{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:36:59Z","timestamp":1792823819063,"version":"4.5.0"},"reference-count":101,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Actas Dermo-Sifiliogr\u00e1ficas"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.ad.2013.10.019","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T16:44:49Z","timestamp":1395679489000},"page":"86-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Filagrina: papel en la barrera cut\u00e1nea y en el desarrollo de patolog\u00eda"],"prefix":"10.1016","volume":"106","author":[{"given":"M.","family":"Armengot-Carbo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1.","family":"Hern\u00e1ndez-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Torrelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ad.2013.10.019_bib0005","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1046\/j.1523-1747.2003.12359.x","article-title":"Barrier function of the skin: \u00abla raison d\u2019\u00eatre\u00bb of the epidermis","volume":"121","author":"Madison","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0010","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1242\/jcs.033969","article-title":"Filaggrin in the frontline: Role in skin barrier function and disease","volume":"122","author":"Sandilands","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ad.2013.10.019_bib0015","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0005-2795(77)90055-1","article-title":"Purification and characterization of a basic protein from the stratum corneum of mammalian epidermis","volume":"491","author":"Dale","year":"1977","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ad.2013.10.019_bib0020","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1073\/pnas.78.7.4097","article-title":"Characterization of a class of cationic proteins that specifically interact with intermediate filaments","volume":"78","author":"Steinert","year":"1981","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ad.2013.10.019_bib0025","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jaci.2012.12.668","article-title":"The multifunctional role of filaggrin in allergic skin disease","volume":"131","author":"McAleer","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0030","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1600-0625.2008.00786.x","article-title":"The skin: An indispensable barrier","volume":"17","author":"Proksch","year":"2008","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0035","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/emm.1999.2","article-title":"Bricks and mortar of the epidermal barrier","volume":"31","author":"Nemes","year":"1999","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.ad.2013.10.019_bib0040","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/1523-1747.ep12273485","article-title":"Ionic calcium reservoirs in mammalian epidermis: Ultrastructural localization by ion-capture cytochemistry","volume":"84","author":"Menon","year":"1985","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0045","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1172\/JCI115617","article-title":"Calcium and potassium are important regulators of barrier homeostasis in murine epidermis","volume":"89","author":"Lee","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ad.2013.10.019_bib0050","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1586\/eci.11.100","article-title":"Filaggrin mutations and atopy: Consequences for future therapeutics","volume":"8","author":"Heimall","year":"2012","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0055","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1242\/jcs.114.17.3069","article-title":"Assembly of the epidermal cornified cell envelope","volume":"114","author":"Kalinin","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ad.2013.10.019_bib0060","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/bies.10144","article-title":"Epithelial barrier function: Assembly and structural features of the cornified cell envelope","volume":"24","author":"Kalinin","year":"2002","journal-title":"Bioessays"},{"key":"10.1016\/j.ad.2013.10.019_bib0065","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrm1619","article-title":"The cornified envelope: A model of cell death in the skin","volume":"6","author":"Candi","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"Suppl 1","key":"10.1016\/j.ad.2013.10.019_bib0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1396-0296.2004.04S1005.x","article-title":"Moisturization and skin barrier function","volume":"17","author":"Rawlings","year":"2004","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.ad.2013.10.019_bib0075","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/jid.2011.393","article-title":"One remarkable molecule: Filaggrin","volume":"132","author":"Brown","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0080","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1016\/j.ajpath.2011.01.053","article-title":"Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function","volume":"178","author":"Gruber","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ad.2013.10.019_bib0085","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2340\/00015555-1531","article-title":"Skin pH: From basic science to basic skin care","volume":"93","author":"Ali","year":"2013","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.ad.2013.10.019_bib0090","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/jid.2010.231","article-title":"Increased sensitivity of histidinemic mice to UVB radiation suggests a crucial role of endogenous urocanic acid in photoprotection","volume":"131","author":"Barresi","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0095","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/0167-5699(92)90005-R","article-title":"Immunosuppression by ultraviolet B radiation: Initiation by urocanic acid","volume":"13","author":"Noonan","year":"1992","journal-title":"Immunol Today"},{"key":"10.1016\/j.ad.2013.10.019_bib0100","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1073\/pnas.0603119103","article-title":"Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor","volume":"103","author":"Walterscheid","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ad.2013.10.019_bib0105","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJMra1011040","article-title":"Filaggrin mutations associated with skin and allergic diseases","volume":"365","author":"Irvine","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ad.2013.10.019_bib0110","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.jaci.2011.12.989","article-title":"Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency","volume":"129","author":"Kezic","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0115","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/1523-1747.ep12338501","article-title":"Genes encoding structural proteins of epidermal cornification and S100 calcium-binding proteins form a gene complex (\u00abepidermal differentiation complex\u00bb) on human chromosome 1q21","volume":"106","author":"Mischke","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0120","doi-asserted-by":"crossref","first-page":"23772","DOI":"10.1016\/S0021-9258(18)35905-2","article-title":"Characterization of the human epidermal profilaggrin gene. Genomic organization and identification of an S-100-like calcium binding domain at the amino terminus","volume":"267","author":"Presland","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ad.2013.10.019_bib0125","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/1523-1747.ep12612770","article-title":"Characterization of two distinct calcium-binding sites in the amino-terminus of human profilaggrin","volume":"104","author":"Presland","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0130","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1038\/jid.2012.174","article-title":"Regulatory role for the profilaggrin N-terminal domain in epidermal homeostasis","volume":"132","author":"Aho","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0135","first-page":"1245","article-title":"Translocation of profilaggrin N-terminal domain into keratinocyte nuclei with fragmented DNA in normal human skin and loricrin keratoderma","volume":"78","author":"Ishida-Yamamoto","year":"1998","journal-title":"Lab Invest"},{"key":"10.1016\/j.ad.2013.10.019_bib0140","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/jid.2011.460","article-title":"Interaction of the profilaggrin N-terminal domain with loricrin in human cultured keratinocytes and epidermis","volume":"132","author":"Yoneda","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0145","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ng1743","article-title":"Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris","volume":"38","author":"Smith","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.ad.2013.10.019_bib0150","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1365-2133.2011.10331.x","article-title":"Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations","volume":"165","author":"Chen","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0155","doi-asserted-by":"crossref","DOI":"10.1111\/bjd.12219","article-title":"Ichthyosis vulgaris - the filaggrin mutation disease","author":"Thyssen","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0160","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1111\/j.1468-3083.2011.04198.x","article-title":"Impact of filaggrin mutations on Raman spectra and biophysical properties of the stratum corneum in mild to moderate atopic dermatitis","volume":"26","author":"Mlitz","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.ad.2013.10.019_bib0165","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/jid.2010.398","article-title":"Full sequencing of the FLG gene in Italian patients with atopic eczema: Evidence of new mutations, but lack of an association","volume":"131","author":"Cascella","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0170","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1038\/jid.2010.115","article-title":"Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model","volume":"130","author":"Mildner","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0175","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jaci.2012.06.046","article-title":"Skin barrier abnormality caused by filaggrin (FLG) mutations is associated with increased serum 25-hydroxyvitamin D concentrations","volume":"130","author":"Thyssen","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0180","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/1523-1747.ep12264813","article-title":"Ichthyosis vulgaris: Identification of a defect in synthesis of filaggrin correlated with an absence of keratohyaline granules","volume":"84","author":"Sybert","year":"1985","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0185","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0923-1811(02)00137-8","article-title":"Changes in environmental humidity affect the water-holding property of the stratum corneum and its free amino acid content, and the expression of filaggrin in the epidermis of hairless mice","volume":"31","author":"Katagiri","year":"2003","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.ad.2013.10.019_bib0190","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1365-2133.2011.10530.x","article-title":"Filaggrin loss-of-function mutation R501X and 22824 carrier status is associated with fissured skin on the hands: Results from a cross-sectional population study","volume":"166","author":"Thyssen","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0195","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jaci.2008.01.013","article-title":"Filaggrin null mutations and childhood atopic eczema: A population-based case-control study","volume":"121","author":"Brown","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0200","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/jid.2011.435","article-title":"Skin barrier disruption: A requirement for allergen sensitization?","volume":"132","author":"De Benedetto","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0205","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.jaci.2003.12.591","article-title":"Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003","volume":"113","author":"Johansson","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0210","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4168\/aair.2011.3.2.67","article-title":"The atopic march: Progression from atopic dermatitis to allergic rhinitis and asthma","volume":"3","author":"Zheng","year":"2011","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.ad.2013.10.019_bib0215","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.1016\/j.jaci.2003.09.033","article-title":"Atopic dermatitis and the atopic march","volume":"112","author":"Spergel","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0220","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1111\/j.1365-2222.2010.03605.x","article-title":"The role of food allergy in the atopic march","volume":"40","author":"Allen","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.ad.2013.10.019_bib0225","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ng1767","article-title":"Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis","volume":"38","author":"Palmer","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.ad.2013.10.019_bib0230","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2340\/0001555565102105","article-title":"Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis","volume":"65","author":"Werner","year":"1985","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.ad.2013.10.019_bib0235","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2340\/0001555575429433","article-title":"Objective assessment of the skin of children affected by atopic dermatitis: A study of pH, capacitance and TEWL in eczematous and clinically uninvolved skin","volume":"75","author":"Seidenari","year":"1995","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.ad.2013.10.019_bib0240","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/sj.jid.5700630","article-title":"Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis","volume":"127","author":"Weidinger","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0245","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ng.358","article-title":"A homozygous frameshift mutation in the mouse FLG gene facilitates enhanced percutaneous allergen priming","volume":"41","author":"Fallon","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.ad.2013.10.019_bib0250","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jaci.2009.05.042","article-title":"Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen","volume":"124","author":"Oyoshi","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0255","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.jaci.2012.01.068","article-title":"Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice","volume":"129","author":"Kawasaki","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0260","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.1365-2133.2010.09866.x","article-title":"Filaggrin null mutations associate with increased frequencies of allergen-specific CD4+ T-helper 2 cells in patients with atopic eczema","volume":"163","author":"McPherson","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0265","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2332\/allergolint.10-RAI-0273","article-title":"Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases","volume":"60","author":"Takai","year":"2011","journal-title":"Allergol Int"},{"key":"10.1016\/j.ad.2013.10.019_bib0270","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.jaci.2006.07.026","article-title":"Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march","volume":"118","author":"Marenholz","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0275","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.jaci.2008.02.014","article-title":"Filaggrin mutations, atopic eczema, hay fever, and asthma in children","volume":"121","author":"Weidinger","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0280","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.jaci.2011.01.031","article-title":"Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy","volume":"127","author":"Brown","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0285","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.jaci.2006.08.030","article-title":"Lack of filaggrin expression in the human bronchial mucosa","volume":"118","author":"Ying","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0290","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/sj.jid.5701208","article-title":"Filaggrin expression in oral, nasal, and esophageal mucosa","volume":"128","author":"De Benedetto","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0295","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1398-9995.2008.01803.x","article-title":"Proactive therapy of atopic dermatitis--an emerging concept","volume":"64","author":"Wollenberg","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.ad.2013.10.019_bib0300","doi-asserted-by":"crossref","first-page":"253","DOI":"10.5021\/ad.2012.24.3.253","article-title":"Long term treatment concepts and proactive therapy for atopic eczema","volume":"24","author":"Wollenberg","year":"2012","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0305","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ad.2011.12.008","article-title":"Atopic dermatitis: Update and proposed management algorithm","volume":"104","author":"Garnacho-Saucedo","year":"2013","journal-title":"Actas Dermosifiliogr"},{"key":"10.1016\/j.ad.2013.10.019_bib0310","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.jaci.2009.03.036","article-title":"Meta-analysis of filaggrin polymorphisms in eczema and asthma: Robust risk factors in atopic disease","volume":"123","author":"Rodr\u00edguez","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0315","doi-asserted-by":"crossref","first-page":"b2433","DOI":"10.1136\/bmj.b2433","article-title":"Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: Systematic review and meta-analysis","volume":"339","author":"Van den Oord","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.ad.2013.10.019_bib0320","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/j.1365-2133.2009.09339.x","article-title":"Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of: Further delineation of the skin phenotype in a prospective epidemiological study of 792 school children","volume":"161","author":"Brown","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0325","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/jid.2008.413","article-title":"Eczema genetics: Current state of knowledge and future goals","volume":"129","author":"Brown","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0330","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1038\/sj.jid.5701206","article-title":"Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema","volume":"128","author":"Brown","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0335","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/sj.jid.5700579","article-title":"Two common loss-of-function mutations within the filaggrin gene predispose for early onset of atopic dermatitis","volume":"127","author":"Stemmler","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0340","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jaci.2012.07.008","article-title":"The persistence of atopic dermatitis and filaggrin (FLG) mutations in a US longitudinal cohort","volume":"130","author":"Margolis","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0345","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1398-9995.2010.02326.x","article-title":"Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema","volume":"65","author":"Jungersted","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.ad.2013.10.019_bib0350","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.jaci.2008.01.026","article-title":"The burden of disease associated with filaggrin mutations: A population-based, longitudinal birth cohort study","volume":"121","author":"Henderson","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0355","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jaci.2009.07.034","article-title":"Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum","volume":"124","author":"Gao","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0360","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1371\/journal.pmed.0050131","article-title":"Gene-environment interaction in the onset of eczema in infancy: Filaggrin loss-of-function mutations enhanced by neonatal cat exposure","volume":"5","author":"Bisgaard","year":"2008","journal-title":"PLoS Med"},{"key":"10.1016\/j.ad.2013.10.019_bib0365","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1111\/j.1398-9995.2009.02080.x","article-title":"Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure","volume":"64","author":"Schuttelaar","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.ad.2013.10.019_bib0370","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.jaci.2010.03.036","article-title":"Elder siblings enhance the effect of filaggrin mutations on childhood eczema: Results from the 2 birth cohort studies LISAplus and GINIplus","volume":"125","author":"Cramer","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0375","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1056\/NEJMra074081","article-title":"Atopic dermatitis","volume":"358","author":"Bieber","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ad.2013.10.019_bib0380","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1365-2133.1990.tb01455.x","article-title":"Assessment of a contact-plate sampling technique and subsequent quantitative bacterial studies in atopic dermatitis","volume":"123","author":"Williams","year":"1990","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0385","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.jaci.2010.09.015","article-title":"Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus","volume":"126","author":"Miajlovic","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0390","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jaci.2008.04.022","article-title":"Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3","volume":"122","author":"Kisich","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0395","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jaci.2012.10.030","article-title":"Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal \u03b1-toxin-induced keratinocyte death","volume":"131","author":"Brauweiler","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0400","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1365-2133.2011.10541.x","article-title":"Filaggrin mutations are associated with recurrent skin infection in Singaporean Chinese patients with atopic dermatitis","volume":"166","author":"Cai","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0405","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0065-2776(09)01203-6","article-title":"Cellular and molecular mechanisms in atopic dermatitis","volume":"102","author":"Oyoshi","year":"2009","journal-title":"Adv Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0410","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1016\/j.jaci.2009.07.012","article-title":"Cytokine modulation of atopic dermatitis filaggrin skin expression","volume":"124","author":"Howell","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0415","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.clim.2007.11.006","article-title":"Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6","volume":"126","author":"Kim","year":"2008","journal-title":"Clin Immunol"},{"key":"10.1016\/j.ad.2013.10.019_bib0420","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/jid.2011.342","article-title":"Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect","volume":"132","author":"Brown","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0425","first-page":"e420","article-title":"DNA methylation of the filaggrin gene adds to the risk of eczema associated with loss-of-function variants","volume":"27","author":"Ziyab","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.ad.2013.10.019_bib0430","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1365-2133.2008.08730.x","article-title":"Loss-of-function polymorphisms in the filaggrin gene are associated with an increased susceptibility to chronic irritant contact dermatitis: A case-control study","volume":"159","author":"De Jongh","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0435","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/bjd.12083","article-title":"Impact of atopic dermatitis and loss-of-function mutations in the filaggrin gene on the development of occupational irritant contact dermatitis","volume":"168","author":"Visser","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0440","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/j.1365-2133.2010.09708.x","article-title":"The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population","volume":"162","author":"Thyssen","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0445","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1600-0536.2010.01815.x","article-title":"Nickel reactivity and filaggrin null mutations--evaluation of the filaggrin bypass theory in a general population","volume":"64","author":"Ross-Hansen","year":"2011","journal-title":"Contact Derm"},{"key":"10.1016\/j.ad.2013.10.019_bib0450","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1365-2133.2009.09245.x","article-title":"Filaggrin mutations may confer susceptibility to chronic hand eczema characterized by combined allergic and irritant contact dermatitis","volume":"161","author":"Molin","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0455","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1038\/sj.jid.5700915","article-title":"Loss-of-function mutations in the filaggrin gene and alopecia areata: Strong risk factor for a severe course of disease in patients comorbid for atopic disease","volume":"127","author":"Betz","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0460","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1038\/sj.jid.5700971","article-title":"Filaggrin mutations are genetic modifying factors exacerbating X-linked ichthyosis","volume":"127","author":"Liao","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0465","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/j.1365-2133.2009.09471.x","article-title":"Increased pachyonychia congenita severity in patients with concurrent keratin and filaggrin mutations","volume":"161","author":"Gruber","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0470","doi-asserted-by":"crossref","first-page":"e000062","DOI":"10.1136\/bmjopen-2011-000062","article-title":"A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: A cross-sectional study","volume":"1","author":"Thyssen","year":"2011","journal-title":"BMJ Open"},{"key":"10.1016\/j.ad.2013.10.019_bib0475","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1038\/jid.2011.23","article-title":"Filaggrin null mutations are not a protective factor for acne vulgaris","volume":"131","author":"Common","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0480","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1038\/sj.jid.5700817","article-title":"Filaggrin null alleles are not associated with psoriasis","volume":"127","author":"Zhao","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0485","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1468-3083.2011.04107.x","article-title":"The filaggrin null genotypes R501X and 22824 seem not to be associated with psoriasis: Results from general population study and meta-analysis","volume":"26","author":"Thyssen","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.ad.2013.10.019_bib0490","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1136\/ard.2007.073239","article-title":"Loss-of-function mutations in the filaggrin gene: No contribution to disease susceptibility, but to autoantibody formation against citrullinated peptides in early rheumatoid arthritis","volume":"67","author":"H\u00fcffmeier","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ad.2013.10.019_bib0495","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1002\/ibd.20926","article-title":"Filaggrin loss-of-function variants are associated with atopic comorbidity in pediatric inflammatory bowel disease","volume":"15","author":"Van Limbergen","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.ad.2013.10.019_bib0500","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/j.1365-2133.2006.07500.x","article-title":"Filaggrin loss-of-function variant contributes to atopic dermatitis risk in the population of Northern Germany","volume":"155","author":"Ruether","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2013.10.019_bib0505","doi-asserted-by":"crossref","first-page":"e5784","DOI":"10.1371\/journal.pone.0005784","article-title":"Carrier status for the common R501X and 22824 filaggrin mutations is not associated with hearing phenotypes in 5,377 children from the ALSPAC cohort","volume":"4","author":"Rodriguez","year":"2009","journal-title":"PLoS ONE"}],"container-title":["Actas Dermo-Sifiliogr\u00e1ficas"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000173101400043X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000173101400043X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T01:03:17Z","timestamp":1757552597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000173101400043X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":101,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S000173101400043X"],"URL":"https:\/\/doi.org\/10.1016\/j.ad.2013.10.019","relation":{},"ISSN":["0001-7310"],"issn-type":[{"value":"0001-7310","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Filagrina: papel en la barrera cut\u00e1nea y en el desarrollo de patolog\u00eda","name":"articletitle","label":"Article Title"},{"value":"Actas Dermo-Sifiliogr\u00e1ficas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ad.2013.10.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Espa\u00f1a, S.L.U. and AEDV. All rights reserved.","name":"copyright","label":"Copyright"}]}}