":"Kaartinen","year":"2002","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.acthis.2006.05.009_bib55","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ng1295-415","article-title":"Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial\u2013mesenchymal interaction","volume":"11","author":"Kaartinen","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.acthis.2006.05.009_bib56","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/dvdy.10161","article-title":"PI-3 kinase activity is required for epithelial\u2013mesenchymal transformation during palate fusion","volume":"225","author":"Kang","year":"2002","journal-title":"Dev Dyn"},{"key":"10.1016\/j.acthis.2006.05.009_bib57","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1034\/j.1600-0544.2003.02236.x","article-title":"Nicotine inhibits palatal fusion and modulates nicotinic receptors and the PI-3 kinase pathway in medial edge epithelia","volume":"6","author":"Kang","year":"2003","journal-title":"Orthod Craniofac Res"},{"key":"10.1016\/j.acthis.2006.05.009_bib58","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1177\/154405910508400801","article-title":"Epithelial\u2013mesenchymal transformation during craniofacial development","volume":"84","author":"Kang","year":"2005","journal-title":"J Dent Res"},{"key":"10.1016\/j.acthis.2006.05.009_bib59","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1290\/1543-706X(2003)039<0098:HOAAAP>2.0.CO;2","article-title":"Homocysteine oxidation and apoptosis: a potential cause of cleft palate","volume":"39","author":"Knott","year":"2003","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"10.1016\/j.acthis.2006.05.009_bib60","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/dvdy.20489","article-title":"Microarray analysis of gene expression during epithelial\u2013mesenchymal transformation","volume":"234","author":"LaGamba","year":"2005","journal-title":"Dev Dyn"},{"key":"10.1016\/j.acthis.2006.05.009_bib61","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ydbio.2003.09.022","article-title":"Snail family members and cell survival in physiological and pathological cleft palates","volume":"265","author":"Martinez-Alvarez","year":"2004","journal-title":"Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib62","first-page":"331","article-title":"Bulging medial edge epithelial cells and palatal fusion","volume":"44","author":"Martinez-Alvarez","year":"2000","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib63","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1006\/dbio.2000.9644","article-title":"Medial edge epithelial cell fate during palatal fusion","volume":"220","author":"Martinez-Alvarez","year":"2000","journal-title":"Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib64","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1177\/00220345720510053301","article-title":"Epithelial changes in the presumptive regions of fusion during secondary palate formation","volume":"51","author":"Mato","year":"1972","journal-title":"J Dent Res"},{"key":"10.1016\/j.acthis.2006.05.009_bib65","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.adnc.2004.12.006","article-title":"Part 1. Understanding the embryology and genetics of cleft lip and palate","volume":"5","author":"Merritt","year":"2005","journal-title":"Adv Neonatal Care"},{"key":"10.1016\/j.acthis.2006.05.009_bib66","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/8773","article-title":"Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure","volume":"22","author":"Miettinen","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.acthis.2006.05.009_bib67","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1083\/jcb.127.6.2021","article-title":"TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors","volume":"127","author":"Miettinen","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib68","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/aja.1001640104","article-title":"Developmental alterations associated with spontaneous cleft lip and palate in CL\/Fr mice","volume":"164","author":"Millicovsky","year":"1982","journal-title":"Am J Anat"},{"key":"10.1016\/j.acthis.2006.05.009_bib69","first-page":"53","article-title":"Active role of embryonic facial epithelium: new evidence of cellular events in morphogenesis","volume":"63","author":"Millicovsky","year":"1981","journal-title":"J Embryol Exp Morphol"},{"key":"10.1016\/j.acthis.2006.05.009_bib70","first-page":"5","article-title":"[On the fusion of the secondary palatal process in the mouse (BALB\/c): distribution of degenerating cells and migration of epithelial cells]","volume":"62","author":"Miyamoto","year":"1987","journal-title":"Kaibogaku Zasshi"},{"key":"10.1016\/j.acthis.2006.05.009_bib71","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF00185843","article-title":"Cytochemical identification of programmed cell death in the fusing fetal mouse palate by specific labelling of DNA fragmentation","volume":"190","author":"Mori","year":"1994","journal-title":"Anat Embryol (Berl)"},{"issue":"Suppl. 1","key":"10.1016\/j.acthis.2006.05.009_bib72","first-page":"53","article-title":"The development of the palate \u2013 a brief review","volume":"7","author":"Moxham","year":"2003","journal-title":"Eur J Anat"},{"key":"10.1016\/j.acthis.2006.05.009_bib73","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1172\/JCI200422154","article-title":"Cleft palate: players, pathways, and pursuits","volume":"113","author":"Murray","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.acthis.2006.05.009_bib74","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.archoralbio.2004.05.007","article-title":"Transforming growth factor beta (TGFbeta) signalling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT)","volume":"49","author":"Nawshad","year":"2004","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib75","series-title":"Mouse phenotypes. A handbook of mutation analysis","author":"Papaioannou","year":"2005"},{"key":"10.1016\/j.acthis.2006.05.009_bib76","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1097\/00001756-199407000-00006","article-title":"Detection of apoptosis by electron microscopy and in situ labelling in the rat olfactory pit","volume":"5","author":"Pellier","year":"1994","journal-title":"Neuroreport"},{"key":"10.1016\/j.acthis.2006.05.009_bib77","first-page":"171","article-title":"Onset of the acquired potentiality for fusion in the palatal shelves of rats","volume":"16","author":"Pourtois","year":"1966","journal-title":"J Embryol Exp Morphol"},{"key":"10.1016\/j.acthis.2006.05.009_bib78","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0012-1606(76)90292-X","article-title":"Inhibition of palatal epithelial cell death by altered protein synthesis","volume":"54","author":"Pratt","year":"1976","journal-title":"Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib79","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1073\/pnas.72.3.874","article-title":"Epithelial cell death and cyclic AMP increase during palatal development","volume":"72","author":"Pratt","year":"1975","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.acthis.2006.05.009_bib80","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/ng1295-409","article-title":"Transforming growth factor-beta 3 is required for secondary palate fusion","volume":"11","author":"Proetzel","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.acthis.2006.05.009_bib81","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.semcdb.2005.06.008","article-title":"Reiterated Wnt and BMP signals in neural crest development","volume":"16","author":"Raible","year":"2005","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib82","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2174\/156652405774641043","article-title":"Craniofacial anomalies: from development to molecular pathogenesis","volume":"5","author":"Rice","year":"2005","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.acthis.2006.05.009_bib83","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.tox.2004.10.015","article-title":"Effect of N\u2032-nitrosonornicotine (NNN) on murine palatal fusion in vitro","volume":"207","author":"Saito","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.acthis.2006.05.009_bib84","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1126\/science.154.3749.604","article-title":"Death in embryonic systems","volume":"154","author":"Saunders","year":"1966","journal-title":"Science"},{"key":"10.1016\/j.acthis.2006.05.009_bib85","first-page":"227","article-title":"Cell release from the palatal shelves and the fusion line","volume":"11","author":"Schupbach","year":"1983","journal-title":"J Biol Buccale"},{"issue":"Suppl. 2","key":"10.1016\/j.acthis.2006.05.009_bib86","first-page":"293","article-title":"Fate of unfused medial edge epithelia in rat fetuses with experimentally induced cleft palate: I. From 16.3 to 17.7 days of gestation","author":"Schupbach","year":"1986","journal-title":"J Craniofac Genet Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib87","first-page":"1","article-title":"Light microscopic and histochemical observations on the development of the palate in the Golden Syrian hamster","volume":"117","author":"Shah","year":"1974","journal-title":"J Anat"},{"key":"10.1016\/j.acthis.2006.05.009_bib88","first-page":"41","article-title":"An ultrastructural and histochemical study of the development of secondary palate in Japanese quail, Coturnix coturnix japonica","volume":"5","author":"Shah","year":"1985","journal-title":"J Craniofac Genet Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib89","first-page":"299","article-title":"In vitro development of the hamster and chick secondary palate","volume":"5","author":"Shah","year":"1985","journal-title":"J Craniofac Genet Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib90","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/aja.1001890405","article-title":"Toward the origin of the secondary palate. A possible homologue in the embryo of fish, Onchorhynchus kisutch, with description of changes in the basement membrane area","volume":"189","author":"Shah","year":"1990","journal-title":"Am J Anat"},{"key":"10.1016\/j.acthis.2006.05.009_bib91","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/0003-9969(88)90012-X","article-title":"Histological evidence of fusion between the posterior palatal shelves and the floor of the mouth in Alligator mississippiensis","volume":"33","author":"Shah","year":"1988","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib92","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3382\/ps.0670865","article-title":"Embryogenesis of the secondary palate in pigeons","volume":"67","author":"Shah","year":"1988","journal-title":"Poult Sci"},{"key":"10.1016\/j.acthis.2006.05.009_bib93","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1177\/00220345690480050801","article-title":"Electron microscopic and histochemical examination of oral epithelial\u2013mesenchymal interaction (programmed cell death)","volume":"48","author":"Shapiro","year":"1969","journal-title":"J Dent Res"},{"key":"10.1016\/j.acthis.2006.05.009_bib94","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1177\/10454411950060030301","article-title":"Programmed cell death and cell transformation in craniofacial development","volume":"6","author":"Shuler","year":"1995","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.acthis.2006.05.009_bib95","first-page":"463","article-title":"Molecular and morphologic changes during the epithelial\u2013mesenchymal transformation of palatal shelf medial edge epithelium in vitro","volume":"35","author":"Shuler","year":"1991","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib96","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/0012-1606(92)90071-N","article-title":"Medial edge epithelium fate traced by cell lineage analysis during epithelial\u2013mesenchymal transformation in vivo","volume":"154","author":"Shuler","year":"1992","journal-title":"Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib97","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0003-9969(70)90055-5","article-title":"Fine structure of mouse embryonic palatal epithelium prior to and after midline fusion","volume":"15","author":"Smiley","year":"1970","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib98","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.acthis.2006.05.009_bib99","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1597\/1545-1569_1998_035_0351_caoscp_2.3.co_2","article-title":"Classic and occult submucous cleft palates: a histopathologic analysis","volume":"35","author":"Stal","year":"1998","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.acthis.2006.05.009_bib100","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1006\/dbio.2000.9946","article-title":"Epithelial\u2013mesenchymal transformation is the mechanism for fusion of the craniofacial primordia involved in morphogenesis of the chicken lip","volume":"228","author":"Sun","year":"2000","journal-title":"Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib101","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1242\/dev.125.1.95","article-title":"TGFbeta3 promotes transformation of chicken palate medial edge epithelium to mesenchyme in vitro","volume":"125","author":"Sun","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.acthis.2006.05.009_bib102","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1387\/ijdb.15005573","article-title":"Programmed cell death is not a necessary prerequisite for fusion of the fetal mouse palate","volume":"48","author":"Takahara","year":"2004","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib103","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1387\/ijdb.041840tt","article-title":"Terminal differentiation of palatal medial edge epithelial cells in vitro is not necessarily dependent on palatal shelf contact and midline epithelial seam formation","volume":"48","author":"Takigawa","year":"2004","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib104","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1679\/aohc.58.191","article-title":"Apoptosis and heterophagy of medial edge epithelial cells of the secondary palatine shelves during fusion","volume":"58","author":"Taniguchi","year":"1995","journal-title":"Arch Histol Cytol"},{"key":"10.1016\/j.acthis.2006.05.009_bib105","first-page":"121","article-title":"[Role of the mesenchyme in the fusion of palatine shelves (author's transl)]","volume":"67","author":"Tassin","year":"1978","journal-title":"Arch Anat Microsc Morphol Exp"},{"key":"10.1016\/j.acthis.2006.05.009_bib106","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1242\/dev.126.17.3869","article-title":"Pathogenesis of cleft palate in TGF-beta3 knockout mice","volume":"126","author":"Taya","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.acthis.2006.05.009_bib107","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.semcdb.2005.06.007","article-title":"Specification of neural crest cell formation and migration in mouse embryos","volume":"16","author":"Trainor","year":"2005","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib108","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/tera.1420150116","article-title":"Epithelial breakdown in the palatal processes of mouse fetuses with spontaneous cleft lip and palate","volume":"15","author":"Tsai","year":"1977","journal-title":"Teratology"},{"key":"10.1016\/j.acthis.2006.05.009_bib109","first-page":"333","article-title":"TGF-beta3 is required for the adhesion and intercalation of medial edge epithelial cells during palate fusion","volume":"46","author":"Tudela","year":"2002","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib110","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1091\/mbc.e04-08-0658","article-title":"TGF-{beta} and the Smad signaling pathway support transcriptomic reprogramming during epithelial\u2013mesenchymal cell transition","volume":"16","author":"Valcourt","year":"2005","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.acthis.2006.05.009_bib111","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.ydbio.2005.07.027","article-title":"Fate-mapping of the epithelial seam during palatal fusion rules out epithelial\u2013mesenchymal transformation","volume":"285","author":"Vaziri","year":"2005","journal-title":"Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib112","first-page":"99","article-title":"Deficient and delayed primary palatal fusion and mesenchymal bridge formation in cleft lip-liable strains of mice","volume":"15","author":"Wang","year":"1995","journal-title":"J Craniofac Genet Dev Biol"},{"key":"10.1016\/j.acthis.2006.05.009_bib113","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/ar.1091800111","article-title":"Alterations in the epithelial surface of human palatal shelves prior to and during fusion: a scanning electron microscopic study","volume":"180","author":"Waterman","year":"1974","journal-title":"Anat Rec"},{"key":"10.1016\/j.acthis.2006.05.009_bib114","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/ar.1091760311","article-title":"Alterations in the epithelial surface of A-Jax mouse palatal shelves prior to and during palatal fusion: a scanning electron microscopic study","volume":"176","author":"Waterman","year":"1973","journal-title":"Anat Rec"},{"key":"10.1016\/j.acthis.2006.05.009_bib115","series-title":"Cleft lip and palate: from origin to treatment","author":"Wyszynski","year":"2002"}],"container-title":["Acta Histochemica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128106000791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128106000791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:54:22Z","timestamp":1758736462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065128106000791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":115,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0065128106000791"],"URL":"https:\/\/doi.org\/10.1016\/j.acthis.2006.05.009","relation":{},"ISSN":["0065-1281"],"issn-type":[{"value":"0065-1281","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Palatal fusion \u2013 Where do the midline cells go?","name":"articletitle","label":"Article Title"},{"value":"Acta Histochemica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acthis.2006.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}