{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:11:44Z","timestamp":1792127504186,"version":"4.4.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":2618,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Actas Dermo-Sifiliogr\u00e1ficas"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.ad.2012.03.005","type":"journal-article","created":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T07:26:49Z","timestamp":1341473209000},"page":"29-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Dermatitis de contacto al\u00e9rgica por fragancias. Parte II"],"prefix":"10.1016","volume":"104","author":[{"given":"M.P.","family":"Arribas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Soro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.F.","family":"Silvestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ad.2012.03.005_bib0005","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1600-0536.2010.01739.x","article-title":"Fragrance contact allergy: a 4-year retrospective study","volume":"63","author":"Cuesta","year":"2010","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0010","doi-asserted-by":"crossref","first-page":"789","DOI":"10.2165\/00128071-200304110-00006","article-title":"Fragrance contact allergy. A clinical review","volume":"4","author":"Johansen","year":"2003","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.ad.2012.03.005_bib0015","doi-asserted-by":"crossref","unstructured":"Katz AS, Sheretz F. Facial dermatitis: patch test results and final diagnosis. Am J Contact Dermatol 1999;10: 153-6.","DOI":"10.1016\/S1046-199X(99)90058-1"},{"key":"10.1016\/j.ad.2012.03.005_bib0020","first-page":"304","article-title":"Contact allergy to individual fragrance mix constituents in relation to primary site of dermatitis","volume":"43","author":"Buckley","year":"2000","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0025","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1046\/j.1365-2133.1998.02363.x","article-title":"Allergens in combination have a synergistic effect on the elicitation response: a study of fragrance-sensitized individuals","volume":"139","author":"Johansen","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2012.03.005_bib0030","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-0536.2007.01287.x","article-title":"Frequency and trends in fragrance allergy over a 15-year period","volume":"58","author":"Nardelli","year":"2008","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0035","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.0105-1873.2004.00302.x","article-title":"Contact allergy to fragrances: frequencies of sensitization from 1996 to 2002. Results of IVDK","volume":"50","author":"Schnuch","year":"2004","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0040","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1034\/j.1600-0536.2003.480201.x","article-title":"Fragrance allergy and hand eczema- a review","volume":"48","author":"Heydorn","year":"2003","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0045","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-0536.1997.tb00418.x","article-title":"Adverse reactions to fragrances: a clinical review","volume":"36","author":"De Grott","year":"1997","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0050","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1600-0536.1989.tb04746.x","article-title":"Clinical patch test data evaluated by multivariate analysis","volume":"21","author":"Christophersen","year":"1989","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0055","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1600-0536.1993.tb03373.x","article-title":"Frequency of false-negative reactions to the fragrance mix","volume":"28","author":"De Groot","year":"1993","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0060","first-page":"120","article-title":"Contact allergens in persons with leg ulcers: a Canadian study in contact sensitization","volume":"7","author":"Smart","year":"2008","journal-title":"Int J Wound"},{"key":"10.1016\/j.ad.2012.03.005_bib0065","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1600-0536.1987.tb01473.x","article-title":"Contact dermatitis to geraniol in a leg ulcer","volume":"16","author":"Guerra","year":"1987","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0070","first-page":"80","article-title":"Identification of risk products for fragrance contact allergy: a case referent study based on patients histories","volume":"2","author":"Johansen","year":"1998","journal-title":"Am J Contact Dermatol"},{"key":"10.1016\/j.ad.2012.03.005_bib0075","first-page":"317","article-title":"A diagnostic pearl in allergic contact dermatitis to fragrantes: the atomizar sign","volume":"82","author":"Jacob","year":"2008","journal-title":"Cutis"},{"key":"10.1016\/j.ad.2012.03.005_bib0080","first-page":"688","article-title":"Contact allergy in chronic eczematous lip dermatitis","volume":"18","author":"Schena","year":"2008","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.ad.2012.03.005_bib0085","unstructured":"Von Krogh G, Maibach HI. The contact urticaria syndrome. En: Marzulli FN, Maibach HI, editors. Dermatotoxicology. 2nd ed. New York; 1983. p. 301."},{"key":"10.1016\/j.ad.2012.03.005_bib0090","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1600-0536.1999.tb06173.x","article-title":"Contact urticaria syndrome from constituents of balsam of Per\u00fa and fragrance mix in a patient with chronic urticaria","volume":"41","author":"Cancian","year":"1999","journal-title":"Contact Dermatitis Hemisphere Pub Corp"},{"key":"10.1016\/j.ad.2012.03.005_bib0095","first-page":"31","article-title":"Formes cliniques des manifestations cutane\u00e9s d\u00e1llergic aux parfums","volume":"113","author":"Meynadier","year":"1986","journal-title":"Ann Dermatol Veneorol"},{"key":"10.1016\/j.ad.2012.03.005_bib0100","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1365-2133.1982.tb00356.x","article-title":"The relationship between exposure to fragrance materials and persistent light reactions in the photosensitivity dermatitis","volume":"107","author":"Addo","year":"1982","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2012.03.005_bib0105","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0190-9622(80)80390-2","article-title":"6-Methylcoumarin photocontact dermatitis","volume":"2","author":"Jackson","year":"1980","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.ad.2012.03.005_bib0110","first-page":"305","article-title":"The standard battery of photopatch test in France. Prospective study by the French Society for Photodermatology","volume":"13","author":"Leonard","year":"1994","journal-title":"Nouv Dermatol"},{"key":"10.1016\/j.ad.2012.03.005_bib0115","first-page":"103","article-title":"Different clinical presentations in photosensitivity to musk ambrette","volume":"6","author":"S\u00e1nchez-Pedre\u00f1o","year":"1989","journal-title":"Photodermatol"},{"key":"10.1016\/j.ad.2012.03.005_bib0120","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1046\/j.1365-2133.2002.04993.x","article-title":"Evaluation of the role of contact sensitization and photosensitivity in the pathogenesis of poikiloderma of Civatte","volume":"147","author":"Katoulis","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2012.03.005_bib0125","first-page":"136","article-title":"Photoallergic contact sensitization to 6-methylcoumarin in poikiloderma of Civatte","volume":"16","author":"Vachiramon","year":"2005","journal-title":"Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0130","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1600-0536.1981.tb03989.x","article-title":"Berloque dermatitis - a continuing cosmetic problem","volume":"7","author":"Zaynoun","year":"1981","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0135","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1365-4362.1976.tb01825.x","article-title":"Pigmented cosmetic dermatitis","volume":"15","author":"Nakayama","year":"1976","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.ad.2012.03.005_bib0140","first-page":"186","article-title":"Bullous contact allergy from cinnamon","volume":"36","author":"Goh","year":"1988","journal-title":"Dermatosen"},{"key":"10.1016\/j.ad.2012.03.005_bib0145","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0190-9622(81)70128-2","article-title":"A case of contact dermatitis, erythema multiforme and toxic epidermal necrolysis","volume":"5","author":"Thompson","year":"1981","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.ad.2012.03.005_bib0150","first-page":"3","article-title":"Allergen of the Year: fragrance","volume":"18","author":"Storrs Frances","year":"2007","journal-title":"Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0155","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1046\/j.1365-2133.2001.04345.x","article-title":"The significance of fragrance mix, balsam of Peru, colophony and propolis as screening tools in the detection of fragrance allergy","volume":"145","author":"W\u00f6hrl","year":"2001","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2012.03.005_bib0160","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1600-0536.1999.tb06178.x","article-title":"Colophony allergy: a review","volume":"41","author":"Downs","year":"1999","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0165","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-0536.1999.tb05994.x","article-title":"Routine patch testing with the sesquiterpene lactone mix in Europe: a 2-year experience. A multicentre study of the EECDRG","volume":"40","author":"Paulsen","year":"1999","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0170","first-page":"1","article-title":"Contact allergy to fragrances: clinical and experimental investigations of the fragrance mix and its ingredients","volume":"46","author":"Johansen","year":"2002","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0175","unstructured":"Rietschel RL, Fowler JF, Fisher AA. Fisher's Contact dermatitis. 6 ed. Hamilton, Ontario:BC Decker; 2008."},{"key":"10.1016\/j.ad.2012.03.005_bib0180","first-page":"231","article-title":"Some experiences of war-time industrial dermatoses","volume":"28","author":"Bonnevie","year":"1948","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"10.1016\/j.ad.2012.03.005_bib0185","first-page":"93","article-title":"Contact allergy to balsam of Peru ii. Patch test results in 102 patients with selected balsam of Peru constituents","volume":"12","author":"Hausen","year":"2001","journal-title":"Am J Contact Dermat"},{"key":"10.1016\/j.ad.2012.03.005_bib0190","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1001\/archderm.1977.01640050083012","article-title":"Perfume dermatitis","volume":"113","author":"Larsen","year":"1977","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.ad.2012.03.005_bib0195","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0190-9622(79)70010-7","article-title":"Allergic contact dermatitis to the perfume in Mycolog cream","volume":"1","author":"Larsen","year":"1979","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.ad.2012.03.005_bib0200","first-page":"384","article-title":"Patch testing with fragrance mix at 16% and 8%, and its individual constituient","volume":"20","author":"Enders","year":"1989","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0205","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0001-7310(04)79199-1","article-title":"Estudio epidemiol\u00f3gico de la dermatitis al\u00e9rgica de contacto en Espa\u00f1a (2001)","volume":"95","author":"Garc\u00eda-Bravo","year":"2004","journal-title":"Actas Dermosifilogr"},{"key":"10.1016\/j.ad.2012.03.005_bib0210","first-page":"77","article-title":"Fragrance contact dermatitis-a worldwide multicenter investigation","volume":"7","author":"Larsen","year":"1996","journal-title":"Am J Contact Dermat"},{"key":"10.1016\/j.ad.2012.03.005_bib0215","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1600-0536.2010.01737.x","article-title":"Fragrance mix ii in the baseline series contributes significantly to detection of fragrance allergy","volume":"63","author":"Heisterberg","year":"2010","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0220","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.0105-1873.2005.00565.x","article-title":"Patch testing with a new fragrance mix detects additional patients sensitive to perfums and missed by the current fragrance mix","volume":"52","author":"Frosch","year":"2005","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0225","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.0105-1873.2005.00563.x","article-title":"Patch testing with a new fragrance mix-reactivity to the individual constituents and chemical detection in relevant cosmetic productos","volume":"52","author":"Frosch","year":"2005","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0230","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1600-0536.2007.01292.x","article-title":"Recommendation to include fragrance mix 2 and Hydroxyisohexyl 3- cyclohexene carboxaldehyde (Lyral) in the European baseline patch test series","volume":"58","author":"Bruze","year":"2008","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0235","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1600-0536.2010.01753.x","article-title":"Patch testing with fragrances mix ii: results of the IVDK 2005-2008","volume":"63","author":"Krautheim","year":"2010","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0240","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.0105-1873.2005.00605.x","article-title":"Selected oxidized fragrance terpenes are common contact allergens","volume":"52","author":"Matura","year":"2005","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0245","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1600-0536.2011.01873.x","article-title":"Allergy to oxidized linalool in the UK","volume":"64","author":"Buckley","year":"2011","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0250","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1600-0536.2006.01062.x","article-title":"Majantol\u2013a new fragrance allergen","volume":"57","author":"Schnuch","year":"2007","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0255","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1034\/j.1600-0536.2002.460302.x","article-title":"Fragrance contact dermatitis\u2013a world wide multicentre investigation (part iii)","volume":"46","author":"Larsen","year":"2002","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0536.2007.01088.x","article-title":"Sensitization to 26 fragrances to be labelled according to current European regulation. Results of the IVDK and review of the literature","volume":"57","author":"Schnuch","year":"2007","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0265","unstructured":"Directive 2003\/15\/EC of the European Parliament and of the Council Directive of 27 February 2003 amending Council Directive of 27 July 1976 on the approximation of the laws of the Members States relating to cosmetic products (76\/768\/EEC). OJEU. 2003;L66:26\u201335."},{"key":"10.1016\/j.ad.2012.03.005_bib0270","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1600-0536.2008.01478.x","article-title":"Is low content in atranol\/chloroatranol safe in oak moss-sensitized individuals","volume":"60","author":"Nardelli","year":"2009","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.ad.2012.03.005_bib0275","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2340\/0001555572264265","article-title":"Skin sensitization to cinnamic alcohol: the role of skin metabolism","volume":"72","author":"Basketter","year":"1992","journal-title":"Acta Derm Veneorol (Stockh)"},{"key":"10.1016\/j.ad.2012.03.005_bib0280","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.fct.2004.09.014","article-title":"Fragrances material review on cinnamaldehyde","volume":"43","author":"Cocchiara","year":"2005","journal-title":"Food Chem Toxicol"}],"container-title":["Actas Dermo-Sifiliogr\u00e1ficas"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001731012001950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001731012001950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:59:09Z","timestamp":1757552349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001731012001950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0001731012001950"],"URL":"https:\/\/doi.org\/10.1016\/j.ad.2012.03.005","relation":{},"ISSN":["0001-7310"],"issn-type":[{"value":"0001-7310","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dermatitis de contacto al\u00e9rgica por fragancias. Parte II","name":"articletitle","label":"Article Title"},{"value":"Actas Dermo-Sifiliogr\u00e1ficas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ad.2012.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Espa\u00f1a, S.L. and AEDV.","name":"copyright","label":"Copyright"}]}}