{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:37:03Z","timestamp":1771634223562,"version":"3.50.1"},"reference-count":89,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Foundation S\u00e3o Paulo Research","award":["2008\/05314-5"],"award-info":[{"award-number":["2008\/05314-5"]}]},{"name":"Foundation S\u00e3o Paulo Research","award":["2012\/00259-1"],"award-info":[{"award-number":["2012\/00259-1"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Histochemica"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.acthis.2017.05.001","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T13:04:17Z","timestamp":1494507857000},"page":"481-494","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Submucosal neurons and enteric glial cells expressing the P2X7 receptor in rat experimental colitis"],"prefix":"10.1016","volume":"119","author":[{"given":"Marcos Vin\u00edcius","family":"da Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Rosa","family":"Marosti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Eus\u00e9bio","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Palombit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Castelucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.acthis.2017.05.001_bib0005","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1124\/pr.58.3.3","article-title":"International union of pharmacology LVIII. Update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy","volume":"58","author":"Abbracchio","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.acthis.2017.05.001_bib0010","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tins.2008.10.001","article-title":"Purinergic signalling in the nervous system: an overview","volume":"32","author":"Abbracchio","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.acthis.2017.05.001_bib0015","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pharmthera.2013.04.002","article-title":"The role of purinergic pathways in the pathophysiology of gut diseases: pharmacological modulation and potential therapeutic applications","volume":"139","author":"Antonioli","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.acthis.2017.05.001_bib0020","doi-asserted-by":"crossref","first-page":"e116253","DOI":"10.1371\/journal.pone.0116253","article-title":"Involvement of the P2X7 purinergic receptor in colonic motor dysfunction associated with bowel inflammation in rats","volume":"9","author":"Antonioli","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.acthis.2017.05.001_bib0025","first-page":"G622","article-title":"Disruption of colonic electrolyte transport in experimental colitis","volume":"268","author":"Bell","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0030","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1007\/s00424-014-1609-9","article-title":"Communication between mast cells and rat submucosal neurons","volume":"467","author":"Bell","year":"2015","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.acthis.2017.05.001_bib0035","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1469-7793.2000.00551.x","article-title":"Descending inhibitory reflexes involve P2X receptor-mediated transmission from interneurons to motor neurons in guinea-pig ileum","volume":"528","author":"Bian","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0040","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.autneu.2004.10.006","article-title":"Myenteric plexus injury and apoptosis in experimental colitis","volume":"117","author":"Boyer","year":"2005","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.acthis.2017.05.001_bib0045","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbadis.2011.06.004","article-title":"Mast cell-nerve axis with a focus on the human gut","volume":"1822","author":"Buhner","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.acthis.2017.05.001_bib0050","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0306-3623(85)90001-1","article-title":"Is there a basis for distinguishing two types of P2-purinoceptor?","volume":"16","author":"Burnstock","year":"1985","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0055","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/B978-0-12-385526-8.00011-4","article-title":"P2X receptors in health and disease","volume":"61","author":"Burnstock","year":"2011","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11302-013-9397-9","article-title":"Purinergic signalling in the gastrointestinal tract and related organs in health and disease","volume":"10","author":"Burnstock","year":"2014","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.acthis.2017.05.001_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.autneu.2015.05.006","article-title":"Purinergic signalling and the autonomic nervous system in health and disease","volume":"191","author":"Burnstock","year":"2015","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.acthis.2017.05.001_bib0070","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.neuropharm.2015.05.031","article-title":"An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration","volume":"104","author":"Burnstock","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.acthis.2017.05.001_bib0075","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuroscience.2005.03.052","article-title":"Effect of N-methyl-d-aspartate receptor blockade on neuronal plasticity and gastrointestinal transit delay induced by ischemia\/reperfusion in rats","volume":"134","author":"Calcina","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.acthis.2017.05.001_bib0080","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00418-002-0404-4","article-title":"The distribution of purine P2X2 receptors in the guinea-pig enteric nervous system","volume":"117","author":"Castelucci","year":"2002","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00441-002-0615-y","article-title":"Effects of pre- and postnatal protein deprivation and postnatal refeeding on myenteric neurons of the rat large intestine: a quantitative morphological study","volume":"310","author":"Castelucci","year":"2002","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.acthis.2017.05.001_bib0090","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s11302-008-9104-4","article-title":"Purinergic receptors and gastrointestinal secretomotor function","volume":"4","author":"Christofi","year":"2008","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.acthis.2017.05.001_bib0095","doi-asserted-by":"crossref","first-page":"e372","DOI":"10.1111\/j.1365-2982.2011.01748.x","article-title":"Proinflammatory stimuli activates human-derived enteroglial cells and induces autocrine nitric oxide production","volume":"23","author":"Cirillo","year":"2011","journal-title":"Neurogastroenterol. Motil."},{"issue":"2","key":"10.1016\/j.acthis.2017.05.001_bib0100","first-page":"238","article-title":"Clinicopathologic study of dextran sulfate sodium experimental murine colitis","volume":"69","author":"Cooper","year":"1993","journal-title":"Lab. Invest."},{"key":"10.1016\/j.acthis.2017.05.001_bib0105","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jneuroim.2009.11.011","article-title":"Peripheral origin of IL-1beta production in the rodent hippocampus under in vivo systemic bacterial lipopolysaccharide (LPS) challenge and its regulation by P2X7 receptors","volume":"219","author":"Cs\u00f6lle","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0110","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00418-014-1270-6","article-title":"Differential effects of experimental ulcerative colitis on P2X7 receptor expression in enteric neurons","volume":"143","author":"da Silva","year":"2015","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0115","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrgastro.2015.186","article-title":"Immunopathogenesis of IBD: current state of the art","volume":"13","author":"de Souza","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0120","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.tips.2007.07.002","article-title":"Liaisons dangereuses: P2X7 and the inflammasome","volume":"28","author":"di Virgilio","year":"2007","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.acthis.2017.05.001_bib0125","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.4049\/jimmunol.157.5.2174","article-title":"Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance","volume":"157","author":"Elson","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0130","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1078\/0940-2993-00318","article-title":"The effects of sodium phosphate and polyethylene glycol-electrolyte bowel preparation solutions on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat","volume":"55","author":"Erdogan","year":"2003","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0135","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3109\/00365529309096063","article-title":"The effect of exogenous administration of Lactobacillus reuteri R2LC and oat fiber on acetic acid-induced colitis in the rat","volume":"28","author":"Fabia","year":"1993","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0140","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/297409a0","article-title":"Evidence for the presence of S-100 protein in the glial component of the human enteric nervous system","volume":"297","author":"Ferri","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.acthis.2017.05.001_bib0145","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.pharmthera.2005.06.002","article-title":"Involvement of P2 receptors in the growth and survival of neurons in the CNS","volume":"109","author":"Franke","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.acthis.2017.05.001_bib0150","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1007\/s00424-006-0071-8","article-title":"P2 receptors and neuronal injury","volume":"452","author":"Franke","year":"2006","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.acthis.2017.05.001_bib0155","series-title":"The Enteric Nervous System","author":"Furness","year":"2006"},{"key":"10.1016\/j.acthis.2017.05.001_bib0160","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nrgastro.2012.32","article-title":"The enteric nervous system and neurogastroenterology","volume":"9","author":"Furness","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0165","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-1838(00)00130-2","article-title":"Multiple mechanisms of fast excitatory synaptic transmission in the enteric nervous system","volume":"81","author":"Galligan","year":"2000","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.acthis.2017.05.001_bib0170","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1046\/j.1365-2982.2002.00363.x","article-title":"Ligand-gated ion channels in the enteric nervous system","volume":"14","author":"Galligan","year":"2002","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.acthis.2017.05.001_bib0175","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1055\/s-2008-1034000","article-title":"Alterations of the intestinal mucosal block in ulcerative colitis and Crohn\u2019s disease\u2014immunological and ultrastructural findings, and considerations of the pathogenesis","volume":"197","author":"Gebbers","year":"1985","journal-title":"Klin. Padiatr."},{"key":"10.1016\/j.acthis.2017.05.001_bib0180","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1046\/j.1365-2982.1998.00102.x","article-title":"Structural abnormalities of the nervous system in Crohn\u2019s disease and ulcerative colitis","volume":"10","author":"Geboes","year":"1998","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.acthis.2017.05.001_bib0185","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0028-3908(02)00294-0","article-title":"P2 receptors in the murine gastrointestinal tract","volume":"43","author":"Giaroni","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.acthis.2017.05.001_bib0190","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00441-013-1620-z","article-title":"Differential effects of undernourishment on the differentiation and maturation of rat enteric neurons","volume":"353","author":"Girotti","year":"2013","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.acthis.2017.05.001_bib0195","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.autneu.2006.03.003","article-title":"Effects of pre- and postnatal protein deprivation and postnatal refeeding on myenteric neurons of the rat small intestine: a quantitative morphological study","volume":"126\u2013127","author":"Gomes","year":"2006","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.acthis.2017.05.001_bib0200","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrgastro.2012.138","article-title":"Novel functional roles for enteric glia in the gastrointestinal tract","volume":"9","author":"Gulbransen","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0205","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nm.2679","article-title":"Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis","volume":"18","author":"Gulbransen","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.acthis.2017.05.001_bib0210","doi-asserted-by":"crossref","first-page":"883","DOI":"10.7326\/0003-4819-105-6-883","article-title":"Increased intestinal permeability in patients with Crohn\u2019s disease and their relatives. A possible etiologic factor","volume":"105","author":"Hollander","year":"1986","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.acthis.2017.05.001_bib0215","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/cne.1387","article-title":"P2X7 receptors in the enteric nervous system of guinea-pig small intestine","volume":"440","author":"Hu","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0220","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.3748\/wjg.v13.i42.5581","article-title":"Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease","volume":"13","author":"Kawada","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0225","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.1365-2982.2005.00703.x","article-title":"Indiscriminate loss of myenteric neurones in the TNBS-inflamed guinea-pig distal colon","volume":"17","author":"Linden","year":"2005","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.acthis.2017.05.001_bib0230","doi-asserted-by":"crossref","first-page":"G1096","DOI":"10.1152\/ajpgi.00176.2012","article-title":"Colitis is associated with a loss of intestinofugal neurons","volume":"303","author":"Linden","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0235","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1023\/B:DDAS.0000037815.63547.08","article-title":"Structural and neuronal changes in rat ileum after ischemia with reperfusion","volume":"49","author":"Lindestr\u00f6m","year":"2004","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.acthis.2017.05.001_bib0240","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1365-2982.2004.00607.x","article-title":"Plasticity of the enteric nervous system during intestinal inflammation","volume":"17","author":"Lomax","year":"2005","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.acthis.2017.05.001_bib0245","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1113\/jphysiol.2005.084285","article-title":"Synaptic facilitation and enhanced neuronal excitability in the submucosal plexus during experimental colitis in guinea-pig","volume":"564","author":"Lomax","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0250","first-page":"58","article-title":"Human gastric blood flow: methodological and physiological considerations","volume":"105","author":"Lundgren","year":"1984","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0255","first-page":"489","article-title":"Differential effects of intestinal ischemia and reperfusion in rat enteric neurons and glial cells expressing P2X2 receptors","volume":"30","author":"Marosti","year":"2015","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0260","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbadis.2013.10.012","article-title":"Prophylactic systemic P2X7 receptor blockade prevents experimental colitis","volume":"1842","author":"Marques","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.acthis.2017.05.001_bib0265","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1007\/s10620-015-3663-3","article-title":"The effect of ischemia and reperfusion on enteric glial cells and contractile activity in the ileum","volume":"60","author":"Mendes","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.acthis.2017.05.001_bib0270","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.3748\/wjg.v16.i29.3651","article-title":"Effects of protein deprivation and re-feeding on P2X2 receptors in enteric neurons","volume":"16","author":"Misawa","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0275","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.3748\/wjg.v18.i34.4693","article-title":"Expression of the P2X2 receptor in different classes of ileum myenteric neurons in the female obese ob\/ob mouse","volume":"18","author":"Mizuno","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0280","doi-asserted-by":"crossref","first-page":"13911","DOI":"10.3748\/wjg.v20.i38.13911","article-title":"Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice (ob\/ob)","volume":"20","author":"Mizuno","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0285","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0016-5085(89)80079-4","article-title":"Hapten-induced model of chronic inflammation and ulceration in the rat colon","volume":"96","author":"Morris","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.acthis.2017.05.001_bib0290","doi-asserted-by":"crossref","first-page":"G1028","DOI":"10.1152\/ajpgi.00066.2003","article-title":"Human ENS regulates the intestinal epithelial barrier permeability and a tight junction-associated protein ZO-1 via VIPergic pathways","volume":"285","author":"Neunlist","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0295","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1053\/j.gastro.2014.09.040","article-title":"Enteric glial cells: recent developments and future directions","volume":"147","author":"Neunlist","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.acthis.2017.05.001_bib0300","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/01.MIB.0000441201.10454.06","article-title":"Overexpression of ATP-activated P2X7 receptors in the intestinal mucosa is implicated in the pathogenesis of Crohn\u2019s disease","volume":"20","author":"Neves","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.acthis.2017.05.001_bib0305","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.acthis.2016.06.006","article-title":"The dual anti-inflammatory and antioxidant activities of natural honey promote cell proliferation and neural regeneration in a rat model of colitis","volume":"118","author":"Nooh","year":"2016","journal-title":"Acta Histochem."},{"key":"10.1016\/j.acthis.2017.05.001_bib0310","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1007\/s10620-013-2847-y","article-title":"Effects of ischemia and reperfusion on subpopulations of rat enteric neurons expressing the P2X7 receptor","volume":"58","author":"Palombit","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.acthis.2017.05.001_bib0315","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1007\/s10620-011-1588-z","article-title":"Effects of ischemia and reperfusion on P2X2 receptor expressing neurons of the rat ileum enteric nervous system","volume":"56","author":"Paulino","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.acthis.2017.05.001_bib0320","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1023\/A:1012313424144","article-title":"Morphological and functional alterations of the myenteric plexus in rats with TNBS-induced colitis","volume":"26","author":"Poli","year":"2001","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.acthis.2017.05.001_bib0325","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1566-0702(02)00179-0","article-title":"The distribution of P2X3 purine receptor subunits in the guinea pig enteric nervous system","volume":"101","author":"Poole","year":"2002","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.acthis.2017.05.001_bib0330","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1365-2982.2005.00687.x","article-title":"Glial cells in the gut","volume":"17","author":"R\u00fchl","year":"2005","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.acthis.2017.05.001_bib0335","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/157016109787354123","article-title":"Purines as neurotransmitters and neuromodulators in blood vessels","volume":"7","author":"Ralevic","year":"2009","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0340","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00401-009-0549-5","article-title":"The reactions of specific neuron types to intestinal ischemia in the guinea pig enteric nervous system","volume":"118","author":"Rivera","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0345","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.coph.2012.09.011","article-title":"The roles of purinergic signaling during gastrointestinal inflammation","volume":"12","author":"Roberts","year":"2012","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0350","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00441-004-1002-7","article-title":"The distribution of P2X5 purinergic receptors in the enteric nervous system of mouse","volume":"319","author":"Ruan","year":"2005","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.acthis.2017.05.001_bib0355","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/ar.a.10024","article-title":"Morphology and distribution of nitric oxide synthase- neurokinin-1 receptor-, calretinin-, calbindin-, and neurofilament-M-immunoreactive neurons in the myenteric and submucosal plexuses of the rat small intestine","volume":"271","author":"Sayegh","year":"2003","journal-title":"Anat. Rec. A: Discov. Mol. Cell. Evol. Biol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0360","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1365-2982.2001.00265.x","article-title":"Neurotransmitter coding of enteric neurones in the submucous plexus is changed in non-inflamed rectum of patients with Crohn\u2019s disease","volume":"13","author":"Schneider","year":"2001","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.acthis.2017.05.001_bib0365","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/1097-0185(20010101)262:1<79::AID-AR1013>3.0.CO;2-K","article-title":"Consequences of intestinal inflammation on the enteric nervous system: neuronal activation induced by inflammatory mediators","volume":"262","author":"Sharkey","year":"2001","journal-title":"Anat. Rec."},{"key":"10.1016\/j.acthis.2017.05.001_bib0370","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.tips.2014.08.002","article-title":"P2X7 receptor: an emerging target in central nervous system diseases","volume":"35","author":"Sperl\u00e1gh","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.acthis.2017.05.001_bib0375","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.pneurobio.2006.03.007","article-title":"P2X7 receptors in the nervous system","volume":"78","author":"Sperl\u00e1gh","year":"2006","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0380","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00418-002-0447-6","article-title":"Neurochemical identification of enteric neurons expressing P2X3 receptors in the guinea-pig ileum","volume":"118","author":"van Nassauw","year":"2002","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0385","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1017\/S1740925X11000068","article-title":"The role of enteric glia in gut inflammation","volume":"6","author":"von Boyen","year":"2010","journal-title":"Neuron Glia Biol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0390","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1136\/gut.2003.012625","article-title":"Proinflammatory cytokines increase glial fibrillary acidic protein expression in enteric glia","volume":"53","author":"von Boyen","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.acthis.2017.05.001_bib0395","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00441-003-0716-2","article-title":"Glial cells, but not interstitial cells, express P2X7, an ionotropic purinergic receptor, in rat gastrointestinal musculature","volume":"312","author":"Vanderwinden","year":"2003","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.acthis.2017.05.001_bib0400","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2174\/187152712803581137","article-title":"P2X7 receptors: channels, pores and more","volume":"11","author":"Volont\u00e9","year":"2012","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.acthis.2017.05.001_bib0405","doi-asserted-by":"crossref","first-page":"8063","DOI":"10.1073\/pnas.93.15.8063","article-title":"Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry","volume":"93","author":"Vulchanova","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.acthis.2017.05.001_bib0410","doi-asserted-by":"crossref","first-page":"19108","DOI":"10.1038\/srep19108","article-title":"Extracellular ATP mediates inflammatory responses in colitis via P2X7 receptor signaling","volume":"6","author":"Wan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.acthis.2017.05.001_bib0415","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00418-004-0680-2","article-title":"Development of nerves expressing P2X3 receptors in the myenteric plexus of rat stomach","volume":"122","author":"Xiang","year":"2004","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0420","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00418-004-0620-1","article-title":"P2X2 and P2X3 purinoceptors in the rat enteric nervous system","volume":"121","author":"Xiang","year":"2004","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0425","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00418-005-0043-7","article-title":"Distribution of P2Y2 receptors in the guinea pig enteric nervous system and its coexistence with P2X2 and P2X3 receptors neuropeptide Y, nitric oxide synthase and calretinin","volume":"124","author":"Xiang","year":"2005","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0430","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1365-2982.2001.00276.x","article-title":"ATP-gated ion channel P2X(3) is increased in human inflammatory bowel disease","volume":"13","author":"Yiangou","year":"2001","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.acthis.2017.05.001_bib0435","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00418-009-0659-0","article-title":"Expression of P2X6 receptors in the enteric nervous system of the rat gastrointestinal tract","volume":"133","author":"Yu","year":"2010","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.acthis.2017.05.001_bib0440","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s11302-013-9356-5","article-title":"Distribution of purinergic P2X receptors in the equine digit, cervical spinal cord and dorsal root ganglia","volume":"9","author":"Zamboulis","year":"2013","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.acthis.2017.05.001_bib0445","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ejphar.2013.01.018","article-title":"Extracellular ATP signaling in equine digital blood vessels","volume":"702","author":"Zerpa","year":"2013","journal-title":"Eur. J. Pharmacol."}],"container-title":["Acta Histochemica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128117300016?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128117300016?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T14:17:12Z","timestamp":1692800232000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065128117300016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":89,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0065128117300016"],"URL":"https:\/\/doi.org\/10.1016\/j.acthis.2017.05.001","relation":{},"ISSN":["0065-1281"],"issn-type":[{"value":"0065-1281","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Submucosal neurons and enteric glial cells expressing the P2X7 receptor in rat experimental colitis","name":"articletitle","label":"Article Title"},{"value":"Acta Histochemica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acthis.2017.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}