{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:31:29Z","timestamp":1790962289184,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Cardiovascular Diseases"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.acvd.2023.07.008","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T04:37:54Z","timestamp":1694234274000},"page":"467-473","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Independent association of aortic stenosis with many known cardiovascular risk factors and many inflammatory diseases"],"prefix":"10.1016","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7492-0510","authenticated-orcid":false,"given":"Mohammad Reza","family":"Movahed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3257-9948","authenticated-orcid":false,"given":"Brandon","family":"Timmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4982-8709","authenticated-orcid":false,"given":"Mehrtash","family":"Hashemzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.acvd.2023.07.008_bib0210","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.amjmed.2016.10.005","article-title":"Aortic stenosis: pathophysiology, diagnosis, and therapy","volume":"130","author":"Joseph","year":"2017","journal-title":"Am J Med"},{"key":"10.1016\/j.acvd.2023.07.008_bib0215","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.mayocp.2018.01.020","article-title":"Management of patients with aortic valve stenosis","volume":"93","author":"Kanwar","year":"2018","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.acvd.2023.07.008_bib0220","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jcmg.2022.10.009","article-title":"Aortic stenosis progression: a systematic review and meta-analysis","volume":"16","author":"Willner","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.acvd.2023.07.008_bib0225","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jjcc.2017.11.007","article-title":"Mechanisms of aortic stenosis","volume":"71","author":"Akahori","year":"2018","journal-title":"J Cardiol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0230","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/1753944712439337","article-title":"Pathophysiologic mechanisms of calcific aortic stenosis","volume":"6","author":"Alexopoulos","year":"2012","journal-title":"Ther Adv Cardiovasc Dis"},{"key":"10.1016\/j.acvd.2023.07.008_bib0235","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.jacc.2012.02.093","article-title":"Calcific aortic stenosis: a disease of the valve and the myocardium","volume":"60","author":"Dweck","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carpath.2012.06.005","article-title":"The progression of calcific aortic valve disease through injury, cell dysfunction, and disruptive biologic and physical force feedback loops","volume":"22","author":"Li","year":"2013","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0245","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ijcard.2009.03.108","article-title":"Molecular and cellular mechanisms of aortic stenosis","volume":"135","author":"Yetkin","year":"2009","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0250","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1476-7120-4-27","article-title":"Epidemiology and cardiovascular risk factors of aortic stenosis","volume":"4","author":"Faggiano","year":"2006","journal-title":"Cardiovasc Ultrasound"},{"key":"10.1016\/j.acvd.2023.07.008_bib0255","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/clc.4960141210","article-title":"Development and progression of aortic valve stenosis: atherosclerosis risk factors\u00a0\u2013\u00a0a causal relationship? A clinical morphologic study","volume":"14","author":"Mohler","year":"1991","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0260","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0735-1097(96)00563-3","article-title":"Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study","volume":"29","author":"Stewart","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0265","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.jacc.2017.01.025","article-title":"Association between cardiovascular risk factors and aortic stenosis: the CANHEART Aortic Stenosis Study","volume":"69","author":"Yan","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0270","doi-asserted-by":"crossref","first-page":"e008901","DOI":"10.1161\/CIRCIMAGING.119.008901","article-title":"Impact of cumulative smoking exposure on subclinical degenerative aortic valve disease in apparently healthy male workers","volume":"12","author":"Yamaura","year":"2019","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.acvd.2023.07.008_bib0275","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0735-1097(01)01422-X","article-title":"Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease? Insights from a population-based study","volume":"38","author":"Agmon","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0280","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0002-9149(02)03010-2","article-title":"Relation between cardiovascular risk factors and nonrheumatic severe calcific aortic stenosis among patients with a three-cuspid aortic valve","volume":"91","author":"Peltier","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0285","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00019501-200509000-00007","article-title":"Aortic valve calcification: association with bone mineral density and cardiovascular risk factors","volume":"16","author":"Aksoy","year":"2005","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.acvd.2023.07.008_bib0290","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.jacc.2013.05.047","article-title":"The obesity paradox in aortic stenosis: to be or not to be","volume":"62","author":"Dumesnil","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0295","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/icvts\/ivx191","article-title":"The \u2018obesity paradox\u2019 does exist in patients undergoing transcatheter aortic valve implantation for aortic stenosis: a systematic review and meta-analysis","volume":"25","author":"Lv","year":"2017","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.acvd.2023.07.008_bib0300","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1093\/eurheartj\/ehx140","article-title":"Overall and abdominal obesity and incident aortic valve stenosis: two prospective cohort studies","volume":"38","author":"Larsson","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acvd.2023.07.008_bib0305","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jacc.2019.10.050","article-title":"Obesity as a causal risk factor for aortic valve stenosis","volume":"75","author":"Kaltoft","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0310","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.hfc.2019.06.003","article-title":"Hypertensive heart disease and obesity: a review","volume":"15","author":"Saliba","year":"2019","journal-title":"Heart Fail Clin"},{"key":"10.1016\/j.acvd.2023.07.008_bib0315","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1177\/1479164118820657","article-title":"Aortic stenosis and diabetes mellitus: an ominous combination","volume":"16","author":"Banovic","year":"2019","journal-title":"Diab Vasc Dis Res"},{"key":"10.1016\/j.acvd.2023.07.008_bib0320","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ecl.2017.10.010","article-title":"Pathogenesis of cardiovascular disease in diabetes","volume":"47","author":"Haas","year":"2018","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.acvd.2023.07.008_bib0325","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2174\/1573402114666180416161326","article-title":"Hypertension and aortic stenosis: a review","volume":"14","author":"Rassa","year":"2018","journal-title":"Curr Hypertens Rev"},{"key":"10.1016\/j.acvd.2023.07.008_bib0330","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1067\/mhj.2001.113218","article-title":"Prognostic implications of left ventricular hypertrophy","volume":"141","author":"Vakili","year":"2001","journal-title":"Am Heart J"},{"key":"10.1016\/j.acvd.2023.07.008_bib0335","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/eci.12169","article-title":"Impact of hypertension and renin-angiotensin system inhibitors in aortic stenosis","volume":"43","author":"Capoulade","year":"2013","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.acvd.2023.07.008_bib0340","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/MOL.0000000000000794","article-title":"Dyslipidemia and aortic valve disease","volume":"32","author":"Mata","year":"2021","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0345","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1093\/ndt\/13.8.2037","article-title":"Cardiac valve calcification in haemodialysis patients: role of calcium-phosphate metabolism","volume":"13","author":"Ribeiro","year":"1998","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.acvd.2023.07.008_bib0350","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jacc.2018.10.068","article-title":"Kidney dysfunction and the risk of developing aortic stenosis","volume":"73","author":"Vavilis","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0355","doi-asserted-by":"crossref","first-page":"e009980","DOI":"10.1161\/JAHA.118.009980","article-title":"Characteristics and outcomes of patients with aortic stenosis and chronic kidney disease","volume":"8","author":"Patel","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.acvd.2023.07.008_bib0360","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3109\/14017431.2015.1006671","article-title":"Impact of chronic obstructive pulmonary disease on survival and symptoms of severe aortic valve stenosis","volume":"49","author":"Poulsen","year":"2015","journal-title":"Scand Cardiovasc J"},{"key":"10.1016\/j.acvd.2023.07.008_bib0365","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1042\/CS20210835","article-title":"Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics","volume":"136","author":"Brassington","year":"2022","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.acvd.2023.07.008_bib0370","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s00380-008-1103-4","article-title":"Effects of chronic obstructive pulmonary disease on coronary atherosclerosis","volume":"24","author":"Topsakal","year":"2009","journal-title":"Heart Vessels"},{"key":"10.1016\/j.acvd.2023.07.008_bib0375","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.amjcard.2007.03.048","article-title":"Characterization of valvular heart disease in rheumatoid arthritis by transesophageal echocardiography and clinical correlates","volume":"100","author":"Roldan","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0380","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1536\/ihj.27.137","article-title":"A case of Sjogren's syndrome with valvular diseases","volume":"27","author":"Tsuji","year":"1986","journal-title":"Jpn Heart J"},{"key":"10.1016\/j.acvd.2023.07.008_bib0385","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3899\/jrheum.201025","article-title":"Increased prevalence of moderate to severe mitral and aortic valve dysfunction in systemic sclerosis: a case-control study","volume":"48","author":"Narvaez","year":"2021","journal-title":"J Rheumatol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0390","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jacc.2021.04.078","article-title":"Race\/ethnicity and prevalence of aortic stenosis by echocardiography in the multi-ethnic study of atherosclerosis","volume":"78","author":"Czarny","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0395","doi-asserted-by":"crossref","first-page":"e000879","DOI":"10.1161\/JAHA.114.000879","article-title":"Racial differences in the prevalence of severe aortic stenosis","volume":"3","author":"Patel","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.acvd.2023.07.008_bib0400","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.amjcard.2016.06.039","article-title":"Sex, race, and socioeconomic disparities in patients with aortic stenosis (from a nationwide inpatient sample)","volume":"118","author":"Beydoun","year":"2016","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0405","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.amjcard.2012.11.051","article-title":"Prevalence of mitral valve prolapse and congenital bicuspid aortic valves in black and white patients undergoing cardiac valve operations","volume":"111","author":"Novaro","year":"2013","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.acvd.2023.07.008_bib0410","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/jama.2012.96867","article-title":"Prespecified falsification end points: can they validate true observational associations?","volume":"309","author":"Prasad","year":"2013","journal-title":"JAMA"}],"container-title":["Archives of Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875213623001638?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875213623001638?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:48:43Z","timestamp":1761745723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875213623001638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S1875213623001638"],"URL":"https:\/\/doi.org\/10.1016\/j.acvd.2023.07.008","relation":{},"ISSN":["1875-2136"],"issn-type":[{"value":"1875-2136","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Independent association of aortic stenosis with many known cardiovascular risk factors and many inflammatory diseases","name":"articletitle","label":"Article Title"},{"value":"Archives of Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acvd.2023.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}