{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:21:06Z","timestamp":1758759666762,"version":"3.44.0"},"reference-count":86,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Histochemica"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.acthis.2022.151960","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T13:42:40Z","timestamp":1664804560000},"page":"151960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adrenal histological and functional changes after hepatic encephalopathy: From mice model to an integrative bioinformatics analysis"],"prefix":"10.1016","volume":"124","author":[{"given":"Ali","family":"Sepehri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gila Pirzad","family":"Jahromi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Shahbazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedayat","family":"Sahraei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boshra","family":"Hatef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gholam Hossein","family":"Meftahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajad Sahab","family":"Negah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.acthis.2022.151960_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19051308","article-title":"Insulin-Like Growth Factor (IGF) system in liver diseases","volume":"19","author":"Adamek","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"146","key":"10.1016\/j.acthis.2022.151960_bib2","doi-asserted-by":"crossref","DOI":"10.3791\/59587","article-title":"Determining bile duct density in the mouse liver","author":"Adams","year":"2019","journal-title":"J. Vis. Exp.: JoVE"},{"issue":"7","key":"10.1016\/j.acthis.2022.151960_bib3","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jnr.22311","article-title":"Chronic hyperammonemia alters the circadian rhythms of corticosteroid hormone levels and of motor activity in rats","volume":"88","author":"Ahabrach","year":"2010","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.acthis.2022.151960_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029531","article-title":"A Switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease","volume":"7","author":"Ahmed","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.acthis.2022.151960_bib5","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.jceh.2014.06.004","article-title":"Pathogenesis of hepatic encephalopathy: role of ammonia and systemic inflammation","volume":"5","author":"Aldridge","year":"2015","journal-title":"J. Clin. Exp. Hepatol."},{"key":"10.1016\/j.acthis.2022.151960_bib6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.5005\/jp-journals-10018-1040","article-title":"Features of hormonal disturbances in cirrhotic patients with hepatic encephalopathy","volume":"2","author":"Arafa","year":"2012","journal-title":"Eur. J. hepato-Gastroenterol."},{"issue":"4","key":"10.1016\/j.acthis.2022.151960_bib7","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.jhep.2017.11.005","article-title":"Hepatic encephalopathy: classification and treatment","volume":"68","author":"Bajaj","year":"2018","journal-title":"J. Hepatol."},{"issue":"D1","key":"10.1016\/j.acthis.2022.151960_bib8","doi-asserted-by":"crossref","first-page":"D1067","DOI":"10.1093\/nar\/gkr968","article-title":"GeneWeaver: a web-based system for integrative functional genomics","volume":"40","author":"Baker","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.acthis.2022.151960_bib9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12974-020-01746-z","article-title":"Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-\u03baB pathway","volume":"17","author":"Balzano","year":"2020","journal-title":"J. Neuroinflamm."},{"issue":"3","key":"10.1016\/j.acthis.2022.151960_bib10","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.jhep.2019.01.008","article-title":"Chronic hyperammonemia induces peripheral inflammation that leads to cognitive impairment in rats: reversed by anti-TNF-\u03b1 treatment","volume":"73","author":"Balzano","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.acthis.2022.151960_bib11","unstructured":"bdel Moety, A.A., Mansour, A.R., Azzam, E.Z., Elsayed, R.A., 2016. Comparative Study between Serum and Salivary Cortisol Levels to Assess Adrenal Cortisol Insufficiency in Patients with Cirrhosis."},{"issue":"2","key":"10.1016\/j.acthis.2022.151960_bib12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jhep.2003.12.007","article-title":"Infection, inflammation and hepatic encephalopathy, synergism redefined","volume":"40","author":"Blei","year":"2004","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.acthis.2022.151960_bib13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/10253890.2019.1610742","article-title":"Sex-dependent effects of MC4R genotype on HPA axis tone: implications for stress-associated cardiometabolic disease","volume":"22","author":"Chaffin","year":"2019","journal-title":"Stress (Amst., Neth. )"},{"issue":"4","key":"10.1016\/j.acthis.2022.151960_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1365-2613.2008.00576.x","article-title":"Single dose intravenous thioacetamide administration as a model of acute liver damage in rats","volume":"89","author":"Chen","year":"2008","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.acthis.2022.151960_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhepr.2021.100352","article-title":"The neurogliovascular unit in hepatic encephalopathy","author":"Claeys","year":"2021","journal-title":"JHEP Rep."},{"issue":"1\u20132","key":"10.1016\/j.acthis.2022.151960_bib16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0303-7207(00)00407-X","article-title":"GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant","volume":"173","author":"Cole","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.acthis.2022.151960_bib17","series-title":"Encyclopedia of Neuroscience","first-page":"1139","article-title":"Proopiomelanocortin","author":"Day","year":"2009"},{"issue":"7","key":"10.1016\/j.acthis.2022.151960_bib18","article-title":"Environmental enrichment rescues female-specific hyperactivity of the hypothalamic-pituitary-adrenal axis in a model of Huntington's disease","volume":"2","author":"Du","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.acthis.2022.151960_bib19","first-page":"EJ15","article-title":"Resveratrol alleviates endotoxemia-associated adrenal insufficiency by suppressing oxidative\/nitrative stress","author":"Duan","year":"2016","journal-title":"Endocr. J."},{"key":"10.1016\/j.acthis.2022.151960_bib20","unstructured":"Dutt, M., Wehrle, C.J., Jialal, I., 2020. Physiology, adrenal gland. StatPearls [Internet]."},{"issue":"4","key":"10.1016\/j.acthis.2022.151960_bib21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1677\/JME-08-0189","article-title":"Telomeres and telomerase in adrenocortical tissue maintenance, carcinogenesis, and aging","volume":"43","author":"Else","year":"2009","journal-title":"J. Mol. Endocrinol."},{"issue":"7","key":"10.1016\/j.acthis.2022.151960_bib22","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1073\/pnas.0230450100","article-title":"Insulin-degrading enzyme regulates the levels of insulin, amyloid \u03b2-protein, and the \u03b2-amyloid precursor protein intracellular domain in vivo","volume":"100","author":"Farris","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.acthis.2022.151960_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jhep.2010.06.034","article-title":"Assessment of adrenocortical reserve in stable patients with cirrhosis","volume":"54","author":"Fede","year":"2011","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.acthis.2022.151960_bib24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3727\/105221618X15287315176503","article-title":"Direct comparison of the thioacetamide and azoxymethane models of type A hepatic encephalopathy in mice","volume":"18","author":"Grant","year":"2018","journal-title":"Gene Expr."},{"issue":"4","key":"10.1016\/j.acthis.2022.151960_bib25","doi-asserted-by":"crossref","DOI":"10.1515\/jib-2021-0031","article-title":"Glioblastoma gene network reconstruction and ontology analysis by online bioinformatics tools","volume":"18","author":"Gubanova","year":"2021","journal-title":"J. Integr. Bioinforma."},{"key":"10.1016\/j.acthis.2022.151960_bib26","first-page":"1","article-title":"Impact of non-synonymous mutations on the structure and function of telomeric repeat binding factor 1","author":"Habib","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"2","key":"10.1016\/j.acthis.2022.151960_bib27","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1053\/jhep.2002.34514","article-title":"The clinical importance of adrenal insufficiency in acute hepatic dysfunction","volume":"36","author":"Harry","year":"2002","journal-title":"Hepatol. (Baltim. Md.)"},{"issue":"10","key":"10.1016\/j.acthis.2022.151960_bib28","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.3748\/wjg.v20.i10.2595","article-title":"Management of thrombocytopenia due to liver cirrhosis: a review","volume":"20","author":"Hayashi","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"5","key":"10.1016\/j.acthis.2022.151960_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12050403","article-title":"NAFLD aggravates septic shock due to inadequate adrenal response and 11\u03b2-HSDs dysregulation in rats","volume":"12","author":"Huang","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.acthis.2022.151960_bib30","doi-asserted-by":"crossref","DOI":"10.1136\/jim-2021-002213","article-title":"Telomere length in patients with alcohol-associated liver disease: a brief report","author":"Huda","year":"2022","journal-title":"J. Invest. Med."},{"issue":"14","key":"10.1016\/j.acthis.2022.151960_bib31","first-page":"5264","article-title":"Interferon can block telomere erosion and in rare cases result in hepatocellular carcinoma development with telomeric repeat binding factor 1 overexpression in chronic hepatitis C","volume":"9","author":"Igarashi","year":"2003","journal-title":"Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.acthis.2022.151960_bib32","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1016\/j.ajpath.2011.07.014","article-title":"Melanocortin 4 receptor-deficient mice as a novel mouse model of nonalcoholic steatohepatitis","volume":"179","author":"Itoh","year":"2011","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.acthis.2022.151960_bib33","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.nbd.2010.10.021","article-title":"NF-\u03baB in the mechanism of brain edema in acute liver failure: studies in transgenic mice","volume":"41","author":"Jayakumar","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.acthis.2022.151960_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124582","article-title":"Role of ALADIN in human adrenocortical cells for oxidative stress response and steroidogenesis","volume":"10","author":"J\u00fchlen","year":"2015","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.acthis.2022.151960_bib35","article-title":"Compensation for chronic oxidative stress in ALADIN null mice","volume":"7","author":"J\u00fchlen","year":"2018","journal-title":"Biol. Open"},{"issue":"8","key":"10.1016\/j.acthis.2022.151960_bib36","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1210\/jc.2002-020965","article-title":"Diagnostic and prognostic value of fas and telomeric-repeat binding factor-1 genes in adrenal tumors","volume":"88","author":"Kanauchi","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.acthis.2022.151960_bib37","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1001\/jamainternmed.2019.2248","article-title":"Association of weight loss interventions with changes in biomarkers of nonalcoholic fatty liver disease: a systematic review and meta-analysis","volume":"179","author":"Koutoukidis","year":"2019","journal-title":"JAMA Intern. Med."},{"issue":"W1","key":"10.1016\/j.acthis.2022.151960_bib38","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.acthis.2022.151960_bib39","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.3892\/mmr.2017.6265","article-title":"Insulin-like growth factor 1 receptor-mediated cell survival in hypoxia depends on the promotion of autophagy via suppression of the PI3K\/Akt\/mTOR signaling pathway","volume":"15","author":"Liu","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"7","key":"10.1016\/j.acthis.2022.151960_bib40","doi-asserted-by":"crossref","first-page":"983","DOI":"10.2174\/1574893616666210528162945","article-title":"Long non-coding RNAs in heart failure: a deep belief network based cluster analysis","volume":"16","author":"Madhavan","year":"2021","journal-title":"Curr. Bioinforma."},{"issue":"4","key":"10.1016\/j.acthis.2022.151960_bib41","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jcmgh.2019.08.002","article-title":"Ammonia-induced brain edema requires macrophage and T cell expression of toll-like receptor 9","volume":"8","author":"Manakkat Vijay","year":"2019","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"7","key":"10.1016\/j.acthis.2022.151960_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102351","article-title":"Low levels of blood lipids are associated with etiology and lethal outcome in acute liver failure","volume":"9","author":"Manka","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.acthis.2022.151960_bib43","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1210\/me.2015-1087","article-title":"Suppression of the HPA axis during cholestasis can be attributed to hypothalamic bile acid signaling","volume":"29","author":"McMillin","year":"2015","journal-title":"Mol. Endocrinol. (Baltim., Md.)"},{"key":"10.1016\/j.acthis.2022.151960_bib44","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3389\/fnins.2017.00617","article-title":"Bile acid signaling pathways from the enterohepatic circulation to the central nervous system","volume":"11","author":"Mertens","year":"2017","journal-title":"Front. Neurosci."},{"issue":"4","key":"10.1016\/j.acthis.2022.151960_bib45","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0739-7240(94)90002-7","article-title":"Increased free cortisol in plasma of dogs with portosystemic encephalopathy (PSE)","volume":"11","author":"Meyer","year":"1994","journal-title":"Domest. Anim. Endocrinol."},{"issue":"4","key":"10.1016\/j.acthis.2022.151960_bib46","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1590\/S0004-282X2010000400022","article-title":"A thioacetamide-induced hepatic encephalopathy model in C57BL\/6 mice: a behavioral and neurochemical study","volume":"68","author":"Miranda","year":"2010","journal-title":"Arq. De. neuro-Psiquiatr."},{"issue":"5","key":"10.1016\/j.acthis.2022.151960_bib47","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jhep.2009.10.037","article-title":"Bile acids modulate glucocorticoid metabolism and the hypothalamic\u2013pituitary\u2013adrenal axis in obstructive jaundice","volume":"52","author":"Mneilly","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.acthis.2022.151960_bib48","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/2354253","article-title":"Evaluation of adrenal function in nonhospitalized patients with cirrhosis","volume":"2017","author":"Moini","year":"2017","journal-title":"Can. J. Gastroenterol. Hepatol."},{"issue":"7","key":"10.1016\/j.acthis.2022.151960_bib49","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s40273-018-0641-6","article-title":"Systematic review of the economic burden of overt hepatic encephalopathy and pharmacoeconomic impact of rifaximin","volume":"36","author":"Neff","year":"2018","journal-title":"PharmacoEconomics"},{"issue":"1","key":"10.1016\/j.acthis.2022.151960_bib50","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JOE-12-0501","article-title":"Melanocortin receptor accessory proteins in adrenal gland physiology and beyond","volume":"217","author":"Novoselova","year":"2013","journal-title":"J. Endocrinol."},{"issue":"1","key":"10.1016\/j.acthis.2022.151960_bib51","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0002-9440(10)62233-X","article-title":"Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 Is related to telomere shortening during human multistep hepatocarcinogenesis","volume":"166","author":"Oh","year":"2005","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.acthis.2022.151960_bib52","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1530\/ERC-15-0426","article-title":"IGF2 and IGF1R in pediatric adrenocortical tumors: roles in metastasis and steroidogenesis","volume":"23","author":"Peixoto Lira","year":"2016","journal-title":"Endocr. -Relat. Cancer"},{"issue":"2","key":"10.1016\/j.acthis.2022.151960_bib53","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1172\/JCI104043","article-title":"Adrenocortical steroid metabolism and adrenal cortical function in liver disease","volume":"39","author":"Peterson","year":"1960","journal-title":"J. Clin. Investig."},{"issue":"14","key":"10.1016\/j.acthis.2022.151960_bib54","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1080\/15384101.2015.1046647","article-title":"Modulation of insulin degrading enzyme activity and liver cell proliferation","volume":"14","author":"Pivovarova","year":"2015","journal-title":"Cell Cycle (Georget. Tex.)"},{"key":"10.1016\/j.acthis.2022.151960_bib55","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.trsl.2018.07.005","article-title":"Silencing of telomere-binding protein adrenocortical dysplasia (ACD) homolog enhances radiosensitivity in glioblastoma cells","volume":"202","author":"Polito","year":"2018","journal-title":"Transl. Res."},{"key":"10.1016\/j.acthis.2022.151960_bib56","first-page":"221","article-title":"Oxidative stress and adrenal insufficiency","author":"Prasad","year":"2014","journal-title":"J. Endocrinol."},{"issue":"1","key":"10.1016\/j.acthis.2022.151960_bib57","doi-asserted-by":"crossref","first-page":"G182","DOI":"10.1152\/ajpgi.00205.2011","article-title":"Suppression of the HPA axis during extrahepatic biliary obstruction induces cholangiocyte proliferation in the rat","volume":"302","author":"Quinn","year":"2012","journal-title":"Am. J. Physiol. -Gastrointest. Liver Physiol."},{"issue":"6","key":"10.1016\/j.acthis.2022.151960_bib58","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.dld.2014.01.159","article-title":"Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms","volume":"46","author":"Quinn","year":"2014","journal-title":"Dig. Liver Dis.: Off. J. Ital. Soc. Gastroenterol. Ital. Assoc. Study Liver"},{"issue":"1","key":"10.1016\/j.acthis.2022.151960_bib59","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/liv.14680","article-title":"Factors associated with health-related quality of life in patients with cirrhosis: a systematic review","volume":"41","author":"Rabiee","year":"2021","journal-title":"Liver Int.: Off. J. Int. Assoc. Study Liver"},{"issue":"11","key":"10.1016\/j.acthis.2022.151960_bib60","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nrm3461","article-title":"Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions","volume":"13","author":"Raices","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.acthis.2022.151960_bib61","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5005\/jp-journals-10018-1237","article-title":"Adrenal insufficiency in cirrhosis patients: evaluation of 108 case series","volume":"7","author":"Rakici","year":"2017","journal-title":"Eur. J. Hepato-Gastroenterol."},{"key":"10.1016\/j.acthis.2022.151960_bib62","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/936031","article-title":"Amplification of the insulin-like growth factor 1 receptor gene is a rare event in adrenocortical adenocarcinomas: searching for potential mechanisms of overexpression","volume":"2014","author":"Ribeiro","year":"2014","journal-title":"BioMed. Res. Int."},{"issue":"1","key":"10.1016\/j.acthis.2022.151960_bib63","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0739-7240(94)00005-L","article-title":"Chronic glucocorticoid excess and impaired osmoregulation of vasopressin release in dogs with hepatic encephalopathy","volume":"12","author":"Rothuizen","year":"1995","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.acthis.2022.151960_bib64","first-page":"2016","article-title":"The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins","author":"Rouillard","year":"2016","journal-title":"Database"},{"key":"10.1016\/j.acthis.2022.151960_bib65","article-title":"Use of the Open Field Maze to measure locomotor and anxiety-like behavior in mice","volume":"96","author":"Seibenhener","year":"2015","journal-title":"J. Vis. Exp.: JoVE"},{"key":"10.1016\/j.acthis.2022.151960_bib66","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.toxrep.2021.04.011","article-title":"Drug-induced-acute liver failure: a critical appraisal of the thioacetamide model for the study of hepatic encephalopathy","volume":"8","author":"Sepehrinezhad","year":"2021","journal-title":"Toxicol. Rep."},{"issue":"27","key":"10.1016\/j.acthis.2022.151960_bib67","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.3748\/wjg.v16.i27.3347","article-title":"Changing face of hepatic encephalopathy: role of inflammation and oxidative stress","volume":"16","author":"Seyan","year":"2010","journal-title":"World J. Gastroenterol.: WJG"},{"issue":"3","key":"10.1016\/j.acthis.2022.151960_bib68","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1017\/S1431927620001397","article-title":"Tramadol promotes oxidative stress, fibrosis, apoptosis, ultrastructural and biochemical alterations in the adrenal cortex of adult male rat with possible reversibility after withdrawal","volume":"26","author":"Shalaby","year":"2020","journal-title":"Microsc. Microanal."},{"issue":"1","key":"10.1016\/j.acthis.2022.151960_bib69","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11011-006-9042-1","article-title":"Role of ammonia and inflammation in minimal hepatic encephalopathy","volume":"22","author":"Shawcross","year":"2007","journal-title":"Metab. brain Dis."},{"key":"10.1016\/j.acthis.2022.151960_bib70","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1749-6632.2012.06633.x","article-title":"Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction","volume":"1261","author":"Silverman","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"11","key":"10.1016\/j.acthis.2022.151960_bib71","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.dld.2018.05.011","article-title":"Relative adrenal insufficiency in cirrhotic patients with ascites (hepatoadrenal syndrome)","volume":"50","author":"Singh","year":"2018","journal-title":"Dig. Liver Dis.: Off. J. Ital. Soc. Gastroenterol. Ital. Assoc. Study Liver"},{"issue":"4","key":"10.1016\/j.acthis.2022.151960_bib72","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/path.5777","article-title":"Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases","volume":"255","author":"Sousa","year":"2021","journal-title":"J. Pathol."},{"issue":"5","key":"10.1016\/j.acthis.2022.151960_bib73","doi-asserted-by":"crossref","first-page":"460","DOI":"10.2174\/1574893613666181112130346","article-title":"In-silico identification of drug lead molecule against pesticide exposed-neurodevelopmental disorders through network-based computational model approach","volume":"14","author":"Srivastava","year":"2019","journal-title":"Curr. Bioinforma."},{"key":"10.1016\/j.acthis.2022.151960_bib74","series-title":"Introduction to Biliary Atresia","first-page":"255","article-title":"Long-term complications of cirrhosis\/hepatic encephalopathy","author":"Suzuki","year":"2021"},{"issue":"3 Pt 1","key":"10.1016\/j.acthis.2022.151960_bib75","first-page":"G404","article-title":"Defective interleukin-1-induced ACTH release in cholestatic rats: impaired hypothalamic PGE2 release","volume":"268","author":"Swain","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.acthis.2022.151960_bib76","first-page":"37.","article-title":"The STRING database in 2017: quality-controlled protein\u2013protein association networks, made broadly accessible","author":"Szklarczyk","year":"2016","journal-title":"Nucleic Acids Res. gkw9"},{"issue":"5","key":"10.1016\/j.acthis.2022.151960_bib77","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.jhep.2010.05.020","article-title":"Characterising adrenal function using directly measured plasma free cortisol in stable severe liver disease","volume":"53","author":"Tan","year":"2010","journal-title":"J. Hepatol."},{"issue":"12","key":"10.1016\/j.acthis.2022.151960_bib78","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1111\/apt.15749","article-title":"Outcomes after hepatic encephalopathy in population-based cohorts of patients with cirrhosis","volume":"51","author":"Tapper","year":"2020","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.acthis.2022.151960_bib79","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1478-3231.2010.02431.x","article-title":"Assessment of adrenal function in cirrhotic patients using concentration of serum-free and salivary cortisol","volume":"31","author":"Thevenot","year":"2011","journal-title":"Liver Int."},{"issue":"4","key":"10.1016\/j.acthis.2022.151960_bib80","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/hep.21101","article-title":"Adrenal insufficiency in patients with cirrhosis, severe sepsis and septic shock","volume":"43","author":"Tsai","year":"2006","journal-title":"Hepatol. (Baltim. Md.)"},{"issue":"5","key":"10.1016\/j.acthis.2022.151960_bib81","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1080\/10409238.2017.1337707","article-title":"Multiple functions of insulin-degrading enzyme: a metabolic crosslight?","volume":"52","author":"Tundo","year":"2017","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.acthis.2022.151960_bib82","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1172\/JCI9238","article-title":"Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity","volume":"106","author":"Vaisse","year":"2000","journal-title":"J. Clin. Investig."},{"issue":"2","key":"10.1016\/j.acthis.2022.151960_bib83","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/hep.27210","article-title":"Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver","volume":"60","author":"Vilstrup","year":"2014","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"10.1016\/j.acthis.2022.151960_bib84","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.freeradbiomed.2015.02.024","article-title":"Overproduction of nitric oxide by endothelial cells and macrophages contributes to mitochondrial oxidative stress in adrenocortical cells and adrenal insufficiency during endotoxemia","volume":"83","author":"Wang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.acthis.2022.151960_bib85","doi-asserted-by":"crossref","first-page":"36045","DOI":"10.1038\/srep36045","article-title":"HULC cooperates with MALAT1 to aggravate liver cancer stem cells growth through telomere repeat-binding factor 2","volume":"6","author":"Wu","year":"2016","journal-title":"Sci. Rep."},{"issue":"15","key":"10.1016\/j.acthis.2022.151960_bib86","doi-asserted-by":"crossref","first-page":"7354","DOI":"10.1111\/jcmm.16764","article-title":"LncRNA MAYA promotes iron overload and hepatocyte senescence through inhibition of YAP in non-alcoholic fatty liver disease","volume":"25","author":"Yuan","year":"2021","journal-title":"J. Cell. Mol. Med."}],"container-title":["Acta Histochemica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128122001192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128122001192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T18:15:35Z","timestamp":1758737735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065128122001192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":86,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0065128122001192"],"URL":"https:\/\/doi.org\/10.1016\/j.acthis.2022.151960","relation":{},"ISSN":["0065-1281"],"issn-type":[{"type":"print","value":"0065-1281"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adrenal histological and functional changes after hepatic encephalopathy: From mice model to an integrative bioinformatics analysis","name":"articletitle","label":"Article Title"},{"value":"Acta Histochemica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acthis.2022.151960","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"151960"}}