{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:52:58Z","timestamp":1787237578418,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2023MS08064"],"award-info":[{"award-number":["2023MS08064"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Histochemica"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.acthis.2025.152279","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T09:45:30Z","timestamp":1754732730000},"page":"152279","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["USP22-mediated PNMA5 deubiquitination promotes proliferation, migration and invasion of prostate cancer cells"],"prefix":"10.1016","volume":"127","author":[{"given":"Hong","family":"Zhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Tana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigemutu","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuenbilige","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.acthis.2025.152279_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/cells9122653","article-title":"Androgen receptor signaling pathway in prostate cancer: from genetics to clinical applications","volume":"9","author":"Aurilio","year":"2020","journal-title":"Cells"},{"issue":"Pt 2","key":"10.1016\/j.acthis.2025.152279_bib2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.semcancer.2020.03.008","article-title":"Dissenting degradation: deubiquitinases in cell cycle and cancer","volume":"67","author":"Bonacci","year":"2020","journal-title":"Semin Cancer Biol."},{"issue":"2-3","key":"10.1016\/j.acthis.2025.152279_bib3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10555-013-9474-0","article-title":"Androgen receptor signaling in prostate cancer","volume":"33","author":"Culig","year":"2014","journal-title":"Cancer Metastas. Rev."},{"issue":"15","key":"10.1016\/j.acthis.2025.152279_bib4","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1177\/15353702231191186","article-title":"Ubiquitination detection techniques","volume":"248","author":"De Silva","year":"2023","journal-title":"Exp. Biol. Med."},{"issue":"5","key":"10.1016\/j.acthis.2025.152279_bib5","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/PPO.0000000000000216","article-title":"The role of testosterone in the treatment of Castration-Resistant prostate cancer","volume":"22","author":"Drazer","year":"2016","journal-title":"Cancer J."},{"issue":"1","key":"10.1016\/j.acthis.2025.152279_bib6","first-page":"5","article-title":"Prostate cancer between prognosis and adequate\/proper therapy","volume":"10","author":"Grozescu","year":"2017","journal-title":"J. Med. Life"},{"key":"10.1016\/j.acthis.2025.152279_bib7","article-title":"Immune evasion and drug resistance mediated by USP22 in cancer: novel targets and mechanisms","volume":"13","author":"Guo","year":"2022","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.acthis.2025.152279_bib8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/ncpuro1296","article-title":"Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion","volume":"6","author":"Harris","year":"2009","journal-title":"Nat. Clin. Pr. Urol."},{"key":"10.1016\/j.acthis.2025.152279_bib9","article-title":"PNMA5 promotes bone metastasis of Non-small-Cell lung cancer as a target of BMP2 signaling","volume":"9","author":"Huang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.acthis.2025.152279_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009427","article-title":"MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells","volume":"5","author":"Iwata","year":"2010","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.acthis.2025.152279_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166813","article-title":"Loss of USP22 alleviates cardiac hypertrophy induced by pressure overload through HiF1-alpha-TAK1 signaling pathway","volume":"1869","author":"Jiang","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"4","key":"10.1016\/j.acthis.2025.152279_bib12","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1038\/s41418-019-0420-8","article-title":"USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity","volume":"27","author":"Kosinsky","year":"2020","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.acthis.2025.152279_bib13","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/bju.15542","article-title":"Safety and survival of docetaxel and cabazitaxel in metastatic castration-resistant prostate cancer","volume":"129","author":"Kreis","year":"2022","journal-title":"BJU Int"},{"issue":"10","key":"10.1016\/j.acthis.2025.152279_bib14","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1038\/s41418-023-01219-9","article-title":"USP2 promotes tumor immune evasion via deubiquitination and stabilization of PD-L1","volume":"30","author":"Kuang","year":"2023","journal-title":"Cell Death Differ."},{"issue":"9","key":"10.1016\/j.acthis.2025.152279_bib15","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1007\/s00432-016-2205-5","article-title":"Distinct functional domains of PNMA5 mediate protein-protein interaction, nuclear localization, and apoptosis signaling in human cancer cells","volume":"142","author":"Lee","year":"2016","journal-title":"J. Cancer Res Clin. Oncol."},{"issue":"1","key":"10.1016\/j.acthis.2025.152279_bib16","doi-asserted-by":"crossref","first-page":"7677","DOI":"10.1038\/s41467-022-35469-x","article-title":"PRDM1\/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.acthis.2025.152279_bib17","first-page":"2231","article-title":"PNMA5 accelerated cellular proliferation, invasion and migration in colorectal cancer","volume":"14","author":"Lin","year":"2022","journal-title":"Am. J. Transl. Res."},{"issue":"5","key":"10.1016\/j.acthis.2025.152279_bib18","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3892\/ol.2020.12108","article-title":"USP22 promotes proliferation in renal cell carcinoma by stabilizing survivin","volume":"20","author":"Lin","year":"2020","journal-title":"Oncol. Lett."},{"issue":"2","key":"10.1016\/j.acthis.2025.152279_bib19","first-page":"84","article-title":"Effects of androgen deprivation therapy for prostate cancer on gut microbiota and treatment","volume":"103","author":"Liu","year":"2023","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"4","key":"10.1016\/j.acthis.2025.152279_bib20","doi-asserted-by":"crossref","first-page":"389","DOI":"10.6061\/clinics\/2012(04)13","article-title":"Castration-resistant prostate cancer: systemic therapy in 2012","volume":"67","author":"Maluf","year":"2012","journal-title":"Clin. (Sao Paulo)"},{"issue":"3","key":"10.1016\/j.acthis.2025.152279_bib21","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1158\/0008-5472.CAN-19-1033","article-title":"USP22 functions as an oncogenic driver in prostate cancer by regulating cell proliferation and DNA repair","volume":"80","author":"McCann","year":"2020","journal-title":"Cancer Res"},{"key":"10.1016\/j.acthis.2025.152279_bib22","article-title":"Deubiquitination in prostate cancer progression: role of USP22","volume":"6","author":"Nag","year":"2020","journal-title":"J. Cancer Metastas.. Treat."},{"issue":"3","key":"10.1016\/j.acthis.2025.152279_bib23","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1158\/2159-8290.CD-12-0027","article-title":"USP2a activation of MYC in prostate cancer","volume":"2","author":"Nelson","year":"2012","journal-title":"Cancer Discov."},{"key":"10.1016\/j.acthis.2025.152279_bib24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cellsig.2018.01.022","article-title":"PNMA family: protein interaction network and cell signalling pathways implicated in cancer and apoptosis","volume":"45","author":"Pang","year":"2018","journal-title":"Cell Signal."},{"issue":"11","key":"10.1016\/j.acthis.2025.152279_bib25","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1038\/nm.3739","article-title":"Ubiquitination in disease pathogenesis and treatment","volume":"20","author":"Popovic","year":"2014","journal-title":"Nat. Med."},{"issue":"17","key":"10.1016\/j.acthis.2025.152279_bib26","doi-asserted-by":"crossref","first-page":"8625","DOI":"10.1158\/0008-5472.CAN-06-1374","article-title":"The isopeptidase USP2a protects human prostate cancer from apoptosis","volume":"66","author":"Priolo","year":"2006","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.acthis.2025.152279_bib27","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.21037\/tcr-20-2013","article-title":"PNMA5 knockdown suppresses the proliferation, invasion, and metastasis of epithelial ovarian cancer cells","volume":"9","author":"Qiao","year":"2020","journal-title":"Transl. Cancer Res."},{"issue":"Pt 3","key":"10.1016\/j.acthis.2025.152279_bib28","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.semcancer.2021.09.007","article-title":"Microbiota and prostate cancer","volume":"86","author":"Rizzo","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"1","key":"10.1016\/j.acthis.2025.152279_bib29","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1158\/0008-5472.CAN-13-1954","article-title":"USP22 regulates oncogenic signaling pathways to drive lethal cancer progression","volume":"74","author":"Schrecengost","year":"2014","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.acthis.2025.152279_bib30","first-page":"151","article-title":"Prostate cancer pathology: recent updates and controversies","volume":"115","author":"Sehn","year":"2018","journal-title":"Mo Med."},{"issue":"17","key":"10.1016\/j.acthis.2025.152279_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27175730","article-title":"Prostate cancer review: genetics, diagnosis, treatment options, and alternative approaches","volume":"27","author":"Sekhoacha","year":"2022","journal-title":"Molecules"},{"issue":"14","key":"10.1016\/j.acthis.2025.152279_bib32","doi-asserted-by":"crossref","first-page":"12654","DOI":"10.18632\/oncotarget.3705","article-title":"High USP22 expression indicates poor prognosis in hepatocellular carcinoma","volume":"6","author":"Tang","year":"2015","journal-title":"Oncotarget"},{"issue":"17-18","key":"10.1016\/j.acthis.2025.152279_bib33","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1101\/gad.315739.118","article-title":"Genetics and biology of prostate cancer","volume":"32","author":"Wang","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.acthis.2025.152279_bib34","article-title":"Clinicopathological and prognostic value of USP22 expression in gastric cancer: a systematic review and Meta-Analysis and database validation","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Surg."},{"issue":"5","key":"10.1016\/j.acthis.2025.152279_bib35","first-page":"5567","article-title":"Ubiquitin-specific peptidase 22 promotes proliferation and metastasis in human colon cancer","volume":"18","author":"Yuan","year":"2019","journal-title":"Oncol. Lett."},{"issue":"5","key":"10.1016\/j.acthis.2025.152279_bib36","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1002\/cam4.2071","article-title":"Candidate genes involved in metastasis of colon cancer identified by integrated analysis","volume":"8","author":"Zhou","year":"2019","journal-title":"Cancer Med."},{"issue":"33","key":"10.1016\/j.acthis.2025.152279_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado1533","article-title":"Epinephrine promotes breast cancer metastasis through a ubiquitin-specific peptidase 22-mediated lipolysis circuit","volume":"10","author":"Zhou","year":"2024","journal-title":"Sci. Adv."}],"container-title":["Acta Histochemica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128125000510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128125000510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:32:14Z","timestamp":1772793134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065128125000510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0065128125000510"],"URL":"https:\/\/doi.org\/10.1016\/j.acthis.2025.152279","relation":{},"ISSN":["0065-1281"],"issn-type":[{"value":"0065-1281","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"USP22-mediated PNMA5 deubiquitination promotes proliferation, migration and invasion of prostate cancer cells","name":"articletitle","label":"Article Title"},{"value":"Acta Histochemica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acthis.2025.152279","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152279"}}