{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:47:27Z","timestamp":1782895647150,"version":"3.54.5"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Actas Urol\u00f3gicas Espa\u00f1olas (English Edition)"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.acuroe.2026.501935","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:02:38Z","timestamp":1771952558000},"page":"501935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term endocrine sequelae in testicular cancer: clinical manifestations, mechanisms, and follow-up considerations"],"prefix":"10.1016","volume":"50","author":[{"given":"C.S.","family":"Gonz\u00e1lez Beltr\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6945-8261","authenticated-orcid":false,"given":"H.A.","family":"Garc\u00eda-Perdomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.F.","family":"Garc\u00eda Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.acuroe.2026.501935_bib0005","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/02841860310023174","article-title":"Long-term sequelae after cancer therapy","volume":"43","author":"Foss\u00e5","year":"2004","journal-title":"Acta Oncol (Madr)."},{"key":"10.1016\/j.acuroe.2026.501935_bib0010","first-page":"10","article-title":"Hypogonadism and sexual dysfunction in testicular tumor survivors: a systematic review","author":"La Vignera","year":"2019","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"1","key":"10.1016\/j.acuroe.2026.501935_bib0015","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12610-024-00230-5","article-title":"Association between low total serum testosterone and body mass index in Australian survivors of testicular cancer: a retrospective analysis","volume":"34","author":"Kim","year":"2024","journal-title":"Basic Clin Androl."},{"issue":"1","key":"10.1016\/j.acuroe.2026.501935_bib0025","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin."},{"key":"10.1016\/j.acuroe.2026.501935_bib0030","unstructured":"Testicular Cancer EAU Guidelines on. 2025."},{"issue":"21","key":"10.1016\/j.acuroe.2026.501935_bib0035","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1056\/NEJMra1407550","article-title":"Testicular cancer \u2014 discoveries and updates","volume":"371","author":"Hanna","year":"2014","journal-title":"N Engl J Med [Internet]"},{"issue":"2","key":"10.1016\/j.acuroe.2026.501935_bib0040","first-page":"93","article-title":"The Eighth Edition AJCC Cancer Staging Manual: continuing to build a bridge from a population\u2010based to a more \u201cpersonalized\u201d approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J Clin."},{"issue":"6","key":"10.1016\/j.acuroe.2026.501935_bib0045","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.eururo.2015.07.044","article-title":"Guidelines on testicular cancer: 2015 update","volume":"68","author":"Albers","year":"2015","journal-title":"Eur Urol [Internet]"},{"issue":"6","key":"10.1016\/j.acuroe.2026.501935_bib0050","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1001\/jama.299.6.672","article-title":"Medical treatment of advanced testicular cancer","volume":"299","author":"Feldman","year":"2008","journal-title":"JAMA [Internet]."},{"key":"10.1016\/j.acuroe.2026.501935_bib0055","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nrc1568","article-title":"Testicular germ-cell tumours in a broader perspective","volume":"5","author":"Oosterhuis","year":"2005","journal-title":"Nat Rev Cancer."},{"issue":"10029","key":"10.1016\/j.acuroe.2026.501935_bib0060","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/S0140-6736(15)00991-5","article-title":"Testicular germ cell tumours","volume":"387","author":"Rajpert-De Meyts","year":"2016","journal-title":"Lancet [Internet]"},{"issue":"4","key":"10.1016\/j.acuroe.2026.501935_bib0065","doi-asserted-by":"crossref","first-page":"558","DOI":"10.6004\/jnccn.2012.0053","article-title":"Hypogonadism and infertility in testicular cancer survivors","volume":"10","author":"Jacobs","year":"2012","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.acuroe.2026.501935_bib0070","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.urolonc.2015.01.014","article-title":"Hypogonadism and fertility issues following primary treatment for testicular cancer","volume":"33","author":"Oldenburg","year":"2015","journal-title":"Urol Oncol Semin Original Invest"},{"issue":"4","key":"10.1016\/j.acuroe.2026.501935_bib0075","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1530\/EJE-07-0684","article-title":"Risk factors for post-treatment hypogonadism in testicular cancer patients","volume":"158","author":"Eberhard","year":"2008","journal-title":"Eur J Endocrinol [Internet]"},{"issue":"21","key":"10.1016\/j.acuroe.2026.501935_bib0080","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1093\/jnci\/dji339","article-title":"Paternity following treatment for testicular cancer","volume":"97","author":"Bryd\u00f8y","year":"2005","journal-title":"J Natl Cancer Inst."},{"issue":"2","key":"10.1016\/j.acuroe.2026.501935_bib0085","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/annonc\/mdl372","article-title":"Components of the metabolic syndrome in long-term survivors of testicular cancer","volume":"18","author":"Haugnes","year":"2007","journal-title":"Ann of Oncol [Internet]"},{"key":"10.1016\/j.acuroe.2026.501935_bib0090","series-title":"StatPearls [Internet]","article-title":"Male hypogonadism","author":"Sizar","year":"2025"},{"key":"10.1016\/j.acuroe.2026.501935_bib0095","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1210\/jc.2018-00229","article-title":"Testosterone therapy in men with hypogonadism: an endocrine society","volume":"103","author":"Bhasin","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 3","key":"10.1016\/j.acuroe.2026.501935_bib0100","article-title":"Indications for the use of human chorionic gonadotropic hormone for the management of infertility in hypogonadal men","volume":"7","author":"Lee","year":"2018","journal-title":"Transl Androl Urol [Internet]"},{"issue":"8","key":"10.1016\/j.acuroe.2026.501935_bib0105","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1200\/JCO.2000.18.8.1725","article-title":"Cardiovascular morbidity in long-term survivors of metastatic testicular cancer","volume":"18","author":"Meinardi","year":"2000","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.acuroe.2026.501935_bib0110","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/0284186X.2021.2024880","article-title":"Thyroid hypofunction in aging testicular cancer survivors","volume":"61","author":"Fung","year":"2022","journal-title":"Acta Oncol [Internet]."},{"issue":"2","key":"10.1016\/j.acuroe.2026.501935_bib0115","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ijrobp.2012.09.001","article-title":"Second solid cancers after radiation therapy: a systematic review of the epidemiologic studies of the radiation dose-response relationship","volume":"86","author":"Berrington De Gonzalez","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys [Internet]"},{"issue":"10","key":"10.1016\/j.acuroe.2026.501935_bib0120","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/thy.2016.0229","article-title":"2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis","volume":"26","author":"Ross","year":"2016","journal-title":"Thyroid"},{"issue":"4","key":"10.1016\/j.acuroe.2026.501935_bib0125","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11764-007-0038-6","article-title":"Endocrine sequelae of cancer and cancer treatments","volume":"1","author":"Stava","year":"2007","journal-title":"J Cancer Survivorship."},{"key":"10.1016\/j.acuroe.2026.501935_bib0130","first-page":"2368","article-title":"Androgen physiology, pharmacology, use and misuse","volume":"2\u20132","author":"Handelsman","year":"2020","journal-title":"Endocrinology: Adult and Pediatric [Internet]"},{"issue":"4","key":"10.1016\/j.acuroe.2026.501935_bib0135","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000356507","article-title":"2013 ETA guideline: management of subclinical hypothyroidism","volume":"2","author":"Pearce","year":"2014","journal-title":"Eur Thyroid J [Internet]"},{"issue":"3","key":"10.1016\/j.acuroe.2026.501935_bib0140","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1200\/JCO.1999.17.3.941","article-title":"Semen quality and reproductive hormones before orchiectomy in men with testicular cancer","volume":"17","author":"Petersen","year":"1999","journal-title":"J Clin Oncol [Internet]"},{"issue":"4","key":"10.1016\/j.acuroe.2026.501935_bib0145","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/humrep\/12.4.755","article-title":"Testicular cancer and spermatogenesis","volume":"12","author":"Botchan","year":"1997","journal-title":"Human Reprod [Internet]"},{"key":"10.1016\/j.acuroe.2026.501935_bib0150","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/jncimonographs\/lgi003","article-title":"Spermatogenesis after cancer treatment: damage and recovery","author":"Howell","year":"2005","journal-title":"J Natl Cancer Inst Monogr."},{"issue":"12","key":"10.1016\/j.acuroe.2026.501935_bib0155","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1093\/humrep\/del292","article-title":"Sperm DNA integrity in testicular cancer patients","volume":"21","author":"St\u00e5hl","year":"2006","journal-title":"Human Reprod [Internet]"},{"issue":"5","key":"10.1016\/j.acuroe.2026.501935_bib0160","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1210\/jc.2004-0802","article-title":"Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression","volume":"90","author":"Coviello","year":"2005","journal-title":"J Clin Endocrinol Metabol [Internet]"},{"issue":"4","key":"10.1016\/j.acuroe.2026.501935_bib0165","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1200\/JCO.1997.15.4.1444","article-title":"Sexuality and fertility in long-term survivors of testicular cancer","volume":"15","author":"Arai","year":"1997","journal-title":"J Clin Oncol [Internet]"},{"issue":"6","key":"10.1016\/j.acuroe.2026.501935_bib0170","doi-asserted-by":"crossref","first-page":"473","DOI":"10.4149\/neo_2009_06_473","article-title":"Damage of hormonal function and bone metabolism in long-term survivors of testicular cancer","volume":"56","author":"Ondrusova","year":"2009","journal-title":"Neoplasma [Internet]"},{"issue":"1","key":"10.1016\/j.acuroe.2026.501935_bib0175","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/bco2.183","article-title":"Risk of osteoporosis in testicular germ cell tumour survivors: a systematic review of the literature","volume":"4","author":"Vrouwe","year":"2022","journal-title":"BJUI Compass [Internet]"},{"issue":"5","key":"10.1016\/j.acuroe.2026.501935_bib0180","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/andr.12383","article-title":"Risk of low bone mineral density in testicular germ cell cancer survivors: association with hypogonadism and treatment modality","volume":"5","author":"Isaksson","year":"2017","journal-title":"Andrology [Internet]."},{"issue":"1","key":"10.1016\/j.acuroe.2026.501935_bib0185","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1200\/JCO.1997.15.1.239","article-title":"Fertility after chemotherapy for testicular germ cell cancers","volume":"15","author":"Lampe","year":"1997","journal-title":"J Clin Oncol [Internet]"}],"container-title":["Actas Urol\u00f3gicas Espa\u00f1olas (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173578626000752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173578626000752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:14:59Z","timestamp":1782893699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2173578626000752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2173578626000752"],"URL":"https:\/\/doi.org\/10.1016\/j.acuroe.2026.501935","relation":{},"ISSN":["2173-5786"],"issn-type":[{"value":"2173-5786","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term endocrine sequelae in testicular cancer: clinical manifestations, mechanisms, and follow-up considerations","name":"articletitle","label":"Article Title"},{"value":"Actas Urol\u00f3gicas Espa\u00f1olas (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acuroe.2026.501935","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.acuro.2026.501935","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 AEU. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"501935"}}