{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:38:52Z","timestamp":1790116732234,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jada.ada.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of the American Dental Association"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.adaj.2023.02.018","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T17:24:24Z","timestamp":1682702664000},"page":"486-494","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of full pulpotomy using a calcium silicate\u2013based bioactive ceramic in adult permanent teeth with symptoms indicative of irreversible pulpitis"],"prefix":"10.1016","volume":"154","author":[{"given":"Xiaomiao","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Roy","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0107-3335","authenticated-orcid":false,"given":"Xiaogang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.adaj.2023.02.018_bib1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/iej.13080","article-title":"European Society of Endodontology position statement: management of deep caries and the exposed pulp","volume":"52","author":"Duncan","year":"2019","journal-title":"Int Endod J"},{"issue":"12","key":"10.1016\/j.adaj.2023.02.018_bib3","first-page":"1932","article-title":"Correlation between clinical and histologic pulp diagnoses","volume":"40","author":"Ricucci","year":"2014","journal-title":"J\u00a0Endod"},{"issue":"7 suppl","key":"10.1016\/j.adaj.2023.02.018_bib4","first-page":"S2","article-title":"The caries process and its effect on the pulp: the science is changing and so is our understanding","volume":"34","author":"Bj\u00f8rndal","year":"2008","journal-title":"J\u00a0Endod"},{"issue":"1","key":"10.1016\/j.adaj.2023.02.018_bib5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/aej.12392","article-title":"Vital pulp therapy of mature permanent teeth with irreversible pulpitis from the perspective of pulp biology","volume":"46","author":"Lin","year":"2020","journal-title":"Aust Endod J"},{"issue":"2","key":"10.1016\/j.adaj.2023.02.018_bib6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00784-014-1244-z","article-title":"Five-year results of vital pulp therapy in permanent molars with irreversible pulpitis: a non-inferiority multicenter randomized clinical trial","volume":"19","author":"Asgary","year":"2015","journal-title":"Clin Oral Investig"},{"issue":"4","key":"10.1016\/j.adaj.2023.02.018_bib7","first-page":"529","article-title":"Treatment outcomes of 4 vital pulp therapies in mature molars","volume":"44","author":"Asgary","year":"2018","journal-title":"J\u00a0Endod"},{"issue":"2","key":"10.1016\/j.adaj.2023.02.018_bib8","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00784-012-0712-6","article-title":"One-year results of vital pulp therapy in permanent molars with irreversible pulpitis: an ongoing multicenter, randomized, non-inferiority clinical trial","volume":"17","author":"Asgary","year":"2013","journal-title":"Clin Oral Investig"},{"issue":"3","key":"10.1016\/j.adaj.2023.02.018_bib9","first-page":"151","article-title":"Long-term outcomes of pulpotomy in permanent teeth with irreversible pulpitis: a multi-center randomized controlled trial","volume":"30","author":"Asgary","year":"2017","journal-title":"Am J Dent"},{"issue":"6","key":"10.1016\/j.adaj.2023.02.018_bib10","first-page":"932","article-title":"Full pulpotomy with biodentine in symptomatic young permanent teeth with carious exposure","volume":"44","author":"Taha","year":"2018","journal-title":"J\u00a0Endod"},{"issue":"8","key":"10.1016\/j.adaj.2023.02.018_bib11","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/iej.12903","article-title":"Outcome of full pulpotomy using Biodentine in adult patients with symptoms indicative of irreversible pulpitis","volume":"51","author":"Taha","year":"2018","journal-title":"Int Endod J"},{"issue":"2","key":"10.1016\/j.adaj.2023.02.018_bib12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1365-2591.1993.tb00557.x","article-title":"Success of pulpotomy in the management of hyperplastic pulpitis","volume":"26","author":"Cali\u015fkan","year":"1993","journal-title":"Int Endod J"},{"issue":"3","key":"10.1016\/j.adaj.2023.02.018_bib13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1365-2591.1995.tb00293.x","article-title":"Pulpotomy of carious vital teeth with periapical involvement","volume":"28","author":"Cali\u015fkan","year":"1995","journal-title":"Int Endod J"},{"issue":"1","key":"10.1016\/j.adaj.2023.02.018_bib14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/0972-0707.53340","article-title":"Permanent molar pulpotomy with a new endodontic cement: a case series","volume":"12","author":"Asgary","year":"2009","journal-title":"J\u00a0Conserv Dent"},{"issue":"2","key":"10.1016\/j.adaj.2023.02.018_bib15","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/iej.12614","article-title":"Mineral trioxide aggregate pulpotomy for permanent molars with clinical signs indicative of irreversible pulpitis: a preliminary study","volume":"50","author":"Qudeimat","year":"2017","journal-title":"Int Endod J"},{"issue":"11","key":"10.1016\/j.adaj.2023.02.018_bib16","first-page":"1603","article-title":"Outcomes of vital pulp therapy using mineral trioxide aggregate or biodentine: a prospective randomized clinical trial","volume":"44","author":"Awawdeh","year":"2018","journal-title":"J\u00a0Endod"},{"key":"10.1016\/j.adaj.2023.02.018_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2021.103288","article-title":"TERT promoter mutations and melanoma survival: a comprehensive literature review and meta-analysis","volume":"160","author":"Gandini","year":"2021","journal-title":"Crit Rev Oncol Hematol"},{"issue":"3","key":"10.1016\/j.adaj.2023.02.018_bib18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s40368-014-0114-3","article-title":"Biodentine\u2122 material characteristics and clinical applications: a review of the literature","volume":"15","author":"Rajasekharan","year":"2014","journal-title":"Eur Arch Paediatr Dent"},{"issue":"6","key":"10.1016\/j.adaj.2023.02.018_bib19","first-page":"793","article-title":"Biocompatibility of two novel root repair materials","volume":"37","author":"Ma","year":"2011","journal-title":"J\u00a0Endod"},{"issue":"6","key":"10.1016\/j.adaj.2023.02.018_bib20","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1016\/j.tripleo.2009.02.024","article-title":"Assessment of a new root canal sealer's apical sealing ability","volume":"107","author":"Zhang","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"11","key":"10.1016\/j.adaj.2023.02.018_bib21","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.joen.2011.06.022","article-title":"Antibacterial activity of endosequence root repair material and ProRoot MTA against clinical isolates of Enterococcus faecalis","volume":"37","author":"Lovato","year":"2011","journal-title":"J Endod"},{"issue":"6","key":"10.1016\/j.adaj.2023.02.018_bib22","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4103\/jispcd.JISPCD_249_19","article-title":"Comparison between iRoot BP Plus (EndoSequence Root Repair Material) and mineral trioxide aggregate as pulp-capping agents: a systematic review","volume":"9","author":"Mahgoub","year":"2019","journal-title":"J\u00a0Int Soc Prev Community Dent"},{"issue":"5","key":"10.1016\/j.adaj.2023.02.018_bib23","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/edt.12563","article-title":"The effect of partial pulpotomy with iRoot BP Plus in traumatized immature permanent teeth: a randomized prospective controlled trial","volume":"36","author":"Yang","year":"2020","journal-title":"Dent Traumatol"},{"issue":"12","key":"10.1016\/j.adaj.2023.02.018_bib24","first-page":"945","article-title":"Clinical efficacy observation of direct pulp capping using iRoot BP Plus therapy in mature permanent teeth with carious pulp exposure","volume":"55","author":"Liu","year":"2020","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"issue":"11","key":"10.1016\/j.adaj.2023.02.018_bib25","first-page":"1125","article-title":"Vital pulp therapy in permanent teeth with irreversible pulpitis caused by caries: a prospective cohort study","volume":"11","author":"Guan","year":"2021","journal-title":"J\u00a0Pers Med"},{"issue":"9","key":"10.1016\/j.adaj.2023.02.018_bib26","first-page":"1417","article-title":"Partial pulpotomy in mature permanent teeth with clinical signs indicative of irreversible pulpitis: a randomized clinical trial","volume":"43","author":"Taha","year":"2017","journal-title":"J\u00a0Endod"},{"issue":"9","key":"10.1016\/j.adaj.2023.02.018_bib27","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/iej.12793","article-title":"Minimally invasive endodontics: a new diagnostic system for assessing pulpitis and subsequent treatment needs","volume":"50","author":"Wolters","year":"2017","journal-title":"Int Endod J"},{"issue":"3","key":"10.1016\/j.adaj.2023.02.018_bib28","first-page":"383","article-title":"Long-term pulpal and restorative outcomes of pulpotomy in mature permanent teeth","volume":"46","author":"Tan","year":"2020","journal-title":"J\u00a0Endod"},{"issue":"1","key":"10.1016\/j.adaj.2023.02.018_bib29","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0030-4220(70)90416-0","article-title":"Diagnosis of diseases of the pulp","volume":"29","author":"Baume","year":"1970","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"10","key":"10.1016\/j.adaj.2023.02.018_bib30","first-page":"551","article-title":"A\u00a0clinical study of direct pulp capping applied to carious-exposed pulps","volume":"22","author":"Matsuo","year":"1996","journal-title":"J\u00a0Endod"},{"issue":"1","key":"10.1016\/j.adaj.2023.02.018_bib43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0099-2399(83)80005-3","article-title":"Histological appearance of pulps after exposure by a crown fracture, partial pulpotomy, and clinical diagnosis of healing","volume":"9","author":"Cvek","year":"1983","journal-title":"J Endod"},{"issue":"5","key":"10.1016\/j.adaj.2023.02.018_bib31","doi-asserted-by":"crossref","first-page":"406","DOI":"10.4103\/1735-3327.166187","article-title":"Outcomes of vital pulp therapy in permanent teeth with different medicaments based on review of the literature","volume":"12","author":"Akhlaghi","year":"2015","journal-title":"Dent Res J (Isfahan)"},{"issue":"8","key":"10.1016\/j.adaj.2023.02.018_bib32","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.joen.2015.03.017","article-title":"Tomographic evaluation of reparative dentin formation after direct pulp capping with Ca(OH)2, MTA, Biodentine, and dentin bonding system in human teeth","volume":"41","author":"Nowicka","year":"2015","journal-title":"J Endod"},{"issue":"2","key":"10.1016\/j.adaj.2023.02.018_bib33","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1365-2591.2007.01329.x","article-title":"Histological, ultrastructural and quantitative investigations on the response of healthy human pulps to experimental capping with mineral trioxide aggregate: a randomized controlled trial","volume":"41","author":"Nair","year":"2008","journal-title":"Int Endod J"},{"issue":"10","key":"10.1016\/j.adaj.2023.02.018_bib34","doi-asserted-by":"crossref","first-page":"e1249","DOI":"10.4317\/jced.54103","article-title":"Composition and physicochemical properties of calcium silicate based sealers: a review article","volume":"9","author":"Jafari","year":"2017","journal-title":"J\u00a0Clin Exp Dent"},{"issue":"1","key":"10.1016\/j.adaj.2023.02.018_bib35","first-page":"163","article-title":"Ion release, microstructural, and biological properties of iRoot BP Plus and ProRoot MTA exposed to an acidic environment","volume":"43","author":"Tian","year":"2017","journal-title":"J\u00a0Endod"},{"key":"10.1016\/j.adaj.2023.02.018_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2019.06.005","article-title":"Pulpotomy for mature carious teeth with symptoms of irreversible pulpitis: a systematic review","volume":"88","author":"Cushley","year":"2019","journal-title":"J\u00a0Dent"},{"issue":"1","key":"10.1016\/j.adaj.2023.02.018_bib37","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00784-016-1798-z","article-title":"Prognostic factors in direct pulp capping with mineral trioxide aggregate or calcium hydroxide: 2- to 6-year follow-up","volume":"21","author":"\u00c7al\u0131\u015fkan","year":"2017","journal-title":"Clin Oral Investig"},{"issue":"9","key":"10.1016\/j.adaj.2023.02.018_bib38","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1007\/s00784-018-2767-5","article-title":"Clinical evaluation of direct pulp capping using a calcium silicate cement-treatment outcomes over an average period of 2.3 years","volume":"23","author":"Harms","year":"2019","journal-title":"Clin Oral Investig"},{"issue":"3","key":"10.1016\/j.adaj.2023.02.018_bib39","first-page":"341","article-title":"Outcomes of direct pulp capping by using either ProRoot mineral trioxide aggregate or Biodentine in permanent teeth with carious pulp exposure in 6- to 18-year-old patients: a randomized controlled trial","volume":"44","author":"Parinyaprom","year":"2018","journal-title":"J\u00a0Endod"},{"issue":"3","key":"10.1016\/j.adaj.2023.02.018_bib40","first-page":"352","article-title":"Comparison of iRoot BP Plus and calcium hydroxide as pulpotomy materials in permanent incisors with complicated crown fractures: a retrospective study","volume":"46","author":"Rao","year":"2020","journal-title":"J\u00a0Endod"},{"issue":"1","key":"10.1016\/j.adaj.2023.02.018_bib41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2209\/tdcpublication.2016-0016","article-title":"Relationship between time from full pulpotomy to definitive diagnosis of vertical root fracture and patient age","volume":"58","author":"Yoshino","year":"2017","journal-title":"Bull Tokyo Dent Coll"},{"key":"10.1016\/j.adaj.2023.02.018_bib42","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jdent.2018.04.007","article-title":"Changes in the radicular pulp-dentine complex in healthy intact teeth and in response to deep caries or restorations: a histological and histobacteriological study","volume":"73","author":"Ricucci","year":"2018","journal-title":"J Dent"}],"container-title":["The Journal of the American Dental Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817723001162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817723001162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T08:52:48Z","timestamp":1723193568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002817723001162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S0002817723001162"],"URL":"https:\/\/doi.org\/10.1016\/j.adaj.2023.02.018","relation":{},"ISSN":["0002-8177"],"issn-type":[{"value":"0002-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of full pulpotomy using a calcium silicate\u2013based bioactive ceramic in adult permanent teeth with symptoms indicative of irreversible pulpitis","name":"articletitle","label":"Article Title"},{"value":"The Journal of the American Dental Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adaj.2023.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Dental Association. All rights reserved.","name":"copyright","label":"Copyright"}]}}