{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T17:05:51Z","timestamp":1769015151685,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005122","name":"Japanese Physical Therapy Association","doi-asserted-by":"publisher","award":["006"],"award-info":[{"award-number":["006"]}],"id":[{"id":"10.13039\/501100005122","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K17625"],"award-info":[{"award-number":["22K17625"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Histochemica"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.acthis.2024.152172","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T13:12:41Z","timestamp":1719580361000},"page":"152172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of sex differences on osteoarthritic changes after anterior cruciate ligament reconstruction in rats"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3394-7458","authenticated-orcid":false,"given":"Akinori","family":"Kaneguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Kanehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Yamaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Umehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.acthis.2024.152172_bib1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/acr.22715","article-title":"Association of body composition and hormonal and inflammatory factors with tibial cartilage volume and sex difference in cartilage volume in young adults","volume":"68","author":"Antony","year":"2016","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"5","key":"10.1016\/j.acthis.2024.152172_bib2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.arthro.2004.03.006","article-title":"Arthroscopic evaluation of the articular cartilage after anterior cruciate ligament reconstruction: a short-term prospective study of 105 patients","volume":"20","author":"Asano","year":"2004","journal-title":"Arthroscopy"},{"issue":"3","key":"10.1016\/j.acthis.2024.152172_bib3","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1007\/s00167-019-05461-y","article-title":"Post-traumatic osteoarthritis diagnosed within 5 years following ACL reconstruction","volume":"28","author":"Bodkin","year":"2020","journal-title":"Knee Surg. Sports Trauma. Arthrosc."},{"issue":"3","key":"10.1016\/j.acthis.2024.152172_bib4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.joca.2009.11.009","article-title":"Osteoarthritis may not be a one-way-road of cartilage loss--comparison of spatial patterns of cartilage change between osteoarthritic and healthy knees","volume":"18","author":"Buck","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.acthis.2024.152172_bib5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bone.2017.09.018","article-title":"Bone replaces articular cartilage in the rat knee joint after prolonged immobilization","volume":"106","author":"Campbell","year":"2018","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.acthis.2024.152172_bib6","first-page":"917","article-title":"Anterior cruciate ligament injury: diagnosis, management, and prevention","volume":"82","author":"Cimino","year":"2010","journal-title":"Am. Fam. Physician"},{"issue":"4","key":"10.1016\/j.acthis.2024.152172_bib7","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/art.39005","article-title":"Early knee osteoarthritis is evident one year following anterior cruciate ligament reconstruction: a magnetic resonance imaging evaluation","volume":"67","author":"Culvenor","year":"2015","journal-title":"Arthritis Rheuma"},{"issue":"11","key":"10.1016\/j.acthis.2024.152172_bib8","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.joca.2007.04.017","article-title":"Reliability, reproducibility and variability of the traditional Histologic\/Histochemical Grading System vs the new OARSI Osteoarthritis Cartilage Histopathology Assessment System","volume":"15","author":"Custers","year":"2007","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.acthis.2024.152172_bib9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/jor.1100100107","article-title":"The reliability of the Mankin score for osteoarthritis","volume":"10","author":"van der Sluijs","year":"1992","journal-title":"J. Orthop. Res.: Off. Publ. Orthop. Res. Soc."},{"issue":"1","key":"10.1016\/j.acthis.2024.152172_bib10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/art.38881","article-title":"Five-year followup of knee joint cartilage thickness changes after acute rupture of the anterior cruciate ligament","volume":"67","author":"Eckstein","year":"2015","journal-title":"Arthritis Rheuma"},{"key":"10.1016\/j.acthis.2024.152172_bib11","article-title":"Post-traumatic knee osteoarthritis; the role of inflammation and hemarthrosis on disease progression","volume":"9","author":"Evers","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"1","key":"10.1016\/j.acthis.2024.152172_bib12","doi-asserted-by":"crossref","DOI":"10.1177\/23259671211062238","article-title":"Clinical outcomes and osteoarthritis at very long-term follow-up After ACL Reconstruction: a systematic review and meta-analysis","volume":"10","author":"Grassi","year":"2022","journal-title":"Orthop. J. Sports Med."},{"issue":"8","key":"10.1016\/j.acthis.2024.152172_bib13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11926-019-0837-6","article-title":"The role of chondrocyte morphology and volume in controlling phenotype-implications for osteoarthritis, cartilage repair, and cartilage engineering","volume":"21","author":"Hall","year":"2019","journal-title":"Curr. Rheuma Rep."},{"issue":"2","key":"10.1016\/j.acthis.2024.152172_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.semarthrit.2009.03.006","article-title":"Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics","volume":"39","author":"Herrero-Beaumont","year":"2009","journal-title":"Semin Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.acthis.2024.152172_bib15","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/jor.24849","article-title":"Towards understanding mechanistic subgroups of osteoarthritis: 8-year cartilage thickness trajectory analysis","volume":"39","author":"Iriondo","year":"2021","journal-title":"J. Orthop. Res.: Off. Publ. Orthop. Res. Soc."},{"issue":"3","key":"10.1016\/j.acthis.2024.152172_bib16","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/03008207.2019.1693548","article-title":"A rat model of arthrofibrosis developed after anterior cruciate ligament reconstruction without rigid joint immobilization","volume":"62","author":"Kaneguchi","year":"2021","journal-title":"Connect Tissue Res"},{"issue":"10","key":"10.1016\/j.acthis.2024.152172_bib17","doi-asserted-by":"crossref","DOI":"10.1177\/23259671221123543","article-title":"Effects of joint immobilization and treadmill exercise on articular cartilage after ACL reconstruction in rats","volume":"10","author":"Kaneguchi","year":"2022","journal-title":"Orthop. J. Sports Med."},{"key":"10.1016\/j.acthis.2024.152172_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2023.109183","article-title":"The combined effects of treadmill exercise and steroid administration on anterior cruciate ligament reconstruction-induced joint contracture and muscle atrophy in rats","volume":"192","author":"Kaneguchi","year":"2023","journal-title":"Steroids"},{"issue":"2","key":"10.1016\/j.acthis.2024.152172_bib19","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1080\/03008207.2022.2141627","article-title":"The effects of the amount of weight bearing on articular cartilage early after ACL reconstruction in rats","volume":"62","author":"Kaneguchi","year":"2023","journal-title":"Connect Tissue Res."},{"issue":"7","key":"10.1016\/j.acthis.2024.152172_bib20","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1177\/0363546515582024","article-title":"Sex influences the biomechanical outcomes of anterior cruciate ligament reconstruction in a preclinical large animal model","volume":"43","author":"Kiapour","year":"2015","journal-title":"Am. J. Sports Med"},{"issue":"8","key":"10.1016\/j.acthis.2024.152172_bib21","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1007\/s00167-011-1723-6","article-title":"Quantitative magnetic resonance imaging (MRI) morphological analysis of knee cartilage in healthy and anterior cruciate ligament-injured knees","volume":"20","author":"Li","year":"2012","journal-title":"Knee Surg. Sports Trauma. Arthrosc."},{"issue":"12","key":"10.1016\/j.acthis.2024.152172_bib22","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1177\/0363546511424720","article-title":"Predictors of radiographic knee osteoarthritis after anterior cruciate ligament reconstruction","volume":"39","author":"Li","year":"2011","journal-title":"Am. J. Sports Med"},{"issue":"5","key":"10.1016\/j.acthis.2024.152172_bib23","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1177\/03635465221079327","article-title":"Predictors of osteoarthritis development at a median 25 years after anterior cruciate ligament reconstruction using a patellar tendon autograft","volume":"50","author":"Lindanger","year":"2022","journal-title":"Am. J. Sports Med"},{"issue":"12","key":"10.1016\/j.acthis.2024.152172_bib24","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1002\/art.25002","article-title":"Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development","volume":"60","author":"Little","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.acthis.2024.152172_bib25","article-title":"Sex-specific reduction in inflammation of osteoarthritic human chondrocytes and nutraceutical-dependent extracellular matrix formation","volume":"14","author":"Mallah","year":"2021","journal-title":"J. Immunol. Regen. Med"},{"issue":"5","key":"10.1016\/j.acthis.2024.152172_bib26","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1177\/0300985815588611","article-title":"Animal models of osteoarthritis: comparisons and key considerations","volume":"52","author":"McCoy","year":"2015","journal-title":"Vet. Pathol."},{"issue":"6","key":"10.1016\/j.acthis.2024.152172_bib27","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1177\/0363546516631936","article-title":"Degenerative changes in the knee 2 years after anterior cruciate ligament rupture and related risk factors: a prospective observational follow-up study","volume":"44","author":"van Meer","year":"2016","journal-title":"Am. J. Sports Med"},{"issue":"3","key":"10.1016\/j.acthis.2024.152172_bib28","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.joca.2007.07.002","article-title":"Alteration in articular cartilage of rat knee joints after spinal cord injury","volume":"16","author":"Moriyama","year":"2008","journal-title":"Osteoarthr. Cartil."},{"issue":"4","key":"10.1016\/j.acthis.2024.152172_bib29","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1177\/1947603517700955","article-title":"Controlling abnormal joint movement inhibits response of osteophyte formation","volume":"9","author":"Murata","year":"2018","journal-title":"Cartilage"},{"issue":"Suppl 3","key":"10.1016\/j.acthis.2024.152172_bib30","doi-asserted-by":"crossref","first-page":"S106","DOI":"10.1016\/j.joca.2010.05.024","article-title":"Cartilage, bone and synovial histomorphometry in animal models of osteoarthritis","volume":"18","author":"Pastoureau","year":"2010","journal-title":"Osteoarthr. Cartil."},{"issue":"9","key":"10.1016\/j.acthis.2024.152172_bib31","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1177\/03635465221102118","article-title":"Effects of male and female sex on the development of posttraumatic osteoarthritis in the porcine knee after anterior cruciate ligament surgery","volume":"50","author":"Pinette","year":"2022","journal-title":"Am. J. Sports Med"},{"issue":"1","key":"10.1016\/j.acthis.2024.152172_bib32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jor.25142","article-title":"Articular cartilage thickness changes differ between males and females 4 years following anterior cruciate ligament reconstruction","volume":"40","author":"Pius","year":"2022","journal-title":"J. Orthop. Res.: Off. Publ. Orthop. Res. Soc."},{"issue":"3","key":"10.1016\/j.acthis.2024.152172_bib33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00296-004-0582-6","article-title":"Macroscopic and radiological grading of osteoarthritis correlates inadequately with cartilage height and histologically demonstrable damage to cartilage structure","volume":"25","author":"Saal","year":"2005","journal-title":"Rheuma Int"},{"issue":"2","key":"10.1016\/j.acthis.2024.152172_bib34","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/art.20020","article-title":"Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3","volume":"50","author":"Sharif","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.acthis.2024.152172_bib35","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.pop.2013.08.003","article-title":"Diagnosis and treatment of osteoarthritis","volume":"40","author":"Taruc-Uy","year":"2013","journal-title":"Prim. Care"},{"issue":"6","key":"10.1016\/j.acthis.2024.152172_bib36","doi-asserted-by":"crossref","first-page":"491","DOI":"10.4085\/1062-6050-51.5.08","article-title":"Epidemiology of Posttraumatic Osteoarthritis","volume":"52","author":"Thomas","year":"2017","journal-title":"J. Athl. Train."},{"issue":"1","key":"10.1016\/j.acthis.2024.152172_bib37","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13075-020-02156-5","article-title":"Post-traumatic osteoarthritis following ACL injury","volume":"22","author":"Wang","year":"2020","journal-title":"Arthritis Res Ther."}],"container-title":["Acta Histochemica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128124000400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128124000400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:55:26Z","timestamp":1732323326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065128124000400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S0065128124000400"],"URL":"https:\/\/doi.org\/10.1016\/j.acthis.2024.152172","relation":{},"ISSN":["0065-1281"],"issn-type":[{"value":"0065-1281","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of sex differences on osteoarthritic changes after anterior cruciate ligament reconstruction in rats","name":"articletitle","label":"Article Title"},{"value":"Acta Histochemica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acthis.2024.152172","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152172"}}