{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:57:56Z","timestamp":1782698276003,"version":"3.54.5"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Histochemica"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.acthis.2017.07.006","type":"journal-article","created":{"date-parts":[[2017,8,5]],"date-time":"2017-08-05T07:46:48Z","timestamp":1501919208000},"page":"648-662","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["The impact of aged garlic extract on adriamycin-induced testicular changes in adult male Wistar rats"],"prefix":"10.1016","volume":"119","author":[{"given":"Ashraf Youssef","family":"Nasr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.acthis.2017.07.006_bib0005","first-page":"160","article-title":"Amelioration of cisplatin induced testicular injury by different garlic preparations in experimental rat","volume":"5","author":"Abd El-Gany","year":"2016","journal-title":"World J. Pharm. Res."},{"key":"10.1016\/j.acthis.2017.07.006_bib0010","first-page":"366","article-title":"Protective effect of quercetin and or zinc against lead toxicity on rat testes","volume":"9","author":"Abd El-Latief","year":"2015","journal-title":"Global J. Pharmacol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0015","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3923\/ajava.2016.653.664","article-title":"Protective effect of nano-selenium and ionized selenium against the testicular damage, endocrine disruptor and testicular ultrastructure of Bisphenol A in albino male rats","volume":"11","author":"Abdel-Halim","year":"2016","journal-title":"Asian J. Anim. Vet. Adv."},{"key":"10.1016\/j.acthis.2017.07.006_bib0020","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0025","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ijcard.2004.11.004","article-title":"Endurance training attenuates doxorubicin-induced cardiac oxidative damage in mice","volume":"100","author":"Antonio","year":"2005","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0030","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.bcp.2003.08.039","article-title":"Evidence that activation of nuclear factor-\u03baB is essential for the cytotoxic effects of doxorubicin and its analogues","volume":"67","author":"Ashikawa","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0035","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.fertnstert.2005.11.035","article-title":"Lycopene prevents adriamycin-induced testicular toxicity in rats","volume":"85","author":"Atessahin","year":"2006","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.acthis.2017.07.006_bib0040","unstructured":"Bancroft, J., Gamble, M., 2008. Theory and Practice of Histological Techniques. 6th ed. Churchill Livingstone, London. 165\u2013175, 340\u2013348."},{"key":"10.1016\/j.acthis.2017.07.006_bib0045","first-page":"36","article-title":"The study of the radiation protection of Aged Garlic Extract to the Radiation effects in Male Rat's sperm","volume":"1","author":"Bertrand","year":"2016","journal-title":"Int. J. Biochem. Biophys. Mol. Biol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0050","series-title":"Handbook of Radioimmunoassay","author":"Braham","year":"1977"},{"key":"10.1016\/j.acthis.2017.07.006_bib0055","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/907162","article-title":"The antioxidant mechanisms underlying the effects of aged garlic extract and S-allylcysteine-induced protection","author":"Col\u00edn-Gonz\u00e1lez","year":"2012","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.acthis.2017.07.006_bib0060","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.fct.2010.11.033","article-title":"Light and Elecron microscopic study of the toxic effect of prolonged lead exposure on seminiferous tubules of albino rats and the possible protective effect of ascorbic acid","volume":"49","author":"El- Shafai","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0065","first-page":"S53","article-title":"Histopathological and Ultrastructural effects of methyl parathion on rat testis and protection by selenium","volume":"3","author":"El-Gerbed","year":"2013","journal-title":"J. Appl. Pharm. Sci."},{"key":"10.1016\/j.acthis.2017.07.006_bib0070","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.acthis.2017.07.006_bib0075","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1046\/j.1442-2042.2003.00572.x","article-title":"Protecting spermatogonia from apoptosis induced by doxorubicine using the luteinizing hormone-releasing hormone analog leuprorelin","volume":"10","author":"Endo","year":"2007","journal-title":"Int. J. Urol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0080","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.mrfmmm.2008.09.003","article-title":"Mutation research\/Fundamental and molecular mechanisms of mutagenesis","volume":"648","author":"Fimognari","year":"2008","journal-title":"Mut. Res."},{"key":"10.1016\/j.acthis.2017.07.006_bib0085","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.1016\/j.febslet.2005.09.097","article-title":"Focal adhesion molecules as potential target of lead toxicity in NRK-52E cell line","volume":"579","author":"Giuliani","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.acthis.2017.07.006_bib0090","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00204-011-0774-2","article-title":"Antioxidant activity of food constituents: an overview","volume":"86","author":"Gulcin","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0095","series-title":"Principles and Techniques of Electron Microscopy: Biological Applications","first-page":"4","article-title":"Chemical fixation","author":"Hayat","year":"2000"},{"key":"10.1016\/j.acthis.2017.07.006_bib0100","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.urology.2003.08.029","article-title":"Fertility after high-dose chemotherapy for testicular cancer","volume":"63","author":"Ishikawa","year":"2004","journal-title":"Urology"},{"key":"10.1016\/j.acthis.2017.07.006_bib0105","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3390\/molecules21040430","article-title":"Comparison of anti-oxidant and anti-inflammatory effects between fresh and aged black garlic extracts","volume":"21","author":"Jeong","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.acthis.2017.07.006_bib0110","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s00383-006-1668-x","article-title":"Protective effects of leflunomide against ischemia reperfusion injury of the rat liver","volume":"22","author":"Karaman","year":"2006","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.acthis.2017.07.006_bib0115","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/0006-291X(76)90747-6","article-title":"Glutathione peroxidase activity in selenium deficient rat liver","volume":"71","author":"Lawrence","year":"1976","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.acthis.2017.07.006_bib0120","first-page":"406","article-title":"The effect of lead acetate on testicular structure and protective effect of vitamin E in adult albino rat","volume":"31","author":"Makhlouf","year":"2008","journal-title":"Egypt. J. Histol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0125","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12935-014-0092-x","article-title":"Aged garlic extract protects against oxidative stress and renal changes in cisplatin-treated adult male rats","volume":"14","author":"Nasr","year":"2014","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.acthis.2017.07.006_bib0130","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.acthis.2017.07.006_bib0135","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S1470-2045(05)70070-X","article-title":"Fertility preservation: an emerging discipline in the care of young patients with cancer","volume":"6","author":"Oktay","year":"2005","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0140","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.etp.2010.11.001","article-title":"Resveratrol attenuates doxorubicin-induced cellular damage by modulating nitric oxide and apoptosis","volume":"64","author":"Oktem","year":"2012","journal-title":"Exp. Toxocol. Pathol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0145","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/B:MCBI.0000049385.13773.23","article-title":"Remedial effect of DL- \u03b1- lipoic acid against adriamycin induced testicular lipid peroxidation","volume":"267","author":"Prahalathan","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.acthis.2017.07.006_bib0150","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cccn.2005.04.025","article-title":"Protective effect of lipoic acid on adriamycin-induced testicular toxicity","volume":"360","author":"Prahalathan","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.acthis.2017.07.006_bib0155","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.cbi.2005.12.007","article-title":"Modulatory role of lipoic acid on adriamycin-induced testicular injury","volume":"160","author":"Prahalathan","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.acthis.2017.07.006_bib0160","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.fct.2014.02.031","article-title":"Propolis attenuates doxorubicin-induced testicular toxicity in rats","volume":"67","author":"Rizk","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0165","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/j.1939-4640.2005.tb02883.x","article-title":"Cisplatin- induced long- term failure of spermatogenesis in adult C57\/B1\/6J mice","volume":"26","author":"Sawhney","year":"2005","journal-title":"J. Androl."},{"key":"10.1016\/j.acthis.2017.07.006_bib0170","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1016\/j.theriogenology.2004.10.003","article-title":"The effect of ascorbic acid supplementation on sperm quality, lipid peroxidation and testosterone levels of male Wistar rats","volume":"63","author":"Sonmez","year":"2005","journal-title":"Theriogenology"},{"key":"10.1016\/j.acthis.2017.07.006_bib0175","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","article-title":"A simple method for clinical assay of superoxide dismutase","volume":"34","author":"Sun","year":"1988","journal-title":"Clin. Chem."},{"key":"10.1016\/j.acthis.2017.07.006_bib0180","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.fct.2010.12.005","article-title":"Hesperetin protects testicular toxicity of doxorubicin in rat: role of NF kappa B, p38 and caspase-3","volume":"49","author":"Trivedi","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0185","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.etp.2014.12.002","article-title":"Effect of resveratrol on doxorubicin induced testicular damage in rats","volume":"67","author":"Turedi","year":"2015","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0190","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.fertnstert.2007.04.059","article-title":"Improvement of cisplatin-induced injuries to sperm quality, the oxidant-antioxidant system, and the histologic structure of the rat testis by ellagic acid","volume":"89","author":"Turk","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.acthis.2017.07.006_bib0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4161\/21565562.2014.979099","article-title":"Morphologic manifestations of testicular and epididymal toxicity","volume":"4","author":"Vidal","year":"2014","journal-title":"Spermatogenesis"},{"key":"10.1016\/j.acthis.2017.07.006_bib0200","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/ptr.3633","article-title":"Protective effect of lycium barbarum polysaccharides against doxorubicin-induced testicular toxicity in rats","volume":"26","author":"Xin","year":"2012","journal-title":"Phytother. Res."},{"key":"10.1016\/j.acthis.2017.07.006_bib0205","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1124\/mol.105.013383","article-title":"Molecular pharmacology of the interaction of anthracyclines with iron","volume":"68","author":"Xu","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0210","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.bcp.2007.06.031","article-title":"Protection by doxycycline against doxorubicin-induced oxidative stress and apoptosis in mouse testes","volume":"74","author":"Yeh","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.acthis.2017.07.006_bib0215","first-page":"1830","article-title":"Time-dependent toxic effect of N-ethyl-N-nitrosourea on the testes of male C57BL\/6J mice: a histological and ultrastructural study","volume":"8","author":"Yin","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."}],"container-title":["Acta Histochemica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128117301472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128117301472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T20:43:27Z","timestamp":1659300207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065128117301472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S0065128117301472"],"URL":"https:\/\/doi.org\/10.1016\/j.acthis.2017.07.006","relation":{},"ISSN":["0065-1281"],"issn-type":[{"value":"0065-1281","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of aged garlic extract on adriamycin-induced testicular changes in adult male Wistar rats","name":"articletitle","label":"Article Title"},{"value":"Acta Histochemica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acthis.2017.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}