{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:07:10Z","timestamp":1767924430656,"version":"3.49.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008532","name":"Universidade Federal do Rio Grande do Norte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008093","name":"Schulich School of Medicine and Dentistry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Histochemica"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.acthis.2019.151452","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T17:07:31Z","timestamp":1569258451000},"page":"151452","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Actinic cheilitis: Morphometric parameters and its relationship with the degree of epithelial dysplasia"],"prefix":"10.1016","volume":"122","author":[{"given":"Amanda Katarinny Goes","family":"Gonzaga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Porpino","family":"Mafra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leorik Pereira","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roseana","family":"de Almeida Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9lia Batista","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le\u00e3o Pereira","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.acthis.2019.151452_bib0005","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/odi.12484","article-title":"A comparative study using WHO and binary oral epithelial dysplasia grading systems in actinic cheilitis","volume":"22","author":"C\u00e2mara","year":"2016","journal-title":"Oral Dis."},{"key":"10.1016\/j.acthis.2019.151452_bib0010","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.1364\/BOE.8.005218","article-title":"Raman spectral post-processing for oral tissue discrimination\u2014a step for an automatized diagnostic system","volume":"8","author":"Carvalho","year":"2017","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.acthis.2019.151452_bib0015","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.joms.2006.09.016","article-title":"Actinic cheilitis: clinical and histological features","volume":"66","author":"Cavalcante","year":"2008","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.acthis.2019.151452_bib0020","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1364\/BOE.7.004210","article-title":"Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis","volume":"7","author":"Cosci","year":"2016","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.acthis.2019.151452_bib0025","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/ijd.12332","article-title":"Actinic cheilitis: clinicopathologic profile and association with degree of dysplasia","volume":"53","author":"De Santana Sarmento","year":"2014","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.acthis.2019.151452_bib0030","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1601-0825.2012.01910.x","article-title":"Prevalence and factors associated to actinic cheilitis in beach workers","volume":"18","author":"De Souza Lucena","year":"2012","journal-title":"Oral Dis."},{"key":"10.1016\/j.acthis.2019.151452_bib0035","series-title":"WHO Classification of Head and Neck Tumours","first-page":"112","author":"El-Naggar","year":"2017"},{"key":"10.1016\/j.acthis.2019.151452_bib0040","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-0714.2004.0037n.x","article-title":"Interobserver reliability in the histopathologic diagnosis of oral pre-malignant and malignant lesions","volume":"33","author":"Fischer","year":"2004","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.acthis.2019.151452_bib0045","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.bjoms.2014.06.010","article-title":"Optical diagnostic techniques for use in lesions of the head and neck: review of the latest developments","volume":"52","author":"Green","year":"2014","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.acthis.2019.151452_bib0050","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.joms.2013.04.015","article-title":"Cyclo-oxygenase-2 expression is associated with vascular endothelial growth factor C expression and lymph node metastasis in oral squamous cell carcinoma","volume":"71","author":"Kono","year":"2013","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.acthis.2019.151452_bib0055","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/jop.12410","article-title":"Pattern of galectins expression in actinic cheilitis with different risks of malignant transformation","volume":"45","author":"Lopes","year":"2016","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.acthis.2019.151452_bib0060","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1590\/abd1806-4841.20153848","article-title":"Clinicopathological profile and management of 161 cases of actinic cheilitis","volume":"90","author":"Lopes","year":"2015","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.acthis.2019.151452_bib0065","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12105-017-0792-3","article-title":"Update from the 4th edition of the world health organization of head and neck tumours: tumours of the oral cavity and mobile tongue","volume":"11","author":"M\u00fcller","year":"2017","journal-title":"Head Neck Pathol."},{"key":"10.1016\/j.acthis.2019.151452_bib0070","article-title":"Evaluation of actinic cheilitis using fluorescence lifetime spectroscopy","volume":"9703","author":"Nogueira","year":"2016","journal-title":"Proc. SPIE"},{"key":"10.1016\/j.acthis.2019.151452_bib0075","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.oooo.2016.05.005","article-title":"Disordered arrangements of basal cells as a prognostic factor for oral epithelial dysplasia: a morphometric study of 96 cases","volume":"122","author":"Okamura","year":"2016","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"10.1016\/j.acthis.2019.151452_bib0080","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1590\/abd1806-4841.20153302","article-title":"Histopathological analysis of the therapeutic response to cryotherapy with liquid nitrogen in patients with multiple actinic keratosis","volume":"90","author":"Oliveira","year":"2015","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.acthis.2019.151452_bib0085","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/odi.12597","article-title":"Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems","volume":"23","author":"Pilati","year":"2017","journal-title":"Oral Dis."},{"key":"10.1016\/j.acthis.2019.151452_bib0090","doi-asserted-by":"crossref","first-page":"7635","DOI":"10.1007\/s13277-014-1989-7","article-title":"Ki-67, TGF-\u03b21, and elastin content are significantly altered in lip carcinogenesis","volume":"35","author":"Salvadori","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.acthis.2019.151452_bib0095","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1468-3083.2010.03777.x","article-title":"Non-invasive diagnosis and monitoring of actinic cheilitis with reflectance confocal microscopy","volume":"25","author":"Ulrich","year":"2011","journal-title":"J. Eur. Acad. Dermatol. Venereol."}],"container-title":["Acta Histochemica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128119302107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128119302107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T03:59:33Z","timestamp":1762228773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065128119302107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0065128119302107"],"URL":"https:\/\/doi.org\/10.1016\/j.acthis.2019.151452","relation":{},"ISSN":["0065-1281"],"issn-type":[{"value":"0065-1281","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Actinic cheilitis: Morphometric parameters and its relationship with the degree of epithelial dysplasia","name":"articletitle","label":"Article Title"},{"value":"Acta Histochemica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acthis.2019.151452","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"151452"}}