{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:36:27Z","timestamp":1791920187049,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,6]],"date-time":"2023-08-06T00:00:00Z","timestamp":1691280000000},"content-version":"vor","delay-in-days":217,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000038","name":"US Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015015","name":"Government of South Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jada.ada.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of the American Dental Association"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.adaj.2022.10.014","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T20:24:57Z","timestamp":1672863897000},"page":"53-64.e14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Injectable and topical local anesthetics for acute dental pain"],"prefix":"10.1016","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1788-6234","authenticated-orcid":false,"given":"Anna","family":"Miroshnychenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7713-6171","authenticated-orcid":false,"given":"Sara","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3457-0533","authenticated-orcid":false,"given":"Maria","family":"Azab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yetiani","family":"Roldan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Diaz Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3403-720X","authenticated-orcid":false,"given":"Divyalakshmi","family":"Tamilselvan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3755-4053","authenticated-orcid":false,"given":"Leon","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0517-1266","authenticated-orcid":false,"given":"Olivia","family":"Urquhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8894-0678","authenticated-orcid":false,"given":"Malavika","family":"Tampi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1402-4068","authenticated-orcid":false,"given":"Deborah E.","family":"Polk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3191-1371","authenticated-orcid":false,"given":"Elliott V.","family":"Hersh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3546-3526","authenticated-orcid":false,"given":"Alonso","family":"Carrasco-Labra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6010-9900","authenticated-orcid":false,"given":"Romina","family":"Brignardello-Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.adaj.2022.10.014_bib1","first-page":"649","article-title":"Survey of local anesthetic use by Ontario dentists","volume":"75","author":"Gaffen","year":"2009","journal-title":"J\u00a0Can Dent Assoc"},{"issue":"9","key":"10.1016\/j.adaj.2022.10.014_bib2","first-page":"546","article-title":"An update on local anesthetics in dentistry","volume":"68","author":"Haas","year":"2002","journal-title":"J\u00a0Can Dent Assoc"},{"issue":"11","key":"10.1016\/j.adaj.2022.10.014_bib3","first-page":"1626","article-title":"Analgesic efficacy and safety of an intraoral lidocaine patch","volume":"127","author":"Hersh","year":"1996","journal-title":"JADA"},{"issue":"1","key":"10.1016\/j.adaj.2022.10.014_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00784-020-03675-w","article-title":"Effectiveness of anesthetic solutions for pain control in lower third molar extraction surgeries: a systematic review of randomized clinical trials with network meta-analysis","volume":"25","author":"Rossi","year":"2021","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.adaj.2022.10.014_bib5","series-title":"Framing Opioid Prescribing Guidelines for Acute Pain: Developing the Evidence","year":"2019"},{"issue":"3","key":"10.1016\/j.adaj.2022.10.014_bib6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/jrsm.46","article-title":"Pooling health-related quality of life outcomes in meta-analysis-a tutorial and review of methods for enhancing interpretability","volume":"2","author":"Thorlund","year":"2011","journal-title":"Res Synth Methods"},{"issue":"12","key":"10.1016\/j.adaj.2022.10.014_bib7","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.jclinepi.2011.03.017","article-title":"GRADE guidelines, 7: rating the quality of evidence\u2014inconsistency","volume":"64","author":"Guyatt","year":"2011","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.adaj.2022.10.014_bib8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jclinepi.2017.05.006","article-title":"The GRADE\u00a0Working Group clarifies the construct of\u00a0certainty of evidence","volume":"87","author":"Hultcrantz","year":"2017","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.adaj.2022.10.014_bib9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jclinepi.2021.03.026","article-title":"GRADE guidelines, 32: GRADE offers guidance on choosing targets of GRADE certainty of evidence ratings","volume":"137","author":"Zeng","year":"2021","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.adaj.2022.10.014_bib10","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"540","key":"10.1016\/j.adaj.2022.10.014_bib11","first-page":"2","article-title":"Post intra-alveolar extraction analgesia of bupivacaine and lidocaine: a randomized controlled clinical trial","volume":"9","author":"Adelusi","year":"2019","journal-title":"Dent."},{"issue":"5","key":"10.1016\/j.adaj.2022.10.014_bib12","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S0278-2391(99)90063-0","article-title":"Bupivacaine versus lidocaine for third molar surgery: a double-blind, randomized, crossover study","volume":"57","author":"Bouloux","year":"1999","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"1","key":"10.1016\/j.adaj.2022.10.014_bib13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2298\/VSP1501050B","article-title":"Quality of analgesia after lower third molar surgery: a randomised, double-blind study of levobupivacaine, bupivacaine and lidocaine with epinephrine","volume":"72","author":"Brajkovi\u0107","year":"2015","journal-title":"Vojnosanit Pregl"},{"issue":"1","key":"10.1016\/j.adaj.2022.10.014_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tripleo.2007.11.024","article-title":"A\u00a0comparison of the clinical anesthetic efficacy of 4% articaine and 0.5% bupivacaine (both with 1:200,000 epinephrine) for lower third molar removal","volume":"106","author":"Gregorio","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"1","key":"10.1016\/j.adaj.2022.10.014_bib15","first-page":"6","article-title":"Effective postoperative pain prevention through administration of bupivacaine and diclofenac","volume":"41","author":"Hyrk\u00e4s","year":"1994","journal-title":"Anesth Prog"},{"issue":"5","key":"10.1016\/j.adaj.2022.10.014_bib16","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1016\/j.tripleo.2006.02.024","article-title":"Postoperative analgesia after lower third molar surgery: contribution of the use of long-acting local anesthetics, low-power laser, and diclofenac","volume":"102","author":"Markovi\u0107","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"9","key":"10.1016\/j.adaj.2022.10.014_bib17","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1007\/s00784-018-2386-1","article-title":"Double-blind, randomized controlled clinical trial on analgesic efficacy of local anesthetics articaine and bupivacaine after impacted third molar extraction","volume":"22","author":"Olmedo-Gaya","year":"2018","journal-title":"Clin Oral Investig"},{"issue":"2","key":"10.1016\/j.adaj.2022.10.014_bib18","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.4317\/jced.50869","article-title":"Comparative split-mouth study of the anesthetic efficacy of 4% articaine versus 0.5% bupivacaine in impacted mandibular third molar extraction","volume":"5","author":"Pellicer-Chover","year":"2013","journal-title":"J\u00a0Clin Exp Dent"},{"issue":"1","key":"10.1016\/j.adaj.2022.10.014_bib19","first-page":"1","article-title":"Comparison between lidocaine and bupivacaine as local anesthetics with diflunisal for postoperative pain control after lower third molar surgery","volume":"35","author":"Rosenquist","year":"1988","journal-title":"Anesth Prog"},{"issue":"3","key":"10.1016\/j.adaj.2022.10.014_bib20","doi-asserted-by":"crossref","first-page":"e462","DOI":"10.4317\/medoral.17628","article-title":"Bupivacaine 0.5% versus articaine 4% for the removal of lower third molars: a crossover randomized controlled trial","volume":"17","author":"Sancho-Puchades","year":"2012","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"2","key":"10.1016\/j.adaj.2022.10.014_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.aat.2014.04.006","article-title":"Comparison of 4% articaine and 0.5% bupivacaine anesthetic efficacy in orthodontic extractions: prospective, randomized crossover study","volume":"52","author":"Thakare","year":"2014","journal-title":"Acta Anaesthesiol Taiwan"},{"issue":"10","key":"10.1016\/j.adaj.2022.10.014_bib22","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.jcms.2019.07.019","article-title":"A\u00a0randomized anesthethic potency comparison between ropivacaine and bupivacaine on the perioperative regional anesthesia in lower third molar surgery","volume":"47","author":"Tijanic","year":"2019","journal-title":"J\u00a0Craniomaxillofac Surg"},{"issue":"1","key":"10.1016\/j.adaj.2022.10.014_bib23","first-page":"20","article-title":"Bupivacaine anesthesia and post-operative analgesia in oral surgery","volume":"26","author":"Trieger","year":"1979","journal-title":"Anesth Prog"},{"issue":"3","key":"10.1016\/j.adaj.2022.10.014_bib24","doi-asserted-by":"crossref","first-page":"e390","DOI":"10.4317\/medoral.16.e390","article-title":"Comparative study of two local anesthetics in the surgical extraction of mandibular third molars: bupivacaine and articaine","volume":"16","author":"Trullenque-Eriksson","year":"2011","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"6","key":"10.1016\/j.adaj.2022.10.014_bib25","first-page":"272","article-title":"Use of verbal descriptors, thermal scores and electrical pulp testing as predictors of tooth pain before and after application of benzocaine gels into cavities of teeth with pulpitis","volume":"36","author":"Gangarosa","year":"1989","journal-title":"Anesth Prog"},{"issue":"5","key":"10.1016\/j.adaj.2022.10.014_bib26","first-page":"517","article-title":"An evaluation of 10 percent and 20 percent benzocaine gels in patients with acute toothaches: efficacy, tolerability and compliance with label dose administration directions","volume":"144","author":"Hersh","year":"2013","journal-title":"JADA"},{"issue":"2","key":"10.1016\/j.adaj.2022.10.014_bib27","first-page":"52","article-title":"Analgesic onset time as a measure of topical anesthetic efficacy in spontaneous toothache pain: a pilot study","volume":"4","author":"Hersh","year":"1993","journal-title":"J\u00a0Clin Dent"},{"issue":"4","key":"10.1016\/j.adaj.2022.10.014_bib28","first-page":"103","article-title":"A\u00a0study of benzocaine gel dosing for toothache","volume":"16","author":"Hersh","year":"2005","journal-title":"J\u00a0Clin Dent"},{"issue":"6","key":"10.1016\/j.adaj.2022.10.014_bib29","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/0030-4220(82)90342-5","article-title":"Efficacy of using benzocaine for temporary relief of toothache","volume":"53","author":"Sveen","year":"1982","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"1","key":"10.1016\/j.adaj.2022.10.014_bib30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/idj.12060","article-title":"Efficacy and safety of bupivacaine versus lidocaine in dental treatments: a meta-analysis of randomised controlled trials","volume":"64","author":"Su","year":"2014","journal-title":"Int Dent J"},{"issue":"4","key":"10.1016\/j.adaj.2022.10.014_bib31","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cden.2010.06.015","article-title":"Local anesthetics: pharmacology and toxicity","volume":"54","author":"Moore","year":"2010","journal-title":"Dent Clin North Am"}],"container-title":["The Journal of the American Dental Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000281772200681X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000281772200681X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T11:31:11Z","timestamp":1723203071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000281772200681X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S000281772200681X"],"URL":"https:\/\/doi.org\/10.1016\/j.adaj.2022.10.014","relation":{},"ISSN":["0002-8177"],"issn-type":[{"value":"0002-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Injectable and topical local anesthetics for acute dental pain","name":"articletitle","label":"Article Title"},{"value":"The Journal of the American Dental Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adaj.2022.10.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Dental Association.","name":"copyright","label":"Copyright"}]}}