{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:53:11Z","timestamp":1791582791068,"version":"4.3.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jada.ada.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of the American Dental Association"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.adaj.2026.06.015","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:09:46Z","timestamp":1791580186000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single-center experience in the management of medication-related osteonecrosis of the jaw"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-0876","authenticated-orcid":false,"given":"Reema","family":"Mahmoud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2232-833X","authenticated-orcid":false,"given":"Leonid","family":"Groysman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-7668","authenticated-orcid":false,"given":"Shlomi","family":"Kleinman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4540-8405","authenticated-orcid":false,"given":"Gilad","family":"Wasserman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3610-6512","authenticated-orcid":false,"given":"Clariel","family":"Ianculovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Peleg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-8623","authenticated-orcid":false,"given":"Amir","family":"Shuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.adaj.2026.06.015_bib1","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1016\/j.joms.2012.05.019","article-title":"Resective surgical approach shows a high performance in the management of advanced cases of bisphosphonate-related osteonecrosis of the jaws: a retrospective survey of 347 cases","volume":"70","author":"Graziani","year":"2012","journal-title":"J Oral Maxillofac Surg"},{"issue":"10","key":"10.1016\/j.adaj.2026.06.015_bib2","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw: 2014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"issue":"9","key":"10.1016\/j.adaj.2026.06.015_bib3","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"issue":"5","key":"10.1016\/j.adaj.2026.06.015_bib4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","article-title":"Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases","volume":"62","author":"Ruggiero","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"issue":"3","key":"10.1016\/j.adaj.2026.06.015_bib5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.joms.2006.11.003","article-title":"American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons Position Paper on bisphosphonate-related osteonecrosis of the jaws","volume":"65","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"issue":"8","key":"10.1016\/j.adaj.2026.06.015_bib6","first-page":"584","article-title":"Effectiveness of treatments for medication-related osteonecrosis of the jaw: a systematic review and meta-analysis","volume":"148","author":"El-Rabbany","year":"2017","journal-title":"JADA"},{"issue":"5","key":"10.1016\/j.adaj.2026.06.015_bib7","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","article-title":"American Association of Oral and Maxillofacial Surgeons\u2019 position paper on medication-related osteonecrosis of the jaws: 2022 update","volume":"80","author":"Ruggiero","year":"2022","journal-title":"J Oral Maxillofac Surg"},{"issue":"8","key":"10.1016\/j.adaj.2026.06.015_bib8","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.jcms.2017.05.027","article-title":"The impact of surgical intervention and antibiotics on MRONJ stage II and III: retrospective study","volume":"45","author":"Zirk","year":"2017","journal-title":"J Craniomaxillofac Surg"},{"issue":"4","key":"10.1016\/j.adaj.2026.06.015_bib10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jcms.2020.02.017","article-title":"Medication-related osteonecrosis of the jaw (MRONJ) stage III: conservative and conservative surgical approaches versus an aggressive surgical intervention\u2014a systematic review","volume":"4","author":"Vanpoecke","year":"2020","journal-title":"J Craniomaxillofac Surg"},{"issue":"1","key":"10.1016\/j.adaj.2026.06.015_bib11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00774-016-0810-7","article-title":"Antiresorptive agent-related osteonecrosis of the jaw","volume":"35","author":"Yoneda","year":"2017","journal-title":"J Bone Miner Metab"},{"issue":"3","key":"10.1016\/j.adaj.2026.06.015_bib12","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jcms.2018.12.014","article-title":"Is the conservative non-surgical management of medication-related osteonecrosis of the jaw an appropriate treatment option for early stages? A long-term single-center cohort study","volume":"47","author":"Ristow","year":"2019","journal-title":"J Craniomaxillofac Surg"},{"issue":"7624","key":"10.1016\/j.adaj.2026.06.015_bib13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"61","author":"von Elm","year":"2008","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.adaj.2026.06.015_bib14","series-title":"The International Classification of Diseases","year":"1977"},{"issue":"11","key":"10.1016\/j.adaj.2026.06.015_bib15","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","article-title":"Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment","volume":"63","author":"Marx","year":"2005","journal-title":"J Oral Maxillofac Surg"},{"issue":"11","key":"10.1016\/j.adaj.2026.06.015_bib16","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1016\/j.joms.2018.05.025","article-title":"Nonsurgical management of medication-related osteonecrosis of the jaws using local wound care","volume":"76","author":"Hadaya","year":"2018","journal-title":"J Oral Maxillofac Surg"},{"issue":"2","key":"10.1016\/j.adaj.2026.06.015_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.tripleo.2011.02.037","article-title":"Osteonecrosis of the jaw in oncology patients treated with bisphosphonates: prospective experience of a dental oncology referral center","volume":"112","author":"Nicolatou-Galitis","year":"2011","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"2","key":"10.1016\/j.adaj.2026.06.015_bib18","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.joms.2010.06.200","article-title":"Relevance of a prolonged preoperative antibiotic regime in the treatment of bisphosphonate-related osteonecrosis of the jaw","volume":"69","author":"Hoefert","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"issue":"5","key":"10.1016\/j.adaj.2026.06.015_bib19","first-page":"E318","article-title":"Osteochemonecrosis of the jaws due to bisphosphonate treatments: update","volume":"13","author":"G\u00f3mez Font","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"2","key":"10.1016\/j.adaj.2026.06.015_bib20","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/annonc\/mdn630","article-title":"Initial experience with conservative treatment in cancer patients with osteonecrosis of the jaw (ONJ) and predictors of outcome","volume":"20","author":"Van den Wyngaert","year":"2009","journal-title":"Ann Oncol"},{"issue":"2","key":"10.1016\/j.adaj.2026.06.015_bib21","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1177\/039463201002300224","article-title":"Clinical experience with spiramycin in bisphosphonate-associated osteonecrosis of the jaw","volume":"23","author":"Gasparini","year":"2010","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"4","key":"10.1016\/j.adaj.2026.06.015_bib22","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.joms.2013.12.007","article-title":"Management of antiresorptive osteonecrosis of the jaws with primary surgical resection","volume":"72","author":"Carlson","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"issue":"1","key":"10.1016\/j.adaj.2026.06.015_bib23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ijom.2018.07.002","article-title":"Comparison of the histopathological characteristics of osteomyelitis, medication-related osteonecrosis of the jaw, and osteoradionecrosis","volume":"48","author":"Shuster","year":"2019","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"12","key":"10.1016\/j.adaj.2026.06.015_bib24","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/S0278-2391(10)80131-4","article-title":"Osteomyelitis of the jaws: a 50-year perspective","volume":"51","author":"Hudson","year":"1993","journal-title":"J Oral Maxillofac Surg"},{"issue":"4","key":"10.1016\/j.adaj.2026.06.015_bib25","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.coms.2011.07.011","article-title":"How can we diagnose and treat osteomyelitis of the jaws as early as possible?","volume":"23","author":"Koorbusch","year":"2011","journal-title":"Oral Maxillofac Surg Clin North Am"},{"issue":"5 suppl","key":"10.1016\/j.adaj.2026.06.015_bib26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.joms.2009.01.006","article-title":"The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws","volume":"67","author":"Carlson","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"issue":"12 suppl","key":"10.1016\/j.adaj.2026.06.015_bib27","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1016\/j.joms.2015.09.024","article-title":"Disease stage and mode of therapy are important determinants of treatment outcomes for medication-related osteonecrosis of the jaw","volume":"73","author":"Ruggiero","year":"2015","journal-title":"J Oral Maxillofac Surg"},{"issue":"8","key":"10.1016\/j.adaj.2026.06.015_bib28","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.bjoms.2016.06.015","article-title":"Conservative surgical management of patients with bisphosphonate-related osteonecrosis of the jaws: a series of 120 patients","volume":"54","author":"Nisi","year":"2016","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"4","key":"10.1016\/j.adaj.2026.06.015_bib29","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00432-014-1853-6","article-title":"Risk factors influencing the duration of treatment with bisphosphonates until occurrence of an osteonecrosis of the jaw in 963 cancer patients","volume":"141","author":"Gabbert","year":"2015","journal-title":"J Cancer Res Clin Oncol"},{"issue":"2","key":"10.1016\/j.adaj.2026.06.015_bib30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.coms.2014.01.005","article-title":"Anti-resorptive osteonecrosis of the jaws: facts forgotten, questions answered, lessons learned","volume":"26","author":"Carlson","year":"2014","journal-title":"Oral Maxillofac Surg Clin North Am"}],"container-title":["The Journal of the American Dental Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817726004320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817726004320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:09:55Z","timestamp":1791580195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002817726004320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":29,"alternative-id":["S0002817726004320"],"URL":"https:\/\/doi.org\/10.1016\/j.adaj.2026.06.015","relation":{},"ISSN":["0002-8177"],"issn-type":[{"value":"0002-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-center experience in the management of medication-related osteonecrosis of the jaw","name":"articletitle","label":"Article Title"},{"value":"The Journal of the American Dental Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adaj.2026.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Dental Association. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}