{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:13:45Z","timestamp":1772748825912,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2009\/18440-1"],"award-info":[{"award-number":["2009\/18440-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/14464-9"],"award-info":[{"award-number":["2013\/14464-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Histochemica"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.acthis.2020.151635","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T21:50:14Z","timestamp":1601416214000},"page":"151635","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["CCNA1 gene as a potential diagnostic marker in papillary thyroid cancer"],"prefix":"10.1016","volume":"122","author":[{"given":"Raissa Monteiro","family":"da Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce Nascimento","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Uno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Chammas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Aur\u00e9lio Vamondes","family":"Kulcsar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Barros","family":"Sant\u2019Anna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata de Azevedo","family":"Canevari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.acthis.2020.151635_bib0005","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s12022-017-9496-1","article-title":"Comparison of consecutive results from fine needle aspiration and core needle biopsy in thyroid nodules","volume":"28","author":"Ahn","year":"2017","journal-title":"Endocr. Pathol."},{"key":"10.1016\/j.acthis.2020.151635_bib0010","doi-asserted-by":"crossref","first-page":"604","DOI":"10.21037\/gs.2016.12.06","article-title":"Robotic retroauricular thyroid surgery","volume":"5","author":"Alabbas","year":"2016","journal-title":"Gland Surg."},{"key":"10.1016\/j.acthis.2020.151635_bib0015","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4174\/astr.2017.92.3.117","article-title":"Significance of micrometastases in the calculation of the lymph node ratio for papillary thyroid cancer","volume":"92","author":"Chang","year":"2017","journal-title":"Ann. Surg. Treat. Res."},{"key":"10.1016\/j.acthis.2020.151635_bib0020","doi-asserted-by":"crossref","DOI":"10.3233\/CBM-170784","article-title":"Predictive gene signatures of nodal metastasis in papillary thyroid carcinoma","author":"Choi","year":"2018","journal-title":"Cancer Biomark."},{"key":"10.1016\/j.acthis.2020.151635_bib0025","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s13402-017-0368-y","article-title":"Concomitant high expression of ER\u03b136, GRP78 and GRP94 is associated with aggressive papillary thyroid cancer behavior","volume":"41","author":"Dai","year":"2018","journal-title":"Cell. Oncol."},{"key":"10.1016\/j.acthis.2020.151635_bib0030","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s13304-017-0468-2","article-title":"Surgical approach to level VI in papillary thyroid carcinoma: an overview","volume":"69","author":"De Crea","year":"2017","journal-title":"Updates Surg."},{"key":"10.1016\/j.acthis.2020.151635_bib0035","first-page":"5399","article-title":"Predictive value of sphingosine kinase 1 expression in papillary thyroid carcinoma","volume":"37","author":"Do","year":"2017","journal-title":"Anticancer Res."},{"key":"10.1016\/j.acthis.2020.151635_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-015-1348-0","article-title":"Clusterin transcript variants expression in thyroid tumor: A potential marker of malignancy?","volume":"15","author":"Fuzio","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.acthis.2020.151635_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-017-3475-2","article-title":"Trop2 enhances invasion of thyroid cancer by inducing MMP2 through ERK and JNK pathways","volume":"17","author":"Guan","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.acthis.2020.151635_bib0050","first-page":"97","article-title":"Classification and general considerations of thyroid Cancer","author":"Hiroshi","year":"2018","journal-title":"Forsch. heute \u2013 Zukunft morgen"},{"key":"10.1016\/j.acthis.2020.151635_bib0055","first-page":"T301","article-title":"Molecular approaches to thyroid cancer diagnosis","volume":"21","author":"Hsiao","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.acthis.2020.151635_bib0060","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3233\/CBM-161723","article-title":"Expressions of miRNAs in papillary thyroid carcinoma and their associations with the clinical characteristics of PTC","volume":"18","author":"Hu","year":"2017","journal-title":"Cancer Biomark."},{"key":"10.1016\/j.acthis.2020.151635_bib0065","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejca.2016.08.007","article-title":"CyclinA1 expression and paclitaxel resistance in human ovarian cancer cells","volume":"67","author":"Huang","year":"2016","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.acthis.2020.151635_bib0070","doi-asserted-by":"crossref","first-page":"69638","DOI":"10.18632\/oncotarget.11922","article-title":"Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma","volume":"7","author":"Jung","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.acthis.2020.151635_bib0075","first-page":"1","article-title":"Cyclin A1 modulates the expression of vascular endothelial growth factor and promotes hormone-dependent growth and angiogenesis of breast cancer","volume":"8","author":"Khaja","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.acthis.2020.151635_bib0080","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.1158\/1078-0432.CCR-14-0297","article-title":"Dnamethylation status of key cell-cycle regulators such as CDKNA2\/P16 and CCNA1 correlates with treatment response to doxorubicin and 5-fluorouracil in locally advanced breast tumors","volume":"20","author":"Klajic","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.acthis.2020.151635_bib0085","doi-asserted-by":"crossref","first-page":"31780","DOI":"10.18632\/oncotarget.5566","article-title":"Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2","volume":"6","author":"Liang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.acthis.2020.151635_bib0090","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/bjs.7330","article-title":"Detection of cervical metastatic lymph nodes in papillary thyroid carcinoma by Fourier transform infrared spectroscopy","volume":"98","author":"Liu","year":"2011","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.acthis.2020.151635_bib0095","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s11010-013-1801-9","article-title":"Cyclin A1 is a transcriptional target of PITX2 and overexpressed in papillary thyroid carcinoma","volume":"384","author":"Liu","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.acthis.2020.151635_bib0100","doi-asserted-by":"crossref","first-page":"R499","DOI":"10.1530\/ERC-16-0372","article-title":"Application of molecular biology of differentiated thyroid cancer for clinical prognostication","volume":"23","author":"Marotta","year":"2016","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.acthis.2020.151635_bib0105","doi-asserted-by":"crossref","first-page":"6485","DOI":"10.3892\/ol.2017.7072","article-title":"Expression of cancer\/testis antigens MAGE-A, MAGE-C1, GAGE and CTAG1B in benign and malignant thyroid diseases","volume":"14","author":"Melo","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.acthis.2020.151635_bib0110","first-page":"1","article-title":"Methylated host cell gene promoters and human papillomavirus type 16 and 18 predicting cervical lesions and cancer","volume":"10","author":"MilutinGa\u0161perov","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.acthis.2020.151635_bib0115","doi-asserted-by":"crossref","first-page":"158","DOI":"10.5858\/arpa.2014-0468-RA","article-title":"Five top stories in thyroid pathology","volume":"140","author":"Moghaddam","year":"2016","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.acthis.2020.151635_bib0120","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/his.12499","article-title":"Cyclin A1 expression predicts progression in pT1 urothelial carcinoma of bladder: a tissue microarray study of 149 patients treated by transurethral resection","volume":"66","author":"Munari","year":"2015","journal-title":"Histopathology"},{"key":"10.1016\/j.acthis.2020.151635_bib0125","doi-asserted-by":"crossref","DOI":"10.3348\/kjr.2017.18.1.217","article-title":"Core needle biopsy of the thyroid: 2016 consensus statement and recommendations from Korean society of thyroid radiology","author":"Na","year":"2017","journal-title":"Korean J. Radiol."},{"key":"10.1016\/j.acthis.2020.151635_bib0130","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1530\/ERC-16-0432","article-title":"Thyroid nodules and cancer management guidelines: comparisons and controversies","volume":"24","author":"Nabhan","year":"2017","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.acthis.2020.151635_bib0135","first-page":"30","article-title":"Diagnosis and treatment of patients with thyroid cancer","volume":"8","author":"Nguyen","year":"2015","journal-title":"Am. Heal. Drug Benefits"},{"key":"10.1016\/j.acthis.2020.151635_bib0140","first-page":"5","article-title":"BRAF vs RAS oncogenes: are mutations of the same pathway equal? Differential signalling and therapeutic implications","author":"Oikonomou","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.acthis.2020.151635_bib0145","first-page":"1","article-title":"Predictive factors of right paraesophageal lymph node metastasis in papillary thyroid carcinoma: single center experience and meta-Analysis","volume":"12","author":"Park","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.acthis.2020.151635_bib0150","first-page":"16","volume":"29","author":"Pfaffl","year":"2001"},{"key":"10.1016\/j.acthis.2020.151635_bib0155","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s40618-017-0735-6","article-title":"The role of microRNAs in different types of thyroid carcinoma: a comprehensive analysis to find new miRNA supplementary therapies","volume":"41","author":"Pishkari","year":"2018","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.acthis.2020.151635_bib0160","first-page":"329","article-title":"Thyroid nodules","volume":"96","author":"Popoveniuc","year":"2012","journal-title":"Med. Clin. NA"},{"key":"10.1016\/j.acthis.2020.151635_bib0165","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1089\/thy.2011.0169","article-title":"Three-gene molecular diagnostic model for thyroid Cancer","volume":"22","author":"Prasad","year":"2012","journal-title":"Thyroid"},{"key":"10.1016\/j.acthis.2020.151635_bib0170","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1056\/NEJMoa1406470","article-title":"Lenvatinib versus placebo in radioiodine-refractory thyroid cancer","volume":"372","author":"Schlumberger","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.acthis.2020.151635_bib0175","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000016659","article-title":"Occult papillary thyroid cancer presenting as cystic metastasis of the lateral neck","volume":"98","author":"Schwaiger","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.acthis.2020.151635_bib0180","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/modpathol.2011.188","article-title":"The new molecular markers DDIT3, STT3A, ARG2 and FAM129A are not useful in diagnosing thyroid follicular tumors","volume":"25","author":"Sigstad","year":"2012","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.acthis.2020.151635_bib0185","series-title":"XXII Encontro Latino Americano de Inicia\u00e7\u00e3o Cient\u00edfica, XVIII Encontro Latino Americano de P\u00f3s-Gradua\u00e7\u00e3o e VIII Encontro de Inicia\u00e7\u00e3o \u00e0 Doc\u00eancia - Universidade do Vale do Para\u00edba, 2018. S\u00e3o Jos\u00e9 dos Campos. Analls","first-page":"2018","article-title":"Poder Diagn\u00f3stico de genes da via MAPK\/ERK em les\u00f5es de tireoide","author":"Silva","year":"2018"},{"key":"10.1016\/j.acthis.2020.151635_bib0190","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00428-013-1521-2","article-title":"Prognostic biomarkers in thyroid cancer","volume":"464","author":"Soares","year":"2014","journal-title":"Virchows Arch."},{"key":"10.1016\/j.acthis.2020.151635_bib0195","first-page":"49","article-title":"Papillary thyroid carcinoma presenting as a cystic neck lesion: case series","volume":"30","author":"Subha","year":"2018","journal-title":"Iran. J. Otorhinolaryngol."},{"key":"10.1016\/j.acthis.2020.151635_bib0200","first-page":"1","article-title":"Effects of first radioiodine ablation on functions of salivary glands in patients with differentiated thyroid cancer","volume":"96","author":"Upadhyaya","year":"2017","journal-title":"Medicine (United States)"},{"key":"10.1016\/j.acthis.2020.151635_bib0205","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.22293","article-title":"Overexpression miR-211-5p hinders the proliferation, migration, and invasion of thyroid tumor cells by downregulating SOX11","volume":"32","author":"Wang","year":"2018","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.acthis.2020.151635_bib0210","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.oraloncology.2007.05.008","article-title":"Promoter hypermethylation of CCNA1, RARRES1, and HRASLS3 in nasopharyngeal carcinoma","volume":"44","author":"Yanatatsaneejit","year":"2008","journal-title":"Oral Oncol."},{"key":"10.1016\/j.acthis.2020.151635_bib0215","first-page":"2015","article-title":"Correlation of CCNA1 promoter methylation with malignant tumors: a meta-analysis introduction","author":"Yang","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.acthis.2020.151635_bib0220","first-page":"7799","article-title":"MicroRNA-139 targets fibronectin 1 to inhibit papillary thyroid carcinoma progression","volume":"14","author":"Ye","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.acthis.2020.151635_bib0225","doi-asserted-by":"crossref","DOI":"10.1530\/JOE-17-0266","article-title":"Key signaling pathways in thyroid cancer","author":"Zaballos","year":"2017","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.acthis.2020.151635_bib0230","first-page":"1","article-title":"Plasma lncRNA GAS8-AS1 as a potential biomarker of papillary thyroid carcinoma in chinese patients","volume":"2017","author":"Zhang","year":"2017","journal-title":"Int. J. Endocrinol."}],"container-title":["Acta Histochemica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128120301343?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128120301343?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T18:12:03Z","timestamp":1758737523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065128120301343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0065128120301343"],"URL":"https:\/\/doi.org\/10.1016\/j.acthis.2020.151635","relation":{},"ISSN":["0065-1281"],"issn-type":[{"value":"0065-1281","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CCNA1 gene as a potential diagnostic marker in papillary thyroid cancer","name":"articletitle","label":"Article Title"},{"value":"Acta Histochemica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acthis.2020.151635","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"151635"}}