{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:15:37Z","timestamp":1789805737313,"version":"4.0.1"},"reference-count":113,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Addiction Neuroscience"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.addicn.2026.100263","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:41:37Z","timestamp":1781246497000},"page":"100263","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Nicotine self-administration suppresses both pro- and anti-inflammatory accumbens cytokines but does not induce apoptosis in female rats"],"prefix":"10.1016","volume":"20","author":[{"given":"Ashley M.","family":"White","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl L.","family":"Richie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Percell T.","family":"Kendrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen R.","family":"McNealy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Flight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunter N.B.","family":"Moseley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa L.","family":"Corley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2372-9323","authenticated-orcid":false,"given":"Cassandra D.","family":"Gipson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.addicn.2026.100263_bib0001","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/aje\/kwt335","article-title":"The 2014 Surgeon General's report: commemorating the 50th Anniversary of the 1964 Report of the Advisory Committee to the US Surgeon General and updating the evidence on the health consequences of cigarette smoking","volume":"179","author":"Alberg","year":"2014","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.addicn.2026.100263_bib0002","article-title":"Centers for Disease Control and Prevention (US); National Center for Chronic Disease Prevention and Health Promotion (US); Office on Smoking and Health (US). A Report of the Surgeon General","year":"2010","journal-title":"How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease"},{"key":"10.1016\/j.addicn.2026.100263_bib0003","article-title":"QuickStats: number of Deaths from 10 Leading Causes\u2014National Vital Statistics System, United States","year":"2010","journal-title":"Morbidity Mortality Weekly Report"},{"issue":"24","key":"10.1016\/j.addicn.2026.100263_bib0004","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1001\/jama.2020.6647","article-title":"Smoking cessation-progress, barriers, and new opportunities: the surgeon general's report on smoking cessation","volume":"323","author":"Adams","year":"2020","journal-title":"JAMA, J. Am. Med. Assoc."},{"issue":"2","key":"10.1016\/j.addicn.2026.100263_bib0005","first-page":"384","article-title":"Re: smoking Cessation: a Report of the Surgeon General","volume":"204","author":"Chang","year":"2020","journal-title":"J. Urol."},{"issue":"13","key":"10.1016\/j.addicn.2026.100263_bib0006","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1002\/cncr.28695","article-title":"The 2014 Surgeon General's report: \"The health consequences of smoking\u201350 years of progress\": a paradigm shift in cancer care","volume":"120","author":"Warren","year":"2014","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.addicn.2026.100263_bib0007","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/BF02245088","article-title":"The scientific case that nicotine is addictive","volume":"117","author":"Stolerman","year":"1995","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.addicn.2026.100263_bib0008","doi-asserted-by":"crossref","first-page":"633","DOI":"10.15585\/mmwr.mm7329a1","article-title":"Adult Adult Smoking Cessation \u2014 United States, 2022","volume":"73","author":"VanFrank B","year":"2024","journal-title":"MMWR. Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.addicn.2026.100263_bib0009","doi-asserted-by":"crossref","DOI":"10.1001\/jamapsychiatry.2025.1976","article-title":"Cigarette Smoking During Recovery From Substance Use Disorders","author":"Parks","year":"2025","journal-title":"JAMa Psychiatry"},{"issue":"4","key":"10.1016\/j.addicn.2026.100263_bib0010","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1136\/tc.2005.015487","article-title":"Nicotine replacement therapy for long-term smoking cessation: a meta-analysis","volume":"15","author":"Etter","year":"2006","journal-title":"Tob. Control"},{"issue":"12","key":"10.1016\/j.addicn.2026.100263_bib0011","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.addbeh.2008.05.012","article-title":"Relapse to smoking after 1 year of abstinence: a meta-analysis","volume":"33","author":"Hughes","year":"2008","journal-title":"Addict. Behav."},{"key":"10.1016\/j.addicn.2026.100263_bib0012","doi-asserted-by":"crossref","DOI":"10.4178\/epih.e2021043","article-title":"Patterns and predictors of smoking relapse among inpatient smoking intervention participants: a 1-year follow-up study in Korea","volume":"43","author":"Lee","year":"2021","journal-title":"Epidemiol. Health"},{"key":"10.1016\/j.addicn.2026.100263_bib0013","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1186\/1471-2458-13-592","article-title":"Long-term follow-up of a high- and a low-intensity smoking cessation intervention in a dental setting\u2013a randomized trial","volume":"13","author":"Nohlert","year":"2013","journal-title":"BMC Public Health"},{"issue":"8000","key":"10.1016\/j.addicn.2026.100263_bib0014","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41586-023-06968-8","article-title":"Smoking changes adaptive immunity with persistent effects","volume":"626","author":"Saint-Andr\u00e9","year":"2024","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.addicn.2026.100263_bib0015","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bpsgos.2023.08.019","article-title":"The role of microglia in sex- and region-specific blood-brain barrier integrity during nicotine withdrawal","volume":"4","author":"Kumar","year":"2024","journal-title":"Biol. Psychiatry Glob. Open. Sci."},{"issue":"10","key":"10.1016\/j.addicn.2026.100263_bib0016","doi-asserted-by":"crossref","first-page":"eaax7031","DOI":"10.1126\/sciadv.aax7031","article-title":"Microglia morphology and proinflammatory signaling in the nucleus accumbens during nicotine withdrawal","volume":"5","author":"Adeluyi","year":"2019","journal-title":"Sci. Adv."},{"issue":"3","key":"10.1016\/j.addicn.2026.100263_bib0017","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.4049\/jimmunol.182.3.1730","article-title":"Nicotinic attenuation of central nervous system inflammation and autoimmunity","volume":"182","author":"Shi","year":"2009","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.addicn.2026.100263_bib0018","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1365-2567.2003.01655.x","article-title":"Evidence for the immunosuppressive role of nicotine on human dendritic cell functions","volume":"109","author":"Nouri-Shirazi","year":"2003","journal-title":"Immunology"},{"issue":"5","key":"10.1016\/j.addicn.2026.100263_bib0019","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12797","article-title":"Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine-seeking behavior","volume":"25","author":"Namba","year":"2020","journal-title":"Addict. Biol."},{"key":"10.1016\/j.addicn.2026.100263_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1570565","article-title":"Toward understanding sexual immune dimorphism in humans","volume":"16","author":"Nowak","year":"2025","journal-title":"Front. Immunol."},{"issue":"6760","key":"10.1016\/j.addicn.2026.100263_bib0021","first-page":"599","article-title":"Sex differences in tissue-specific immunity and immunology","volume":"389","author":"Sharma","year":"2025","journal-title":"Science (1979)"},{"issue":"10","key":"10.1016\/j.addicn.2026.100263_bib0022","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.addicn.2026.100263_bib0023","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1037\/1064-1297.15.1.21","article-title":"Gender differences in acute tobacco withdrawal: effects on subjective, cognitive, and physiological measures","volume":"15","author":"Leventhal","year":"2007","journal-title":"Exp. Clin. Psychopharmacol."},{"issue":"4","key":"10.1016\/j.addicn.2026.100263_bib0024","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0306-4603(96)00063-9","article-title":"Gender differences in the outcome of an unaided smoking cessation attempt","volume":"22","author":"Ward","year":"1997","journal-title":"Addict. Behav."},{"key":"10.1016\/j.addicn.2026.100263_bib0025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ypmed.2016.07.013","article-title":"Sex\/gender differences in smoking cessation: a review","volume":"92","author":"Smith","year":"2016","journal-title":"Prev. Med."},{"issue":"5","key":"10.1016\/j.addicn.2026.100263_bib0026","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1093\/ntr\/ntv207","article-title":"Sex Differences in Varenicline Efficacy for Smoking Cessation: a Meta-Analysis","volume":"18","author":"McKee","year":"2016","journal-title":"Nicotine Tob. Res."},{"issue":"4","key":"10.1016\/j.addicn.2026.100263_bib0027","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/14622299050011431","article-title":"Sex differences in nicotine effects and self-administration: review of human and animal evidence","volume":"1","author":"Perkins","year":"1999","journal-title":"Nicotine Tob. Res."},{"issue":"1","key":"10.1016\/j.addicn.2026.100263_bib0028","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s40429-013-0003-6","article-title":"Women and Smoking: the Effect of Gender on the Epidemiology, Health Effects, and Cessation of Smoking","volume":"1","author":"Allen","year":"2014","journal-title":"Curr. Addict. Rep."},{"issue":"6663","key":"10.1016\/j.addicn.2026.100263_bib0029","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/34413","article-title":"Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine","volume":"391","author":"Picciotto","year":"1998","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.addicn.2026.100263_bib0030","doi-asserted-by":"crossref","first-page":"9124","DOI":"10.1073\/pnas.1220591110","article-title":"Reinstatement of nicotine seeking is mediated by glutamatergic plasticity","volume":"110","author":"Gipson","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"7","key":"10.1016\/j.addicn.2026.100263_bib0031","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s00213-018-4879-7","article-title":"Pharmacological modulation of the \u03b17 nicotinic acetylcholine receptor in a mouse model of mecamylamine-precipitated nicotine withdrawal","volume":"235","author":"Jackson","year":"2018","journal-title":"Psychopharmacology (Berl)"},{"issue":"50","key":"10.1016\/j.addicn.2026.100263_bib0032","doi-asserted-by":"crossref","first-page":"11244","DOI":"10.1523\/JNEUROSCI.3009-04.2004","article-title":"Precise localization of alpha7 nicotinic acetylcholine receptors on glutamatergic axon terminals in the rat ventral tegmental area","volume":"24","author":"Jones","year":"2004","journal-title":"J. Neurosci."},{"issue":"7340","key":"10.1016\/j.addicn.2026.100263_bib0033","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nature09797","article-title":"Habenular alpha5 nicotinic receptor subunit signalling controls nicotine intake","volume":"471","author":"Fowler","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.addicn.2026.100263_bib0034","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1124\/pr.116.012484","article-title":"The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis","volume":"68","author":"Scofield","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.addicn.2026.100263_bib0035","first-page":"466","article-title":"Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction","volume":"8","author":"van Huijstee","year":"2014","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.addicn.2026.100263_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2025.106994","article-title":"Immune control of the basal ganglia network: interleukin-17 as a key modulator of striatal synaptic plasticity","volume":"213","author":"Mancini","year":"2025","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.addicn.2026.100263_bib0037","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/npp.2016.199","article-title":"Inflammation, glutamate, and glia: a trio of trouble in mood disorders","volume":"42","author":"Haroon","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"10","key":"10.1016\/j.addicn.2026.100263_bib0038","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1002\/jnr.21325","article-title":"Neuroinflammation and regulation of glial glutamate uptake in neurological disorders","volume":"85","author":"Tilleux","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.addicn.2026.100263_bib0039","first-page":"397","article-title":"Nicotine is an Immunosuppressant: implications for Women's Health and Disease","author":"White","year":"2024","journal-title":"J. Neuroimmunol."},{"issue":"3","key":"10.1016\/j.addicn.2026.100263_bib0040","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0286-21.2022","article-title":"Ovarian hormones regulate nicotine consumption and accumbens glutamatergic plasticity in female rats","volume":"9","author":"Maher","year":"2022","journal-title":"eNeuro"},{"issue":"1","key":"10.1016\/j.addicn.2026.100263_bib0041","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s12974-016-0725-1","article-title":"Immunomodulatory effects of nicotine on interleukin 1\u03b2 activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism","volume":"13","author":"Revathikumar","year":"2016","journal-title":"J. Neuroinflammation"},{"issue":"12","key":"10.1016\/j.addicn.2026.100263_bib0042","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.130181","article-title":"Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage","volume":"3","author":"Sheridan","year":"2013","journal-title":"Open. Biol."},{"issue":"1","key":"10.1016\/j.addicn.2026.100263_bib0043","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2174\/1389203711314010004","article-title":"Neuron-microglia interaction in neuroinflammation","volume":"14","author":"Suzumura","year":"2013","journal-title":"Curr. Protein Pept. Sci."},{"issue":"3","key":"10.1016\/j.addicn.2026.100263_bib0044","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H","article-title":"TNF alpha and the TNF receptor superfamily: structure-function relationship(s)","volume":"50","author":"Idriss","year":"2000","journal-title":"Microsc. Res. Tech."},{"issue":"7","key":"10.1016\/j.addicn.2026.100263_bib0045","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/89490","article-title":"CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity","volume":"4","author":"Bezzi","year":"2001","journal-title":"Nat. Neurosci."},{"issue":"30","key":"10.1016\/j.addicn.2026.100263_bib0046","doi-asserted-by":"crossref","first-page":"21362","DOI":"10.1074\/jbc.M600504200","article-title":"Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner","volume":"281","author":"Takeuchi","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.addicn.2026.100263_bib0047","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/0304-3940(92)90071-E","article-title":"Tumor necrosis factor alters synaptic transmission in rat hippocampal slices","volume":"146","author":"Tancredi","year":"1992","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.addicn.2026.100263_bib0048","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1006\/frne.2001.0214","article-title":"Chemokines and their receptors in the central nervous system","volume":"22","author":"Bajetto","year":"2001","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.addicn.2026.100263_bib0049","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainresbull.2018.11.017","article-title":"Fractalkine\/CX3CR1 is involved in the cross-talk between neuron and glia in neurological diseases","volume":"146","author":"Luo","year":"2019","journal-title":"Brain Res. Bull."},{"issue":"2","key":"10.1016\/j.addicn.2026.100263_bib0050","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0014-5793(98)00583-3","article-title":"Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?","volume":"429","author":"Nishiyori","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.addicn.2026.100263_bib0051","article-title":"Fractalkine Mediates Communication between Pathogenic Proteins and Microglia: implications of Anti-Inflammatory Treatments in Different Stages of Neurodegenerative Diseases","volume":"2012","author":"Desforges","year":"2012","journal-title":"Int. J. Alzheimers. Dis."},{"key":"10.1016\/j.addicn.2026.100263_bib0052","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3389\/fncel.2014.00360","article-title":"Fractalkine is a \"find-me\" signal released by neurons undergoing ethanol-induced apoptosis","volume":"8","author":"Sokolowski","year":"2014","journal-title":"Front. Cell Neurosci."},{"issue":"3","key":"10.1016\/j.addicn.2026.100263_bib0053","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00213-006-0441-0","article-title":"Guidelines on nicotine dose selection for in vivo research","volume":"190","author":"Matta","year":"2007","journal-title":"Psychopharmacology (Berl.)"},{"issue":"2","key":"10.1016\/j.addicn.2026.100263_bib0054","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1037\/pha0000670","article-title":"Xylazine suppresses fentanyl consumption during self-administration and induces a unique sex-specific withdrawal syndrome that is not altered by naloxone in rats","volume":"32","author":"Khatri","year":"2024","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.addicn.2026.100263_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108756","article-title":"Natural and synthetic estrogens specifically alter nicotine demand and cue-induced nicotine seeking in female rats","volume":"198","author":"Maher","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.addicn.2026.100263_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2023.110983","article-title":"Synthetic contraceptive hormones occlude the ability of nicotine to reduce ethanol consumption in ovary-intact female rats","volume":"252","author":"Maher","year":"2023","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.addicn.2026.100263_bib0057","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.maturitas.2016.01.015","article-title":"Modeling menopause: the utility of rodents in translational behavioral endocrinology research","volume":"87","author":"Koebele","year":"2016","journal-title":"Maturitas"},{"key":"10.1016\/j.addicn.2026.100263_bib0058","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.brainres.2013.01.020","article-title":"Translational cognitive endocrinology: designing rodent experiments with the goal to ultimately enhance cognitive health in women","volume":"1514","author":"Mennenga","year":"2013","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.addicn.2026.100263_bib0059","first-page":"619","article-title":"Fractin immunostaining for the detection of apoptotic cells and apoptotic bodies in formalin-fixed and paraffin-embedded tissue","volume":"79","author":"Suurmeijer","year":"1999","journal-title":"Lab. Invest."},{"key":"10.1016\/j.addicn.2026.100263_bib0060","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/2051-5960-2-16","article-title":"Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury","volume":"2","author":"Sokolowski","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"issue":"2","key":"10.1016\/j.addicn.2026.100263_bib0061","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0165-0270(80)90021-7","article-title":"AChE-stained horizontal sections of the rat brain in stereotaxic coordinates","volume":"3","author":"Paxinos","year":"1980","journal-title":"J. Neurosci. Methods"},{"issue":"43","key":"10.1016\/j.addicn.2026.100263_bib0062","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.21105\/joss.01686","article-title":"Welcome to the Tidyverse","volume":"4","author":"Wickham","year":"2019","journal-title":"J. Open. Source Softw."},{"key":"10.1016\/j.addicn.2026.100263_bib0063","unstructured":"R Core Development Team, R: a language and environment for statistical computing. 2025, R Foundation for Statistical Computing: vienna, Austria."},{"issue":"1","key":"10.1016\/j.addicn.2026.100263_bib0064","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J. Stat. Softw."},{"issue":"13","key":"10.1016\/j.addicn.2026.100263_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v082.i13","article-title":"Tests in linear mixed effects models","volume":"82","author":"Kuznetsova","year":"2017","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.addicn.2026.100263_bib0066","article-title":"emmeans: estimated Marginal Means, aka Least-Squares Means_","author":"Lenth","year":"2023","journal-title":"R package version 1.8. 5"},{"issue":"2","key":"10.1016\/j.addicn.2026.100263_bib0067","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.lmot.2008.10.004","article-title":"Mixed effects modeling of Morris water maze data: advantages and cautionary notes","volume":"40","author":"Young","year":"2009","journal-title":"Learn Motiv"},{"issue":"2","key":"10.1016\/j.addicn.2026.100263_bib0068","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/jeab.316","article-title":"Discounting: a practical guide to multilevel analysis of choice data","volume":"109","author":"Young","year":"2018","journal-title":"J. Exp. Anal. Behav."},{"key":"10.1016\/j.addicn.2026.100263_bib0069","article-title":"Information-content-informed kendall-tau correlation methodology: interpreting missing values as useful information","author":"Flight","year":"2025","journal-title":"bioRxiv."},{"issue":"4","key":"10.1016\/j.addicn.2026.100263_bib0070","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.immuni.2024.03.012","article-title":"The NLR family of innate immune and cell death sensors","volume":"57","author":"Sundaram","year":"2024","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.addicn.2026.100263_bib0071","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jmb.2017.09.019","article-title":"How inflammasomes inform adaptive immunity","volume":"430","author":"Evavold","year":"2018","journal-title":"J. Mol. Biol."},{"issue":"44","key":"10.1016\/j.addicn.2026.100263_bib0072","doi-asserted-by":"crossref","first-page":"27715","DOI":"10.1074\/jbc.271.44.27715","article-title":"Brain glutamate transporter proteins form homomultimers","volume":"271","author":"Haugeto","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.addicn.2026.100263_bib0073","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.neuron.2016.03.030","article-title":"Microglial TNF-\u03b1 suppresses cocaine-induced plasticity and behavioral sensitization","volume":"90","author":"Lewitus","year":"2016","journal-title":"Neuron"},{"issue":"41","key":"10.1016\/j.addicn.2026.100263_bib0074","doi-asserted-by":"crossref","first-page":"37993","DOI":"10.1074\/jbc.M106434200","article-title":"Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)","volume":"276","author":"Garton","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.addicn.2026.100263_bib0075","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.it.2011.05.005","article-title":"ADAM17: a molecular switch to control inflammation and tissue regeneration","volume":"32","author":"Scheller","year":"2011","journal-title":"Trends. Immunol."},{"key":"10.1016\/j.addicn.2026.100263_bib0076","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2147\/ITT.S277991","article-title":"Emerging role of fractalkine in the treatment of rheumatic diseases","volume":"9","author":"Tanaka","year":"2020","journal-title":"Immunotargets. Ther."},{"key":"10.1016\/j.addicn.2026.100263_bib0077","article-title":"Immunomodulatory role of metalloproteinase ADAM17 in tumor development","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.addicn.2026.100263_bib0078","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1517\/14728222.11.10.1287","article-title":"Tackling EGFR signaling with TACE antagonists: a rational target for metalloprotease inhibitors in cancer","volume":"11","author":"Kenny","year":"2007","journal-title":"Expert Opin. Ther. Targets"},{"issue":"5","key":"10.1016\/j.addicn.2026.100263_bib0079","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1747-0285.2010.00950.x","article-title":"Tumor necrosis factor alpha converting enzyme: an encouraging target for various inflammatory disorders","volume":"75","author":"Bahia","year":"2010","journal-title":"Chem. Biol. Drug Des."},{"issue":"3","key":"10.1016\/j.addicn.2026.100263_bib0080","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41419-024-06559-z","article-title":"Cellular heterogeneity in TNF\/TNFR1 signalling: live cell imaging of cell fate decisions in single cells","volume":"15","author":"Preedy","year":"2024","journal-title":"Cell Death. Dis."},{"issue":"3","key":"10.1016\/j.addicn.2026.100263_bib0081","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.smim.2014.05.004","article-title":"Regulation of NF-\u03baB by TNF family cytokines","volume":"26","author":"Hayden","year":"2014","journal-title":"Semin. Immunol."},{"issue":"5","key":"10.1016\/j.addicn.2026.100263_bib0082","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41577-022-00792-3","article-title":"Death by TNF: a road to inflammation","volume":"23","author":"van Loo","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.addicn.2026.100263_bib0083","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1213448","article-title":"Role of tumor necrosis factor-alpha in the central nervous system: a focus on autoimmune disorders","volume":"14","author":"Gonzalez Caldito","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.addicn.2026.100263_bib0084","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbi.2017.01.021","article-title":"Peripheral inflammatory cytokines and immune balance in Generalised Anxiety Disorder: case-controlled study","volume":"62","author":"Hou","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.addicn.2026.100263_bib0085","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.addicn.2026.100263_bib0086","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2022.110581","article-title":"Peripheral blood inflammatory markers in patients with attention deficit\/hyperactivity disorder (ADHD): a systematic review and meta-analysis","volume":"118","author":"Misiak","year":"2022","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.addicn.2026.100263_bib0087","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bbi.2015.12.017","article-title":"Intracerebroventricular administration of TNF-like weak inducer of apoptosis induces depression-like behavior and cognitive dysfunction in non-autoimmune mice","volume":"54","author":"Wen","year":"2016","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.addicn.2026.100263_bib0088","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/npp.2014.199","article-title":"Effects of centrally administered etanercept on behavior, microglia, and astrocytes in mice following a peripheral immune challenge","volume":"40","author":"Camara","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.addicn.2026.100263_bib0089","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bbi.2018.11.316","article-title":"Brain tumor necrosis factor-alpha mediates anxiety-like behavior in a mouse model of severe obesity","volume":"77","author":"Fourrier","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"7","key":"10.1016\/j.addicn.2026.100263_bib0090","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/cdd.2015.176","article-title":"Inflammasome-dependent IL-1beta release depends upon membrane permeabilisation","volume":"23","author":"Martin-Sanchez","year":"2016","journal-title":"Cell Death. Differ."},{"issue":"13","key":"10.1016\/j.addicn.2026.100263_bib0091","first-page":"20","article-title":"The NLRP3 inflammasome: an overview of mechanisms of activation and regulation","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addicn.2026.100263_bib0092","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jss.2017.05.119","article-title":"Naloxone inhibits nod-like receptor protein 3 inflammasome","volume":"219","author":"Lin","year":"2017","journal-title":"J. Surg. Res."},{"issue":"2","key":"10.1016\/j.addicn.2026.100263_bib0093","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s11481-018-9780-y","article-title":"Inflammasome activation by methamphetamine potentiates lipopolysaccharide stimulation of IL-1beta production in microglia","volume":"13","author":"Xu","year":"2018","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.addicn.2026.100263_bib0094","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107840","article-title":"Cocaine-induced changes in CX(3)CL1 and inflammatory signaling pathways in the hippocampus: association with IL1beta","volume":"162","author":"Montesinos","year":"2020","journal-title":"Neuropharmacology."},{"issue":"4","key":"10.1016\/j.addicn.2026.100263_bib0095","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3934\/Neuroscience.2020025","article-title":"Neuroimmunomodulation by estrogen in health and disease","volume":"7","author":"Priyanka","year":"2020","journal-title":"AIMS Neurosci."},{"issue":"6","key":"10.1016\/j.addicn.2026.100263_bib0096","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036890","article-title":"Estrogen modulates NF\u03baB signaling by enhancing I\u03baB\u03b1 levels and blocking p65 binding at the promoters of inflammatory genes via estrogen receptor-\u03b2","volume":"7","author":"Xing","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.addicn.2026.100263_bib0097","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1165\/ajrcmb.17.1.f132","article-title":"The role of nuclear factor-kappa B in cytokine gene regulation","volume":"17","author":"Blackwell","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"3","key":"10.1016\/j.addicn.2026.100263_bib0098","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1007\/s12035-022-03152-3","article-title":"The interaction between NF-\u03baB and estrogen in Alzheimer's Disease","volume":"60","author":"Mishra","year":"2023","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.addicn.2026.100263_bib0099","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/cns.12538","article-title":"Neuroprotective role of steroidal sex hormones: an overview","volume":"22","author":"Siddiqui","year":"2016","journal-title":"CNS. Neurosci. Ther."},{"issue":"10","key":"10.1016\/j.addicn.2026.100263_bib0100","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1124\/dmd.107.016568","article-title":"Human CYP2A6 is induced by estrogen via estrogen receptor","volume":"35","author":"Higashi","year":"2007","journal-title":"Drug Metab. Dispos."},{"issue":"2","key":"10.1016\/j.addicn.2026.100263_bib0101","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/10550887.2011.554782","article-title":"Nicotine addiction causes unique detrimental effects on women's brains","volume":"30","author":"Raval","year":"2011","journal-title":"J. Addict. Dis."},{"issue":"2","key":"10.1016\/j.addicn.2026.100263_bib0102","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0893-133X(00)00195-0","article-title":"Drug addiction, dysregulation of reward, and allostasis","volume":"24","author":"Koob","year":"2001","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.addicn.2026.100263_bib0103","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0091-3057(96)00438-8","article-title":"Opponent process model and psychostimulant addiction","volume":"57","author":"Koob","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2","key":"10.1016\/j.addicn.2026.100263_bib0104","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1037\/h0036128","article-title":"An opponent-process theory of motivation. I. Temporal dynamics of affect","volume":"81","author":"Solomon","year":"1974","journal-title":"Psychol. Rev."},{"issue":"2\u20133","key":"10.1016\/j.addicn.2026.100263_bib0105","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.drugalcdep.2010.12.027","article-title":"Within-day temporal patterns of smoking, withdrawal symptoms, and craving","volume":"117","author":"Chandra","year":"2011","journal-title":"Drug Alcohol Depend."},{"issue":"7","key":"10.1016\/j.addicn.2026.100263_bib0106","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s00011-011-0323-8","article-title":"Anti-inflammatory properties of N-acetylcysteine on lipopolysaccharide-activated macrophages","volume":"60","author":"Palacio","year":"2011","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.addicn.2026.100263_bib0107","article-title":"Chronic intermittent ethanol and lipopolysaccharide exposure differentially alter Iba1-derived microglia morphology in the prelimbic cortex and nucleus accumbens core of male Long-Evans rats","author":"Siemsen","year":"2020","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.addicn.2026.100263_bib0108","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2025.110681","article-title":"Contraceptive hormone ethinyl estradiol but not levonorgestrel modulates the role of reinforcer-enhancement in nicotine self-administration in ovary-intact female Sprague-Dawley rats","volume":"280","author":"McNealy","year":"2025","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.addicn.2026.100263_bib0109","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s00213-005-2152-3","article-title":"Sex differences in the contribution of nicotine and nonpharmacological stimuli to nicotine self-administration in rats","volume":"180","author":"Chaudhri","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"issue":"3","key":"10.1016\/j.addicn.2026.100263_bib0110","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00213-006-0441-0","article-title":"Guidelines on nicotine dose selection for in vivo research","volume":"190","author":"Matta","year":"2007","journal-title":"Psychopharmacology. (Berl)"},{"key":"10.1016\/j.addicn.2026.100263_bib0111","doi-asserted-by":"crossref","DOI":"10.1016\/j.yhbeh.2024.105506","article-title":"Repeated exposure to physiologically effective doses of contraceptive hormones ethinyl estradiol or levonorgestrel do not alter the reinforcing effects of a brief visual stimulus in ovary-intact rats","volume":"161","author":"McNealy","year":"2024","journal-title":"Horm. Behav."},{"key":"10.1016\/j.addicn.2026.100263_bib0112","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1037\/h0046708","article-title":"Stimulus complexity and sensory reinforcement","volume":"54","author":"Barnes","year":"1961","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.addicn.2026.100263_bib0113","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1037\/h0046113","article-title":"Some effects of light upon the behavior of rodents","volume":"60","author":"Lockard","year":"1963","journal-title":"Psychol. Bull."}],"container-title":["Addiction Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772392526000155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772392526000155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:48:35Z","timestamp":1789804115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772392526000155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":113,"alternative-id":["S2772392526000155"],"URL":"https:\/\/doi.org\/10.1016\/j.addicn.2026.100263","relation":{},"ISSN":["2772-3925"],"issn-type":[{"value":"2772-3925","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicotine self-administration suppresses both pro- and anti-inflammatory accumbens cytokines but does not induce apoptosis in female rats","name":"articletitle","label":"Article Title"},{"value":"Addiction Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addicn.2026.100263","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100263"}}