{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:18:36Z","timestamp":1771373916309,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Histochemica"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.acthis.2019.03.007","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T08:40:26Z","timestamp":1554108026000},"page":"430-436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Stereological examination of curcumin\u2019s effects on hippocampal damage caused by the anti-epileptic drugs phenobarbital and valproic acid in the developing rat brain"],"prefix":"10.1016","volume":"121","author":[{"given":"Burcu","family":"Demirel Y\u0131lmaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu","family":"Eren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilek","family":"Sa\u011f\u0131r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zafer","family":"Eren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe","family":"Ba\u015fard\u0131 G\u00f6k\u00e7e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.acthis.2019.03.007_bib0005","first-page":"611","article-title":"Immediate and delayed treatments with curcumin prevents forebrain ischemia induced neuronal damage and oxidative insult in the rat hippocampus","volume":"31","author":"Al-Omar","year":"2006","journal-title":"Neuro. Chem. Res."},{"key":"10.1016\/j.acthis.2019.03.007_bib0010","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000098053","article-title":"The effects of carbamazepine, valproic acid and phenobarbital on the oxidative and antioxidative balance in epileptic children","volume":"57","author":"Aycicek","year":"2007","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.acthis.2019.03.007_bib0015","series-title":"Theory and Practice of Histological Techniques","author":"Bancroft","year":"2008"},{"key":"10.1016\/j.acthis.2019.03.007_bib0020","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/B978-0-444-52891-9.00043-9","article-title":"The epidemiology of seizure disorders in infancy and childhood: definitions and classifications","volume":"111","author":"Berg","year":"2013","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.acthis.2019.03.007_bib0025","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1532-5415.2000.tb02603.x","article-title":"Cognitive decline is associated with systemic oxidative stress: the EVA study","volume":"48","author":"Berr","year":"2000","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.acthis.2019.03.007_bib0030","doi-asserted-by":"crossref","first-page":"15089","DOI":"10.1073\/pnas.222550499","article-title":"Antiepileptic drugs and apoptotic neurodegeneration in the developing brain","volume":"99","author":"Bittigau","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.acthis.2019.03.007_bib0035","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1749-6632.2003.tb07517.x","article-title":"Antiepileptic drugs and apoptosis in the developing brain","volume":"993","author":"Bittigau","year":"2003","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.acthis.2019.03.007_bib0040","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF02904491","article-title":"Adult structural plasticity and neurogenesis in the mammalian olfactory system","volume":"13","author":"Bonfanti","year":"2002","journal-title":"Rend. Fis. Acc. Lincei."},{"issue":"2","key":"10.1016\/j.acthis.2019.03.007_bib0045","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1684\/epd.2015.0736","article-title":"Incidence, prevalence and aetiology of seizures and epilepsy in children","volume":"17","author":"Camfield","year":"2015","journal-title":"Epileptic Disord."},{"key":"10.1016\/j.acthis.2019.03.007_bib0050","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s12210-012-0192-2","article-title":"Beauty in the brain: for a neuroscience of art","volume":"23","author":"Changeux","year":"2012","journal-title":"Rend. Fis. Acc. Lincei."},{"issue":"3","key":"10.1016\/j.acthis.2019.03.007_bib0055","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1083\/jcb.201306136","article-title":"Death of developing neurons: new insights and implications for connectivity","volume":"203","author":"Dekkers","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.acthis.2019.03.007_bib0060","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","journal-title":"Early Hum. Dev."},{"issue":"2","key":"10.1016\/j.acthis.2019.03.007_bib0065","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.canlet.2004.09.041","article-title":"Chemopreventive and therapeutic effects of curcumin","volume":"223","author":"Duvoix","year":"2005","journal-title":"Cancer Lett."},{"key":"10.1016\/j.acthis.2019.03.007_bib0070","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0014-4886(83)90392-8","article-title":"Ultrastructural evidence of long-lasting cerebellar degeneration after early exposure to phenobarbital in mice","volume":"79","author":"Fishman","year":"1983","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.acthis.2019.03.007_bib0075","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1749-6632.2002.tb02099.x","article-title":"Cognitive impairment of rats caused by oxidative stress and aging and its prevention by vitamin E","volume":"959","author":"Fukui","year":"2002","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.acthis.2019.03.007_bib0080","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.expneurol.2004.01.025","article-title":"Therapeutic doses of topiramate are not toxic to the developing rat brain","volume":"187","author":"Glier","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.acthis.2019.03.007_bib0085","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2818.1987.tb02837.x","article-title":"The efficiency of systematic sampling in stereology and its prediction","volume":"147","author":"Gundersen","year":"1987","journal-title":"J. Microsc."},{"issue":"2","key":"10.1016\/j.acthis.2019.03.007_bib0090","first-page":"313","article-title":"Eff\u0131cacy, pharmacology, and adverse effects of antiepileptic drugs","volume":"19","author":"Holland","year":"2001","journal-title":"Epilepsy."},{"key":"10.1016\/j.acthis.2019.03.007_bib0095","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.eplepsyres.2009.09.019","article-title":"Antiepileptic drugs and brain development","volume":"88","author":"Ikonomidou","year":"2010","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.acthis.2019.03.007_bib0100","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00018-005-5348-0","article-title":"Antiepileptic drugs and the developing brain","volume":"63","author":"Kaindl","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.acthis.2019.03.007_bib0105","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1124\/jpet.107.123133","article-title":"Effects of lamotrigine alone and in combination with mk-801, phenobarbital, or phenytoin on cell death in the neonatal rat brain","volume":"322","author":"Katz","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.acthis.2019.03.007_bib0110","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1212\/01.WNL.0000156156.13641.BA","article-title":"Evidence of increased oxidative damage in subjects with mild cognitiveimpairment","volume":"64","author":"Keller","year":"2005","journal-title":"Neurolog."},{"issue":"1","key":"10.1016\/j.acthis.2019.03.007_bib0115","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1124\/jpet.107.126250","article-title":"Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy","volume":"323","author":"Kim","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.acthis.2019.03.007_bib0120","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neures.2011.12.009","article-title":"Valproic acid improves the tolerance for the stress in learned helplessness rats","volume":"72","author":"Kobayashi","year":"2012","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.acthis.2019.03.007_bib0125","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1046\/j.1365-2818.1997.2180777.x","article-title":"Estimation of the section thickness and optical disector height with a simple calibration method","volume":"187","author":"Korkmaz","year":"1997","journal-title":"J. Microsc."},{"key":"10.1016\/j.acthis.2019.03.007_bib0130","doi-asserted-by":"crossref","first-page":"75","DOI":"10.55730\/1300-0144.5273","article-title":"A morphometric study of the inferior olivary nucleus in rats treated prenatally with diclofenac sodium","volume":"26","author":"Korkmaz","year":"1996","journal-title":"Turk. J. Med. Sci."},{"key":"10.1016\/j.acthis.2019.03.007_bib0135","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1046\/j.1365-2818.2000.00749.x","article-title":"Simplified application of systematic field sampling and low-cost video recording set-up for viewing disector pairs-exemplified in the rat cochlear nucleu","volume":"200","author":"Korkmaz","year":"2000","journal-title":"J. Microsc."},{"key":"10.1016\/j.acthis.2019.03.007_bib0140","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.expneurol.2005.01.006","article-title":"Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain","volume":"193","author":"Mantheya","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.acthis.2019.03.007_bib0145","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.arr.2005.03.002","article-title":"Aging, stress and the hippocampus","volume":"4","author":"Miller","year":"2005","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.acthis.2019.03.007_bib0150","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0167-4943(01)00194-7","article-title":"The curcuma antioxidants: pharmacological effects and prospects for future clinical use","volume":"34","author":"Miquel","year":"2002","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.acthis.2019.03.007_bib0155","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/jmg.37.7.489","article-title":"A clinical study of 57 children with fetal anticonvulsant syndromes","volume":"37","author":"Moore","year":"2000","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.acthis.2019.03.007_bib0160","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.pharep.2014.09.006","article-title":"Protective effects of various dosage of curcumin against morphine induced apoptosis and oxidative stress in rat isolated hippocampus","volume":"67","author":"Motaghinejad","year":"2015","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.acthis.2019.03.007_bib0165","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.peptides.2007.11.020","article-title":"Dose dependent effects of ghrelin on pentylenetetrazoleinduced oxidative stress in a rat seizure model","volume":"29","author":"Obay","year":"2008","journal-title":"Peptides."},{"key":"10.1016\/j.acthis.2019.03.007_bib0170","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tips.2004.01.002","article-title":"Do pediatric drugs cause developing neurons to commit suicide?","volume":"25","author":"Olney","year":"2004","journal-title":"Trends Pharmacol. Science"},{"key":"10.1016\/j.acthis.2019.03.007_bib0175","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.nlm.2015.05.001","article-title":"Curcumin alleviates cisplatin-induced learning and memory impairments","volume":"123","author":"Oz","year":"2015","journal-title":"Neurobiol. Learn Mem."},{"issue":"10","key":"10.1016\/j.acthis.2019.03.007_bib0180","doi-asserted-by":"crossref","first-page":"695","DOI":"10.2165\/00023210-200216100-00004","article-title":"Pharmacological and therapeutic properties of valproate","volume":"16","author":"Perucca","year":"2002","journal-title":"CNS Drugs"},{"key":"10.1016\/j.acthis.2019.03.007_bib0185","first-page":"157","article-title":"Curcumin protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydro pyridine","volume":"10","author":"Rajeswari","year":"2006","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.acthis.2019.03.007_bib0190","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejphar.2010.07.022","article-title":"Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats","volume":"644","author":"Reeta","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.acthis.2019.03.007_bib0195","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrn1430","article-title":"The neurobiology of antiepileptic drugs","volume":"5","author":"Rogawski","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.acthis.2019.03.007_bib0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0361-9230(92)90002-F","article-title":"Hippocampal cholinergic alterations and related behavioral deficits after early exposure to phenobarbital","volume":"29","author":"Roger-Fuchs","year":"1992","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.acthis.2019.03.007_bib0205","article-title":"Effects of prenatal PPAR-\u03b3 agonist rosiglitazone exposure on rat hippocampus development in a time-dependent manner: a stereological and histopathological study","author":"Sa\u011f\u0131r","year":"2017","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.acthis.2019.03.007_bib0210","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.arr.2004.05.002","article-title":"Reactive oxygen species and synaptic plasticity in the aging Hippocampus","volume":"3","author":"Serrano","year":"2004","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.acthis.2019.03.007_bib0215","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.intimp.2010.08.014","article-title":"Immunomodulatory and therapeutic activity of curcumin","volume":"11","author":"Srivastava","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.acthis.2019.03.007_bib0220","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-2818.1984.tb02501.x","article-title":"The unbiased estimation of number and size of arbitrary particles using the disector","volume":"134","author":"Sterio","year":"1984","journal-title":"J. Microsc."},{"key":"10.1016\/j.acthis.2019.03.007_bib0225","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1016\/j.lfs.2005.08.028","article-title":"Prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin","volume":"78","author":"Sumanont","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.acthis.2019.03.007_bib0230","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ejphar.2009.11.053","article-title":"A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis","volume":"628","author":"Tham","year":"2010","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.acthis.2019.03.007_bib0235","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.lfs.2003.06.042","article-title":"Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats","volume":"74","author":"Thiyagarajan","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.acthis.2019.03.007_bib0240","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejphar.2007.08.045","article-title":"The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptor","volume":"578","author":"Wang","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.acthis.2019.03.007_bib0245","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.aanat.2016.04.029","article-title":"Kaempferia parviflora extract ameliorates the cognitive impairments and the reduction in cell proliferation induced by valproic acid treatment in rats","volume":"206","author":"Welbat","year":"2016","journal-title":"Annals of Anatomy."},{"key":"10.1016\/j.acthis.2019.03.007_bib0250","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/ar.1092310411","article-title":"Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator","volume":"231","author":"West","year":"1991","journal-title":"Anat. Rec."},{"issue":"6","key":"10.1016\/j.acthis.2019.03.007_bib0255","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1212\/01.WNL.0000154516.43630.C5","article-title":"Increased rate of major malformations in offspring exposed to valproate during pregnancy","volume":"64","author":"Wyszynski","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.acthis.2019.03.007_bib0260","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1074\/jbc.M404751200","article-title":"Curcumin inhibits formationof amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in-vivo","volume":"280","author":"Yang","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.acthis.2019.03.007_bib0265","first-page":"179","article-title":"Determination of age-related volume changes in rat brain by Cavalieri\u2019s Method","volume":"25","author":"Y\u00fccel","year":"2003","journal-title":"Erciyes Medical Journal."},{"key":"10.1016\/j.acthis.2019.03.007_bib0270","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.brainres.2008.06.117","article-title":"Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats","volume":"1229","author":"Zhao","year":"2008","journal-title":"Brain Res."}],"container-title":["Acta Histochemica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128119300959?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128119300959?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T18:09:32Z","timestamp":1758737372000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065128119300959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0065128119300959"],"URL":"https:\/\/doi.org\/10.1016\/j.acthis.2019.03.007","relation":{},"ISSN":["0065-1281"],"issn-type":[{"value":"0065-1281","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stereological examination of curcumin\u2019s effects on hippocampal damage caused by the anti-epileptic drugs phenobarbital and valproic acid in the developing rat brain","name":"articletitle","label":"Article Title"},{"value":"Acta Histochemica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acthis.2019.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}