{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:28:48Z","timestamp":1780061328114,"version":"3.54.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Actas Dermo-Sifiliogr\u00e1ficas"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.ad.2018.02.009","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T09:06:19Z","timestamp":1524474379000},"page":"529-535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ros\u00e1cea papulopustulosa: respuesta al tratamiento con azitromicina oral"],"prefix":"10.1016","volume":"109","author":[{"given":"M.","family":"Lova Navarro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"S\u00e1nchez-Pedre\u00f1o Guillen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Victoria Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Mart\u00ednez Mench\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Corbal\u00e1n V\u00e9lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fr\u00edas Iniesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ad.2018.02.009_bib0165","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1111\/jdv.14349","article-title":"Swiss S1 guideline for the treatment of rosacea","volume":"31","author":"Anzengruber","year":"2017","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"10.1016\/j.ad.2018.02.009_bib0170","first-page":"505","article-title":"Systemic isotretinoin in the treatment of rosacea - Doxycycline- and placebo-controlled, randomized clinical study","volume":"8","author":"Gollnick","year":"2010","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1016\/j.ad.2018.02.009_bib0175","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1111\/bjd.13408","article-title":"Superiority of ivermectin 1% cream over metronidazole 0 75% cream in treating inflammatory lesions of rosacea: A randomized, investigator-blinded trial","volume":"172","author":"Taieb","year":"2015","journal-title":"Br J Dermatol."},{"key":"10.1016\/j.ad.2018.02.009_bib0180","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ad.2017.01.011","article-title":"Oral ivermectin to treat papulopustular rosacea in a immunocompetent patient","volume":"108","author":"Hern\u00e1ndez-Mart\u00edn","year":"2017","journal-title":"Actas Dermosifiliogr."},{"key":"10.1016\/j.ad.2018.02.009_bib0185","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1365-4632.2008.03445.x","article-title":"Comparison of efficacy of azithromycin vs. doxycycline in the treatment of rosacea: A randomized open clinical trial","volume":"47","author":"Akhyani","year":"2008","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.ad.2018.02.009_bib0190","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3346\/jkms.2011.26.5.694","article-title":"Oral azithromycin for treatment of intractable rosacea","volume":"26","author":"Kim","year":"2011","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.ad.2018.02.009_bib0195","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/archderm.140.4.489","article-title":"Oral use of azithromycin for the treatment of acne rosacea","volume":"140","author":"Fernandez-Obregon","year":"2004","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.ad.2018.02.009_bib0200","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-4632.2004.01958.x","article-title":"Therapeutic potential of azithromycin in rosacea","volume":"43","author":"Bakar","year":"2004","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.ad.2018.02.009_bib0205","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1001\/jamadermatol.2013.7688","article-title":"Severe demodexfolliculorum-associated oculocutaneous rosacea in a girl successfully treated with ivermectin","volume":"150","author":"Brown","year":"2014","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.ad.2018.02.009_bib0210","first-page":"163","article-title":"The role of Chlamydia pneumoniae in the etiology of acne rosacea: Response to the use of oral azithromycin","volume":"79","author":"Fernandez-Obregon","year":"2007","journal-title":"Cutis."},{"key":"10.1016\/j.ad.2018.02.009_bib0215","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1111\/jdv.14352","article-title":"Rosacea is associated with Helicobacter pylori: A systematic review and meta-analysis","volume":"31","author":"J\u00f8rgensen","year":"2017","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"10.1016\/j.ad.2018.02.009_bib0220","first-page":"418","article-title":"Etiopathogenesis of rosacea: A prospective study with a three-year follow-up","volume":"152","author":"Agnoletti","year":"2017","journal-title":"G Ital Dermatol Venereol."},{"key":"10.1016\/j.ad.2018.02.009_bib0225","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1046\/j.1365-2230.2003.01179.x","article-title":"The role of free oxygen radicals in the aetiopathogenesis of rosacea","volume":"28","author":"Oztas","year":"2003","journal-title":"Clin Exp Dermatol."},{"key":"10.1016\/j.ad.2018.02.009_bib0230","first-page":"17","article-title":"Reactive oxygen species and rosacea","volume":"74","author":"Jones","year":"2004","journal-title":"Cutis."},{"key":"10.1016\/j.ad.2018.02.009_bib0235","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/jac\/41.suppl_2.37","article-title":"Anti-inflammatory activity of macrolides: A new therapeutic potential?","volume":"41","author":"Labro","year":"1998","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ad.2018.02.009_bib0240","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2230.2006.02322.x","article-title":"The effect of azithromycin on reactive oxygen species in rosacea","volume":"32","author":"Bakar","year":"2007","journal-title":"Clin Exp Dermatol."},{"key":"10.1016\/j.ad.2018.02.009_bib0245","first-page":"26","article-title":"Rosacea, reactive oxygen species, and azelaic acid","volume":"2","author":"Jones","year":"2009","journal-title":"J Clin Aesthet Dermatol."},{"key":"10.1016\/j.ad.2018.02.009_bib0250","first-page":"573","article-title":"Comparison of anti-inflammatory dose doxycycline versus doxycycline 100mg in the treatment of rosacea","volume":"7","author":"Del Rosso","year":"2008","journal-title":"J Drugs Dermatol"},{"key":"10.1016\/j.ad.2018.02.009_bib0255","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/PSN.0000000000000111","article-title":"Update on the management of rosacea","volume":"35","author":"Weinkle","year":"2015","journal-title":"Plast Surg Nurs."},{"key":"10.1016\/j.ad.2018.02.009_bib0260","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.2217\/fmb.10.96","article-title":"Antibiotic resistance in Chlamydiae","volume":"5","author":"Sandoz","year":"2010","journal-title":"Future Microbiol."},{"key":"10.1016\/j.ad.2018.02.009_bib0265","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1111\/j.1468-3083.2008.02609.x","article-title":"Rosacea\/acne rosacea: Efficacy of combination therapy of azithromycin and topical 0.1% tacrolimus ointment","volume":"22","author":"Sehgal","year":"2008","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.ad.2018.02.009_bib0270","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1365-4632.2007.03360.x","article-title":"Rosacea with extensive extrafacial lesions","volume":"47","author":"Pereira","year":"2008","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.ad.2018.02.009_bib0275","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1346-8138.2005.tb00874.x","article-title":"Azithromycin in the treatment of papulopustular rosacea","volume":"32","author":"Dereli","year":"2005","journal-title":"J Dermatol"},{"key":"10.1016\/j.ad.2018.02.009_bib0280","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1046\/j.1468-3083.2000.00086-2.x","article-title":"A novel treatment for acne vulgaris and rosacea","volume":"14","author":"Elewski","year":"2000","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.ad.2018.02.009_bib0285","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/1346-8138.13756","article-title":"Four cases of Morbihan disease successfully treated with doxycycline","volume":"44","author":"Okubo","year":"2017","journal-title":"J Dermatol."},{"key":"10.1016\/j.ad.2018.02.009_bib0290","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1001\/archdermatol.2012.3109","article-title":"Successful long-term use of oral isotretinoin for the management of Morbihan disease: A case series report and review of the literature","volume":"148","author":"Smith","year":"2012","journal-title":"Arch Dermatol."},{"key":"10.1016\/j.ad.2018.02.009_bib0295","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1365-2230.2011.04042.x","article-title":"Rosacea fulminans in pregnancy: Successful treatment with azithromycin","volume":"36","author":"Fuentelsaz","year":"2011","journal-title":"Clin Exp Dermatol."},{"key":"10.1016\/j.ad.2018.02.009_bib0300","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1007\/BF01975835","article-title":"Phagocyte uptake and transport of azithromycin","volume":"10","author":"McDonald","year":"1991","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"10.1016\/j.ad.2018.02.009_bib0305","first-page":"898","article-title":"Azithromycin as an alternative rosacea therapy when tetracyclines prove problematic","volume":"7","author":"Modi","year":"2008","journal-title":"J Drugs Dermatol."},{"key":"10.1016\/j.ad.2018.02.009_bib0310","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1056\/NEJMoa1003833","article-title":"Azithromycin and the risk of cardiovascular death","volume":"17","author":"Ray","year":"2012","journal-title":"N Engl J Med."},{"key":"10.1016\/j.ad.2018.02.009_bib0315","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/MJT.0000000000000138","article-title":"Azithromycin and risk of cardiovascular death: A meta-analytic review of observational studies","volume":"22","author":"Bin Abdulhak","year":"2015","journal-title":"Am J Ther."},{"key":"10.1016\/j.ad.2018.02.009_bib0320","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.rmed.2014.09.005","article-title":"Long-term macrolide maintenance therapy in non-CF bronchiectasis: Evidence and questions","volume":"108","author":"Haworth","year":"2014","journal-title":"Respir Med."}],"container-title":["Actas Dermo-Sifiliogr\u00e1ficas"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000173101830084X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000173101830084X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T01:07:39Z","timestamp":1757552859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000173101830084X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S000173101830084X"],"URL":"https:\/\/doi.org\/10.1016\/j.ad.2018.02.009","relation":{},"ISSN":["0001-7310"],"issn-type":[{"value":"0001-7310","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ros\u00e1cea papulopustulosa: respuesta al tratamiento con azitromicina oral","name":"articletitle","label":"Article Title"},{"value":"Actas Dermo-Sifiliogr\u00e1ficas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ad.2018.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 AEDV. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}