{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:01:37Z","timestamp":1793732497606,"version":"4.6.1"},"reference-count":65,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T00:00:00Z","timestamp":1680393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jada.ada.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of the American Dental Association"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.adaj.2023.03.014","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T15:43:02Z","timestamp":1685115782000},"page":"580-591.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Systematic review and meta-analysis on the effect of self-assembling peptide P11-4 on arrest, cavitation, and progression of initial caries lesions"],"prefix":"10.1016","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0992-3173","authenticated-orcid":false,"given":"Jeremy Horst","family":"Keeper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Kibbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuli","family":"Thakkar-Samtani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2670-7402","authenticated-orcid":false,"given":"Lisa J.","family":"Heaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Desrosiers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-2800","authenticated-orcid":false,"given":"Kathryn","family":"Vela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5097-4466","authenticated-orcid":false,"given":"Bennett T.","family":"Amaechi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5763-7924","authenticated-orcid":false,"given":"Anahita","family":"Jablonski-Momeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"MacLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Weyant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Ferreira","family":"Zandona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-9652","authenticated-orcid":false,"given":"Woosung","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6184-4213","authenticated-orcid":false,"given":"Nigel","family":"Pitts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8342-4655","authenticated-orcid":false,"given":"Julie","family":"Frantsve-Hawley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.adaj.2023.03.014_bib1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/0022034513490168","article-title":"Global burden of oral conditions in 1990-2010: a\u00a0systematic analysis","volume":"92","author":"Marcenes","year":"2013","journal-title":"J\u00a0Dent Res"},{"issue":"5","key":"10.1016\/j.adaj.2023.03.014_bib2","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1177\/0022034515573272","article-title":"Global burden of untreated caries: a systematic review and metaregression","volume":"94","author":"Kassebaum","year":"2015","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.adaj.2023.03.014_bib3","series-title":"A\u00a0Global Consensus for Achieving a Dental Cavity Free Future: Recommendations for New Caries-Related Policies","author":"Pitts","year":"2021"},{"issue":"307","key":"10.1016\/j.adaj.2023.03.014_bib4","first-page":"1","article-title":"Prevalence of total and untreated dental caries among youth: United States, 2015-2016","author":"Fleming","year":"2018","journal-title":"NCHS Data Brief"},{"issue":"9","key":"10.1016\/j.adaj.2023.03.014_bib5","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.2105\/AJPH.2011.300478","article-title":"The impact of oral health on the academic performance of disadvantaged children","volume":"102","author":"Seirawan","year":"2012","journal-title":"Am J Public Health"},{"issue":"10","key":"10.1016\/j.adaj.2023.03.014_bib6","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.2105\/AJPH.2010.200915","article-title":"Impact of poor oral health on children\u2019s school attendance and performance","volume":"101","author":"Jackson","year":"2011","journal-title":"Am J Public Health"},{"key":"10.1016\/j.adaj.2023.03.014_bib7","series-title":"Mostofsky DI, Fortune F. Behavioral Dentistry","first-page":"165","article-title":"Dental fear and anxiety associated with oral health care: conceptual and clinical issues","author":"Mcneil","year":"2014"},{"issue":"25","key":"10.1016\/j.adaj.2023.03.014_bib8","doi-asserted-by":"crossref","first-page":"935","DOI":"10.15585\/mmwr.mm7025a5","article-title":"QuickStats: percentage of adults who did not get needed dental care because of cost in the past 12 months, by age group and sex: National Health Interview Survey, United States, 2019","volume":"70","year":"2021","journal-title":"Morb Mortal Wkly Rep"},{"key":"10.1016\/j.adaj.2023.03.014_bib9","series-title":"Oral Health: achieving better oral health as part of the universal health coverage and noncommunicable disease agendas towards 2030\u2014report by the director-general","year":"2021"},{"issue":"8","key":"10.1016\/j.adaj.2023.03.014_bib10","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41415-021-2963-6","article-title":"The pieces of the caries puzzle align","volume":"230","author":"Pitts","year":"2021","journal-title":"Br Dent J"},{"issue":"2","key":"10.1016\/j.adaj.2023.03.014_bib11","first-page":"79","article-title":"The American Dental Association Caries Classification System for clinical practice: a report of the American Dental Association Council on Scientific Affairs","volume":"146","author":"Young","year":"2015","journal-title":"JADA"},{"issue":"3","key":"10.1016\/j.adaj.2023.03.014_bib12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1600-0528.2007.00347.x","article-title":"The International Caries Detection and Assessment System (ICDAS): an integrated system for measuring dental caries","volume":"35","author":"Ismail","year":"2007","journal-title":"Community Dent Oral Epidemiol"},{"issue":"1","key":"10.1016\/j.adaj.2023.03.014_bib13","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1111\/cdoe.12025","article-title":"International Caries Detection and Assessment System (ICDAS) and its International Caries Classification and Management System (ICCMS): methods for staging of the caries process and enabling dentists to manage caries","volume":"41","author":"Pitts","year":"2013","journal-title":"Community Dent Oral Epidemiol"},{"issue":"1","key":"10.1016\/j.adaj.2023.03.014_bib14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000503309","article-title":"Terminology of dental caries and dental caries management: consensus report of a workshop organized by ORCA and Cariology Research Group of IADR","volume":"54","author":"Machiulskiene","year":"2020","journal-title":"Caries Res"},{"key":"10.1016\/j.adaj.2023.03.014_bib15","series-title":"White Paper on Dental Caries Prevention and Management. A Summary of the Current Evidence and the Key Issues in Controlling This Preventable Disease","author":"Pitts","year":"2016"},{"issue":"10","key":"10.1016\/j.adaj.2023.03.014_bib16","first-page":"1407","article-title":"Does the cycle of rerestoration lead to larger restorations?","volume":"126","author":"Brantley","year":"1995","journal-title":"JADA"},{"key":"10.1016\/j.adaj.2023.03.014_bib17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/08959374900040010701","article-title":"Clinical studies concerning rerestoration of teeth","volume":"4","author":"Elderton","year":"1990","journal-title":"Adv Dent Res"},{"issue":"10","key":"10.1016\/j.adaj.2023.03.014_bib18","first-page":"837","article-title":"Evidence-based clinical practice guideline on nonrestorative treatments for carious lesions: a report from the American Dental Association","volume":"149","author":"Slayton","year":"2018","journal-title":"JADA"},{"issue":"8","key":"10.1016\/j.adaj.2023.03.014_bib19","first-page":"672","article-title":"Evidence-based clinical practice guideline for the use of pit-and-fissure sealants: a report of the American Dental Association and the American Academy of Pediatric Dentistry","volume":"147","author":"Wright","year":"2016","journal-title":"JADA"},{"issue":"2","key":"10.1016\/j.adaj.2023.03.014_bib20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.17796\/1053-4625-44.2.2","article-title":"Silver diamine fluoride and fluoride varnish may halt interproximal caries progression in the primary dentition","volume":"44","author":"Hammersmith","year":"2020","journal-title":"J\u00a0Clin Pediatr Dent"},{"issue":"3","key":"10.1016\/j.adaj.2023.03.014_bib21","first-page":"537","article-title":"Studies on topical application of Ag (NH3)2F for the control of interproximal caries in human primary molars, 3: clinical trial of Ag(NH3)2F on interproximal caries in human primary molars","volume":"19","author":"Tsutsumi","year":"1981","journal-title":"Jpn J Pediatr Dent"},{"issue":"4","key":"10.1016\/j.adaj.2023.03.014_bib22","first-page":"315","article-title":"Promoting caries arrest in children with silver diamine fluoride: a review","volume":"6","author":"Chu","year":"2008","journal-title":"Oral Health Prev Dent"},{"issue":"2","key":"10.1016\/j.adaj.2023.03.014_bib23","first-page":"94","article-title":"Dental hygienist and patient comparisons of fluoride varnishes to fluoride gels","volume":"74","author":"Warren","year":"2000","journal-title":"J\u00a0Dent Hyg"},{"issue":"3","key":"10.1016\/j.adaj.2023.03.014_bib24","first-page":"133","article-title":"Adolescents\u2019 experiences of participating in a school-based fluoride varnish programme in Sweden","volume":"36","author":"Bergstr\u00f6m","year":"2012","journal-title":"Swed Dent J"},{"issue":"1","key":"10.1016\/j.adaj.2023.03.014_bib25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s12903-020-01195-3","article-title":"Parental acceptance of silver diamine fluoride application on primary dentition: a systematic review and meta-analysis","volume":"20","author":"Sabbagh","year":"2020","journal-title":"BMC Oral Health"},{"issue":"7","key":"10.1016\/j.adaj.2023.03.014_bib26","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1177\/0022034517698419","article-title":"Biomimetic remineralization of carious lesions by self-assembling peptide","volume":"96","author":"Kind","year":"2017","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.adaj.2023.03.014_bib27","series-title":"Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design","author":"Lee","year":"2016"},{"issue":"4","key":"10.1016\/j.adaj.2023.03.014_bib28","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.1038\/sj.bdj.2013.741","article-title":"Treatment of early caries lesions using biomimetic self-assembling peptides: a clinical safety trial","volume":"215","author":"Brunton","year":"2013","journal-title":"Br Dent J"},{"key":"10.1016\/j.adaj.2023.03.014_bib29","series-title":"Cochrane handbook for systematic reviews of interventions version 6.3. Cochrane Training","year":"2022"},{"key":"10.1016\/j.adaj.2023.03.014_bib30","unstructured":"Sch\u00fcnemann H, Bro\u017cek J, Guyatt G, Oxman A, eds. GRADE handbook for grading quality of evidence and strength of recommendations. GRADE Working Group. Updated October 2013. Accessed January 26, 2023. guidelinedevelopment.org\/handbook"},{"issue":"1","key":"10.1016\/j.adaj.2023.03.014_bib31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/0022034518800014","article-title":"Nonrestorative treatments for caries: systematic review and network meta-analysis","volume":"98","author":"Urquhart","year":"2019","journal-title":"J\u00a0Dent Res"},{"issue":"4","key":"10.1016\/j.adaj.2023.03.014_bib32","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1117\/1.1606685","article-title":"Correlation of quantitative light-induced fluorescence and optical coherence tomography applied for detection and quantification of early dental caries","volume":"8","author":"Amaechi","year":"2003","journal-title":"J\u00a0Biomed Opt"},{"issue":"7414","key":"10.1016\/j.adaj.2023.03.014_bib33","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.adaj.2023.03.014_bib34","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.adaj.2023.03.014_bib35","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1038\/s41598-020-60815-8","article-title":"Randomized clinical trial investigating self-assembling peptide P11-4 for treatment of early occlusal caries","volume":"10","author":"Doberdoli","year":"2020","journal-title":"Scientific Reports"},{"issue":"2","key":"10.1016\/j.adaj.2023.03.014_bib36","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/0022034517730531","article-title":"Self-assembling peptide P11-4 and fluoride for regenerating enamel","volume":"97","author":"Alkilzy","year":"2018","journal-title":"J Dent Res"},{"issue":"2","key":"10.1016\/j.adaj.2023.03.014_bib37","first-page":"99","article-title":"Comparative evaluation of resin infiltration and remineralisation of noncavitated smooth surface caries lesions: 6-month results","volume":"17","author":"G\u00f6zetici","year":"2019","journal-title":"Oral Health Prev Dent"},{"issue":"1","key":"10.1016\/j.adaj.2023.03.014_bib38","article-title":"Efficacy of P11-4 for the treatment of initial buccal caries: a randomized clinical trial","volume":"10","author":"Kondelova","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.adaj.2023.03.014_bib39","doi-asserted-by":"crossref","first-page":"6819","DOI":"10.1038\/s41598-020-63633-0","article-title":"Effect of self-assembling peptide P11-4 on orthodontic treatment-induced carious lesions","volume":"10","author":"Welk","year":"2020","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.adaj.2023.03.014_bib40","first-page":"451","article-title":"Effectiveness of self-assembling peptide P11-4 compared to tricalcium phosphate fluoride varnish in remineralization of white spot lesions: a clinical randomized trial","volume":"13","author":"Kobeissi","year":"2020","journal-title":"Int J Clin Pediatr Dent"},{"issue":"2","key":"10.1016\/j.adaj.2023.03.014_bib41","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/154405910308200208","article-title":"Construct and predictive validity of clinical caries diagnostic criteria assessing lesion activity","volume":"82","author":"Nyvad","year":"2003","journal-title":"J\u00a0Dent Res"},{"issue":"5","key":"10.1016\/j.adaj.2023.03.014_bib42","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1159\/000239755","article-title":"In\u00a0vitro comparison of Nyvad\u2019s system and ICDAS-II with Lesion Activity Assessment for evaluation of severity and activity of occlusal caries lesions in primary teeth","volume":"43","author":"Braga","year":"2009","journal-title":"Caries Res"},{"issue":"4","key":"10.1016\/j.adaj.2023.03.014_bib43","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2307\/2529268","article-title":"The estimation and interpretation of attributable risk in health research","volume":"32","author":"Walter","year":"1976","journal-title":"Biometrics"},{"issue":"1","key":"10.1016\/j.adaj.2023.03.014_bib44","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00784-019-02901-4","article-title":"Randomised clinical trial investigating self-assembling peptide P11-4 in the treatment of early caries","volume":"24","author":"Br\u00f6seler","year":"2020","journal-title":"Clin Oral Investig"},{"issue":"11","key":"10.1016\/j.adaj.2023.03.014_bib45","first-page":"852","article-title":"Back to the future: the medical management of caries introduction","volume":"40","author":"Duffin","year":"2012","journal-title":"J\u00a0Calif Dent Assoc"},{"issue":"suppl 2","key":"10.1016\/j.adaj.2023.03.014_bib46","first-page":"S122","article-title":"System level interventions to reduce utilization of general anesthesia to treat dental caries: a practice brief","volume":"80","author":"Ludwig","year":"2020","journal-title":"J\u00a0Public Health Dent"},{"issue":"3","key":"10.1016\/j.adaj.2023.03.014_bib47","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.identj.2021.05.009","article-title":"Silver diamine fluoride protocol for reducing preventable dental hospitalisations in Victorian children","volume":"72","author":"Yawary","year":"2022","journal-title":"Int Dent J"},{"issue":"2","key":"10.1016\/j.adaj.2023.03.014_bib48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.21608\/adjg.2017.5226","article-title":"Remineralization of early carious lesions using biomimetic selfassembling peptides versus fluoride agent: in\u00a0vitro and in\u00a0vivo study","volume":"4","author":"Metwally","year":"2017","journal-title":"Al-Azhar Dent J"},{"issue":"4","key":"10.1016\/j.adaj.2023.03.014_bib49","first-page":"646","article-title":"Comparative study using biomimetic remineralization versus fluoride varnish in management of white spot lesion in post orthodontic treated patient: split mouth randomized clinical trial","volume":"11","author":"Riad","year":"2020","journal-title":"Indian J Public Health Res Develop"},{"issue":"4","key":"10.1016\/j.adaj.2023.03.014_bib50","doi-asserted-by":"crossref","first-page":"349","DOI":"10.21608\/adjg.2018.20020","article-title":"Clinical performance and remineralization potential of different biomimitic materials on white spot lesions","volume":"5","author":"Kamh","year":"2018","journal-title":"Al-Azhar Dent J"},{"issue":"103522","key":"10.1016\/j.adaj.2023.03.014_bib51","article-title":"Arresting early childhood caries using silver and fluoride products: a randomised trial","volume":"103","author":"Gao","year":"2020","journal-title":"J\u00a0Dent"},{"issue":"11","key":"10.1016\/j.adaj.2023.03.014_bib52","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/sim.4780091108","article-title":"The graphical representation of clinical trials with particular reference to measurements over time","volume":"9","author":"Senn","year":"1990","journal-title":"Stat Med"},{"key":"10.1016\/j.adaj.2023.03.014_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2021.103652","article-title":"Efficacy of a self-assembling peptide to remineralize initial caries lesions: a systematic review and meta-analysis","volume":"109","author":"Wierichs","year":"2021","journal-title":"J\u00a0Dent"},{"issue":"5","key":"10.1016\/j.adaj.2023.03.014_bib54","first-page":"135","article-title":"Use of silver diamine fluoride for dental caries management in children and adolescents, including those with special health care needs","volume":"39","author":"Crystal","year":"2017","journal-title":"Pediatr Dent"},{"issue":"suppl 1","key":"10.1016\/j.adaj.2023.03.014_bib55","doi-asserted-by":"crossref","first-page":"C67","DOI":"10.1177\/154405910408301s13","article-title":"Improving clinical visual detection: potential for caries clinical trials","volume":"83","author":"Ekstrand","year":"2004","journal-title":"J\u00a0Dent Res"},{"issue":"2","key":"10.1016\/j.adaj.2023.03.014_bib56","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/0022034512449464","article-title":"Caries clinical trial methods for the assessment of oral care products in the 21st century","volume":"24","author":"Ellwood","year":"2012","journal-title":"Adv Dent Res"},{"issue":"4","key":"10.1016\/j.adaj.2023.03.014_bib57","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/0193841X16660663","article-title":"Generalizing treatment effect estimates from sample to population: a case study in the difficulties of finding sufficient data","volume":"41","author":"Stuart","year":"2017","journal-title":"Eval Rev"},{"key":"10.1016\/j.adaj.2023.03.014_bib58","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jdent.2017.08.015","article-title":"Topical silver diamine fluoride for dental caries arrest in preschool children: a randomized controlled trial and microbiological analysis of caries associated microbes and resistance gene expression","volume":"68","author":"Milgrom","year":"2018","journal-title":"J\u00a0Dent"},{"issue":"1","key":"10.1016\/j.adaj.2023.03.014_bib59","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/0022034517743750","article-title":"Silver fluoride as a treatment for dental caries","volume":"29","author":"Horst","year":"2018","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.adaj.2023.03.014_bib60","volume":"853106","author":"Pitts","year":"2014"},{"issue":"5","key":"10.1016\/j.adaj.2023.03.014_bib61","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41415-019-0678-8","article-title":"CariesCare practice guide: consensus on evidence into practice","volume":"227","author":"Martignon","year":"2019","journal-title":"Br Dent J"},{"issue":"5","key":"10.1016\/j.adaj.2023.03.014_bib62","first-page":"328","article-title":"Approximal and occlusal carious lesions","volume":"147","author":"Rechmann","year":"2016","journal-title":"JADA"},{"issue":"1","key":"10.1016\/j.adaj.2023.03.014_bib63","first-page":"627","article-title":"Knowledge and opinions of French dental students in operative dentistry: management of deep carious lesions","volume":"19","author":"Gasqui","year":"2021","journal-title":"Oral Health Prev Dent"},{"issue":"7","key":"10.1016\/j.adaj.2023.03.014_bib64","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41415-020-2220-4","article-title":"When to intervene in the caries process? A Delphi consensus statement","volume":"229","author":"Banerjee","year":"2020","journal-title":"Br Dent J"},{"issue":"6","key":"10.1016\/j.adaj.2023.03.014_bib65","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1177\/0022034520986794","article-title":"Reorienting oral health services to prevention: economic perspectives","volume":"100","author":"Vernazza","year":"2021","journal-title":"J\u00a0Dent Res"}],"container-title":["The Journal of the American Dental Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817723001897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817723001897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T09:05:13Z","timestamp":1723194313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002817723001897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":65,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S0002817723001897"],"URL":"https:\/\/doi.org\/10.1016\/j.adaj.2023.03.014","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.06.13.22276212","asserted-by":"object"}]},"ISSN":["0002-8177"],"issn-type":[{"value":"0002-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic review and meta-analysis on the effect of self-assembling peptide P11-4 on arrest, cavitation, and progression of initial caries lesions","name":"articletitle","label":"Article Title"},{"value":"The Journal of the American Dental Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adaj.2023.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Dental Association.","name":"copyright","label":"Copyright"}]}}