{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:19:17Z","timestamp":1792001957229,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007904","name":"Texas A&amp;M University System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007904","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jada.ada.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of the American Dental Association"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.adaj.2026.05.008","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:18:12Z","timestamp":1784204292000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of silver diamine fluoride in preventing radiation-induced caries"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3857-3125","authenticated-orcid":false,"given":"Amal A.K.","family":"Noureldin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3933-5337","authenticated-orcid":false,"given":"Amerian","family":"Sones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8073-0617","authenticated-orcid":false,"given":"Luz","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd","family":"Mancl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0784-9181","authenticated-orcid":false,"given":"Peter","family":"Milgrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.adaj.2026.05.008_bib1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S1470-2045(06)70658-1","article-title":"Radiation-related damage to dentition","volume":"7(4)","author":"Kielbassa","year":"2006","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.adaj.2026.05.008_bib2","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1002\/1097-0142(19921015)70:8<2171::AID-CNCR2820700827>3.0.CO;2-S","article-title":"Protocol for prevention and treatment of oral sequelae resulting from head and neck radiation therapy","volume":"70(8)","author":"Jansma","year":"1992","journal-title":"Cancer"},{"key":"10.1016\/j.adaj.2026.05.008_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2019.104484","article-title":"Dental caries following radiotherapy for head and neck cancer: a systematic review","volume":"100","author":"Moore","year":"2020","journal-title":"Oral Oncol"},{"key":"10.1016\/j.adaj.2026.05.008_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/froh.2022.961594","article-title":"Over 300 radiation caries papers: reflections from the rearview mirror","volume":"3","author":"Pedroso","year":"2022","journal-title":"Front Oral Health"},{"key":"10.1016\/j.adaj.2026.05.008_bib5","doi-asserted-by":"crossref","first-page":"626","DOI":"10.4103\/JCDE.JCDE_237_25","article-title":"Effect of radiation on microhardness and ultramorphological changes in dentin: an in vitro analysis","volume":"28(7)","author":"Hegde","year":"2025","journal-title":"J Conserv Dent Endod"},{"key":"10.1016\/j.adaj.2026.05.008_bib6","first-page":"384","article-title":"Caries incidence and microbiology in irradiated patients during a preventive program","volume":"26(5)","author":"Joyston-Bechal","year":"1992","journal-title":"Caries Res"},{"key":"10.1016\/j.adaj.2026.05.008_bib7","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1159\/000088184","article-title":"Persistence of Streptococcus mutans in patients after radiotherapy","volume":"39(6)","author":"Meng","year":"2005","journal-title":"Caries Res"},{"key":"10.1016\/j.adaj.2026.05.008_bib8","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/idh.12338","article-title":"Explorative study on mucosal and major salivary secretion rates, caries and plaque microflora in head and neck cancer patients","volume":"16","author":"Almst\u00e5hl","year":"2018","journal-title":"Int J Dent Hyg"},{"issue":"1","key":"10.1016\/j.adaj.2026.05.008_bib9","article-title":"Radiation-induced dental caries: a narrative review","volume":"17","author":"El Harram","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.adaj.2026.05.008_bib10","article-title":"Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults","volume":"11(11)","author":"Worthington","year":"2024","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.adaj.2026.05.008_bib11","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1177\/0022034508329406","article-title":"Silver diamine fluoride: a \u201csilver-fluoride bullet.\u201d","volume":"88","author":"Rosenblatt","year":"2009","journal-title":"J Dent Res"},{"key":"10.1016\/j.adaj.2026.05.008_bib12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-263X.2011.01149.x","article-title":"Effects of silver diamine fluoride on dentine carious lesions induced by Streptococcus mutans and Actinomyces naeslundii biofilms","volume":"22","author":"Chu","year":"20121","journal-title":"Int J Paediatr Dent"},{"key":"10.1016\/j.adaj.2026.05.008_bib13","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1038\/s41598-021-85748-8","article-title":"Protective effect of titanium tetrafluoride and silver diamine fluoride on radiation-induced dentin caries in vitro","volume":"11(1)","author":"de Souza","year":"2021","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.adaj.2026.05.008_bib14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/idj.12320","article-title":"Mechanisms of silver diamine fluoride on arresting caries: a literature review","volume":"68","author":"Zhao","year":"2018","journal-title":"Int Dent J"},{"key":"10.1016\/j.adaj.2026.05.008_bib15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000488686","article-title":"The effect of silver diamine fluoride in preventing caries in the primary dentition: a systematic review and meta-analysis","volume":"53(1)","author":"Oliveira","year":"2019","journal-title":"Caries Res"},{"key":"10.1016\/j.adaj.2026.05.008_bib16","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13063-020-4088-7","article-title":"Preventing early childhood caries with silver diamine fluoride: protocol for a randomized clinical trial","volume":"21(1)","author":"Gao","year":"2020","journal-title":"Trials"},{"key":"10.1016\/j.adaj.2026.05.008_bib17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/scd.12633","article-title":"Effect of silver diamine fluoride on hyperplastic gingivitis in an adult with intellectual disability: a case report","volume":"42(1)","author":"Lim","year":"2022","journal-title":"Spec Care Dentist"},{"key":"10.1016\/j.adaj.2026.05.008_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2024.104890","article-title":"Efficacy of 38% silver diamine fluoride in reducing gingival inflammation and plaque accumulation in older adults living in retirement homes: a randomized controlled pilot trial","volume":"143","author":"Noureldin","year":"2024","journal-title":"J Dent"},{"issue":"20","key":"10.1016\/j.adaj.2026.05.008_bib40","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.adaj.2026.05.008_bib41","series-title":"ICH Harmonised Guideline: Guideline for Good Clinical Practice E6(R1)","year":"1996"},{"key":"10.1016\/j.adaj.2026.05.008_bib42","doi-asserted-by":"crossref","first-page":"c869","DOI":"10.1136\/bmj.c869","article-title":"CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomized trials","volume":"340","author":"Moher","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.adaj.2026.05.008_bib43","series-title":"The Health Insurance Portability and Accountability Act of 1996. HR 3103, 104th Cong","year":"1995"},{"key":"10.1016\/j.adaj.2026.05.008_bib19","first-page":"63","article-title":"ICDAS II criteria (International Caries Detection and Assessment System)","volume":"49(3)","author":"Dikmen","year":"2015","journal-title":"J Istanb Univ Fac Dent"},{"key":"10.1016\/j.adaj.2026.05.008_bib20","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1159\/000480522","article-title":"Nyvad criteria for caries lesion activity and severity assessment: a validated approach for clinical management and research","volume":"52(5)","author":"Nyvad","year":"2018","journal-title":"Caries Res"},{"key":"10.1016\/j.adaj.2026.05.008_bib21","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1902\/jop.1967.38.6_part2.610","article-title":"The gingival index, the plaque index and the retention index systems","volume":"38(6)","author":"L\u00f6e","year":"1967","journal-title":"J Periodontol"},{"key":"10.1016\/j.adaj.2026.05.008_bib22","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1749-6632.1993.tb18343.x","article-title":"Methods for collecting saliva","volume":"694(1)","author":"Navazesh","year":"1993","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.adaj.2026.05.008_bib23","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international oncology trials","volume":"85(3)","author":"Aaronson","year":"1993","journal-title":"J Natl Cancer Inst"},{"issue":"16","key":"10.1016\/j.adaj.2026.05.008_bib24","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000025540","article-title":"The effect of comprehensive oral care program on oral health and quality of life in patients undergoing radiotherapy for head and neck cancer: a quasi-experimental case-control study","volume":"100","author":"Lee","year":"2021","journal-title":"Medicine"},{"issue":"3","key":"10.1016\/j.adaj.2026.05.008_bib25","first-page":"1","article-title":"mice: multivariate imputation by chained equations in R","volume":"45","author":"Stef van Buuren","year":"2011","journal-title":"J Stat Softw"},{"key":"10.1016\/j.adaj.2026.05.008_bib26","series-title":"Multiple Imputation for Nonresponse in Surveys","author":"Rubin","year":"1987"},{"key":"10.1016\/j.adaj.2026.05.008_bib28","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.dental.2012.04.011","article-title":"Inhibitory effects of silver diamine fluoride at different concentrations on matrix metalloproteinases","volume":"28(8)","author":"Mei","year":"2012","journal-title":"Dent Mater"},{"key":"10.1016\/j.adaj.2026.05.008_bib29","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0030-4220(91)90461-K","article-title":"Efficacy of chlorhexidine gel in reducing Streptococcus mutans and Lactobacillus species in irradiated patients","volume":"71(2)","author":"Epstein","year":"1991","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"4","key":"10.1016\/j.adaj.2026.05.008_bib30","first-page":"428","article-title":"Navigating the complex regulatory landscape of some fluoride caries therapies in the United States: the burden to clinicians","volume":"157","author":"Fontana","year":"2026","journal-title":"JADA"},{"issue":"2","key":"10.1016\/j.adaj.2026.05.008_bib31","first-page":"81","article-title":"In vitro caries lesion rehardening and enamel fluoride uptake from fluoride varnishes as a function of application mode","volume":"26","author":"Lippert","year":"2013","journal-title":"Am J Dent"},{"issue":"4","key":"10.1016\/j.adaj.2026.05.008_bib32","first-page":"291","article-title":"Laboratory investigations into the predicted anticaries efficacy of fluoride varnishes","volume":"36","author":"Lippert","year":"2014","journal-title":"Pediatr Dent"},{"issue":"spec iss B","key":"10.1016\/j.adaj.2026.05.008_bib33","article-title":"Impact of different fluoride varnish formulations on enamel demineralization prevention","volume":"93","author":"Gonzalez-Cabezas","year":"2014","journal-title":"J Dent Res"},{"issue":"7","key":"10.1016\/j.adaj.2026.05.008_bib34","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1007\/s00784-015-1648-4","article-title":"Effect of fluoride varnishes on caries lesions: an in vitro investigation","volume":"20","author":"Al Dehailan","year":"2016","journal-title":"Clin Oral Invest"},{"issue":"18","key":"10.1016\/j.adaj.2026.05.008_bib35","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1001\/jama.2023.20685","article-title":"Screening, referral, behavioral counseling, and preventive interventions for oral health in adults: a systematic review for the US Preventive Services Task Force","volume":"330","author":"Chou","year":"2023","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.adaj.2026.05.008_bib36","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00902-25","article-title":"Impact of fluoride varnish and oral health education on caries increment and dental plaque microbiota among children with early mixed dentition: a 24-month randomized controlled trial","volume":"13","author":"Zeng","year":"2025","journal-title":"Microbiol Spectr"},{"issue":"spec iss B","key":"10.1016\/j.adaj.2026.05.008_bib37","article-title":"Intensive Preventive Dental Program (IPDP) in head and neck cancer","volume":"104","author":"Brennan","year":"2025","journal-title":"J Dent Res"},{"key":"10.1016\/j.adaj.2026.05.008_bib38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jdsr.2022.08.001","article-title":"Silver diamine fluoride therapy for dental care","volume":"58","author":"Zheng","year":"2022","journal-title":"Jpn Dent Sci Rev"},{"key":"10.1016\/j.adaj.2026.05.008_bib39","article-title":"CONSORT 2025 statement: updated guideline for reporting randomised trials","volume":"388","author":"Hopewell","year":"2025","journal-title":"BMJ"},{"key":"10.1016\/j.adaj.2026.05.008_bib44","doi-asserted-by":"crossref","first-page":"e081124","DOI":"10.1136\/bmj-2024-081124","article-title":"CONSORT 2025 explanation and elaboration: updated guideline for reporting randomised trials","volume":"389","author":"Hopewell","year":"2025","journal-title":"BMJ"}],"container-title":["The Journal of the American Dental Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817726003405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817726003405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T02:45:44Z","timestamp":1786070744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002817726003405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":43,"alternative-id":["S0002817726003405"],"URL":"https:\/\/doi.org\/10.1016\/j.adaj.2026.05.008","relation":{},"ISSN":["0002-8177"],"issn-type":[{"value":"0002-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of silver diamine fluoride in preventing radiation-induced caries","name":"articletitle","label":"Article Title"},{"value":"The Journal of the American Dental Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adaj.2026.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Dental Association.","name":"copyright","label":"Copyright"}]}}