{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:15:49Z","timestamp":1793531749788,"version":"4.5.0"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Addiction Neuroscience"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.addicn.2024.100182","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T07:01:39Z","timestamp":1728975699000},"page":"100182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Oral fentanyl consumption and withdrawal impairs fear extinction learning and enhances basolateral amygdala principal neuron excitatory-inhibitory balance in male and female mice"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0146-4459","authenticated-orcid":false,"given":"Anthony M.","family":"Downs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gracianne","family":"Kmiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4717-5698","authenticated-orcid":false,"given":"Zo\u00e9 A.","family":"McElligott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addicn.2024.100182_bib0001","unstructured":"Centers for Disease Control, N. C. f. H. S., Office of Communication. Drug Overdose Deaths in the U.S. Top 100,000 Annually, https:\/\/www.cdc.gov\/nchs\/pressroom\/nchs_press_releases\/2021\/20211117.htm (2021)."},{"key":"10.1016\/j.addicn.2024.100182_bib0002","article-title":"Provisional drug overdose death counts","volume":"12","author":"Ahmad","year":"2021","journal-title":"Natl. Center Health Stat."},{"key":"10.1016\/j.addicn.2024.100182_bib0003","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1056\/NEJMc2304991","article-title":"Fentanyl-Associated Overdose Deaths Outside the Hospital","volume":"389","author":"Jeffery","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addicn.2024.100182_bib0004","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41572-019-0137-5","article-title":"Opioid use disorder","volume":"6","author":"Strang","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.addicn.2024.100182_bib0005","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1172\/JCI125534","article-title":"Heroin addiction engages negative emotional learning brain circuits in rats","volume":"129","author":"Carmack","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addicn.2024.100182_bib0006","doi-asserted-by":"crossref","first-page":"5894","DOI":"10.1523\/JNEUROSCI.0740-06.2006","article-title":"Conditioned withdrawal drives heroin consumption and decreases reward sensitivity","volume":"26","author":"Kenny","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0007","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf0364","article-title":"Cues conditioned to withdrawal and negative reinforcement: neglected but key motivational elements driving opioid addiction","volume":"7","author":"Pantazis","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.addicn.2024.100182_bib0008","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.addbeh.2006.05.022","article-title":"Motives, diversion and routes of administration associated with nonmedical use of prescription opioids","volume":"32","author":"McCabe","year":"2007","journal-title":"Addict. Behav."},{"key":"10.1016\/j.addicn.2024.100182_bib0009","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.addbeh.2018.05.015","article-title":"Oral and non-oral routes of administration among prescription opioid users: pathways, decision-making and directionality","volume":"86","author":"Cicero","year":"2018","journal-title":"Addict. Behav."},{"key":"10.1016\/j.addicn.2024.100182_bib0010","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1021\/acschemneuro.2c00818","article-title":"All Hands on Deck: we Need Multiple Approaches To Uncover the Neuroscience behind the Opioid Overdose Crisis","volume":"14","author":"Bedard","year":"2023","journal-title":"ACS. Chem. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0011","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3109\/15360288.2012.734905","article-title":"Characterization of prescription opioid abuse in the United States: focus on route of administration","volume":"26","author":"Kirsh","year":"2012","journal-title":"J. Pain. Palliat. Care PharmacOther"},{"key":"10.1016\/j.addicn.2024.100182_bib0012","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/ajad.12897","article-title":"Use of \"Lean\" Among Electronic Dance Music Party Attendees","volume":"28","author":"Palamar","year":"2019","journal-title":"Am. J. Addict."},{"key":"10.1016\/j.addicn.2024.100182_bib0013","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.addbeh.2013.03.020","article-title":"Purple drank prevalence and characteristics of misusers of codeine cough syrup mixtures","volume":"38","author":"Agnich","year":"2013","journal-title":"Addict. Behav."},{"key":"10.1016\/j.addicn.2024.100182_bib0014","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0301024","article-title":"Codeine and promethazine: exploratory study on \"lean\" or \"sizzurp\" using national survey data and an online forum","volume":"19","author":"Ware","year":"2024","journal-title":"PLoS. One"},{"key":"10.1016\/j.addicn.2024.100182_bib0015","article-title":"Lean\/Sizzurp Ingredients, Use, and Coping With Mental Health Symptoms","volume":"17","author":"Ware","year":"2023","journal-title":"Subst. Abuse"},{"key":"10.1016\/j.addicn.2024.100182_bib0016","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1477-7517-7-24","article-title":"Route of administration for illicit prescription opioids: a comparison of rural and urban drug users","volume":"7","author":"Young","year":"2010","journal-title":"Harm. Reduct. J."},{"key":"10.1016\/j.addicn.2024.100182_bib0017","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12954-022-00634-4","article-title":"They say it's fentanyl, but they honestly look like Perc 30s\u201d: initiation and use of counterfeit fentanyl pills","volume":"19","author":"Daniulaityte","year":"2022","journal-title":"Harm. Reduct. J."},{"key":"10.1016\/j.addicn.2024.100182_bib0018","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1080\/00952990.2022.2081923","article-title":"Trends in characteristics of fentanyl-related poisonings in the United States, 2015-2021","volume":"48","author":"Palamar","year":"2022","journal-title":"Am. J. Drug Alcohol Abuse"},{"key":"10.1016\/j.addicn.2024.100182_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/02791072.2023.2176954","article-title":"Pressed OXY M30 Pills, Great Press, Potent, Fast Shipping!!!\u201d: availability of Counterfeit and Pharmaceutical Oxycodone Pills on One Major Cryptomarket","volume":"56","author":"Lamy","year":"2024","journal-title":"J. Psychoactive Drugs"},{"key":"10.1016\/j.addicn.2024.100182_bib0020","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1080\/10826084.2022.2120365","article-title":"Fentanyl in Pressed Oxycodone Pills: a Qualitative Analysis of Online Community Experiences with an Emerging Drug Trend","volume":"57","author":"Arya","year":"2022","journal-title":"Subst. Use Misuse"},{"key":"10.1016\/j.addicn.2024.100182_bib0021","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s00213-020-05722-6","article-title":"Aversion-resistant fentanyl self-administration in mice","volume":"238","author":"Monroe","year":"2021","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.addicn.2024.100182_bib0022","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejphar.2016.07.006","article-title":"Oxycodone physical dependence and its oral self-administration in C57BL\/6J mice","volume":"789","author":"Enga","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.addicn.2024.100182_bib0023","doi-asserted-by":"crossref","first-page":"e12828","DOI":"10.1111\/adb.12828","article-title":"Oral prescription opioid-seeking behavior in male and female mice","volume":"25","author":"Phillips","year":"2020","journal-title":"Addict. Biol."},{"key":"10.1016\/j.addicn.2024.100182_bib0024","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejphar.2008.04.007","article-title":"Supraspinally-administered agmatine attenuates the development of oral fentanyl self-administration","volume":"587","author":"Wade","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.addicn.2024.100182_bib0025","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1037\/1064-1297.9.3.251","article-title":"Effects of adolescent nicotine exposure on opioid consumption and neuroendocrine responses in adult male and female rats","volume":"9","author":"Klein","year":"2001","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.addicn.2024.100182_bib0026","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1037\/1064-1297.5.2.99","article-title":"Sex differences in effects of predictable and unpredictable footshock on fentanyl self-administration in rats","volume":"5","author":"Klein","year":"1997","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.addicn.2024.100182_bib0027","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0091-3057(93)90359-2","article-title":"Effect of stress on oral fentanyl consumption in rats in an operant self-administration paradigm","volume":"46","author":"Shaham","year":"1993","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.addicn.2024.100182_bib0028","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0091-3057(99)00262-2","article-title":"Fentanyl self-administration in juvenile rats that were tolerant and dependent to fentanyl as infants","volume":"65","author":"Thornton","year":"2000","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.addicn.2024.100182_bib0029","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.drugalcdep.2018.05.034","article-title":"The effect of quinine in two bottle choice procedures in C57BL6 mice: opioid preference, somatic withdrawal, and pharmacokinetic outcomes","volume":"191","author":"Grim","year":"2018","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.addicn.2024.100182_bib0030","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0091-3057(92)90382-P","article-title":"Effect of stress on oral morphine and fentanyl self-administration in rats","volume":"41","author":"Shaham","year":"1992","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.addicn.2024.100182_bib0031","doi-asserted-by":"crossref","first-page":"e13344","DOI":"10.1111\/adb.13344","article-title":"Rapid appearance of negative emotion during oral fentanyl self-administration in male and female rats","volume":"28","author":"Coffey","year":"2023","journal-title":"Addict. Biol."},{"key":"10.1016\/j.addicn.2024.100182_bib0032","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2022.821080","article-title":"Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL\/6 Mice","volume":"16","author":"Franco","year":"2022","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0033","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.972658","article-title":"Anterior cingulate cortex and its projections to the ventral tegmental area regulate opioid withdrawal, the formation of opioid context associations and context-induced drug seeking","volume":"16","author":"McKendrick","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0034","article-title":"An automated group-housed oral fentanyl self-administration method in mice","author":"Peretz-Rivlin","year":"2024","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.addicn.2024.100182_bib0035","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1007\/s00213-022-06129-1","article-title":"Reinforcing effects of fentanyl and sufentanil aerosol puffs in rats","volume":"239","author":"Shelton","year":"2022","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.addicn.2024.100182_bib0036","doi-asserted-by":"crossref","first-page":"eabc0413","DOI":"10.1126\/sciadv.abc0413","article-title":"Fentanyl vapor self-administration model in mice to study opioid addiction","volume":"6","author":"Moussawi","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.addicn.2024.100182_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114441","article-title":"Probing different paradigms of morphine withdrawal on sleep behavior in male and female C57BL\/6J mice","volume":"448","author":"Bedard","year":"2023","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.addicn.2024.100182_bib0038","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/ejn.14580","article-title":"Divergent behavioral responses in protracted opioid withdrawal in male and female C57BL\/6J mice","volume":"51","author":"Bravo","year":"2020","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0039","doi-asserted-by":"crossref","first-page":"e12748","DOI":"10.1111\/adb.12748","article-title":"Inhibitory transmission in the bed nucleus of the stria terminalis in male and female mice following morphine withdrawal","volume":"25","author":"Luster","year":"2020","journal-title":"Addict. Biol."},{"key":"10.1016\/j.addicn.2024.100182_bib0040","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/sj.npp.1301441","article-title":"Chronic Morphine Selectively Impairs Cued Fear Extinction in Rats: implications for Anxiety Disorders Associated with Opiate Use","volume":"33","author":"Gu","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.addicn.2024.100182_bib0041","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41386-019-0559-5","article-title":"Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma","volume":"45","author":"Pennington","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.addicn.2024.100182_bib0042","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13011-020-00264-8","article-title":"PTSD and opioid use: implications for intervention and policy","volume":"15","author":"Dahlby","year":"2020","journal-title":"Subst. Abuse Treat. Prev. Policy."},{"key":"10.1016\/j.addicn.2024.100182_bib0043","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1016\/j.addbeh.2006.02.007","article-title":"The association of substance use disorders with trauma exposure and PTSD among African American drug users","volume":"31","author":"Johnson","year":"2006","journal-title":"Addict. Behav."},{"key":"10.1016\/j.addicn.2024.100182_bib0044","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1176\/appi.ajp.158.8.1184","article-title":"Substance Use Disorders in Patients With Posttraumatic Stress Disorder: a Review of the Literature","volume":"158","author":"Jacobsen","year":"2001","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.addicn.2024.100182_bib0045","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2020.00006","article-title":"Mechanisms of Shared Vulnerability to Post-traumatic Stress Disorder and Substance Use Disorders","volume":"14","author":"Mar\u00eda-R\u00edos","year":"2020","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0046","doi-asserted-by":"crossref","unstructured":"Bravo, I., Bluitt, M. & McElligott, Z. Examining opioid withdrawal scoring and adaptation of global scoring systems to male and female C57BL\/6J mice. bioRxiv, 2021.2010.2011.463944 (2021). 10.1101\/2021.10.11.463944.","DOI":"10.1101\/2021.10.11.463944"},{"key":"10.1016\/j.addicn.2024.100182_bib0047","article-title":"Xylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to opioid antagonism","volume":"11","author":"Bedard","year":"2024","journal-title":"Add. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0048","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2020.00086","article-title":"Forced Abstinence From Alcohol Induces Sex-Specific Depression-Like Behavioral and Neural Adaptations in Somatostatin Neurons in Cortical and Amygdalar Regions","volume":"14","author":"Dao","year":"2020","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0049","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.alcohol.2022.08.008","article-title":"Tauopathy and alcohol consumption interact to alter locus coeruleus excitatory transmission and excitability in male and female mice","volume":"107","author":"Downs","year":"2023","journal-title":"Alcohol"},{"key":"10.1016\/j.addicn.2024.100182_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.108997","article-title":"Noradrenergic circuits and signaling in substance use disorders","volume":"208","author":"Downs","year":"2022","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.addicn.2024.100182_bib0051","doi-asserted-by":"crossref","first-page":"e13049","DOI":"10.1111\/adb.13049","article-title":"Calcium-permeable AMPA receptor activity and GluA1 trafficking in the basolateral amygdala regulate operant alcohol self-administration","volume":"26","author":"Faccidomo","year":"2021","journal-title":"Addict. Biol."},{"key":"10.1016\/j.addicn.2024.100182_bib0052","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0091-3057(89)90336-5","article-title":"Taste vs. CNS effects in voluntary oral opiate intake: studies with a novel device and technique","volume":"34","author":"Carlson","year":"1989","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.addicn.2024.100182_bib0053","doi-asserted-by":"crossref","first-page":"e12895","DOI":"10.1111\/adb.12895","article-title":"Enduring consequences of perinatal fentanyl exposure in mice","volume":"26","author":"Alipio","year":"2021","journal-title":"Addict. Biol."},{"key":"10.1016\/j.addicn.2024.100182_bib0054","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s002130100793","article-title":"Withdrawal from chronic morphine administration causes prolonged enhancement of immobility in rat forced swimming test","volume":"157","author":"Anraku","year":"2001","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.addicn.2024.100182_bib0055","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1037\/0735-7044.119.4.1034","article-title":"Increased vulnerability to stress following opiate exposures: behavioral and autonomic correlates","volume":"119","author":"Blatchford","year":"2005","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0056","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1037\/0735-7044.120.5.1169","article-title":"Altered responsivity to central administrations of corticotropin-releasing factor in rats with a history of opiate exposures","volume":"120","author":"Blatchford","year":"2006","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0057","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.biopsych.2019.07.027","article-title":"The Negative Affect of Protracted Opioid Abstinence: progress and Perspectives From Rodent Models","volume":"87","author":"Welsch","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.addicn.2024.100182_bib0058","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2019.00311","article-title":"Addiction, Anhedonia, and Comorbid Mood Disorder. A Narrative Review","volume":"10","author":"Destoop","year":"2019","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.addicn.2024.100182_bib0059","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.drugalcdep.2017.03.012","article-title":"Evidence that anhedonia is a symptom of opioid dependence associated with recent use","volume":"177","author":"Garfield","year":"2017","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.addicn.2024.100182_bib0060","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S2215-0366(16)00104-8","article-title":"Neurobiology of addiction: a neurocircuitry analysis","volume":"3","author":"Koob","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.addicn.2024.100182_bib0061","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1523\/JNEUROSCI.4100-03.2004","article-title":"Role of the basolateral amygdala in the storage of fear memories across the adult lifetime of rats","volume":"24","author":"Gale","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0062","doi-asserted-by":"crossref","first-page":"e1194","DOI":"10.1038\/tp.2017.161","article-title":"Basolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction","volume":"7","author":"Sharp","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.addicn.2024.100182_bib0063","doi-asserted-by":"crossref","first-page":"e13253","DOI":"10.1111\/adb.13253","article-title":"Oral oxycodone self-administration leads to features of opioid misuse in male and female mice","volume":"28","author":"Slivicki","year":"2023","journal-title":"Addict. Biol."},{"key":"10.1016\/j.addicn.2024.100182_bib0064","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0230-20.2020","article-title":"Citric Acid Water as an Alternative to Water Restriction for High-Yield Mouse Behavior","volume":"8","author":"Urai","year":"2021","journal-title":"eNeuro"},{"key":"10.1016\/j.addicn.2024.100182_bib0065","doi-asserted-by":"crossref","unstructured":"Catavero, C.M., Marsh, A.E., Downs, A.M., Teklezghi, A.T., Cohen, T.J. & McElligott, Z.A. Effects of Long-Term Alcohol Consumption on Behavior in the P301S (Line PS19) Tauopathy Mouse Model. bioRxiv, 2022.2007.2012.499737 (2022). 10.1101\/2022.07.12.499737.","DOI":"10.1101\/2022.07.12.499737"},{"key":"10.1016\/j.addicn.2024.100182_bib0066","article-title":"GABA Release From Central Amygdala Neurotensin Neurons Differentially Modulates Reward and Consummatory Behavior in Male and Female Mice","author":"Gereau","year":"2023","journal-title":"bioRxiv."},{"key":"10.1016\/j.addicn.2024.100182_bib0067","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1037\/1064-1297.9.3.307","article-title":"Ketoconazole suppresses food restriction-induced increases in heroin self-administration in rats: sex differences","volume":"9","author":"Carroll","year":"2001","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.addicn.2024.100182_bib0068","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0091-3057(02)01039-0","article-title":"Gender differences in the intravenous self-administration of mu opiate agonists","volume":"74","author":"Cicero","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.addicn.2024.100182_bib0069","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s00213-017-4536-6","article-title":"Oxycodone self-administration in male and female rats","volume":"234","author":"Mavrikaki","year":"2017","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.addicn.2024.100182_bib0070","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.bbi.2020.08.022","article-title":"+)-Naloxone blocks Toll-like receptor 4 to ameliorate deleterious effects of stress on male mouse behaviors","volume":"90","author":"Medina-Rodriguez","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.addicn.2024.100182_bib0071","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1460-9568.2008.06321.x","article-title":"Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)","volume":"28","author":"Hutchinson","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0072","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0193-953X(05)70074-5","article-title":"Gender differences in substance use disorders","volume":"22","author":"Brady","year":"1999","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.addicn.2024.100182_bib0073","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.3109\/10826088509056356","article-title":"Ethnic and gender differences among opiate addicts","volume":"20","author":"Kosten","year":"1985","journal-title":"Int. J. Addict."},{"key":"10.1016\/j.addicn.2024.100182_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.yhbeh.2024.105544","article-title":"Sex mechanisms as nonbinary influences on cognitive diversity","volume":"162","author":"Grissom","year":"2024","journal-title":"Horm. Behav."},{"key":"10.1016\/j.addicn.2024.100182_bib0075","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41593-021-00806-8","article-title":"Considering sex as a biological variable will require a global shift in science culture","volume":"24","author":"Shansky","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0076","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1037\/1064-1297.15.2.134","article-title":"Stress and drug-cue-induced craving in opioid-dependent individuals in naltrexone treatment","volume":"15","author":"Hyman","year":"2007","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.addicn.2024.100182_bib0077","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0376-8716(98)00064-7","article-title":"Drug dependence: stress and dysregulation of brain reward pathways","volume":"51","author":"Kreek","year":"1998","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.addicn.2024.100182_bib0078","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cpr.2017.10.012","article-title":"Sex and gender differences in substance use disorders","volume":"66","author":"McHugh","year":"2018","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.addicn.2024.100182_bib0079","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.copsyc.2018.12.020","article-title":"Comorbidity of opioid-related and anxiety-related symptoms and disorders","volume":"30","author":"Langdon","year":"2019","journal-title":"Curr. Opin. Psychol."},{"key":"10.1016\/j.addicn.2024.100182_bib0080","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/pm\/pnac029","article-title":"Mood and Anxiety Symptoms in Persons Taking Prescription Opioids: a Systematic Review with Meta-Analyses of Longitudinal Studies","volume":"23","author":"Leung","year":"2022","journal-title":"Pain Med."},{"key":"10.1016\/j.addicn.2024.100182_bib0081","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/NMD.0000000000000551","article-title":"The Dark Side of Addiction: the Horsley Gantt to Joseph Brady Connection","volume":"205","author":"Koob","year":"2017","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.addicn.2024.100182_bib0082","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1177\/2167702619855659","article-title":"Anhedonia as a key clinical feature in the maintenance and treatment of opioid use disorder","volume":"7","author":"Kiluk","year":"2019","journal-title":"Clin. Psychol. Sci."},{"key":"10.1016\/j.addicn.2024.100182_bib0083","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1124\/jpet.107.119560","article-title":"Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data","volume":"323","author":"Kalvass","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addicn.2024.100182_bib0084","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s11892-022-01473-0","article-title":"The Clash of Two Epidemics: the Relationship Between Opioids and Glucose Metabolism","volume":"22","author":"Koekkoek","year":"2022","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.addicn.2024.100182_bib0085","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cpr.2015.02.007","article-title":"Psychological interventions for post-traumatic stress disorder and comorbid substance use disorder: a systematic review and meta-analysis","volume":"38","author":"Roberts","year":"2015","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.addicn.2024.100182_bib0086","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/10550887.2013.795467","article-title":"Comorbid Posttraumatic Stress Disorder and Opiate Addiction: a Literature Review","volume":"32","author":"Fareed","year":"2013","journal-title":"J. Addict. Dis."},{"key":"10.1016\/j.addicn.2024.100182_bib0087","doi-asserted-by":"crossref","first-page":"6225","DOI":"10.1523\/JNEUROSCI.20-16-06225.2000","article-title":"The Role of Ventromedial Prefrontal Cortex in the Recovery of Extinguished Fear","volume":"20","author":"Quirk","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0088","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neubiorev.2015.08.017","article-title":"The basolateral amygdala in reward learning and addiction","volume":"57","author":"Wassum","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.addicn.2024.100182_bib0089","doi-asserted-by":"crossref","first-page":"12692","DOI":"10.1073\/pnas.1002418107","article-title":"Optical activation of lateral amygdala pyramidal cells instructs associative fear learning","volume":"107","author":"Johansen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.addicn.2024.100182_bib0090","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cell.2015.06.027","article-title":"Neural Representations of Unconditioned Stimuli in Basolateral Amygdala Mediate Innate and Learned Responses","volume":"162","author":"Gore","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.addicn.2024.100182_bib0091","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24031929","article-title":"Opioid-Induced Reductions in Amygdala Lateral Paracapsular GABA Neuron Circuit Activity","volume":"24","author":"Ronstr\u00f6m","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addicn.2024.100182_bib0092","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.nlm.2015.11.006","article-title":"Behavioral and neurophysiological evidence that lateral paracapsular GABAergic synapses in the basolateral amygdala contribute to the acquisition and extinction of fear learning","volume":"127","author":"Skelly","year":"2016","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.addicn.2024.100182_bib0093","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.tins.2016.03.004","article-title":"Prefrontal Cortical Opioids and Dysregulated Motivation: a Network Hypothesis","volume":"39","author":"Baldo","year":"2016","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0094","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/npp.2015.211","article-title":"Opiate Exposure State Controls a D2-CaMKII\u03b1-Dependent Memory Switch in the Amygdala-Prefrontal Cortical Circuit","volume":"41","author":"Rosen","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.addicn.2024.100182_bib0095","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.857550","article-title":"Chronic Alcohol Dysregulates Glutamatergic Function in the Basolateral Amygdala in a Projection-and Sex-Specific Manner","volume":"16","author":"Price","year":"2022","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0096","doi-asserted-by":"crossref","first-page":"13649","DOI":"10.1523\/JNEUROSCI.1792-08.2008","article-title":"Spike-rate coding and spike-time coding are affected oppositely by different adaptation mechanisms","volume":"28","author":"Prescott","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0097","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1113\/jphysiol.2012.237453","article-title":"Postnatal development of electrophysiological properties of principal neurons in the rat basolateral amygdala","volume":"590","author":"Ehrlich","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.addicn.2024.100182_bib0098","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1113\/jphysiol.2011.223784","article-title":"Acute stress induces down-regulation of large-conductance Ca2+-activated potassium channels in the lateral amygdala","volume":"590","author":"Guo","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.addicn.2024.100182_bib0099","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/npp.2014.60","article-title":"Distinct effects of repeated restraint stress on basolateral amygdala neuronal membrane properties in resilient adolescent and adult rats","volume":"39","author":"Hetzel","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.addicn.2024.100182_bib0100","doi-asserted-by":"crossref","first-page":"9730","DOI":"10.1523\/JNEUROSCI.0384-15.2015","article-title":"Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress","volume":"35","author":"Rau","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.addicn.2024.100182_bib0101","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biopsych.2019.05.023","article-title":"Neurobiology of Opioid Addiction: opponent Process, Hyperkatifeia, and Negative Reinforcement","volume":"87","author":"Koob","year":"2020","journal-title":"Biol. Psychiatry"}],"container-title":["Addiction Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772392524000415?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772392524000415?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T03:31:02Z","timestamp":1754105462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772392524000415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":101,"alternative-id":["S2772392524000415"],"URL":"https:\/\/doi.org\/10.1016\/j.addicn.2024.100182","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.11.28.569085","asserted-by":"object"}]},"ISSN":["2772-3925"],"issn-type":[{"value":"2772-3925","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral fentanyl consumption and withdrawal impairs fear extinction learning and enhances basolateral amygdala principal neuron excitatory-inhibitory balance in male and female mice","name":"articletitle","label":"Article Title"},{"value":"Addiction Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addicn.2024.100182","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100182"}}