{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:04:05Z","timestamp":1791230645217,"version":"4.1.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Histochemica"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.acthis.2007.08.001","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T12:59:46Z","timestamp":1196168386000},"page":"86-93","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Immunolocalization of farnesoid X receptor (FXR) in mouse tissues using tissue microarray"],"prefix":"10.1016","volume":"110","author":[{"given":"Hiroyuki","family":"Higashiyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mine","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Asano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.acthis.2007.08.001_bib1","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/hep.20961","article-title":"OSTalpha-OSTbeta: a major basolateral BA and steroid transporter in human intestinal, renal, and biliary epithelia","volume":"42","author":"Ballatori","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.acthis.2007.08.001_bib2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/path.893","article-title":"Tissue microarray (TMA) technology: miniaturized pathology archives for high-throughput in situ studies","volume":"195","author":"Bubendorf","year":"2001","journal-title":"J. Pathol."},{"key":"10.1016\/j.acthis.2007.08.001_bib3","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1016\/j.febslet.2005.06.033","article-title":"Transient impairment of the adaptive response to fasting in FXR-deficient mice","volume":"579","author":"Cariou","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.acthis.2007.08.001_bib4","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1172\/JCI0214505","article-title":"BA-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element","volume":"109","author":"Claudel","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.acthis.2007.08.001_bib5","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S0016-5085(03)00896-5","article-title":"Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression","volume":"125","author":"Claudel","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.acthis.2007.08.001_bib6","doi-asserted-by":"crossref","first-page":"39124","DOI":"10.1074\/jbc.M305079200","article-title":"Coordinated control of cholesterol catabolism to BAs and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle","volume":"278","author":"De Fabiani","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.acthis.2007.08.001_bib7","doi-asserted-by":"crossref","first-page":"890","DOI":"10.2337\/diabetes.53.4.890","article-title":"Glucose regulates the expression of the farnesoid X receptor in liver","volume":"53","author":"Duran-Sandoval","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.acthis.2007.08.001_bib8","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S1097-2765(00)00051-4","article-title":"A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis","volume":"6","author":"Goodwin","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.acthis.2007.08.001_bib9","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1172\/JCI119583","article-title":"Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier","volume":"100","author":"Hanley","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.acthis.2007.08.001_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1146\/annurev.physiol.68.033104.152158","article-title":"LXRS and FXR: the yin and yang of cholesterol and fat metabolism","volume":"68","author":"Kalaany","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.acthis.2007.08.001_bib11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1194\/jlr.M500417-JLR200","article-title":"FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine","volume":"47","author":"Lee","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.acthis.2007.08.001_bib12","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1126\/science.284.5418.1362","article-title":"Identification of a nuclear receptor for bile acids","volume":"284","author":"Makishima","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.acthis.2007.08.001_bib13","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1126\/science.284.5418.1365","article-title":"Bile acids: natural ligands for an orphan nuclear receptor","volume":"284","author":"Parks","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.acthis.2007.08.001_bib14","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1210\/en.2004-0965","article-title":"Regulation of carbohydrate metabolism by the farnesoid X receptor","volume":"146","author":"Stayrook","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.acthis.2007.08.001_bib15","doi-asserted-by":"crossref","first-page":"39313","DOI":"10.1074\/jbc.M007998200","article-title":"The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression","volume":"275","author":"Urizar","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.acthis.2007.08.001_bib16","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S1097-2765(00)80348-2","article-title":"Endogenous bile acids are ligands for the nuclear receptor FXR\/BAR","volume":"3","author":"Wang","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.acthis.2007.08.001_bib17","doi-asserted-by":"crossref","first-page":"23158","DOI":"10.1074\/jbc.M314322200","article-title":"Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1","volume":"279","author":"Yamagata","year":"2004","journal-title":"J. Biol. Chem."}],"container-title":["Acta Histochemica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128107000815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128107000815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T17:01:14Z","timestamp":1786467674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065128107000815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0065128107000815"],"URL":"https:\/\/doi.org\/10.1016\/j.acthis.2007.08.001","relation":{},"ISSN":["0065-1281"],"issn-type":[{"value":"0065-1281","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunolocalization of farnesoid X receptor (FXR) in mouse tissues using tissue microarray","name":"articletitle","label":"Article Title"},{"value":"Acta Histochemica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acthis.2007.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}