{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:52:14Z","timestamp":1761630734636,"version":"3.44.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Actas Dermo-Sifiliogr\u00e1ficas"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.ad.2015.05.011","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T09:56:46Z","timestamp":1437559006000},"page":"846-848","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["\u00bfExploramos correctamente a los pacientes? \u00bfQu\u00e9 nos est\u00e1 pasando?"],"prefix":"10.1016","volume":"106","author":[{"given":"M.","family":"Ivars","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Redondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ad.2015.05.011_bib0095","first-page":"10","article-title":"Cancer statistics, 2005","volume":"55","author":"Jemal","year":"2005","journal-title":"Ca Cancer J Clin"},{"key":"10.1016\/j.ad.2015.05.011_bib0100","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2133.2004.05708.x","article-title":"Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma","volume":"150","author":"Lens","year":"2004","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2015.05.011_bib0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.clindermatol.2008.09.001","article-title":"Melanoma epidemiology and trends","volume":"27","author":"Garbe","year":"2009","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.ad.2015.05.011_bib0110","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-0-387-77574-6_8","article-title":"Epidemiology of melanoma and nonmelanoma skin cancer\u2013the role of sunlight","volume":"624","author":"Leiter","year":"2008","journal-title":"Adv Exp Med Biol"},{"issue":"Suppl 1","key":"10.1016\/j.ad.2015.05.011_bib0115","first-page":"S11","article-title":"High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: long-term survival update","volume":"6","author":"Atkins","year":"2000","journal-title":"Cancer J Sci Am"},{"key":"10.1016\/j.ad.2015.05.011_bib0120","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/CJI.0b013e3182742c27","article-title":"Characterizing the clinical benefit of ipilimumab in patients who progressed on high-dose IL-2","volume":"35","author":"Joseph","year":"2012","journal-title":"J Immunother"},{"key":"10.1016\/j.ad.2015.05.011_bib0125","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1056\/NEJMoa1412082","article-title":"Nivolumab in previously untreated melanoma without BRAF mutation","volume":"372","author":"Robert","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ad.2015.05.011_bib0130","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1470-2045(14)70012-9","article-title":"Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF (V600K) mutation-positive melanoma (BRIM-3): Extended follow-up of a phase 3, randomised, open-label study","volume":"15","author":"McArthur","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ad.2015.05.011_bib0135","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1203421","article-title":"Improved survival with MEK inhibition in BRAF-mutated melanoma","volume":"367","author":"Flaherty","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ad.2015.05.011_bib0140","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaad.2014.09.029","article-title":"Metastatic melanomas of unknown primary show better prognosis than those of known primary: A sistematic review and meta-analysis of observational studies","volume":"72","author":"Bae","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.ad.2015.05.011_bib0145","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1067\/mjd.2002.120531","article-title":"Skin cancer screening by dermatologists: Prevalence and barriers","volume":"46","author":"Federman","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.ad.2015.05.011_bib0150","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1001\/archdermatol.2009.137","article-title":"Routine dermatologist-performed full-body skin examination and early melanoma detection","volume":"145","author":"Kantor","year":"2009","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.ad.2015.05.011_bib0155","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1002\/cncr.10880","article-title":"Thin primary cutaneous melanomas: Associated detection patterns, lesion characteristics, and patient characteristics","volume":"95","author":"Schwartz","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.ad.2015.05.011_bib0160","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/1097-0142(20000715)89:2<342::AID-CNCR19>3.0.CO;2-P","article-title":"Patterns of detection in patients with cutaneous melanoma","volume":"89","author":"Brady","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.ad.2015.05.011_bib0165","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1001\/jama.281.7.640","article-title":"Is physician detection associated with thinner melanomas?","volume":"281","author":"Epstein","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.ad.2015.05.011_bib0170","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jaad.2005.08.065","article-title":"Presentation and detection of invasive melanoma in a high-risk population","volume":"54","author":"McPherson","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.ad.2015.05.011_bib0175","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2230.2004.01628.x","article-title":"Self-detected cutaneous melanomas in Italian patients","volume":"29","author":"Carli","year":"2004","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.ad.2015.05.011_bib0180","doi-asserted-by":"crossref","first-page":"689","DOI":"10.2340\/00015555-1625","article-title":"The importance of a full clinical examination: assessment of index lesions referred to a skin cancer clinic without a total body skin examination would miss one in three melanomas","volume":"93","author":"Aldridge","year":"2013","journal-title":"Acta Derm Venereol"}],"container-title":["Actas Dermo-Sifiliogr\u00e1ficas"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001731015002847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001731015002847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T01:03:49Z","timestamp":1757552629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001731015002847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0001731015002847"],"URL":"https:\/\/doi.org\/10.1016\/j.ad.2015.05.011","relation":{},"ISSN":["0001-7310"],"issn-type":[{"type":"print","value":"0001-7310"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u00bfExploramos correctamente a los pacientes? \u00bfQu\u00e9 nos est\u00e1 pasando?","name":"articletitle","label":"Article Title"},{"value":"Actas Dermo-Sifiliogr\u00e1ficas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ad.2015.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Espa\u00f1a, S.L.U. y AEDV. All rights reserved.","name":"copyright","label":"Copyright"}]}}