{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T21:56:30Z","timestamp":1782338190207,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Cardiovascular Diseases"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.acvd.2016.02.013","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T23:30:49Z","timestamp":1478734249000},"page":"667-678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Optimized management of heart failure patients aged 80 years or more improves outcomes versus usual care: The HF80 randomized trial"],"prefix":"10.1016","volume":"109","author":[{"given":"Charles","family":"Vorilhon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Jean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Mulliez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Clerfond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Sapin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raud","family":"Souteyrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Citron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Motreff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Ren\u00e9","family":"Lusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Eschalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.acvd.2016.02.013_bib0205","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1136\/hrt.2003.025270","article-title":"Clinical epidemiology of heart failure","volume":"93","author":"Mosterd","year":"2007","journal-title":"Heart"},{"key":"10.1016\/j.acvd.2016.02.013_bib0210","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2105\/AJPH.84.1.20","article-title":"Estimating clinical morbidity due to ischemic heart disease and congestive heart failure: the future rise of heart failure","volume":"84","author":"Bonneux","year":"1994","journal-title":"Am J Public Health"},{"key":"10.1016\/j.acvd.2016.02.013_bib0215","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa020265","article-title":"Long-term trends in the incidence of and survival with heart failure","volume":"347","author":"Levy","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.acvd.2016.02.013_bib0220","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/eurheartj\/ehn539","article-title":"Contemporary management of octogenarians hospitalized for heart failure in Europe: Euro Heart Failure Survey II","volume":"30","author":"Komajda","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acvd.2016.02.013_bib0225","first-page":"1429","article-title":"Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). The CONSENSUS Trial Study Group","volume":"316","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1016\/j.acvd.2016.02.013_bib0230","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1056\/NEJM199209033271003","article-title":"Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. The SOLVD Investigators","volume":"327","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.acvd.2016.02.013_bib0235","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0140-6736(98)11181-9","article-title":"The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial","volume":"353","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.acvd.2016.02.013_bib0240","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1001\/jama.283.10.1295","article-title":"Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR\/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group","volume":"283","author":"Hjalmarson","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.acvd.2016.02.013_bib0245","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators","volume":"341","author":"Pitt","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.acvd.2016.02.013_bib0250","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0140-6736(10)61198-1","article-title":"Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study","volume":"376","author":"Swedberg","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.acvd.2016.02.013_bib0255","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1009492","article-title":"Eplerenone in patients with systolic heart failure and mild symptoms","volume":"364","author":"Zannad","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.acvd.2016.02.013_bib0260","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","article-title":"Cardiac-resynchronization therapy for the prevention of heart-failure events","volume":"361","author":"Moss","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.acvd.2016.02.013_bib0265","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acvd.2016.02.013_bib0270","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.acvd.2016.02.013_bib0275","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/eurheartj\/ehi115","article-title":"Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS)","volume":"26","author":"Flather","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acvd.2016.02.013_bib0280","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1056\/NEJMoa0801369","article-title":"Treatment of hypertension in patients 80 years of age or older","volume":"358","author":"Beckett","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.acvd.2016.02.013_bib0285","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.jacc.2013.04.086","article-title":"Safety and efficacy of eplerenone in patients at high risk for hyperkalemia and\/or worsening renal function: analyses of the EMPHASIS-HF study subgroups (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure)","volume":"62","author":"Eschalier","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.acvd.2016.02.013_bib0290","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00228-014-1794-7","article-title":"Heart failure prognosis and management in over-80-year-old patients: data from a French national observational retrospective cohort","volume":"71","author":"Vorilhon","year":"2015","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.acvd.2016.02.013_bib0295","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1053\/euhj.1999.1762","article-title":"A national survey of heart failure in French hospitals. The Myocardiopathy and Heart Failure Working Group of the French Society of Cardiology, the National College of General Hospital Cardiologists and the French Geriatrics Society","volume":"21","author":"Cohen-Solal","year":"2000","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acvd.2016.02.013_bib0300","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/eurheartj\/ehl443","article-title":"Management of octogenarians hospitalized for heart failure in Euro Heart Failure Survey I","volume":"28","author":"Komajda","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acvd.2016.02.013_bib0305","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1388-9842(01)00200-8","article-title":"Heart failure in frail elderly patients: diagnostic difficulties, co-morbidities, polypharmacy and treatment dilemmas","volume":"4","author":"Lien","year":"2002","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.acvd.2016.02.013_bib0310","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejheart.2007.11.004","article-title":"Long-term survival in patients older than 80 years hospitalised for heart failure. A 5-year prospective study","volume":"10","author":"Mahjoub","year":"2008","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.acvd.2016.02.013_bib0315","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1745-6215-13-25","article-title":"Is there benefit in optimising heart failure treatment in over-80 year-old patients? (HF-80 study): study protocol for a randomized controlled trial","volume":"13","author":"Eschalier","year":"2012","journal-title":"Trials"},{"key":"10.1016\/j.acvd.2016.02.013_bib0320","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1157\/13111242","article-title":"[Utility of the Minnesota Living With Heart Failure Questionnaire for assessing quality of life in heart failure patients]","volume":"60","author":"Morcillo","year":"2007","journal-title":"Rev Esp Cardiol"},{"key":"10.1016\/j.acvd.2016.02.013_bib0325","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/0002-9149(93)90582-W","article-title":"Validity of the Minnesota Living with Heart Failure questionnaire as a measure of therapeutic response to enalapril or placebo","volume":"71","author":"Rector","year":"1993","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.acvd.2016.02.013_bib0330","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1136\/hrt.2003.013995","article-title":"Comparison of the short form (SF)-12 health status instrument with the SF-36 in patients with coronary heart disease","volume":"90","author":"Muller-Nordhorn","year":"2004","journal-title":"Heart"},{"key":"10.1016\/j.acvd.2016.02.013_bib0335","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1164\/ajrccm.166.1.at1102","article-title":"ATS statement: guidelines for the six-minute walk test","volume":"166","author":"A.T.S. Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.acvd.2016.02.013_bib0340","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/eurheartj\/1.5.375","article-title":"Recommendations for standardization of measurements from M-mode echocardiograms","volume":"1","author":"Roelandt","year":"1980","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acvd.2016.02.013_bib0345","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.acvd.2016.02.013_bib0350","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1136\/bmj.323.7321.1123","article-title":"Statistics notes: analysing controlled trials with baseline and follow up measurements","volume":"323","author":"Vickers","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.acvd.2016.02.013_bib0355","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00001648-199001000-00010","article-title":"No adjustments are needed for multiple comparisons","volume":"1","author":"Rothman","year":"1990","journal-title":"Epidemiology"},{"key":"10.1016\/j.acvd.2016.02.013_bib0360","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1001\/archinternmed.2011.31","article-title":"The persistent exclusion of older patients from ongoing clinical trials regarding heart failure","volume":"171","author":"Cherubini","year":"2011","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.acvd.2016.02.013_bib0365","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1001\/jama.1992.03490110055029","article-title":"The exclusion of the elderly and women from clinical trials in acute myocardial infarction","volume":"268","author":"Gurwitz","year":"1992","journal-title":"JAMA"},{"key":"10.1016\/j.acvd.2016.02.013_bib0370","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1001\/archinternmed.2011.33","article-title":"Age-based exclusions from cardiovascular clinical trials: implications for elderly individuals (and for all of us): comment on \u201cthe persistent exclusion of older patients from ongoing clinical trials regarding heart failure\u201d","volume":"171","author":"Gurwitz","year":"2011","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.acvd.2016.02.013_bib0375","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ahj.2007.03.025","article-title":"Tolerability and dose-related effects of nebivolol in elderly patients with heart failure: data from the Study of the Effects of Nebivolol Intervention on Outcomes and Rehospitalisation in Seniors with Heart Failure (SENIORS) trial","volume":"154","author":"Dobre","year":"2007","journal-title":"Am Heart J"},{"key":"10.1016\/j.acvd.2016.02.013_bib0380","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/eurheartj\/ehi251","article-title":"Adherence to guidelines is a predictor of outcome in chronic heart failure: the MAHLER survey","volume":"26","author":"Komajda","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acvd.2016.02.013_bib0385","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0002-8703(00)90313-2","article-title":"Management of heart failure among very old persons living in long-term care: has the voice of trials spread? The SAGE Study Group","volume":"139","author":"Gambassi","year":"2000","journal-title":"Am Heart J"},{"key":"10.1016\/j.acvd.2016.02.013_bib0390","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1001\/jama.2009.2","article-title":"BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial","volume":"301","author":"Pfisterer","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.acvd.2016.02.013_bib0395","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"Cohen","year":"1992","journal-title":"Psychol Bull"},{"key":"10.1016\/j.acvd.2016.02.013_bib0400","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2288-2-8","article-title":"Do multiple outcome measures require p-value adjustment?","volume":"2","author":"Feise","year":"2002","journal-title":"BMC Med Res Methodol"}],"container-title":["Archives of Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187521361630170X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187521361630170X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:43:24Z","timestamp":1761745404000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187521361630170X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S187521361630170X"],"URL":"https:\/\/doi.org\/10.1016\/j.acvd.2016.02.013","relation":{},"ISSN":["1875-2136"],"issn-type":[{"value":"1875-2136","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimized management of heart failure patients aged 80 years or more improves outcomes versus usual care: The HF80 randomized trial","name":"articletitle","label":"Article Title"},{"value":"Archives of Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acvd.2016.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}