{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:33:24Z","timestamp":1786998804874,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001488"],"award-info":[{"award-number":["82001488"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["YQ2023H012"],"award-info":[{"award-number":["YQ2023H012"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Histochemica"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.acthis.2026.152356","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:51:37Z","timestamp":1786582297000},"page":"152356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunohistochemical analysis of histone-deacetylases in tongue and oral mucosa of mice during postnatal development and aging"],"prefix":"10.1016","volume":"128","author":[{"given":"Chubo","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huishu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0416-8911","authenticated-orcid":false,"given":"Yuanbo","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.acthis.2026.152356_bib1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/9780470942390.mo140195","article-title":"Aging research using mouse models","volume":"5","author":"Ackert-Bicknell","year":"2015","journal-title":"Curr. Protoc. Mouse Biol."},{"issue":"8","key":"10.1016\/j.acthis.2026.152356_bib2","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.3109\/10428194.2011.570821","article-title":"Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells","volume":"52","author":"Aldana-Masangkay","year":"2011","journal-title":"Leuk. Lymphoma"},{"issue":"1","key":"10.1016\/j.acthis.2026.152356_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11357-017-0004-9","article-title":"Oral health in geroscience: animal models and the aging oral cavity","volume":"40","author":"An","year":"2018","journal-title":"Geroscience"},{"issue":"11-12","key":"10.1016\/j.acthis.2026.152356_bib4","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.exger.2003.09.009","article-title":"The emerging role of epigenetics in cellular and organismal aging","volume":"38","author":"Bandyopadhyay","year":"2003","journal-title":"Exp. Gerontol."},{"issue":"2","key":"10.1016\/j.acthis.2026.152356_bib5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2174\/1874609810902020109","article-title":"Tissular senescence and modifications of oral ecosystem in the elderly: risk factors for mucosal pathologies","volume":"2","author":"Bodineau","year":"2009","journal-title":"Curr. Aging Sci."},{"key":"10.1016\/j.acthis.2026.152356_bib6","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1093\/gerona\/glu042","article-title":"Epigenetics of aging and aging-related disease","volume":"69","author":"Brunet","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"1","key":"10.1016\/j.acthis.2026.152356_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11630-1","article-title":"Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice","volume":"7","author":"Bryant","year":"2017","journal-title":"Sci. Rep."},{"issue":"21","key":"10.1016\/j.acthis.2026.152356_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218134","article-title":"Melatonin and sirtuins in buccal epithelium: potential biomarkers of aging and age-related pathologies","volume":"21","author":"Carbone","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"26","key":"10.1016\/j.acthis.2026.152356_bib9","doi-asserted-by":"crossref","first-page":"23515","DOI":"10.1074\/jbc.M301922200","article-title":"Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity","volume":"278","author":"Chan","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.acthis.2026.152356_bib10","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1089\/ars.2017.7178","article-title":"SIRT1 and SIRT6 signaling pathways in cardiovascular disease protection","volume":"28","author":"D'Onofrio","year":"2018","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.acthis.2026.152356_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrg2485","article-title":"The many roles of histone deacetylases in development and physiology: implications for disease and therapy","volume":"10","author":"Haberland","year":"2009","journal-title":"Nat. Rev. Genet."},{"issue":"18","key":"10.1016\/j.acthis.2026.152356_bib12","doi-asserted-by":"crossref","first-page":"13716","DOI":"10.1074\/jbc.M609751200","article-title":"Enhanced deacetylation of p53 by the anti-apoptotic protein HSCO in association with histone deacetylase 1","volume":"282","author":"Higashitsuji","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.acthis.2026.152356_bib13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/jid.2013.283","article-title":"Disrupted ectodermal organ morphogenesis in mice with a conditional histone deacetylase 1, 2 deletion in the epidermis","volume":"134","author":"Hughes","year":"2014","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.acthis.2026.152356_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1469-7580.2002.00073.x","article-title":"Evolution of the structure and function of the vertebrate tongue","volume":"201","author":"Iwasaki","year":"2002","journal-title":"J. Anat."},{"key":"10.1016\/j.acthis.2026.152356_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng1089","article-title":"Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals","volume":"33","author":"Jaenisch","year":"2003","journal-title":"Nat. Genet."},{"issue":"7288","key":"10.1016\/j.acthis.2026.152356_bib16","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature08980","article-title":"The genetics of ageing","volume":"464","author":"Kenyon","year":"2010","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.acthis.2026.152356_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrm3327","article-title":"Molecular mechanisms and potential functions of histone demethylases","volume":"13","author":"Kooistra","year":"2012","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"6","key":"10.1016\/j.acthis.2026.152356_bib18","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1093\/emboj\/19.6.1176","article-title":"Acetylation: a regulatory modification to rival phosphorylation?","volume":"19","author":"Kouzarides","year":"2000","journal-title":"EMBO J."},{"issue":"8","key":"10.1016\/j.acthis.2026.152356_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/cells12081163","article-title":"Epigenetic mechanisms of aging and aging-associated diseases","volume":"12","author":"la Torre","year":"2023","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.acthis.2026.152356_bib20","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1093\/emboj\/21.11.2672","article-title":"Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression","volume":"21","author":"Lagger","year":"2002","journal-title":"EMBO J."},{"issue":"6","key":"10.1016\/j.acthis.2026.152356_bib21","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.devcel.2010.10.015","article-title":"Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells","volume":"19","author":"LeBoeuf","year":"2010","journal-title":"Dev. Cell."},{"issue":"1","key":"10.1016\/j.acthis.2026.152356_bib22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13578-021-00607-3","article-title":"CpG oligodeoxynucleotides attenuate RORgammat-mediated Th17 response by restoring histone deacetylase-2 in cigarette smoke-exposure asthma","volume":"11","author":"Li","year":"2021","journal-title":"Cell. Biosci."},{"issue":"6","key":"10.1016\/j.acthis.2026.152356_bib23","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Lopez-Otin","year":"2013","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.acthis.2026.152356_bib24","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.tem.2015.06.001","article-title":"SIRT3 regulates progression and development of diseases of aging","volume":"26","author":"McDonnell","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"issue":"14","key":"10.1016\/j.acthis.2026.152356_bib25","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gad.1563807","article-title":"Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility","volume":"21","author":"Montgomery","year":"2007","journal-title":"Genes. Dev."},{"issue":"46","key":"10.1016\/j.acthis.2026.152356_bib26","doi-asserted-by":"crossref","first-page":"20003","DOI":"10.1073\/pnas.1013754107","article-title":"Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents","volume":"107","author":"Namdar","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.acthis.2026.152356_bib27","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/febs.15468","article-title":"Loss of HDAC11 accelerates skeletal muscle regeneration in mice","volume":"288","author":"Nunez-Alvarez","year":"2021","journal-title":"FEBS J."},{"issue":"6","key":"10.1016\/j.acthis.2026.152356_bib28","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1177\/0022034511434055","article-title":"Molecular and cellular regulatory mechanisms of tongue myogenesis","volume":"91","author":"Parada","year":"2012","journal-title":"J. Dent. Res."},{"issue":"6","key":"10.1016\/j.acthis.2026.152356_bib29","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1091\/mbc.e03-08-0624","article-title":"Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis","volume":"15","author":"Paroni","year":"2004","journal-title":"Mol. Biol. Cell."},{"issue":"6","key":"10.1016\/j.acthis.2026.152356_bib30","first-page":"979","article-title":"Histone deacetylase 6 promotes skin wound healing by regulating fibroblast migration and differentiation in aged mice","volume":"74","author":"Qin","year":"2022","journal-title":"Sheng Li Xue Bao"},{"key":"10.1016\/j.acthis.2026.152356_bib31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.exger.2014.03.015","article-title":"Greater organ involution in highly proliferative tissues associated with the early onset and acceleration of ageing in humans","volume":"55","author":"Richardson","year":"2014","journal-title":"Exp. Gerontol."},{"issue":"2","key":"10.1016\/j.acthis.2026.152356_bib32","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1189\/jlb.1A0415-176RRR","article-title":"Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology","volume":"102","author":"Sahakian","year":"2017","journal-title":"J. Leukoc. Biol."},{"issue":"15","key":"10.1016\/j.acthis.2026.152356_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22157821","article-title":"An overview of physical, microbiological and immune barriers of oral mucosa","volume":"22","author":"Senel","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.acthis.2026.152356_bib34","doi-asserted-by":"crossref","first-page":"a018713","DOI":"10.1101\/cshperspect.a018713","article-title":"Erasers of histone acetylation: the histone deacetylase enzymes","volume":"6","author":"Seto","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"16","key":"10.1016\/j.acthis.2026.152356_bib35","doi-asserted-by":"crossref","first-page":"11004","DOI":"10.1074\/jbc.M112.441816","article-title":"A nitric oxide-dependent cross-talk between class I and III histone deacetylases accelerates skin repair","volume":"288","author":"Spallotta","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.acthis.2026.152356_bib36","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.cell.2008.03.025","article-title":"Acetylation is indispensable for p53 activation","volume":"133","author":"Tang","year":"2008","journal-title":"Cell"},{"issue":"34","key":"10.1016\/j.acthis.2026.152356_bib37","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1038\/sj.onc.1203040","article-title":"Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis","volume":"18","author":"Waikel","year":"1999","journal-title":"Oncogene"},{"issue":"24","key":"10.1016\/j.acthis.2026.152356_bib38","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1038\/emboj.2013.243","article-title":"Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis","volume":"32","author":"Winter","year":"2013","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.acthis.2026.152356_bib39","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.molcel.2023.10.006","article-title":"Stress, epigenetics, and aging: unraveling the intricate crosstalk","volume":"84","author":"Wu","year":"2024","journal-title":"Mol. Cell."},{"issue":"5","key":"10.1016\/j.acthis.2026.152356_bib40","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1101\/gad.552310","article-title":"Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression","volume":"24","author":"Yamaguchi","year":"2010","journal-title":"Genes. Dev."},{"key":"10.1016\/j.acthis.2026.152356_bib41","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mad.2016.02.003","article-title":"Regulation of SIRT1 in aging: roles in mitochondrial function and biogenesis","volume":"155","author":"Yuan","year":"2016","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.acthis.2026.152356_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135093","article-title":"m(6)A-mediated HDAC9 upregulation promotes particulate matter-induced airway inflammation via epigenetic control of DUSP9-MAPK axis and acts as an inhaled nanotherapeutic target","volume":"477","author":"Zeng","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"10","key":"10.1016\/j.acthis.2026.152356_bib43","doi-asserted-by":"crossref","DOI":"10.4239\/wjd.v16.i10.108346","article-title":"Potential roles of histone deacetylases in diabetic wound healing","volume":"16","author":"Zhang","year":"2025","journal-title":"World J. Diabetes"},{"issue":"1","key":"10.1016\/j.acthis.2026.152356_bib44","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jid.2021.05.026","article-title":"HDAC1\/2 control proliferation and survival in adult epidermis and pre-basal cell carcinoma through p16 and p53","volume":"142","author":"Zhu","year":"2022","journal-title":"J. Invest. Dermatol."}],"container-title":["Acta Histochemica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128126000413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065128126000413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:58:03Z","timestamp":1786996683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065128126000413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0065128126000413"],"URL":"https:\/\/doi.org\/10.1016\/j.acthis.2026.152356","relation":{},"ISSN":["0065-1281"],"issn-type":[{"value":"0065-1281","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunohistochemical analysis of histone-deacetylases in tongue and oral mucosa of mice during postnatal development and aging","name":"articletitle","label":"Article Title"},{"value":"Acta Histochemica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acthis.2026.152356","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152356"}}