{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:58:05Z","timestamp":1784829485957,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004368","name":"Colgate-Palmolive Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","jada.ada.org","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of the American Dental Association"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.adaj.2019.01.007","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T13:19:25Z","timestamp":1550668765000},"page":"S14-S24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"S","title":["Antimicrobial effects of a stannous fluoride toothpaste in distinct oral microenvironments"],"prefix":"10.1016","volume":"150","author":[{"given":"Violet I.","family":"Haraszthy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Raylae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem K.","family":"Sreenivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.adaj.2019.01.007_bib1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/prd.12012","article-title":"Periodontal self-care: evidence-based support","volume":"62","author":"Drisko","year":"2013","journal-title":"Periodontol. 2000"},{"issue":"suppl 16","key":"10.1016\/j.adaj.2019.01.007_bib2","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1111\/jcpe.12366","article-title":"Primary prevention of periodontitis: managing gingivitis","volume":"42","author":"Chapple","year":"2015","journal-title":"J\u00a0Clin Periodontol"},{"issue":"4","key":"10.1016\/j.adaj.2019.01.007_bib3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/apm.12688","article-title":"Dental biofilm infections: an update","volume":"125","author":"Larsen","year":"2017","journal-title":"APMIS"},{"issue":"1","key":"10.1016\/j.adaj.2019.01.007_bib4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/prd.12222","article-title":"The periodontal war: microbes and immunity","volume":"75","author":"Ebersole","year":"2017","journal-title":"Periodontol. 2000"},{"issue":"suppl 18","key":"10.1016\/j.adaj.2019.01.007_bib5","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1111\/jcpe.12682","article-title":"Role of microbial biofilms in the maintenance of oral health and in the development of dental caries and periodontal diseases. Consensus report of group 1 of the Joint EFP\/ORCA workshop on the boundaries between caries and periodontal disease","volume":"44","author":"Sanz","year":"2017","journal-title":"J\u00a0Clin Periodontol"},{"issue":"2 Pt A","key":"10.1016\/j.adaj.2019.01.007_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.imlet.2014.08.017","article-title":"The oral microbiome and the immunobiology of periodontal disease and caries","volume":"162","author":"Costalonga","year":"2014","journal-title":"Immunol Lett"},{"issue":"12","key":"10.1016\/j.adaj.2019.01.007_bib7","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1177\/0022034515606045","article-title":"Oral microbiome metabolism: from \u201cwho are they?\u201d to \u201cwhat are they doing?\u201d","volume":"94","author":"Takahashi","year":"2015","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.adaj.2019.01.007_bib8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.micpath.2015.10.003","article-title":"Dual lifestyle of Porphyromonas gingivalis in biofilm and gingival cells","volume":"94","author":"Sakanaka","year":"2016","journal-title":"Microb Pathog"},{"issue":"2","key":"10.1016\/j.adaj.2019.01.007_bib9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s00248-016-0854-1","article-title":"The oral microbiome of children: development, disease, and implications beyond oral health","volume":"73","author":"Gomez","year":"2017","journal-title":"Microb Ecol"},{"issue":"3","key":"10.1016\/j.adaj.2019.01.007_bib10","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1600-051X.1980.tb01966.x","article-title":"Effect of stannous fluoride mouthrinse on dental plaque formation","volume":"7","author":"Tinanoff","year":"1980","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.adaj.2019.01.007_bib11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-3-319-31248-4_4","article-title":"The oral microbiota","volume":"902","author":"Arweiler","year":"2016","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"10.1016\/j.adaj.2019.01.007_bib12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1128\/CMR.00014-14","article-title":"The rebirth of culture in microbiology through the example of culturomics to study human gut microbiota","volume":"28","author":"Lagier","year":"2015","journal-title":"Clin Microbiol Rev"},{"issue":"12","key":"10.1016\/j.adaj.2019.01.007_bib13","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1177\/154405910508401214","article-title":"Streptococci dominate the diverse flora within buccal cells","volume":"84","author":"Rudney","year":"2005","journal-title":"J\u00a0Dent Res"},{"issue":"6","key":"10.1016\/j.adaj.2019.01.007_bib14","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.micinf.2016.03.008","article-title":"Autonomous immunity in mucosal epithelial cells: fortifying the barrier against infection","volume":"18","author":"Ross","year":"2016","journal-title":"Microbes Infect"},{"issue":"6","key":"10.1016\/j.adaj.2019.01.007_bib15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1034\/j.1600-051x.2001.028006499.x","article-title":"The intra-oral translocation of periodontopathogens jeopardises the outcome of periodontal therapy: a review of the literature","volume":"28","author":"Quirynen","year":"2001","journal-title":"J\u00a0Clin Periodontol"},{"issue":"10","key":"10.1016\/j.adaj.2019.01.007_bib16","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1600-051X.1990.tb01056.x","article-title":"The effect of triclosan, stannous fluoride and chlorhexidine products on: (II) salivary bacterial counts","volume":"17","author":"Jenkins","year":"1990","journal-title":"J\u00a0Clin Periodontol"},{"issue":"4","key":"10.1016\/j.adaj.2019.01.007_bib17","first-page":"292","article-title":"Streptococcus mutans in plaque and saliva after mouthrinsing with SnF2","volume":"90","author":"Svanberg","year":"1982","journal-title":"Scand J Dent Res"},{"issue":"special number","key":"10.1016\/j.adaj.2019.01.007_bib18","first-page":"2","article-title":"The scientific rationale and development of an optimized stannous fluoride dentifrice, part 1","volume":"18","author":"Burke","year":"1997","journal-title":"Compend Contin Educ Dent"},{"issue":"4","key":"10.1016\/j.adaj.2019.01.007_bib19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/00016358009003492","article-title":"The effects of stannous and stannic ions on the formation and acidogenicity of dental plaque in\u00a0vivo","volume":"38","author":"Ellingsen","year":"1980","journal-title":"Acta Odontol Scand"},{"issue":"4S","key":"10.1016\/j.adaj.2019.01.007_bib20","first-page":"S1","article-title":"Whole mouth health","volume":"150","author":"Ciancio","year":"2019","journal-title":"JADA"},{"issue":"6","key":"10.1016\/j.adaj.2019.01.007_bib21","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3109\/00016356309011240","article-title":"Periodontal disease in pregnancy, I: prevalence and severity","volume":"21","author":"Loe","year":"1963","journal-title":"Acta Odont Scand"},{"issue":"1","key":"10.1016\/j.adaj.2019.01.007_bib22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1902\/jop.1970.41.1.41","article-title":"Reduced plaque formation by the chloromethyl analogue of vitamin C","volume":"41","author":"Turesky","year":"1970","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.adaj.2019.01.007_bib23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.conctc.2017.08.010","article-title":"Microbiological and clinical effects of an oral hygiene regimen","volume":"8","author":"Haraszthy","year":"2017","journal-title":"Contemp Clin Trials Commun"},{"issue":"11","key":"10.1016\/j.adaj.2019.01.007_bib24","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/j.1600-051X.2012.01938.x","article-title":"Whole mouth antimicrobial effects after oral hygiene: comparison of three dentifrice formulations","volume":"39","author":"Fine","year":"2012","journal-title":"J\u00a0Clin Periodontol"},{"issue":"4S","key":"10.1016\/j.adaj.2019.01.007_bib25","first-page":"S5","article-title":"Solving the\u00a0problem with stannous fluoride: Formulation, stabilization, and antimicrobial action","volume":"150","author":"Myers","year":"2019","journal-title":"JADA"},{"issue":"4S","key":"10.1016\/j.adaj.2019.01.007_bib26","first-page":"S38","article-title":"Solving the problem with stannous fluoride: extrinsic stain","volume":"150","author":"Li","year":"2019","journal-title":"JADA"},{"issue":"5","key":"10.1016\/j.adaj.2019.01.007_bib27","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1128\/AEM.35.5.920-924.1978","article-title":"Growth inhibition of Streptococcus mutans and Leuconostoc mesenteroides by sodium fluoride and ionic tin","volume":"35","author":"Yost","year":"1978","journal-title":"Appl Environ Microbiol"},{"issue":"11","key":"10.1016\/j.adaj.2019.01.007_bib28","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0003-9969(87)90007-0","article-title":"Effects of NaF and SnF2 on growth, acid and glucan production of several oral streptococci","volume":"32","author":"Zameck","year":"1987","journal-title":"Arch Oral Biol"},{"issue":"9","key":"10.1016\/j.adaj.2019.01.007_bib29","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1177\/00220345840630090501","article-title":"Anti-bacterial determinants of stannous fluoride","volume":"63","author":"Camosci","year":"1984","journal-title":"J\u00a0Dent Res"},{"issue":"9","key":"10.1016\/j.adaj.2019.01.007_bib30","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1177\/00220345820610091501","article-title":"Effect of Chinese and western antimicrobial agents on selected oral bacteria","volume":"61","author":"Tsao","year":"1982","journal-title":"J\u00a0Dent Res"},{"issue":"1","key":"10.1016\/j.adaj.2019.01.007_bib31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-2842.1986.tb01557.x","article-title":"Safety and antibacterial properties of controlled release SnF2","volume":"13","author":"Tinanoff","year":"1986","journal-title":"J\u00a0Oral Rehabil"},{"issue":"10","key":"10.1016\/j.adaj.2019.01.007_bib32","first-page":"1406","article-title":"The antimicrobial effect of a triclosan\/copolymer dentifrice on oral microorganisms in\u00a0vivo","volume":"137","author":"Fine","year":"2006","journal-title":"JADA"},{"issue":"1","key":"10.1016\/j.adaj.2019.01.007_bib33","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1177\/00220345740530013901","article-title":"Action of Streptococcus mutans on dental enamel pretreated with stannous fluoride","volume":"53","author":"Abramovich","year":"1974","journal-title":"J\u00a0Dent Res"},{"issue":"6","key":"10.1016\/j.adaj.2019.01.007_bib34","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3109\/00016358009033604","article-title":"Uptake and retention of\u00a0tin by S.\u00a0mutans","volume":"38","author":"Attramadal","year":"1980","journal-title":"Acta Odontol Scand"},{"issue":"2","key":"10.1016\/j.adaj.2019.01.007_bib35","first-page":"161","article-title":"In vivo antibacterial effect of tin on the oral microflora","volume":"92","author":"Attramadal","year":"1984","journal-title":"Scand J Dent Res"},{"key":"10.1016\/j.adaj.2019.01.007_bib36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/oxfordjournals.jncimonographs.a003443","article-title":"Biology of oral mucosa and esophagus","volume":"29","author":"Squier","year":"2001","journal-title":"J\u00a0Natl Cancer Inst Monogr"},{"issue":"suppl 1","key":"10.1016\/j.adaj.2019.01.007_bib37","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1002\/JPER.17-0095","article-title":"Dental plaque-induced gingival conditions","volume":"89","author":"Murakami","year":"2018","journal-title":"J\u00a0Periodontol"}],"container-title":["The Journal of the American Dental Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817719300091?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817719300091?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T05:55:45Z","timestamp":1606542945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002817719300091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S0002817719300091"],"URL":"https:\/\/doi.org\/10.1016\/j.adaj.2019.01.007","relation":{},"ISSN":["0002-8177"],"issn-type":[{"value":"0002-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antimicrobial effects of a stannous fluoride toothpaste in distinct oral microenvironments","name":"articletitle","label":"Article Title"},{"value":"The Journal of the American Dental Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adaj.2019.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Dental Association. All rights reserved.","name":"copyright","label":"Copyright"}]}}