{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:31:31Z","timestamp":1760369491347,"version":"3.44.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Spanish Ministry of Science, Innovation and Universities","award":["SAF2017-84454-R"],"award-info":[{"award-number":["SAF2017-84454-R"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Histochemica"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.acthis.2019.03.001","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T21:30:20Z","timestamp":1551821420000},"page":"392-399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intussusceptive lymphangiogenesis in vascular transformation of lymph node sinuses"],"prefix":"10.1016","volume":"121","author":[{"given":"Lucio","family":"D\u00edaz-Flores","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00aa Pino","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Gonz\u00e1lez-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Lucio","family":"D\u00edaz-Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Carrasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"\u00c1lvarez-Arg\u00fcelles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.acthis.2019.03.001_bib0005","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mvr.2013.02.002","article-title":"Intussusceptive remodeling of vascular branch angles in chemically-induced murine colitis","volume":"87","author":"Ackermann","year":"2013","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.acthis.2019.03.001_bib0010","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10456-013-9399-9","article-title":"Sprouting and intussusceptive angiogenesis in postpneumonectomy lung growth: mechanisms of alveolar neovascularization","volume":"17","author":"Ackermann","year":"2014","journal-title":"Angiogenesis"},{"key":"10.1016\/j.acthis.2019.03.001_bib0015","article-title":"Immunohistochemical analysis of endothelial cells in vascular transformation of lymph node sinuses: Vascular or Lymphatic Differentiation?","author":"Basha","year":"2018","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"10.1016\/j.acthis.2019.03.001_bib0020","first-page":"32","article-title":"Intussusceptive microvascular growth, a new mechanism of capillary network formation","volume":"61","author":"Burri","year":"1992","journal-title":"EXS"},{"key":"10.1016\/j.acthis.2019.03.001_bib0025","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0098-2997(02)00096-1","article-title":"Intussusceptive angiogenesis--the alternative to capillary sprouting","volume":"23","author":"Burri","year":"2002","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.acthis.2019.03.001_bib0030","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ar.1092280107","article-title":"A novel mechanism of capillary growth in the rat pulmonary microcirculation","volume":"228","author":"Burri","year":"1990","journal-title":"Anat. Rec."},{"key":"10.1016\/j.acthis.2019.03.001_bib0035","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/dvdy.20184","article-title":"Intussusceptive angiogenesis: its emergence, its characteristics, and its significance","volume":"231","author":"Burri","year":"2004","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.acthis.2019.03.001_bib0040","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/ar.1092160207","article-title":"Scanning electron microscope study of the developing microvasculature in the postnatal rat lung","volume":"216","author":"Caduff","year":"1986","journal-title":"Anat. Rec."},{"key":"10.1016\/j.acthis.2019.03.001_bib0045","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1097\/00000478-199108000-00003","article-title":"Vascular transformation of sinuses in lymph nodes. A study of its morphological spectrum and distinction from Kaposi\u2019s sarcoma","volume":"15","author":"Chan","year":"1991","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.acthis.2019.03.001_bib0050","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1159\/000338278","article-title":"Intussusceptive angiogenesis: a biologically relevant form of angiogenesis","volume":"49","author":"De Spiegelaere","year":"2012","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.acthis.2019.03.001_bib0055","first-page":"1271","article-title":"Intravascular papillary endothelial hyperplasia (IPEH). Evidence supporting a piecemeal mode of angiogenesis from vein endothelium, with vein wall neovascularization and papillary formation","volume":"31","author":"D\u00edaz-Flores","year":"2016","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.acthis.2019.03.001_bib0060","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/ar.23599","article-title":"Piecemeal mechanism combining sprouting and intussusceptive angiogenesis in intravenous papillary formation induced by PGE2 and glycerol","volume":"300","author":"D\u00edaz-Flores","year":"2017","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.acthis.2019.03.001_bib0065","first-page":"1239","article-title":"Morphofunctional basis of the different types of angiogenesis and formation of postnatal angiogenesis-related secondary structures","volume":"32","author":"D\u00edaz-Flores","year":"2017","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.acthis.2019.03.001_bib0070","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.acthis.2018.02.007","article-title":"Sinusoidal hemangioma and intravascular papillary endothelial hyperplasia: interrelated processes that share a histogenetic piecemeal angiogenic mechanism","volume":"120","author":"D\u00edaz-Flores","year":"2018","journal-title":"Acta Histochem."},{"key":"10.1016\/j.acthis.2019.03.001_bib0075","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1159\/000489250","article-title":"Segmentation of dilated hemorrhoidal veins in hemorrhoidal disease","volume":"205","author":"D\u00edaz-Flores","year":"2018","journal-title":"Cells Tissues Organs (Print)"},{"key":"10.1016\/j.acthis.2019.03.001_bib0080","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1161\/01.RES.86.3.286","article-title":"Intussusceptive angiogenesis: its role in embryonic vascular network formation","volume":"86","author":"Djonov","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.acthis.2019.03.001_bib0085","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/dvdy.10119","article-title":"Optimality in the developing vascular system: branching remodeling by means of intussusception as an efficient adaptation mechanism","volume":"224","author":"Djonov","year":"2002","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.acthis.2019.03.001_bib0090","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00441-003-0784-3","article-title":"Vascular remodeling by intussusceptive angiogenesis","volume":"314","author":"Djonov","year":"2003","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.acthis.2019.03.001_bib0095","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.mvr.2009.08.004","article-title":"Computational flow dynamics in a geometric model of intussusceptive angiogenesis","volume":"78","author":"Filipovic","year":"2009","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.acthis.2019.03.001_bib0100","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/jmi.12300","article-title":"Three-dimensional image analytical detection of intussusceptive pillars in murine lung","volume":"260","author":"F\u00f6hst","year":"2015","journal-title":"J. Microsc."},{"key":"10.1016\/j.acthis.2019.03.001_bib0105","first-page":"81","article-title":"Vascular transformation of lymph node sinuses due to venous obstruction","volume":"92","author":"Haferkamp","year":"1971","journal-title":"Arch. Pathol."},{"key":"10.1016\/j.acthis.2019.03.001_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182813","article-title":"Endoglin inhibition leads to intussusceptive angiogenesis via activation of factors related to COUP-TFII signaling pathway","volume":"12","author":"Hlushchuk","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.acthis.2019.03.001_bib0115","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/ar.21110","article-title":"Inflammation-induced intussusceptive angiogenesis in murine colitis","volume":"293","author":"Konerding","year":"2010","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.acthis.2019.03.001_bib0120","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10456-011-9236-y","article-title":"Spatial dependence of alveolar angiogenesis in post-pneumonectomy lung growth","volume":"15","author":"Konerding","year":"2012","journal-title":"Angiogenesis"},{"key":"10.1016\/j.acthis.2019.03.001_bib0125","first-page":"65","article-title":"Angiogenesis and vascular remodeling by intussusception: from form to function","volume":"18","author":"Kurz","year":"2003","journal-title":"News Physiol. Sci."},{"key":"10.1016\/j.acthis.2019.03.001_bib0130","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/dvdy.22618","article-title":"Intravascular pillars and pruning in the extraembryonic vessels of chick embryos","volume":"240","author":"Lee","year":"2011","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.acthis.2019.03.001_bib0135","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1159\/000490905","article-title":"Intussusceptive pillar formation in developing porcine glomeruli","volume":"55","author":"Logothetidou","year":"2018","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.acthis.2019.03.001_bib0140","article-title":"Isolation of human lymphatic endothelial cells by multi-parameter fluorescence-activated cell sorting","volume":"99","author":"Lokmic","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.acthis.2019.03.001_bib0145","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10456-009-9129-5","article-title":"Intussusceptive angiogenesis and its role in vascular morphogenesis, patterning, and remodeling","volume":"12","author":"Makanya","year":"2009","journal-title":"Angiogenesis"},{"key":"10.1016\/j.acthis.2019.03.001_bib0150","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s10456-014-9428-3","article-title":"Intussusceptive angiogenesis: expansion and remodeling of microvascular networks","volume":"17","author":"Mentzer","year":"2014","journal-title":"Angiogenesis"},{"key":"10.1016\/j.acthis.2019.03.001_bib0155","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0344-0338(89)80059-7","article-title":"Vascular transformation of lymph node sinuses--a diagnostic pitfall. Histopathologic and immunohistochemical study","volume":"185","author":"Michael","year":"1989","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.acthis.2019.03.001_bib0160","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/ar.20954","article-title":"Blood flow patterns spatially associated with platelet aggregates in murine colitis","volume":"292","author":"Miele","year":"2009","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.acthis.2019.03.001_bib0165","first-page":"656","article-title":"Vascular transformation of lymph node sinuses. A process displaying a spectrum of histologic features","volume":"114","author":"Ostrowski","year":"1990","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.acthis.2019.03.001_bib0170","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.ajpath.2011.05.033","article-title":"A new mechanism for pillar formation during tumor-induced intussusceptive angiogenesis: inverse sprouting","volume":"179","author":"Paku","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.acthis.2019.03.001_bib0175","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/CIRCRESAHA.108.176446","article-title":"Lycat and cloche at the switch between blood vessel growth and differentiation?","volume":"102","author":"Patan","year":"2008","journal-title":"Circ. Res."},{"issue":"Suppl","key":"10.1016\/j.acthis.2019.03.001_bib0180","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1679\/aohc.55.Suppl_65","article-title":"Intussusceptive microvascular growth: a common alternative to capillary sprouting","volume":"55","author":"Patan","year":"1992","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.acthis.2019.03.001_bib0185","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF00171743","article-title":"Evidence for intussusceptive capillary growth in the chicken chorio-allantoic membrane (CAM)","volume":"187","author":"Patan","year":"1993","journal-title":"Anat. Embryol. (Berl)"},{"key":"10.1016\/j.acthis.2019.03.001_bib0190","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1006\/mvre.1996.0025","article-title":"Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis","volume":"51","author":"Patan","year":"1996","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.acthis.2019.03.001_bib0195","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/mvre.1996.1989","article-title":"Implementation of intussusceptive microvascular growth in the chicken chorioallantoic membrane (CAM)","volume":"53","author":"Patan","year":"1997","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.acthis.2019.03.001_bib0200","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1161\/hh2001.097870","article-title":"Vascular morphogenesis and remodeling in a model of tissue repair: blood vessel formation and growth in the ovarian pedicle after ovariectomy","volume":"89","author":"Patan","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.acthis.2019.03.001_bib0205","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1161\/hh2001.097872","article-title":"Vascular morphogenesis and remodeling in a human tumor xenograft: blood vessel formation and growth after ovariectomy and tumor implantation","volume":"89","author":"Patan","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.acthis.2019.03.001_bib0210","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.canlet.2011.10.040","article-title":"Intussusceptive microvascular growth in tumors","volume":"316","author":"Ribatti","year":"2012","journal-title":"Cancer Lett."},{"key":"10.1016\/j.acthis.2019.03.001_bib0215","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1258\/0022215011908892","article-title":"Vascular transformation of lymph node sinuses","volume":"115","author":"Samet","year":"2001","journal-title":"J. Laryngol. Otol."},{"key":"10.1016\/j.acthis.2019.03.001_bib0220","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00428-008-0636-3","article-title":"Lymph node pathology in pulmonary veno-occlusive disease and pulmonary capillary heamangiomatosis","volume":"453","author":"Thomas de Montpr\u00e9ville","year":"2008","journal-title":"Virchows Arch."},{"key":"10.1016\/j.acthis.2019.03.001_bib0225","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/ar.20767","article-title":"Bimodal oscillation frequencies of blood flow in the inflammatory colon microcirculation","volume":"292","author":"Tsuda","year":"2009","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.acthis.2019.03.001_bib0230","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s11626-008-9134-9","article-title":"Effect of intraluminal pillars on particle motion in bifurcated microchannels","volume":"44","author":"Turhan","year":"2008","journal-title":"In Vitro Cell. Dev. Biol. Anim."}],"container-title":["Acta Histochemica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128118303684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128118303684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T18:09:19Z","timestamp":1758737359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065128118303684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0065128118303684"],"URL":"https:\/\/doi.org\/10.1016\/j.acthis.2019.03.001","relation":{},"ISSN":["0065-1281"],"issn-type":[{"type":"print","value":"0065-1281"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intussusceptive lymphangiogenesis in vascular transformation of lymph node sinuses","name":"articletitle","label":"Article Title"},{"value":"Acta Histochemica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acthis.2019.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}