{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:23:50Z","timestamp":1789759430421,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Actas Dermo-Sifiliogr\u00e1ficas"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ad.2025.104541","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:34:30Z","timestamp":1765211670000},"page":"104541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Overlap Between Psoriasis and Atopic Dermatitis: Therapeutic Approach"],"prefix":"10.1016","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3904-3396","authenticated-orcid":false,"given":"F.","family":"Tous-Romero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Calvo-As\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ad.2025.104541_bib0175","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.3390\/ijms23105518","article-title":"Overlapping features of psoriasis and atopic dermatitis: from genetics to immunopathogenesis to phenotypes","volume":"23","author":"Tsai","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ad.2025.104541_bib0180","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/all.15921","article-title":"Development of a clinical algorithm to predict phenotypic switches between atopic dermatitis and psoriasis (the \u201cFlip-Flop\u201d phenomenon)","volume":"79","author":"M\u00fcller","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.ad.2025.104541_bib0185","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.jaad.2021.05.013","article-title":"Development of psoriasis during treatment with dupilumab: a systematic review","volume":"86","author":"Brumfiel","year":"2022","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.ad.2025.104541_bib0190","article-title":"Tralokinumab-induced psoriasis relapse in a patient with atopic dermatitis","author":"Chiei Gallo","year":"2024","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.ad.2025.104541_bib0195","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.det.2024.02.011","article-title":"Paradoxical psoriasis","volume":"42","author":"Abdelghaffar","year":"2024","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.ad.2025.104541_bib0200","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.coi.2017.08.008","article-title":"Atopic dermatitis and psoriasis: two different immune diseases or one spectrum?","volume":"48","author":"Guttman-Yassky","year":"2017","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.ad.2025.104541_bib0205","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ad.2025.104541_bib0210","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra2023911","article-title":"Atopic dermatitis","volume":"384","author":"St\u00e4nder","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ad.2025.104541_bib0215","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jid.2023.06.194","article-title":"Genomic profiling of the overlap phenotype between psoriasis and atopic dermatitis","volume":"144","author":"Kim","year":"2024","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2025.104541_bib0220","article-title":"Skin barrier-inflammatory pathway is a driver of the psoriasis\u2013atopic dermatitis transition","volume":"11","author":"Dong","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.ad.2025.104541_bib0225","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/ijd.17100","article-title":"Psoriasis dermatitis, a common phenotype of early forms of both psoriasis and atopic dermatitis in children: a prospective multicenter study","volume":"63","author":"Docampo-Sim\u00f3n","year":"2024","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.ad.2025.104541_bib0230","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7527859","article-title":"Atopic dermatitis and psoriasis as overlapping syndromes","volume":"2020","author":"Bozek","year":"2020","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.ad.2025.104541_bib0235","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1073\/pnas.1416922112","article-title":"IL-4 abrogates T(H)17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells","volume":"112","author":"Guenova","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ad.2025.104541_bib0240","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1093\/rheumatology\/keaa568","article-title":"Regulation of entheseal IL-23 expression by IL-4 and IL-13 as an explanation for arthropathy development under dupilumab therapy","volume":"60","author":"Bridgewood","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.ad.2025.104541_bib0245","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.4049\/jimmunol.160.7.3513","article-title":"IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages","volume":"160","author":"Jovanovic","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.ad.2025.104541_bib0250","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4103\/ijd.IJD_448_20","article-title":"Eczematous reactions induced by anti-IL17 agents: report of two cases and possible pathogenic mechanisms","volume":"67","author":"S\u00e1nchez-Vel\u00e1zquez","year":"2022","journal-title":"Indian J Dermatol"},{"key":"10.1016\/j.ad.2025.104541_bib0255","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1080\/14712598.2020.1727439","article-title":"Clinical and histopathological characterization of eczematous eruptions occurring in course of anti IL-17 treatment: a case series and review of the literature","volume":"20","author":"Caldarola","year":"2020","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.ad.2025.104541_bib0260","article-title":"An update on narrowband ultraviolet B therapy for the treatment of skin diseases","volume":"13","author":"Myers","year":"2021","journal-title":"Cureus"},{"key":"10.1016\/j.ad.2025.104541_bib0265","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3892\/etm.2022.11184","article-title":"Phototherapy in dermatological maladies (Review)","volume":"23","author":"Branisteanu","year":"2022","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.ad.2025.104541_bib0270","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1080\/09546634.2021.1914315","article-title":"Effectiveness of ustekinumab in patients with atopic dermatitis: analysis of real-world evidence","volume":"33","author":"Husein-ElAhmed","year":"2022","journal-title":"J Dermatolog Treat"},{"key":"10.1016\/j.ad.2025.104541_bib0275","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/bjd.15493","article-title":"Efficacy and safety of ustekinumab in Japanese patients with severe atopic dermatitis: a randomized, double-blind, placebo-controlled, phase II study","volume":"177","author":"Saeki","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ad.2025.104541_bib0280","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jaci.2020.04.055","article-title":"Phase 2 randomized, double-blind study of IL-17 targeting with secukinumab in atopic dermatitis","volume":"147","author":"Ungar","year":"2021","journal-title":"J Allergy Clin Immunol"},{"issue":"1S","key":"10.1016\/j.ad.2025.104541_bib0285","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1097\/DER.0000000000000645","article-title":"Concurrent atopic dermatitis and psoriasis successfully treated with brodalumab","volume":"32","author":"Gambardella","year":"2021","journal-title":"Dermatitis"},{"key":"10.1016\/j.ad.2025.104541_bib0290","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1080\/09546634.2019.1702147","article-title":"Concomitant atopic dermatitis and psoriasis \u2013 a retrospective review","volume":"32","author":"Barry","year":"2021","journal-title":"J Dermatolog Treat"},{"key":"10.1016\/j.ad.2025.104541_bib0295","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3390\/pharmaceutics17010091","article-title":"Exploring the therapeutic landscape: a narrative review on topical and oral phosphodiesterase-4 inhibitors in dermatology","volume":"17","author":"Carmona-Rocha","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ad.2025.104541_bib0300","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jid.2018.10.043","article-title":"A phase 2 randomized trial of apremilast in patients with atopic dermatitis","volume":"139","author":"Simpson","year":"2019","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ad.2025.104541_bib0305","article-title":"Case report: treatment of psoriasiform dermatitis in patients with malignancy","volume":"11","author":"Mao","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.ad.2025.104541_bib0310","doi-asserted-by":"crossref","DOI":"10.1111\/ijd.17742","article-title":"Rapid clinical improvement with tyrosine kinase 2 inhibitor deucravacitinib in overlapping psoriasis and atopic dermatitis","author":"Tang","year":"2025","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.ad.2025.104541_bib0315","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.ad.2020.12.006","article-title":"Janus kinase inhibitors in dermatology: Part 2: Applications in psoriasis, atopic dermatitis, and other dermatoses","volume":"112","author":"Garcia-Melendo","year":"2021","journal-title":"Actas Dermosifiliogr (Engl Ed)"},{"key":"10.1016\/j.ad.2025.104541_bib0320","first-page":"4298","article-title":"Eczematous reactions in patients with plaque psoriasis receiving biological therapy: an observational study","volume":"28","author":"Burlando","year":"2024","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.ad.2025.104541_bib0325","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/ced\/llae162","article-title":"Efficacy of Janus kinase inhibitors in the treatment of psoriasiform atopic dermatitis","volume":"49","author":"Napolitano","year":"2024","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.ad.2025.104541_bib0330","doi-asserted-by":"crossref","DOI":"10.1080\/09546634.2023.2183729","article-title":"Upadacitinib for the treatment of concomitant psoriasis and atopic dermatitis: a case series","volume":"34","author":"Gargiulo","year":"2023","journal-title":"J Dermatolog Treat"},{"key":"10.1016\/j.ad.2025.104541_bib0335","article-title":"Upadacitinib for the management of overlapping psoriasis and atopic dermatitis: a case series","author":"Carlos","year":"2024","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.ad.2025.104541_bib0340","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000539124","article-title":"Janus kinase inhibitors as successful treatment alternative in dupilumab-induced psoriasis","volume":"16","author":"Weiss","year":"2024","journal-title":"Case Rep Dermatol"}],"container-title":["Actas Dermo-Sifiliogr\u00e1ficas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001731025008178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001731025008178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:42:47Z","timestamp":1781188967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001731025008178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0001731025008178"],"URL":"https:\/\/doi.org\/10.1016\/j.ad.2025.104541","relation":{},"ISSN":["0001-7310"],"issn-type":[{"value":"0001-7310","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overlap Between Psoriasis and Atopic Dermatitis: Therapeutic Approach","name":"articletitle","label":"Article Title"},{"value":"Actas Dermo-Sifiliogr\u00e1ficas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ad.2025.104541","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 AEDV. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"104541"}}