{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:02:56Z","timestamp":1791565376289,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Cardiovascular Diseases"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.acvd.2021.10.010","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T23:46:40Z","timestamp":1639612000000},"page":"17-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Characterizing cardiac phenotype in Friedreich's ataxia: The CARFA study"],"prefix":"10.1016","volume":"115","author":[{"given":"Lise","family":"Legrand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Weinsaft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise","family":"Pousset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Ewenczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrine","family":"Charles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Hatem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Heinzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Biet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Durr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Redheuil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.acvd.2021.10.010_bib0170","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1056\/NEJM199610173351601","article-title":"Clinical and genetic abnormalities in patients with Friedreich's ataxia","volume":"335","author":"Durr","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.acvd.2021.10.010_bib0175","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/hmg\/9.6.887","article-title":"Recent advances in the molecular pathogenesis of Friedreich ataxia","volume":"9","author":"Puccio","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.acvd.2021.10.010_bib0180","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1161\/CIRCULATIONAHA.111.059477","article-title":"The heart in Friedreich ataxia: definition of cardiomyopathy, disease severity, and correlation with neurological symptoms","volume":"125","author":"Weidemann","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.acvd.2021.10.010_bib0185","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1001\/jamaneurol.2015.1855","article-title":"A 22-year follow-up study of long-term cardiac outcome and predictors of survival in Friedreich Ataxia","volume":"72","author":"Pousset","year":"2015","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.acvd.2021.10.010_bib0190","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jns.2011.05.023","article-title":"Mortality in Friedreich ataxia","volume":"307","author":"Tsou","year":"2011","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.acvd.2021.10.010_bib0195","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1177\/0883073812448535","article-title":"Cardiomyopathy in Friedreich ataxia: clinical findings and research","volume":"27","author":"Payne","year":"2012","journal-title":"J Child Neurol"},{"key":"10.1016\/j.acvd.2021.10.010_bib0200","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.amjcard.2011.09.025","article-title":"Analysis of echocardiograms in a large heterogeneous cohort of patients with friedreich ataxia","volume":"109","author":"Regner","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.acvd.2021.10.010_bib0205","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/CIRCULATIONAHA.111.089409","article-title":"Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality","volume":"126","author":"Wong","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.acvd.2021.10.010_bib0210","doi-asserted-by":"crossref","first-page":"643","DOI":"10.2217\/fca.11.45","article-title":"Novel imaging techniques for diffuse myocardial fibrosis","volume":"7","author":"Sado","year":"2011","journal-title":"Future Cardiol"},{"key":"10.1016\/j.acvd.2021.10.010_bib0215","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.jacc.2013.05.077","article-title":"T1 mapping for diffuse myocardial fibrosis: a key biomarker in cardiac disease?","volume":"62","author":"Moon","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.acvd.2021.10.010_bib0220","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ijcard.2015.05.074","article-title":"The cardiomyopathy in Friedreich's ataxia - New biomarker for staging cardiac involvement","volume":"194","author":"Weidemann","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.acvd.2021.10.010_bib0225","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehq443","article-title":"Impaired myocardial perfusion reserve and fibrosis in Friedreich ataxia: a mitochondrial cardiomyopathy with metabolic syndrome","volume":"32","author":"Raman","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acvd.2021.10.010_bib0230","doi-asserted-by":"crossref","first-page":"305","DOI":"10.14503\/THIJ-14-4198","article-title":"Serum versus imaging biomarkers in friedreich ataxia to indicate left ventricular remodeling and outcomes","volume":"43","author":"Mehta","year":"2016","journal-title":"Tex Heart Inst J"},{"key":"10.1016\/j.acvd.2021.10.010_bib0235","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nm.3510","article-title":"Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia","volume":"20","author":"Perdomini","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.acvd.2021.10.010_bib0240","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1002\/ejhf.876","article-title":"Effect of ivabradine in patients with heart failure with preserved ejection fraction: the EDIFY randomized placebo-controlled trial","volume":"19","author":"Komajda","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.acvd.2021.10.010_bib0245","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1097\/HJH.0b013e328302ca14","article-title":"Effects of papillary muscles and trabeculae on left ventricular quantification: increased impact of methodological variability in patients with left ventricular hypertrophy","volume":"26","author":"Janik","year":"2008","journal-title":"J Hypertens"},{"key":"10.1016\/j.acvd.2021.10.010_bib0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.echo.2019.07.010","article-title":"Incremental utility of right ventricular dysfunction in patients with myeloproliferative neoplasm-associated pulmonary hypertension","author":"Kim","year":"2019","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.acvd.2021.10.010_bib0255","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jcmg.2012.08.016","article-title":"Mitral apparatus assessment by delayed enhancement CMR: relative impact of infarct distribution on mitral regurgitation","volume":"6","author":"Chinitz","year":"2013","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.acvd.2021.10.010_bib0260","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1148\/radiol.2482072016","article-title":"Left ventricle: automated segmentation by using myocardial effusion threshold reduction and intravoxel computation at MR imaging","volume":"248","author":"Codella","year":"2008","journal-title":"Radiology"},{"key":"10.1016\/j.acvd.2021.10.010_bib0265","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1161\/CIRCIMAGING.111.966754","article-title":"Improved left ventricular mass quantification with partial voxel interpolation: in vivo and necropsy validation of a novel cardiac MRI segmentation algorithm","volume":"5","author":"Codella","year":"2012","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.acvd.2021.10.010_bib0270","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1532-429X-12-63","article-title":"Automated left ventricular diastolic function evaluation from phase-contrast cardiovascular magnetic resonance and comparison with Doppler echocardiography","volume":"12","author":"Bollache","year":"2010","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.acvd.2021.10.010_bib0275","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12968-017-0389-8","volume":"19","author":"Messroghli","year":"2017","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.acvd.2021.10.010_bib0280","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1161\/CIRCULATIONAHA.106.635409","article-title":"Rapid detection of myocardial infarction by subsecond, free-breathing delayed contrast-enhancement cardiovascular magnetic resonance","volume":"115","author":"Sievers","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.acvd.2021.10.010_bib0285","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.hfc.2017.08.009","article-title":"Galectin-3 in heart failure: an update of the last 3 years","volume":"14","author":"Gehlken","year":"2018","journal-title":"Heart Fail Clin"},{"key":"10.1016\/j.acvd.2021.10.010_bib0290","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1093\/brain\/awn059","article-title":"Composite cerebellar functional severity score: validation of a quantitative score of cerebellar impairment","volume":"131","author":"du Montcel","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.acvd.2021.10.010_bib0295","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1212\/WNL.0000000000001403","article-title":"Quantifiable evaluation of cerebellar signs in children","volume":"84","author":"Filipovic Pierucci","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.acvd.2021.10.010_bib0300","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/jnnp-2017-316964","article-title":"Friedreich and dominant ataxias: quantitative differences in cerebellar dysfunction measurements","volume":"89","author":"Tanguy Melac","year":"2018","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.acvd.2021.10.010_bib0305","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/mds.23879","article-title":"Annual change in Friedreich's ataxia evaluated by the Scale for the Assessment and Rating of Ataxia (SARA) is independent of disease severity","volume":"27","author":"Marelli","year":"2012","journal-title":"Mov Disord"},{"key":"10.1016\/j.acvd.2021.10.010_bib0310","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.jacc.2013.10.084","article-title":"Diffuse myocardial fibrosis evaluated by post-contrast t1 mapping correlates with left ventricular stiffness","volume":"63","author":"Ellims","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.acvd.2021.10.010_bib0315","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nrcardio.2014.159","article-title":"Cardiac MRI: a central prognostic tool in myocardial fibrosis","volume":"12","author":"Ambale-Venkatesh","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.acvd.2021.10.010_bib0320","doi-asserted-by":"crossref","first-page":"e0116396","DOI":"10.1371\/journal.pone.0116396","article-title":"The pathogenesis of cardiomyopathy in Friedreich ataxia","volume":"10","author":"Koeppen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.acvd.2021.10.010_bib0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2011.01.010","article-title":"Friedreich's ataxia: pathology, pathogenesis, and molecular genetics","volume":"303","author":"Koeppen","year":"2011","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.acvd.2021.10.010_bib0330","first-page":"9","article-title":"Significance of NT-proBNP and high-sensitivity Troponin in Friedreich Ataxia","author":"Legrand","year":"2020","journal-title":"J Clin Med"}],"container-title":["Archives of Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875213621002163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875213621002163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:47:17Z","timestamp":1761745637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875213621002163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1875213621002163"],"URL":"https:\/\/doi.org\/10.1016\/j.acvd.2021.10.010","relation":{},"ISSN":["1875-2136"],"issn-type":[{"value":"1875-2136","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterizing cardiac phenotype in Friedreich's ataxia: The CARFA study","name":"articletitle","label":"Article Title"},{"value":"Archives of Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acvd.2021.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}