{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:18:28Z","timestamp":1791649108479,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Cardiovascular Diseases"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.acvd.2020.01.005","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T07:45:18Z","timestamp":1585554318000},"page":"244-251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prognostic value of heart rate reserve is additive to coronary flow velocity reserve during dipyridamole stress echocardiography"],"prefix":"10.1016","volume":"113","author":[{"given":"Lauro","family":"Cortigiani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quirino","family":"Ciampi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Carpeggiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bovenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Picano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.acvd.2020.01.005_bib0155","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.echo.2007.07.003","article-title":"American Society of Echocardiography, American Society of Echocardiography recommendations for performance, interpretation, and application of stress echocardiography","volume":"20","author":"Pellikka","year":"2007","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.acvd.2020.01.005_bib0160","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1093\/eurheartj\/eht296","article-title":"2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology","volume":"34","author":"Montalescot","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acvd.2020.01.005_bib0165","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/ejechocard\/jen175","article-title":"Stress echocardiography expert consensus statement: European Association of Echocardiography (EAE) (a registered branch of the ESC)","volume":"9","author":"Sicari","year":"2008","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.acvd.2020.01.005_bib0170","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijcard.2016.08.313","article-title":"The declining frequency of inducible myocardial ischemia during stress echocardiography over 27 consecutive years (1983-2009)","volume":"224","author":"Carpeggiani","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.acvd.2020.01.005_bib0175","doi-asserted-by":"crossref","first-page":"e008564","DOI":"10.1161\/CIRCIMAGING.118.008564","article-title":"Apparent declining prognostic value of a negative stress echocardiography based on regional wall motion abnormalities in patients with normal resting left ventricular function due to the changing referral profile of the population under study","volume":"12","author":"Cortigiani","year":"2019","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.acvd.2020.01.005_bib0180","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/ehjci\/jex014","article-title":"Comparison of the prognostic value of negative non-invasive cardiac investigations in patients with suspected or known coronary artery disease-a meta-analysis","volume":"18","author":"Smulders","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.acvd.2020.01.005_bib0185","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12947-018-0141-z","article-title":"The new clinical standard of integrated quadruple stress echocardiography with ABCD protocol","volume":"16","author":"Picano","year":"2018","journal-title":"Cardiovasc Ultrasound"},{"key":"10.1016\/j.acvd.2020.01.005_bib0190","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jcmg.2017.01.023","article-title":"Stress echocardiography, carotid arteries, and more: its versatility for our imaging times","volume":"11","author":"Picano","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.acvd.2020.01.005_bib0195","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1016\/j.jacc.2019.08.1046","article-title":"Functional, anatomical, and prognostic correlates of coronary flow velocity reserve during stress echocardiography","volume":"74","author":"Ciampi","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.acvd.2020.01.005_bib0200","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.amjcard.2019.06.017","article-title":"Usefulness of blunted heart rate reserve as an imaging-independent prognostic predictor during dipyridamole stress echocardiography","volume":"124","author":"Cortigiani","year":"2019","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.acvd.2020.01.005_bib0205","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/eurheartj\/eht513","article-title":"Coronary microvascular dysfunction: an update","volume":"35","author":"Crea","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acvd.2020.01.005_bib0210","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1161\/CIRCULATIONAHA.110.940577","article-title":"Chronotropic incompetence: causes, consequences, and management","volume":"123","author":"Brubaker","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.acvd.2020.01.005_bib0215","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12947-016-0092-1","article-title":"Stress echo 2020: the international stress echo study in ischemic and non-ischemic heart disease","volume":"15","author":"Picano","year":"2017","journal-title":"Cardiovasc Ultrasound"},{"key":"10.1016\/j.acvd.2020.01.005_bib0220","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/S0140-6736(94)90508-8","article-title":"Safety and tolerability of dobutamine-atropine stress echocardiography: a prospective, multicentre study. Echo Dobutamine International Cooperative Study Group","volume":"344","author":"Picano","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.acvd.2020.01.005_bib0225","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S0002-9149(00)01424-7","article-title":"Safety, feasibility, and diagnostic accuracy of accelerated high-dose dipyridamole stress echocardiography","volume":"87","author":"Dal Porto","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.acvd.2020.01.005_bib0230","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ijcard.2017.09.172","article-title":"Quality control of regional wall motion analysis in stress Echo 2020","volume":"249","author":"Ciampi","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.acvd.2020.01.005_bib0235","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0735-1097(99)00250-8","article-title":"Cause of death in clinical research: time for a reassessment?","volume":"34","author":"Lauer","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.acvd.2020.01.005_bib0240","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1161\/01.CIR.0000072770.27332.75","article-title":"Prognostic impact of hemodynamic response to adenosine in patients older than age 55 years undergoing vasodilator stress myocardial perfusion study","volume":"107","author":"Abidov","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.acvd.2020.01.005_bib0245","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.amjcard.2005.01.042","article-title":"Heart rate response during dipyridamole stress as a predictor of mortality in patients with normal myocardial perfusion and normal electrocardiograms","volume":"95","author":"Bhatheja","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.acvd.2020.01.005_bib0250","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1001\/jama.281.6.524","article-title":"Impaired chronotropic response to exercise stress testing as a predictor of mortality","volume":"281","author":"Lauer","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.acvd.2020.01.005_bib0255","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1093\/eurheartj\/ehl393","article-title":"Outcomes after normal dobutamine stress echocardiography and predictors of adverse events: long-term follow-up of 3014 patients","volume":"27","author":"Chaowalit","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acvd.2020.01.005_bib0260","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0735-1097(03)00832-5","article-title":"Prognostic significance of impairment of heart rate response to exercise: impact of left ventricular function and myocardial ischemia","volume":"42","author":"Elhendy","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.acvd.2020.01.005_bib0265","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1161\/CIRCRESAHA.116.304679","article-title":"Cardiac innervation and sudden cardiac death","volume":"116","author":"Fukuda","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.acvd.2020.01.005_bib0270","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s10554-018-1501-3","article-title":"Drop-off in positivity rate of stress echocardiography based on regional wall motion abnormalities over the last three decades","volume":"35","author":"Cortigiani","year":"2019","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.acvd.2020.01.005_bib0275","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.echo.2016.02.011","article-title":"Coronary flow velocity reserve assessed by transthoracic doppler: the iPOWER study: factors influencing feasibility and quality","volume":"29","author":"Michelsen","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.acvd.2020.01.005_bib0280","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.echo.2014.05.009","article-title":"Coronary flow velocity reserve during pharmacologic stress echocardiography with normal contractility adds important prognostic value in diabetic and nondiabetic patients","volume":"27","author":"Lowenstein","year":"2014","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.acvd.2020.01.005_bib0285","first-page":"1179","article-title":"The additive prognostic value of coronary flow velocity reserve during exercise echocardiography","volume":"18","author":"Zagatina","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.acvd.2020.01.005_bib0290","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/eurheartj\/eht350","article-title":"Stress echo applications beyond coronary artery disease","volume":"35","author":"Picano","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acvd.2020.01.005_bib0295","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.echo.2017.11.019","article-title":"Integration of wall motion, coronary flow velocity, and left ventricular contractile reserve in a single test: prognostic value of vasodilator stress echocardiography in patients with diabetes","volume":"31","author":"Cortigiani","year":"2018","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.acvd.2020.01.005_bib0300","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/ejhf.776","article-title":"Exercise-induced B-lines identify worse functional and prognostic stage in heart failure patients with depressed left ventricular ejection fraction","volume":"19","author":"Scali","year":"2017","journal-title":"Eur J Heart Fail"}],"container-title":["Archives of Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875213620300619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875213620300619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:45:52Z","timestamp":1761745552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875213620300619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S1875213620300619"],"URL":"https:\/\/doi.org\/10.1016\/j.acvd.2020.01.005","relation":{},"ISSN":["1875-2136"],"issn-type":[{"value":"1875-2136","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic value of heart rate reserve is additive to coronary flow velocity reserve during dipyridamole stress echocardiography","name":"articletitle","label":"Article Title"},{"value":"Archives of Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acvd.2020.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}